Article
Food Science & Technology
Winnie-Pui-Pui Liew, Mohd-Redzwan Sabran, Leslie-Thian-Lung Than, Fauzah Abd-Ghani
Summary: This study investigated the modulation of gut microbiota and proteome in rats exposed to aflatoxin B1 (AFB1) and treated with probiotic Lactobacillus casei Shirota (Lcs). The results showed that Lcs intervention significantly reduced AFB1 biomarkers and alleviated inflammation and abnormal cell growth caused by AFB1.
FOOD AND CHEMICAL TOXICOLOGY
(2022)
Article
Multidisciplinary Sciences
Li-Han Chen, Chun-Hsu Pan, Shih-Yi Huang, Ching-Hung Chan, Hui-Yu Huang
Summary: This study found that the immunomodulatory effects of Lactobacillus casei Shirota fermented beverage (LcSFB) depend on the mode of antigen presentation, enhancing immune response in mice injected with OVA, but attenuating it in mice treated with injection plus intranasal administration.
SCIENTIFIC REPORTS
(2021)
Article
Biotechnology & Applied Microbiology
Ren Yan, Kaicen Wang, Qiangqiang Wang, Huiyong Jiang, Yingfeng Lu, Xiaoxiao Chen, Hua Zhang, Xiaoling Su, Yiling Du, Lifeng Chen, Lanjuan Li, Longxian Lv
Summary: The study investigated the effects of Lactobacillus casei strain Shirota (LcS) on acute liver injury (ALI) and its underlying mechanism. Results showed that pretreatment with LcS reduced hepatic and intestinal damage, lowered inflammatory cytokines levels, and modulated gut microbiota, metabolome and transcriptome profiles. These findings indicate the potential therapeutic benefits of LcS in treating liver diseases, especially ALI.
MICROBIAL BIOTECHNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Guoqiang Yao, Chenxia Cao, Meng Zhang, Lai-Yu Kwok, Heping Zhang, Wenyi Zhang
Summary: The study showed that probiotics can help restore the balance of host gut microbiota and metabolome after antibiotic treatment, with increases in certain microbial populations and short-chain fatty acid levels after antibiotic and probiotic intervention, beneficial bacteria P. goldsteinii strongly correlated with lactobacilli, and probiotics also reduced inflammation levels in rats.
COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL
(2021)
Article
Physiology
Chao Mai, Li Qiu, Yong Zeng, Xingqin Tan
Summary: In this study, it was found that Lactobacillus casei strain Shirota (LcS) enhanced the ability of geniposide to reduce sepsis, inflammation, and oxidative stress by regulating SIRT1 pathway, resulting in decreased inflammatory and oxidative damage in septic mice, similar to the effect of dexamethasone.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Nutrition & Dietetics
Zhe Zhang, Hui Zhou, Meiyu Guan, Xiaohong Zhou, Xi Liang, Youyou Lv, Lu Bai, Junxue Zhang, Pimin Gong, Tongjie Liu, Huaxi Yi, Jingfeng Wang, Lanwei Zhang
Summary: The study found that administration of probiotics and plant extracts significantly improved blood lipid levels and protected liver structure in patients with non-alcoholic fatty liver disease, especially the combination of L. casei YRL577 with TP had a better effect in improving the condition and regulating gene expression.
BRITISH JOURNAL OF NUTRITION
(2021)
Review
Pharmacology & Pharmacy
Chong Song, Xian Long, Jianbin He, Yongpan Huang
Summary: Non-alcoholic fatty liver disease (NAFLD) is a common chronic metabolic liver disorder characterized by fat accumulation in the liver. Inflammation is a significant mechanism that can lead to cell death and tissue injury in NAFLD. Inhibition of inflammation improves NAFLD by reducing fat content, inducing hepato-protective autophagy, overexpressing peroxisome proliferator-activated receptor- gamma (PPAR-gamma), and increasing insulin sensitivity. Understanding the molecular mechanisms and signaling pathways in NAFLD is crucial for its prevention and treatment.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Tomomi Yamazaki, Megumi Ihato
Summary: PPAR-alpha prevents fatty liver caused by excessive sucrose intake through regulating SREBP-1c target gene expression and liver TG accumulation. Gender differences may be related to the expression level of PPAR-gamma.
Article
Cell Biology
Lihui Zhu, Rongrong Liao, Jiwen Huang, Changfeng Xiao, Yunzhou Yang, Huiying Wang, Daqian He, Huaxiang Yan, Changsuo Yang
Summary: This study translated a new probiotic strain, Lactobacillus salivarius SNK-6, that has shown efficacy in alleviating nonalcoholic fatty liver disease (NAFLD), and found that it alleviates liver damage through the miR-130a-5p/MBOAT2 signaling pathway.
