Article
Medicine, Research & Experimental
Wo-Er Jiao, Liu Sun, Shan Xu, Yu-Qin Deng, Yue-Long Qiao, Yang Xi, Ze-Zhang Tao, Shi-Ming Chen
Summary: Notch2 plays a crucial role in the differentiation of Treg cells and the inflammatory response of allergic rhinitis (AR). The expression of Notch2 is decreased in AR patients, and its upregulation leads to reduced allergic inflammation, increased Treg cell differentiation, and reversed T cell imbalance. Notch2 promotes Treg cell differentiation by upregulating FOXP3 expression, thereby inhibiting the inflammatory response of AR significantly.
Article
Medicine, Research & Experimental
Vivek D. Gandhi, Jacqueline-Yvonne Cephus, Allison E. Norlander, Nowrin U. Chowdhury, Jian Zhang, Zachary J. Ceneviva, Elie Tannous, Vasiliy V. Polosukhin, Nathan D. Putz, Nancy Wickersham, Amrit Singh, Lorraine B. Ware, Julie A. Bastarache, Ciara M. Shaver, Hong Wei Chu, R. Stokes Peebles, Dawn C. Newcomb
Summary: Women have a higher prevalence of asthma than men. Androgen receptor signaling has been found to stabilize Treg suppressive function, decrease the number of ST2(+) ex-Tregs and IL-13(+) Th2 cells, and reduce IL-33 production.
JOURNAL OF CLINICAL INVESTIGATION
(2022)
Article
Biochemistry & Molecular Biology
Laetitia Pouzol, Nadege Baumlin, Anna Sassi, Melanie Tunis, Julia Marrie, Enrico Vezzali, Herve Farine, Ulrich Mentzel, Marianne M. Martinic
Summary: Current strategies for treating demyelinating diseases like multiple sclerosis focus on anti-inflammatory or immunomodulatory drugs. The CXCR7 receptor antagonist ACT-1004-1239 shows promise in reducing disease severity, decreasing neuroinflammation, and promoting myelin repair in experimental models.
Article
Biochemistry & Molecular Biology
Jose M. Rojo, Maria Montes-Casado, Laura Aragoneses-Fenoll, Gloria Ojeda, Umberto Dianzani, Pilar Portoles
Summary: In this study, the role of class IA PI3K p110 alpha catalytic subunits in EAE development was analyzed using a model of T cell specific deletion of p110 alpha catalytic chain. The results showed that p110 alpha Delta T mice exhibited lower clinical symptoms and disease scores in EAE, possibly due to altered T cell homeostasis and lower secretion of inflammatory cytokines compared to WT mice.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Immunology
Maryam J. J. Tavaf, Azita Soltanmohammadi, Simin Zargarani, Esmaeil Yazdanpanah, Bizhan Sadighimoghaddam, Bahman Yousefi, Hamid R. R. Sameni, Dariush Haghmorad
Summary: This study utilized an EAE mouse model and found that low-dose and high-dose berberine can decrease the severity of EAE and alleviate its symptoms, possibly through increasing the number and function of Treg and Th2 cells, as well as its anti-inflammatory properties.
IMMUNITY INFLAMMATION AND DISEASE
(2023)
Article
Neurosciences
Itay Lotan, Shuhei Nishiyama, Amy Wright, Jin Myoung Seok, Michael Levy
Summary: This study assessed the changes in visually evoked potentials (VEP) in MOG-EAE DA rats using a minimally invasive recording device and correlated them with histological findings. The results showed that median VEP latencies were significantly prolonged on days 14, 21, and 28 compared to baseline, with the maximal latency observed on day 21. Histological analysis revealed inflammation and demyelination on days 21 and 28, which correlated with the prolonged VEP latencies. These findings suggest that VEPs can serve as reliable biomarkers for optic nerve involvement in EAE, and the minimally invasive device enables the observation of VEP changes over time in MOG-EAE DA rats. The implications of these findings are important for testing new therapies for CNS demyelinating diseases.
Review
Oncology
Farhad Seif, Zahra Torki, Hamidreza Zalpoor, Mehran Habibi, Majid Pornour
Summary: T cells play a crucial role in tumor development and anti-tumor responses in breast cancer patients. The cytokines in the tumor microenvironment can influence the differentiation and function of T cells, thereby affecting breast cancer treatment. This review discusses the factors that affect T cell differentiation in breast cancer, as well as the related clinical trials.
