Article
Biochemistry & Molecular Biology
Thomas Fischer, Oliver Hartmann, Michaela Reissland, Cristian Prieto-Garcia, Kevin Klann, Nikolett Pahor, Christina Schuelein-Voelk, Apoorva Baluapuri, Bulent Polat, Arya Abazari, Elena Gerhard-Hartmann, Hans-Georg Kopp, Frank Essmann, Mathias Rosenfeldt, Christian Muench, Michael Flentje, Markus E. Diefenbacher
Summary: Loss of PTEN leads to increased resistance of lung cancer cells to radiation therapy, but with significant dependence on ATM kinase. Inhibition of ATM can restore sensitivity to radiation therapy and synergize with it.
CELL AND BIOSCIENCE
(2022)
Article
Oncology
Amr Ghaleb, Lucia Roa, Natalia Marchenko
Summary: The biological consequences of low-dose radiation (LDR) in breast cancer are unclear, while high-dose radiation (HDR) promotes DNA repair and cell cycle arrest. Mutant p53 promotes mammary tumorigenesis following LDR, but has negligible effects on tumors carrying the wild-type p53 allele.
Article
Biochemistry & Molecular Biology
Andrey Anisenko, Anastasiia Nefedova, Yulia Agapkina, Marina Gottikh
Summary: The DNA copy of HIV-1 RNA genome integration into the host genome requires repair of single-stranded gaps in cellular DNA, involving the DNA damage response (DDR) kinases ATM, ATR, and DNA-PKcs. Inhibition of DNA-PKcs and ATM, but not ATR, reduces the efficiency of post-integrational DNA repair (PIR), suggesting that the activation of both kinases is crucial for PIR, and their activation depends on the formation of a complex between integrase and Ku70. The elucidation of virus-DDR interactions is essential for understanding host cell modulation and developing strategies against viral infections.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cell Biology
Watanya Trakarnphornsombat, Hiroshi Kimura
Summary: DNA double-strand breaks (DSBs) can cause genetic mutation and histone H2AX is phosphorylated by kinases such as ATM, ATR, and DNA-PK upon DSB induction. The accumulation kinetics of ?-H2AX were similar in ATM-proficient and-deficient cells, but delayed in the presence of a DNA-PK inhibitor. Ku80 (XRCC5) diffuses freely in the nucleus, while ATM repeatedly binds to and dissociates from chromatin. ATM accumulation at damage sites is regulated by the histone acetyltransferase MOF, but does not necessarily reflect in the ?-H2AX level, suggesting distinct actions of ATM and DNA-PK in immediate ?-H2AX accumulation.
JOURNAL OF CELL SCIENCE
(2023)
Article
Food Science & Technology
Yue Zhang, Jianhui Liu, Xiangyang Li, Guiqing Zhou, Yujian Sang, Mingyuan Zhang, Leqiang Gao, Jinglong Xue, Moxuan Zhao, Huanling Yu, Xianqing Zhou
Summary: The study aimed to investigate the effects of selenium on male reproductive function and its possible mechanisms. Excessive selenium intake damaged the tissue structure of the testes and epididymides of mice, resulting in decreased sperm quality and quantity. Furthermore, excessive selenium induced oxidative stress, DNA damage, and disrupted telomere function. These effects led to germ cell senescence and apoptosis in the testes.
FOOD AND CHEMICAL TOXICOLOGY
(2023)
Article
Cell Biology
Yen-Ni Teng, Huei-Cih Chang, Yu-Ying Chao, Hui-Ling Cheng, Wei-Chih Lien, Chia-Yih Wang
Summary: Etoposide was shown to inhibit adrenocortical tumor cell growth by inducing cellular senescence rather than apoptosis, through markers such as enlarged nuclei, elevated levels of p53 and p21, and upregulation of senescence-associated beta-galactosidase. The drug also induced multiple centrosomes and primary cilia, triggering senescence, and activated DNA-PK-Chk2 signaling pathway to facilitate autophagy, further leading to cellular senescence.