Article
Cell Biology
Yongqiang Ma, Zhi Tan, Qiang Li, Wenling Fan, Guangshun Chen, Yangyang Bin, Yi Zhou, Junfang Yi, Xiaohua Luo, Jieqiong Tan, Zhongzhou Si, Jiequn Li
Summary: By comparing liver gene expression between FXR knockout mice and MAFLD patients, this study identified new pathogenic pathways and target genes, shedding light on the pathogenesis of MAFLD. These findings may provide new insights into the pathophysiology of MAFLD and offer novel therapeutic targets for the future.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Cell Biology
Daisuke Aibara, Ai Sakaguchi, Kimihiko Matsusue
Summary: Oxysterol-binding protein-like 3 (OSBPL3) is highly expressed in fatty liver disease in humans and mice. It is also highly expressed in different mouse models of fatty liver disease and is associated with advanced non-alcoholic fatty liver disease (NAFLD) in humans. PPAR gamma positively regulates Osbpl3 transcription by binding to specific elements in its upstream region.
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2023)
Article
Endocrinology & Metabolism
Chenxiao Zhang, Tengfei Ma, Chang Liu, Ding Ma, Jian Wang, Meng Liu, Jinjun Ran, Xueting Wang, Xiaobei Deng
Summary: PM2.5 exposure can lead to extensive metabolic disturbances, particularly in lipid and amino acid metabolism. It is associated with the enrichment of disease pathways and signaling pathways related to non-alcoholic fatty liver disease, type II diabetes mellitus, TGF-beta, AMPK, and mTOR. Accumulation of acylcarnitine in liver tissue restricts lipid consumption and contributes to hepatic steatosis. The aberrant expression of key transcription factors, such as PPARs and SREBP1, may play a regulatory role in lipid metabolic disorders.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Nutrition & Dietetics
Wing-Yan Wong, Brandon Dow Chan, Tung-Ting Sham, Magnolia Muk-Lan Lee, Chi-On Chan, Chung-Ting Chau, Daniel Kam-Wah Mok, Yiu-Wa Kwan, William Chi-Shing Tai
Summary: Inflammatory bowel disease (IBD) is a chronic intestinal inflammation characterized by altered gut microbiota composition. Probiotic treatment with Lactobacillus casei strain Shirota (LcS) has been shown to ameliorate colitis severity in mice. This study demonstrated that LcS treatment improved intestinal integrity and altered bile acid metabolism, leading to anti-inflammatory effects by stabilizing inhibitor of NF-kappa B alpha (I kappa B alpha) expression and suppressing pro-inflammatory mediators.
FRONTIERS IN NUTRITION
(2022)
Article
Chemistry, Medicinal
Jingjing Li, Chuanyong Guo, Jianye Wu
Summary: Liver fibrosis is a common process in the development of liver diseases to cirrhosis. The activation of Peroxisome proliferator-activated receptors (PPARs) plays a crucial role in fibrosis by regulating downstream pathways. Research on PPAR-γ ligands and other novel drugs has become a focus in recent years for potential treatment of liver fibrosis.
DRUG DESIGN DEVELOPMENT AND THERAPY
(2021)
Article
Multidisciplinary Sciences
Hye-Young Seo, So-Hee Lee, Ji Yeon Park, Eugene Han, Sol Han, Jae Seok Hwang, Mi Kyung Kim, Byoung Kuk Jang
Summary: This study demonstrates the potential of lobeglitazone in inhibiting liver inflammation and fibrosis by reducing NLRP3 inflammasome activation and production of proinflammatory cytokines.