MOLECULAR THERAPY-ONCOLYTICS
(2023)
Article
Immunology
Rui Ma, Yaojuan Chu, Mengmeng Dou, Yilei Jing, Xiaoyu Zhao, Xinyu Li, Silu Li, Yuan Zhang, Limei Wang, Lin Zhu
Summary: In this study, it was found that matrine (MAT) treatment can promote the maturation of oligodendrocytes (OLs) and myelin repair by regulating the Wnt/β-catenin/TCF7L2 signaling pathway, leading to a reduction in the activation of Wnt3a and β-catenin in the central nervous system (CNS) of experimental autoimmune encephalomyelitis (EAE) mice. This finding is of significant importance for the repair of neurological damage in multiple sclerosis and EAE.
JOURNAL OF NEUROIMMUNOLOGY
(2022)
Review
Oncology
Antonietta Arcella, Massimo Sanchez
Summary: Glioblastoma multiforme (GBM) is a primary malignant brain tumor with aggressive cell proliferation and invasion, and conventional therapies have limited effectiveness. Combining natural substances with the chemotherapy drug TMZ significantly inhibits tumor growth and proliferation, improving treatment outcomes.
JOURNAL OF CHEMOTHERAPY
(2021)
Article
Computer Science, Artificial Intelligence
Flavio Bertini, Davide Allevi, Gianluca Lutero, Laura Calza, Danilo Montesi
Summary: Alzheimer's disease is the main form of dementia worldwide, with current pharmacological treatments only able to alleviate symptoms rather than halt the degenerative process. Research suggests that speech changes may be an early indication of cognitive defects, and an automated method using speech features has been proposed for classifying Alzheimer's disease patients.
COMPUTER SPEECH AND LANGUAGE
(2022)
Article
Biochemistry & Molecular Biology
Vito Antonio Baldassarro, Marco Sanna, Andrea Bighinati, Michele Sannia, Marco Gusciglio, Luciana Giardino, Luca Lorenzini, Laura Calza
Summary: In this study, the modification of 80 genes involved in synaptic plasticity after traumatic spinal cord injury (SCI) was investigated at different times using bioinformatic analysis. The results showed different gene expression regulation in spinal cord segments rostral and caudal to the lesion, as well as long-lasting changes in key proteins in various areas of the brain and spinal cord. This suggests that molecular mapping is a useful tool to study brain and spinal cord reorganization after SCI.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cell Biology
Maria Giovanna Scioli, Gabriele Storti, Alessandra Bielli, Massimo Sanchez, Manuel Scimeca, Jeffrey M. Gimble, Valerio Cervelli, Augusto Orlandi
Summary: The study reveals the crucial role of CD146 in ASC properties and osteochondrogenic commitment, with CD146(+) ASCs showing superior chondrogenic potential and CD146(-) ASCs demonstrating greater osteogenic capacity.
JOURNAL OF CELLULAR PHYSIOLOGY
(2022)
Article
Oncology
Maria Antonietta Oliva, Salvatore Castaldo, Rossella Rotondo, Sabrina Staffieri, Massimo Sanchez, Antonietta Arcella
Summary: The study demonstrates that p-Coumaric acid (pCA) has potential anticancer activity in treating glioblastoma by inducing cell cycle arrest and apoptosis, affecting cell growth and viability of U87Mg cells.
JOURNAL OF CHEMOTHERAPY
(2022)
Article
Nutrition & Dietetics
Giulia Lorenzoni, Rita Di Benedetto, Marco Silano, Dario Gregori
Summary: The study revealed that there is a diversity in the nutrient profile of ultra-processed foods (UPFs) in the Italian market, showing variability in nutritional composition even within the same category of UPFs as demonstrated by different FOPL schemes applied.
Article
Virology
Flavia Ferrantelli, Chiara Chiozzini, Francesco Manfredi, Patrizia Leone, Massimo Spada, Antonio Di Virgilio, Andrea Giovannelli, Massimo Sanchez, Andrea Cara, Zuleika Michelini, Maurizio Federico
Summary: Engineered extracellular vesicles can induce a potent SARS-CoV-2 CD8(+) T cell immune response and generate long-lasting lung-specific immune memory. This immunization approach is significant in addressing the limitations of current anti-SARS-CoV-2 vaccines.