Review
Biochemistry & Molecular Biology
Wonyoung Choi, Eun Sook Lee
Summary: The DNA damage response (DDR) pathway plays a critical role in maintaining genome stability and defects in this pathway are associated with cancer. Exploiting vulnerabilities in this pathway has led to successful anticancer therapies, such as PARP inhibitors. This review discusses key elements of the DDR pathway and the development of pharmacologic inhibitors. It also highlights the importance of biomarker studies and combination strategies in optimizing clinical benefits.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Oncology
Lindsey Carlsen, Wafik S. El-Deiry
Summary: DNA damage response inhibitors are effective anti-cancer agents that sensitize tumor cells to radiotherapy and chemotherapy while also stimulating immune responses. However, the contribution of different inhibitors and genetic aberrations in cancers to immune mechanisms is not well-characterized, limiting the optimization of treatment regimens.
FRONTIERS IN ONCOLOGY
(2022)
Review
Oncology
Marwan Kwok, Angelo Agathanggelou, Nicholas Davies, Tatjana Stankovic
Summary: The p53 pathway is crucial in maintaining genome integrity and its loss of function is associated with the development and therapeutic resistance in chronic lymphocytic leukemia. Therapeutic strategies targeting p53 pathway defects include activating wild-type p53, restoring tumor suppressive function in mutant p53, inducing synthetic lethality by targeting collateral genome maintenance pathways, and harnessing the immunogenicity of p53 pathway aberrations.
Article
Biochemistry & Molecular Biology
Aaron Mendez-Bermudez, Liudmyla Lototska, Melanie Pousse, Florent Tessier, Oliver Croce, Chrysa M. Latrick, Veronica Cherdyntseva, Joe Nassour, Jiang Xiaohua, Yiming Lu, Corinne Abbadie, Sarantis Gagos, Jing Ye, Eric Gilson
Summary: Cellular senescence triggers various types of heterochromatin remodeling, including decondensation, DNA damage, and illegitimate recombination. In this study, it was discovered that at the onset of senescence, pericentromeric heterochromatin is specifically dismantled due to telomere shortening or genotoxic stress. This process is initiated by the TP53-TRF2 axis and involves the downregulation of TRF2, resulting in heterochromatin decondensation and DNA breaks.
NUCLEIC ACIDS RESEARCH
(2022)
Article
Genetics & Heredity
Eva-Maria Faulhaber, Tina Jost, Julia Symank, Julian Scheper, Felix Buerkel, Rainer Fietkau, Markus Hecht, Luitpold Distel
Summary: The combination of kinase inhibitors targeting components of the DNA damage repair pathway and ionizing radiation therapy could potentially improve tumor control, increase cell death in malignant cells, have limited impact on healthy cells, reduce metastasis formation, and enhance treatment outcomes for HPV-negative tumors.
Review
Cell Biology
Venturina Stagni, Alessandra Ferri, Claudia Cirotti, Daniela Barila
Summary: There is a strong interplay between autophagy and genomic stability, with recent evidence linking DNA Damage Response (DDR) and autophagy in influencing cell fate. ATM kinase plays a crucial role in balancing senescence and apoptosis in response to stimuli, and its aberrant deregulation is linked to the development of pathologies like cancer and neurodegeneration.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Cell Biology
Julio Aguado, Cecilia Gomez-Inclan, Hannah C. Leeson, Martin F. Lavin, Yosef Shiloh, Ernst J. Wolvetang
Summary: Ataxia-telangiectasia (A-T) is a complex disorder characterized by progressive cerebellar degeneration, immunodeficiency, radiation sensitivity, genome instability, and predisposition to cancer. The premature aging component of A-T is of great importance in driving the disease.
AGEING RESEARCH REVIEWS
(2022)
Article
Cell Biology
Na-Lee Ka, Ga Young Lim, Sewon Hwang, Seung-Su Kim, Mi-Ock Lee
Summary: The role of IFI16 in DNA repair enhances STING-type-I IFN signaling, offering potential therapeutic strategies for triple-negative breast cancer patients.
Article
Medicine, Research & Experimental
Andreas Becker, Axel Krebs-Brown, Claudia Vetter, Tanja Reuter, Almudena Rodriguez-Gutierrez, Xiaoli You, Michael Lissy
Summary: This study evaluated the pharmacokinetics of the orally administered DNA-dependent protein kinase inhibitor Peposertib under different food conditions, comparing it in tablet form and as an oral suspension. The results showed a slight food effect on the tablets, while the oral suspension exhibited higher drug concentrations and faster time to reach maximum concentration. All treatments in the study were well-tolerated by healthy volunteers.