Article
Substance Abuse
Marianne Landmann, Sabine Wagnerberger, Giridhar Kanuri, Doreen Ziegenhardt, Ina Bergheim
ALCOHOL AND ALCOHOLISM
(2015)
Article
Nutrition & Dietetics
Giridhar Kanuri, Marianne Landmann, Josephine Priebs, Astrid Spruss, Marina Loescher, Doreen Ziegenhardt, Carolin Roehi, Christian Degen, Ina Bergheim
EUROPEAN JOURNAL OF NUTRITION
(2016)
Article
Nutrition & Dietetics
Cheng Jun Jin, Anna Janina Engstler, Cathrin Sellmann, Doreen Ziegenhardt, Marianne Landmann, Giridhar Kanuri, Hakima Lounis, Markus Schroder, Walter Vetter, Ina Bergheim
BRITISH JOURNAL OF NUTRITION
(2016)
Article
Multidisciplinary Sciences
Giridhar Kanuri, Ritica Sawhney, Jeeva Varghese, Madonna Britto, Arun Shet
Article
Nutrition & Dietetics
Giridhar Kanuri, Sabine Wagnerberger, Marianne Landmann, Eva Prigl, Claus Hellerbrand, Stephan C. Bischoff, Ina Bergheim
EUROPEAN JOURNAL OF NUTRITION
(2015)
Article
Hematology
Giridhar Kanuri, Deepti Chichula, Ritica Sawhney, Kevin Kuriakose, Sherwin De'Souza, Faye Pais, Karthika Arumugam, Arun S. Shet
Review
Biochemistry & Molecular Biology
Giridhar Kanuri, Ina Bergheim
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2013)
Article
Gastroenterology & Hepatology
Giridhar Kanuri, Ruth Ladurner, Julia Skibovskaya, Astrid Spruss, Alfred Koenigsrainer, Stephan C. Bischoff, Ina Bergheim
LIVER INTERNATIONAL
(2015)
Article
Nutrition & Dietetics
Marianne Landmann, Giridhar Kanuri, Astrid Spruss, Carolin Stahl, Ina Bergheim
Article
Biology
Satish Kumar Kalagotla, Suryakanth Gangashetty, Kanuri Giridhar
Summary: This study introduces a novel stacking technique that outperforms other models in terms of model performance when compared with AdaBoost in the context of the PIMA Indian diabetes dataset. The proposed technique integrated intelligent models and led to an improvement in model performance, demonstrating its potential for broader applications in other datasets such as Cleveland heart disease and Wisconsin breast cancer diagnostic datasets.
COMPUTERS IN BIOLOGY AND MEDICINE
(2021)
Meeting Abstract
Hematology
G. Kanuri, D. Chichula, S. Majumdar, J. P. Rao, A. Shet
Meeting Abstract
Hematology
S. Majumdar, G. Kanuri, A. Shet
Meeting Abstract
Hematology
Giridhar Kanuri, Ritica Sawhney, Girish Raju, Jeeva Varghese, Madonna Britto, Arun Shet
AMERICAN JOURNAL OF HEMATOLOGY
(2016)
Meeting Abstract
Hematology
Kanuri Giridhar, Sawhney Ritica, Chichula Deepti, Arun S. Shet
Article
Biochemistry & Molecular Biology
Xinyu Wang, Jun Huang, Huan Li, Yanlong Li, Shuang Cai, Bangxin Xue, Zhekun Zhu, Xiangzhou Zeng, Xiangfang Zeng
Summary: Embryo development plays a crucial role in pregnancy outcome and lifelong health. A high throughput screening cell model was established to select nutrients that can enhance embryonic development. Resveratrol was identified as a potential candidate for promoting embryo development.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Ren Yoshitomi, Motofumi Kumazoe, Kwan-Woo Lee, Yuki Marugame, Yoshinori Fujimura, Hirofumi Tachibana
Summary: This study investigated the connection between food components and circular RNA (circRNA), as well as the regulatory effect of (-)-Epigallocatechin-3-O-gallate (EGCG) on circRNA expression in the liver. The results showed that EGCG treatment altered the expression of circRNAs in mice livers, and one upregulated circRNA (mmu_circRNA_011775) affected the expression of genes related to liver fibrosis and the cardiovascular system.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
ViVi Tang Kang Wee, Hitoshi Shirakawa, Sung-Ling Yeh, Chiu-Li Yeh
Summary: This study investigated the effects of fermented rice bran (FRB) on modulating intestinal aryl hydrocarbon receptor (AhR) expression, innate lymphoid cell (ILC)3 populations, the fecal microbiota distribution, and their associations with dextran sodium sulfate (DSS)-induced acute colitis. The results showed that FRB supplementation can improve gut health, alleviate colitis symptoms, and have anti-colitis effects by enhancing ILC3 and AhR functions.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Xinzhuang Ma, Xijuan Ren, Xuemin Zhang, Guangyin Wang, Hui Liu, Li Wang
Summary: The study demonstrates that rutin can ameliorate kidney damage caused by PFOA exposure by improving oxidative stress and regulating lipid metabolism.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Ya-Jie Ding, Xue-Ning Li, Zhe Xiao, Chen-Yang Li, Li-Hong Jia
Summary: This study investigates the impact of maternal vitamin D levels during pregnancy on infantile eczema. The findings suggest that lower prenatal maternal vitamin D levels increase the risk of eczema in infants aged 0-1 year. Furthermore, the study indicates that infants with eczema have lower expression of the Foxp3 gene in cord blood and decreased placental FOXP3 protein expression. These results suggest that vitamin D may affect the development of infantile eczema through the regulation of gene and protein expression in cord blood and placenta.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Shujing Liu, Shiyu Song, Shuan Wang, Tonghui Cai, Lian Qin, Xinzhuang Wang, Guangming Zhu, Haibo Wang, Wenqi Yang, Chunlu Fang, Yuan Wei, Fu Zhou, Yang Yu, Shaozhang Lin, Shuang Peng, Liangming Li