Article
Biochemistry & Molecular Biology
Manuele Gori, Sara Maria Giannitelli, Gianluca Vadala, Rocco Papalia, Loredana Zollo, Massimo Sanchez, Marcella Trombetta, Alberto Rainer, Giovanni Di Pino, Vincenzo Denaro
Summary: The organic zwitterionic-poly(sulfobetaine methacrylate) [poly(SBMA)]-hydrogel has been demonstrated as an effective coating to reduce foreign-body reaction caused by intraneural electrodes. This hydrogel exhibits low fouling characteristics and can be successfully coated on Polyimide surfaces through covalent bonds, showing potential for long-term release of anti-fibrotic drugs. Its properties make it a promising diffusion-based delivery system for slow and controlled anti-inflammatory and anti-fibrotic drug release in vivo.
Article
Immunology
Francesco Manfredi, Chiara Chiozzini, Flavia Ferrantelli, Patrizia Leone, Andrea Giovannelli, Massimo Sanchez, Maurizio Federico
Summary: This study proposes an innovative strategy for anti-SARS-CoV-2 immune response using extracellular vesicles (EVs). By fusing SARS-CoV-2 N with Nef(mut) or a deletion mutant of Nef(mut), the researchers successfully induced immune responses in human cells. The findings demonstrate the potential of engineered EVs to elicit a strong immune response in human cells.
Article
Cell Biology
Alessio Lanna, Bruno Vaz, Clara D'Ambra, Salvatore Valvo, Claudia Vuotto, Valerio Chiurchiu, Oliver Devine, Massimo Sanchez, Giovanna Borsellino, Arne N. Akbar, Marco De Bardi, Derek W. Gilroy, Michael L. Dustin, Brendan Blumer, Michael Karin
Summary: It was discovered that some T cells can elongate telomeres by acquiring telomere vesicles from antigen-presenting cells, independently of telomerase action, which contributes to delaying the aging process.
NATURE CELL BIOLOGY
(2022)
Article
Immunology
Martina Musella, Andrea Guarracino, Nicoletta Manduca, Claudia Galassi, Eliana Ruggiero, Alessia Potenza, Ester Maccafeo, Gwenola Manic, Luca Mattiello, Sara Soliman Abdel Rehim, Michele Signore, Marco Pietrosanto, Manuela Helmer-Citterich, Matteo Pallocca, Maurizio Fanciulli, Tiziana Bruno, Francesca De Nicola, Giacomo Corleone, Anna Di Benedetto, Cristiana Ercolani, Edoardo Pescarmona, Laura Pizzuti, Francesco Guidi, Francesca Sperati, Sara Vitale, Daniele Macchia, Massimo Spada, Giovanna Schiavoni, Fabrizio Mattei, Adele De Ninno, Luca Businaro, Valeria Lucarini, Laura Bracci, Eleonora Arico, Giovanna Ziccheddu, Francesco Facchiano, Stefania Rossi, Massimo Sanchez, Alessandra Boe, Mauro Biffoni, Ruggero De Maria, Ilio Vitale, Antonella Sistigu
Summary: The study demonstrates that type I interferons can promote the formation of cancer stem cells by upregulating the chromatin remodeling factor KDM1B. Inhibition of KDM1B could potentially prevent stem cell expansion and increase the long-term benefit of therapy.
Article
Cell Biology
Daniela Peruzzu, Zaira Boussadia, Federica Fratini, Francesca Spadaro, Lucia Bertuccini, Massimo Sanchez, Maria Carollo, Paola Matarrese, Mario Falchi, Francesca Iosi, Carla Raggi, Isabella Parolini, Alessandra Care, Massimo Sargiacomo, Maria Cristina Gagliardi, Katia Fecchi
Summary: In this study, the role of cholesterol transport in the endosomal degradative-secretory system was explored using the U18666A inhibitor in a metastatic human melanoma cell line (WM266-4). The results showed that U18666A induced a shift of Cav-1 from the plasma membrane to the endolysosomal compartment, affecting the formation and release of small extracellular vesicles (sEVs). The inhibitor also altered the protein composition of sEVs and reduced their transfer capacity on target cells.
Article
Cell Biology
Agnese Stanzani, Anna Sansone, Cinzia Brenna, Vito Antonio Baldassarro, Giuseppe Alastra, Luca Lorenzini, Chryssostomos Chatgilialoglu, Ilaria Laface, Carla Ferreri, Luca Maria Neri, Laura Calza
Summary: The study analyzed changes in lipid composition due to inflammatory conditions. The fatty acid composition was measured in erythrocytes and spinal cord tissue of mice affected by experimental allergic encephalomyelitis (EAE). The results showed a decrease in PUFAs and an increase in SFAs in the membrane during the acute phase of EAE, while PUFAs decreased in the spinal cord tissue.
