The Agonists of Peroxisome Proliferator-Activated Receptor-γ for Liver Fibrosis

Immunity as Cornerstone of Non-Alcoholic Fatty Liver Disease: The Contribution of Oxidative Stress in the Disease Progression

(2021) Marcello Dallio et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Crosstalk between PPARs and gut microbiota in NAFLD

(2021) Liwei Wu et al.   BIOMEDICINE & PHARMACOTHERAPY

Identification of Lineage-specific Transcription Factors That Prevent Activation of Hepatic Stellate Cells and Promote Fibrosis Resolution

(2020) Xiao Liu et al.   GASTROENTEROLOGY

Therapeutic potential of PPARγ natural agonists in liver diseases

(2020) Liwei Wu et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Peroxisome Proliferator-Activated Receptors as a Therapeutic Target in Asthma

(2020) Oxana Yu. Kytikova et al.   PPAR Research

Bergenin Exerts Hepatoprotective Effects by Inhibiting the Release of Inflammatory Factors, Apoptosis and Autophagy via the PPAR-γ Pathway

(2020) Shihao Xiang et al.   Drug Design Development and Therapy

Differential effects of selective- and pan-PPAR agonists on experimental steatohepatitis and hepatic macrophages

(2020) Sander Lefere et al.   JOURNAL OF HEPATOLOGY

PPAR-Gamma Agonist Pioglitazone Reduced CD68+ but Not CD163+ Macrophage Dermal Infiltration in Obese Psoriatic Patients

(2020) Ya. O. Yemchenko et al.   PPAR Research

Loss of Hepatocyte-Specific PPARγ Expression Ameliorates Early Events of Steatohepatitis in Mice Fed the Methionine and Choline-Deficient Diet

(2020) Jose Cordoba-Chacon   PPAR Research

Efficient drug and gene delivery to liver fibrosis: rationale, recent advances, and perspectives

(2020) Somayeh Mahdinloo et al.   Acta Pharmaceutica Sinica B

Crocin attenuates CCl4-induced liver fibrosis via PPAR-γ mediated modulation of inflammation and fibrogenesis in rats

(2020) J Chhimwal et al.   HUMAN & EXPERIMENTAL TOXICOLOGY

The roles of PPARγ and its agonists in autoimmune diseases: A comprehensive review

(2020) Yu Liu et al.   JOURNAL OF AUTOIMMUNITY

Peroxisome proliferator-activated receptor γ inhibits hepatic stellate cell activation regulated by miR-942 in chronic hepatitis B liver fibrosis

(2020) Le Tao et al.   LIFE SCIENCES

The role of Peroxisome Proliferator-Activated Receptors (PPAR) in immune responses

(2020) Anthos Christofides et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Redox Regulation of PPARγ in Polarized Macrophages

(2020) Verena Trümper et al.   PPAR Research

The PPAR α/γ Agonist Saroglitazar Improves Insulin Resistance and Steatohepatitis in a Diet Induced Animal Model of Nonalcoholic Fatty Liver Disease

(2020) Divya P. Kumar et al.   Scientific Reports

The T Cell Receptor Immune Repertoire Protects the Liver From Reconsitution

(2020) Qing Liang et al.   Frontiers in Immunology

Molecular Pathways Modulated by Mesenchymal Stromal Cells and Their Extracellular Vesicles in Experimental Models of Liver Fibrosis

(2020) Giulia Chiabotto et al.   Frontiers in Cell and Developmental Biology

Molecular Mechanisms That Link Oxidative Stress, Inflammation, and Fibrosis in the Liver

(2020) Erika Ramos-Tovar et al.   Antioxidants

HCC surveillance after SVR in patients with F3/F4 fibrosis

(2020) George N. Ioannou   JOURNAL OF HEPATOLOGY

Peroxisome proliferator-activated receptors in the pathogenesis and therapies of liver fibrosis

(2020) Xin Han et al.   PHARMACOLOGY & THERAPEUTICS

Umbelliferone Ameliorates CCl4-Induced Liver Fibrosis in Rats by Upregulating PPARγ and Attenuating Oxidative Stress, Inflammation, and TGF-β1/Smad3 Signaling

(2019) Ayman M. Mahmoud et al.   INFLAMMATION

Protective effect of cultured bear bile powder against dimethylnitrosamine-induced hepatic fibrosis in rats