Summary: Long-term consumption of a high-fat diet disrupts energy balance and leads to weight gain. The fat mass and obesity-associated (FTO) gene is involved in high-fat diet-induced obesity. The hypothalamus plays a crucial role in regulating energy balance, and high-fat diet-induced hypothalamic leptin resistance contributes to obesity. The study reveals that FTO is associated with hypothalamic leptin resistance and provides new insight into its role in obesity.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Shuang Liu, Xiaoling Chen, Jun He, Yuheng Luo, Ping Zheng, Bing Yu, Daiwen Chen, Zhiqing Huang
Summary: This study found that oleanolic acid promotes the transformation of fast muscle fibers to slow muscle fibers through the TGR5-mediated CaN/NFATc1 signaling pathway.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Huijuan Hu, Fan Li, Shaoli Cheng, Tingting Qu, Fanqi Shen, Jie Cheng, Lina Chen, Zhenghang Zhao, Hao Hu
Summary: Long-term alternate-day fasting can ameliorate obesity-induced anxiety-like behavior and hippocampal damage, but it can cause anxiety in normal-weight mice. Short-term alternate-day fasting does not produce adverse emotional reactions in normal-weight mice.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Jannis Ulke, Christian Schwedler, Janine Krueger, Vanessa Stein, Peter Geserick, Andre Kleinridders, Kai Kappert
Summary: This study characterized the glycosylation pattern of PTPRJ in the liver and found that high-fat diet-induced obesity altered the glycosylation pattern of PTPRJ. These findings provide new insights into the role of glycosylation in metabolic disorders.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Shuang Liu, Marii Mochizuki, Yasuyuki Suzuki, Erika Takemasa, Akiko Yano, Matome Imai, Masaki Mogi
Summary: This study evaluated the feasibility and efficacy of leucine supplementation in offsetting immune dysfunction in sarcopenia. The results showed that leucine supplementation not only improved muscle mass and restored mitochondrial respiratory function, but also reduced inflammation levels. These findings are important for the rational design and optimization of leucine supplementation in patients with sarcopenia and autoimmune diseases.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Review
Biochemistry & Molecular Biology
Zhan Su, Jun Fang, Bin Yao, Gang Liu
Summary: Osteoporosis is a serious skeletal disorder that can be prevented and treated by polyphenols, which have antioxidant and anti-allergy properties. Polyphenols affect bone metabolism and density by inhibiting oxidative stress and exhibiting antibacterial effects. This article provides an overview of the preventive and therapeutic effects of polyphenols on osteoporosis and discusses the mechanisms involved.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Qian Zhang, Xinhua Xiao, Jia Zheng, Ming Li, Miao Yu, Fan Ping, Tong Wang, Xiaojing Wang
Summary: Maternal high-fat diet can affect the structure and function of offspring's pancreas, leading to weight gain, glucose metabolism disorders, and insulin secretion defects. The study found that this may be related to DNA methylation of specific genes in the pancreas.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Hanaa Mousa, Aisha Al Saei, Rozaimi Mohamad Razali, Susu M. Zughaier
Summary: Vitamin D deficiency and dyslipidemia have significant implications for human health. This study investigates the proteomic profiles of individuals with and without these conditions, revealing decreased HDL-associated apolipoproteins and increased acute-phase proteins. Pathway analysis highlights inflammatory and cancer pathways associated with vitamin D deficiency and dyslipidemia.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Qi-Lan Jiang, Tao Li, Qin Xu, Yang Zeng, Wei Wang, Bo-Tao Zhang, Qing-Ping Yao, Rui Jiang, Jun Jiang
Summary: Environmental factors, especially dietary habits, play a significant role in the susceptibility and progression of cardiovascular diseases through epigenetic modification. This study found that a methyl donor diet can attenuate balloon injury-induced intimal hyperplasia in rat carotid arteries, potentially by influencing the composition and function of the extracellular matrix.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Review
Biochemistry & Molecular Biology
Jiayi Cai, Yajie Qiao, Lingbin Chen, Youguang Lu, Dali Zheng
Summary: The Notch signaling pathway plays a regulatory role in normal biological processes such as cellular differentiation, apoptosis, and stem cell self-renewal. Dysregulation of this pathway is associated with various types of cancer. Natural products targeting the Notch pathway have shown potential as chemopreventive and anti-cancer agents, providing a feasible solution to fight against cancer by either alone or in combination with current therapeutic agents.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)