Article
Cell Biology
Marzia Moretti, Riccardo Caraffi, Luca Lorenzini, Ilaria Ottonelli, Michele Sannia, Giuseppe Alastra, Vito Antonio Baldassarro, Alessandro Giuliani, Jason Thomas Duskey, Maura Cescatti, Barbara Ruozi, Luigi Aloe, Maria Angela Vandelli, Luciana Giardino, Giovanni Tosi, Laura Calza
Summary: Spinal cord injury (SCI) causes sensory and motor disabilities without any cure. To improve myelin repair and limit degeneration, a multitherapy using nanomedicines loaded with T3, ibuprofen, and mNGF was developed. In vitro experiments confirmed the efficacy of T3-NMeds in promoting oligodendrocyte precursor cell differentiation. In vivo rat experiments showed short-term anti-inflammatory effects and long-term improvements in myelination, suggesting the potential effectiveness of this multiple treatment for SCIs.
Article
Biochemistry & Molecular Biology
Giovanna Mangiapane, Isabella Parolini, Kristel Conte, Matilde Clarissa Malfatti, Jessica Corsi, Massimo Sanchez, Agostina Pietrantoni, Vito G. D'Agostino, Gianluca Tell
Summary: The study elucidated the mechanisms by which APE1 is secreted through exosomes and revealed its delivery in response to genotoxic stresses, shedding new light on its noncanonical biological functions in cancer biology.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Xinyu Wang, Jun Huang, Huan Li, Yanlong Li, Shuang Cai, Bangxin Xue, Zhekun Zhu, Xiangzhou Zeng, Xiangfang Zeng
Summary: Embryo development plays a crucial role in pregnancy outcome and lifelong health. A high throughput screening cell model was established to select nutrients that can enhance embryonic development. Resveratrol was identified as a potential candidate for promoting embryo development.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Ren Yoshitomi, Motofumi Kumazoe, Kwan-Woo Lee, Yuki Marugame, Yoshinori Fujimura, Hirofumi Tachibana
Summary: This study investigated the connection between food components and circular RNA (circRNA), as well as the regulatory effect of (-)-Epigallocatechin-3-O-gallate (EGCG) on circRNA expression in the liver. The results showed that EGCG treatment altered the expression of circRNAs in mice livers, and one upregulated circRNA (mmu_circRNA_011775) affected the expression of genes related to liver fibrosis and the cardiovascular system.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
ViVi Tang Kang Wee, Hitoshi Shirakawa, Sung-Ling Yeh, Chiu-Li Yeh
Summary: This study investigated the effects of fermented rice bran (FRB) on modulating intestinal aryl hydrocarbon receptor (AhR) expression, innate lymphoid cell (ILC)3 populations, the fecal microbiota distribution, and their associations with dextran sodium sulfate (DSS)-induced acute colitis. The results showed that FRB supplementation can improve gut health, alleviate colitis symptoms, and have anti-colitis effects by enhancing ILC3 and AhR functions.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Xinzhuang Ma, Xijuan Ren, Xuemin Zhang, Guangyin Wang, Hui Liu, Li Wang
Summary: The study demonstrates that rutin can ameliorate kidney damage caused by PFOA exposure by improving oxidative stress and regulating lipid metabolism.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Ya-Jie Ding, Xue-Ning Li, Zhe Xiao, Chen-Yang Li, Li-Hong Jia
Summary: This study investigates the impact of maternal vitamin D levels during pregnancy on infantile eczema. The findings suggest that lower prenatal maternal vitamin D levels increase the risk of eczema in infants aged 0-1 year. Furthermore, the study indicates that infants with eczema have lower expression of the Foxp3 gene in cord blood and decreased placental FOXP3 protein expression. These results suggest that vitamin D may affect the development of infantile eczema through the regulation of gene and protein expression in cord blood and placenta.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Shujing Liu, Shiyu Song, Shuan Wang, Tonghui Cai, Lian Qin, Xinzhuang Wang, Guangming Zhu, Haibo Wang, Wenqi Yang, Chunlu Fang, Yuan Wei, Fu Zhou, Yang Yu, Shaozhang Lin, Shuang Peng, Liangming Li
Summary: Long-term consumption of a high-fat diet disrupts energy balance and leads to weight gain. The fat mass and obesity-associated (FTO) gene is involved in high-fat diet-induced obesity. The hypothalamus plays a crucial role in regulating energy balance, and high-fat diet-induced hypothalamic leptin resistance contributes to obesity. The study reveals that FTO is associated with hypothalamic leptin resistance and provides new insight into its role in obesity.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Shuang Liu, Xiaoling Chen, Jun He, Yuheng Luo, Ping Zheng, Bing Yu, Daiwen Chen, Zhiqing Huang