(2019) Min Zheng et al.   BIOMEDICINE & PHARMACOTHERAPY

The dual PPAR-α/γ agonist saroglitazar ameliorates thioacetamide-induced liver fibrosis in rats through regulating leptin

(2019) Mirhan N. Makled et al.   NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY

15-Deoxy-∆-12,14-Prostaglandin J2 (15d-PGJ2), an Endogenous Ligand of PPAR-γ: Function and Mechanism

(2019) Jingjing Li et al.   PPAR Research

GDF10 blocks hepatic PPARγ activation to protect against diet-induced liver injury

(2019) Khrystyna Platko et al.   Molecular Metabolism

Rosiglitazone ameliorates bile duct ligation-induced liver fibrosis by down-regulating NF-κB-TNF-α signaling pathway in a PPARγ-dependent manner

(2019) Zhuo Wei et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Docosahexaenoic acid inhibits hepatic stellate cell activation to attenuate liver fibrosis in a PPARγ-dependent manner

(2019) Jianlin He et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Beneficial Effects of the Peroxisome Proliferator-Activated Receptor α/γ Agonist Aleglitazar on Progressive Hepatic and Splanchnic Abnormalities in Cirrhotic Rats with Portal Hypertension

(2018) Hung-Cheng Tsai et al.   AMERICAN JOURNAL OF PATHOLOGY

rSjP40 protein promotes PPARγ expression in LX-2 cells through microRNA-27b

(2018) Dandan Zhu et al.   FASEB JOURNAL

Fucosterol Protects against Concanavalin A-Induced Acute Liver Injury: Focus on P38 MAPK/NF-κB Pathway Activity

(2018) Wenhui Mo et al.   Gastroenterology Research and Practice

Ligand Activation of PPARγ by Ligustrazine Suppresses Pericyte Functions of Hepatic Stellate Cells via SMRT-Mediated Transrepression of HIF-1α

(2018) Feng Zhang et al.   Theranostics

Exercise rescues the immune response fine-tuned impaired by peroxisome proliferator-activated receptors γ deletion in macrophages

(2018) Loreana Sanches Silveira et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Docosahexaenoic acid attenuates carbon tetrachloride-induced hepatic fibrosis in rats

(2017) Jianlin He et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Antifibrotic effect of total flavonoids of Astmgali Radix on dimethylnitrosamine-induced liver cirrhosis in rats

(2016) Yang Cheng et al.   Chinese Journal of Integrative Medicine

GATA binding protein 3 is correlated with leptin regulation of PPARγ1 in hepatic stellate cells

(2016) Wei Guan et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Galanin receptor 2 mediates antifibrogenic effects of galanin on hepatic stellate cells

(2016) Lingnan He et al.   Experimental and Therapeutic Medicine

Curcumin regulates peroxisome proliferator-activated receptor-γ coactivator-1α expression by AMPK pathway in hepatic stellate cells in vitro

(2015) Xuguang Zhai et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Resveratrol Regulates the Quiescence-Like Induction of Activated Stellate Cells by Modulating the PPARγ/SIRT1 Ratio

(2015) Izabel Cristina Custódio de Souza et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Astaxanthin Inhibits Proliferation and Induces Apoptosis of Human Hepatocellular Carcinoma Cells via Inhibition of Nf-Κb P65 and Wnt/Β-Catenin in Vitro

(2015) Jingjing Li et al.   Marine Drugs

Astaxanthin Pretreatment Attenuates Hepatic Ischemia Reperfusion-Induced Apoptosis and Autophagy via the ROS/MAPK Pathway in Mice

(2015) Jingjing Li et al.   Marine Drugs

GATA binding protein 2 mediates leptin inhibition of PPARγ1 expression in hepatic stellate cells and contributes to hepatic stellate cell activation

(2014) Qian Zhou et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

The protective effects ofAcanthus ilicifoliusalkaloid A and its derivatives on pro- and anti-inflammatory cytokines in rats with hepatic fibrosis

(2014) Kyi Kyi Wai et al.   BIOTECHNOLOGY AND APPLIED BIOCHEMISTRY

Curcumin regulates delta-like homolog 1 expression in activated hepatic stellate cell

(2014) Jianwei Qiu et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Curcumin attenuates angiogenesis in liver fibrosis and inhibits angiogenic properties of hepatic stellate cells