CTS-CLINICAL AND TRANSLATIONAL SCIENCE
(2023)
Article
Biochemistry & Molecular Biology
Wen-Hsing Cheng, Ryan T. Y. Wu, Min Wu, Caroline R. B. Rocourt, Jose A. Carrillo, Jiuzhou Song, Christina T. Bohr, Tiffany J. Tzeng
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2012)
Review
Cell Biology
Shu Zhang, Caroline Rocourt, Wen-Hsing Cheng
MECHANISMS OF AGEING AND DEVELOPMENT
(2010)
Review
Nutrition & Dietetics
Caroline R. B. Rocourt, Wen-Hsing Cheng
Meeting Abstract
Biochemistry & Molecular Biology
Tiffany J. Tzeng, Ryan T. Y. Wu, Caroline R. B. Rocourt, Wen-Hsing Cheng
Meeting Abstract
Biochemistry & Molecular Biology
Caroline R. B. Rocourt, Min Wu, Benjamin P. C. Chen, Wen-Hsing Cheng
Meeting Abstract
Biochemistry & Molecular Biology
Caroline Rocourt, Wen-Hsing Cheng
Meeting Abstract
Biochemistry & Molecular Biology
Caroline Rocourt, Wen-Hsing Cheng
Article
Biochemistry & Molecular Biology
Xinyu Wang, Jun Huang, Huan Li, Yanlong Li, Shuang Cai, Bangxin Xue, Zhekun Zhu, Xiangzhou Zeng, Xiangfang Zeng
Summary: Embryo development plays a crucial role in pregnancy outcome and lifelong health. A high throughput screening cell model was established to select nutrients that can enhance embryonic development. Resveratrol was identified as a potential candidate for promoting embryo development.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Ren Yoshitomi, Motofumi Kumazoe, Kwan-Woo Lee, Yuki Marugame, Yoshinori Fujimura, Hirofumi Tachibana
Summary: This study investigated the connection between food components and circular RNA (circRNA), as well as the regulatory effect of (-)-Epigallocatechin-3-O-gallate (EGCG) on circRNA expression in the liver. The results showed that EGCG treatment altered the expression of circRNAs in mice livers, and one upregulated circRNA (mmu_circRNA_011775) affected the expression of genes related to liver fibrosis and the cardiovascular system.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
ViVi Tang Kang Wee, Hitoshi Shirakawa, Sung-Ling Yeh, Chiu-Li Yeh
Summary: This study investigated the effects of fermented rice bran (FRB) on modulating intestinal aryl hydrocarbon receptor (AhR) expression, innate lymphoid cell (ILC)3 populations, the fecal microbiota distribution, and their associations with dextran sodium sulfate (DSS)-induced acute colitis. The results showed that FRB supplementation can improve gut health, alleviate colitis symptoms, and have anti-colitis effects by enhancing ILC3 and AhR functions.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Xinzhuang Ma, Xijuan Ren, Xuemin Zhang, Guangyin Wang, Hui Liu, Li Wang
Summary: The study demonstrates that rutin can ameliorate kidney damage caused by PFOA exposure by improving oxidative stress and regulating lipid metabolism.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Ya-Jie Ding, Xue-Ning Li, Zhe Xiao, Chen-Yang Li, Li-Hong Jia
Summary: This study investigates the impact of maternal vitamin D levels during pregnancy on infantile eczema. The findings suggest that lower prenatal maternal vitamin D levels increase the risk of eczema in infants aged 0-1 year. Furthermore, the study indicates that infants with eczema have lower expression of the Foxp3 gene in cord blood and decreased placental FOXP3 protein expression. These results suggest that vitamin D may affect the development of infantile eczema through the regulation of gene and protein expression in cord blood and placenta.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Shujing Liu, Shiyu Song, Shuan Wang, Tonghui Cai, Lian Qin, Xinzhuang Wang, Guangming Zhu, Haibo Wang, Wenqi Yang, Chunlu Fang, Yuan Wei, Fu Zhou, Yang Yu, Shaozhang Lin, Shuang Peng, Liangming Li
Summary: Long-term consumption of a high-fat diet disrupts energy balance and leads to weight gain. The fat mass and obesity-associated (FTO) gene is involved in high-fat diet-induced obesity. The hypothalamus plays a crucial role in regulating energy balance, and high-fat diet-induced hypothalamic leptin resistance contributes to obesity. The study reveals that FTO is associated with hypothalamic leptin resistance and provides new insight into its role in obesity.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Shuang Liu, Xiaoling Chen, Jun He, Yuheng Luo, Ping Zheng, Bing Yu, Daiwen Chen, Zhiqing Huang