Summary: This study found that oleanolic acid promotes the transformation of fast muscle fibers to slow muscle fibers through the TGR5-mediated CaN/NFATc1 signaling pathway.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Huijuan Hu, Fan Li, Shaoli Cheng, Tingting Qu, Fanqi Shen, Jie Cheng, Lina Chen, Zhenghang Zhao, Hao Hu
Summary: Long-term alternate-day fasting can ameliorate obesity-induced anxiety-like behavior and hippocampal damage, but it can cause anxiety in normal-weight mice. Short-term alternate-day fasting does not produce adverse emotional reactions in normal-weight mice.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Jannis Ulke, Christian Schwedler, Janine Krueger, Vanessa Stein, Peter Geserick, Andre Kleinridders, Kai Kappert
Summary: This study characterized the glycosylation pattern of PTPRJ in the liver and found that high-fat diet-induced obesity altered the glycosylation pattern of PTPRJ. These findings provide new insights into the role of glycosylation in metabolic disorders.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Shuang Liu, Marii Mochizuki, Yasuyuki Suzuki, Erika Takemasa, Akiko Yano, Matome Imai, Masaki Mogi
Summary: This study evaluated the feasibility and efficacy of leucine supplementation in offsetting immune dysfunction in sarcopenia. The results showed that leucine supplementation not only improved muscle mass and restored mitochondrial respiratory function, but also reduced inflammation levels. These findings are important for the rational design and optimization of leucine supplementation in patients with sarcopenia and autoimmune diseases.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Review
Biochemistry & Molecular Biology
Zhan Su, Jun Fang, Bin Yao, Gang Liu
Summary: Osteoporosis is a serious skeletal disorder that can be prevented and treated by polyphenols, which have antioxidant and anti-allergy properties. Polyphenols affect bone metabolism and density by inhibiting oxidative stress and exhibiting antibacterial effects. This article provides an overview of the preventive and therapeutic effects of polyphenols on osteoporosis and discusses the mechanisms involved.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Qian Zhang, Xinhua Xiao, Jia Zheng, Ming Li, Miao Yu, Fan Ping, Tong Wang, Xiaojing Wang
Summary: Maternal high-fat diet can affect the structure and function of offspring's pancreas, leading to weight gain, glucose metabolism disorders, and insulin secretion defects. The study found that this may be related to DNA methylation of specific genes in the pancreas.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Hanaa Mousa, Aisha Al Saei, Rozaimi Mohamad Razali, Susu M. Zughaier
Summary: Vitamin D deficiency and dyslipidemia have significant implications for human health. This study investigates the proteomic profiles of individuals with and without these conditions, revealing decreased HDL-associated apolipoproteins and increased acute-phase proteins. Pathway analysis highlights inflammatory and cancer pathways associated with vitamin D deficiency and dyslipidemia.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Qi-Lan Jiang, Tao Li, Qin Xu, Yang Zeng, Wei Wang, Bo-Tao Zhang, Qing-Ping Yao, Rui Jiang, Jun Jiang
Summary: Environmental factors, especially dietary habits, play a significant role in the susceptibility and progression of cardiovascular diseases through epigenetic modification. This study found that a methyl donor diet can attenuate balloon injury-induced intimal hyperplasia in rat carotid arteries, potentially by influencing the composition and function of the extracellular matrix.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Review
Biochemistry & Molecular Biology
Jiayi Cai, Yajie Qiao, Lingbin Chen, Youguang Lu, Dali Zheng
Summary: The Notch signaling pathway plays a regulatory role in normal biological processes such as cellular differentiation, apoptosis, and stem cell self-renewal. Dysregulation of this pathway is associated with various types of cancer. Natural products targeting the Notch pathway have shown potential as chemopreventive and anti-cancer agents, providing a feasible solution to fight against cancer by either alone or in combination with current therapeutic agents.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)