(2014) Feng Zhang et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

microRNA-34a and microRNA-34c promote the activation of human hepatic stellate cells by targeting peroxisome proliferator-activated receptor γ

(2014) XIAOFEI LI et al.   Molecular Medicine Reports

Hydroxysafflor yellow A suppresses liver fibrosis induced by carbon tetrachloride with high-fat diet by regulating PPAR-γ/p38 MAPK signaling

(2014) Q. Liu et al.   PHARMACEUTICAL BIOLOGY

Hepatic PPARs: Their Role in Liver Physiology, Fibrosis and Treatment

(2013) E. Zardi et al.   CURRENT MEDICINAL CHEMISTRY

Anti-fibrotic effects of puerarin on CCl4-induced hepatic fibrosis in rats possibly through the regulation of PPAR-γ expression and inhibition of PI3K/Akt pathway

(2013) Chao Guo et al.   FOOD AND CHEMICAL TOXICOLOGY

Nuclear control of inflammation and fibrosis in nonalcoholic steatohepatitis: therapeutic potential of dual peroxisome proliferator-activated receptor alpha/delta agonism

(2013) Pablo Quintero et al.   HEPATOLOGY

Hepatoprotective effects of the dual peroxisome proliferator-activated receptor alpha/delta agonist, GFT505, in rodent models of nonalcoholic fatty liver disease/nonalcoholic steatohepatitis

(2013) Bart Staels et al.   HEPATOLOGY

DNA methylation patterns of peroxisome proliferator-activated receptor gamma gene associated with liver fibrosis and inflammation in chronic hepatitis B

(2013) Q. Zhao et al.   JOURNAL OF VIRAL HEPATITIS

Telmisartan, an AT1 receptor blocker and a PPAR gamma activator, alleviates liver fibrosis induced experimentally by Schistosoma mansoni infection

(2013) Yasmeen M Attia et al.   Parasites & Vectors

Nanomedicines of Hedgehog Inhibitor and PPAR-γ Agonist for Treating Liver Fibrosis

(2013) Virender Kumar et al.   PHARMACEUTICAL RESEARCH

Peroxisome proliferator-activated receptor-γ as a therapeutic target for hepatic fibrosis: from bench to bedside

(2012) Feng Zhang et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Couple Dynamics: PPARγ and Its Ligand Partners

(2012) Shanghai Yu et al.   STRUCTURE

Peroxisome proliferator-activated receptor-γ cross-regulation of signaling events implicated in liver fibrogenesis

(2011) Feng Zhang et al.   CELLULAR SIGNALLING

Peroxisome proliferator-activated receptor gamma inhibits hepatic fibrosis in rats

(2011) Zheng Wang et al.   Hepatobiliary & Pancreatic Diseases International

Rosmarinic acid and baicalin epigenetically derepress peroxisomal proliferator-activated receptor γ in hepatic stellate cells for their antifibrotic effect

(2011) Melissa D. Yang et al.   HEPATOLOGY

Effectiveness of the PPARγ agonist, GW570, in liver fibrosis

(2010) Liu Yang et al.   INFLAMMATION RESEARCH

Peroxisome proliferator-activated receptors gamma reverses hepatic nutritional fibrosis in mice and suppresses activation of hepatic stellate cells in vitro

(2010) Jun Yu et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Protective effects of baicalin on carbon tetrachloride induced liver injury by activating PPARγ and inhibiting TGFβ1

(2010) Hongxiang Qiao et al.   PHARMACEUTICAL BIOLOGY

Vitamin C deficiency attenuates liver fibrosis by way of up-regulated peroxisome proliferator-activated receptor-gamma expression in senescence marker protein 30 knockout mice

(2009) Jin-Kyu Park et al.   HEPATOLOGY

PI-3 K/AKT and ERK signaling pathways mediate leptin-induced inhibition of PPARγ gene expression in primary rat hepatic stellate cells

(2009) Yajun Zhou et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

15-Deoxy-Δ12,14-prostaglandin J2 inhibits fibrogenic response in human hepatoma cells

(2009) Fat-Moon Suk et al.   TOXICOLOGY LETTERS

Rosiglitazone prevents murine hepatic fibrosis induced by Schistosoma japonicum

(2008) Hui Chen et al.   WORLD JOURNAL OF GASTROENTEROLOGY