Summary: This study found that oleanolic acid promotes the transformation of fast muscle fibers to slow muscle fibers through the TGR5-mediated CaN/NFATc1 signaling pathway.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Huijuan Hu, Fan Li, Shaoli Cheng, Tingting Qu, Fanqi Shen, Jie Cheng, Lina Chen, Zhenghang Zhao, Hao Hu
Summary: Long-term alternate-day fasting can ameliorate obesity-induced anxiety-like behavior and hippocampal damage, but it can cause anxiety in normal-weight mice. Short-term alternate-day fasting does not produce adverse emotional reactions in normal-weight mice.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Jannis Ulke, Christian Schwedler, Janine Krueger, Vanessa Stein, Peter Geserick, Andre Kleinridders, Kai Kappert
Summary: This study characterized the glycosylation pattern of PTPRJ in the liver and found that high-fat diet-induced obesity altered the glycosylation pattern of PTPRJ. These findings provide new insights into the role of glycosylation in metabolic disorders.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Shuang Liu, Marii Mochizuki, Yasuyuki Suzuki, Erika Takemasa, Akiko Yano, Matome Imai, Masaki Mogi
Summary: This study evaluated the feasibility and efficacy of leucine supplementation in offsetting immune dysfunction in sarcopenia. The results showed that leucine supplementation not only improved muscle mass and restored mitochondrial respiratory function, but also reduced inflammation levels. These findings are important for the rational design and optimization of leucine supplementation in patients with sarcopenia and autoimmune diseases.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Review
Biochemistry & Molecular Biology
Zhan Su, Jun Fang, Bin Yao, Gang Liu
Summary: Osteoporosis is a serious skeletal disorder that can be prevented and treated by polyphenols, which have antioxidant and anti-allergy properties. Polyphenols affect bone metabolism and density by inhibiting oxidative stress and exhibiting antibacterial effects. This article provides an overview of the preventive and therapeutic effects of polyphenols on osteoporosis and discusses the mechanisms involved.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Qian Zhang, Xinhua Xiao, Jia Zheng, Ming Li, Miao Yu, Fan Ping, Tong Wang, Xiaojing Wang
Summary: Maternal high-fat diet can affect the structure and function of offspring's pancreas, leading to weight gain, glucose metabolism disorders, and insulin secretion defects. The study found that this may be related to DNA methylation of specific genes in the pancreas.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Hanaa Mousa, Aisha Al Saei, Rozaimi Mohamad Razali, Susu M. Zughaier
Summary: Vitamin D deficiency and dyslipidemia have significant implications for human health. This study investigates the proteomic profiles of individuals with and without these conditions, revealing decreased HDL-associated apolipoproteins and increased acute-phase proteins. Pathway analysis highlights inflammatory and cancer pathways associated with vitamin D deficiency and dyslipidemia.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Qi-Lan Jiang, Tao Li, Qin Xu, Yang Zeng, Wei Wang, Bo-Tao Zhang, Qing-Ping Yao, Rui Jiang, Jun Jiang
Summary: Environmental factors, especially dietary habits, play a significant role in the susceptibility and progression of cardiovascular diseases through epigenetic modification. This study found that a methyl donor diet can attenuate balloon injury-induced intimal hyperplasia in rat carotid arteries, potentially by influencing the composition and function of the extracellular matrix.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Review
Biochemistry & Molecular Biology
Jiayi Cai, Yajie Qiao, Lingbin Chen, Youguang Lu, Dali Zheng
Summary: The Notch signaling pathway plays a regulatory role in normal biological processes such as cellular differentiation, apoptosis, and stem cell self-renewal. Dysregulation of this pathway is associated with various types of cancer. Natural products targeting the Notch pathway have shown potential as chemopreventive and anti-cancer agents, providing a feasible solution to fight against cancer by either alone or in combination with current therapeutic agents.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)