Article
Gastroenterology & Hepatology
Muhammad Rehan, Ibrahim Al-Bahadly, David G. Thomas, Wayne Young, Leo K. Cheng, Ebubekir Avci
Summary: Smart capsules are rapidly advancing and have the potential to become important tools for diagnosing and monitoring gut health. They can measure physiological parameters and develop sampling devices for better understanding of gut health. This review provides an overview of the current status of smart capsules and discusses the challenges they face, as well as their prospects in healthcare. The development of robotic capsules for collecting gut microbiota samples is also highlighted as a game-changing advancement.
Article
Multidisciplinary Sciences
Na Tian, Yinyin Yan, Na Chen, Siyao Xu, Rui Chu, Mengting Wang, Surong Duan, Hongyan Ren, Shuhua Song, Li Wang, Xiaoqin Ma, Mei Xu, Li Na, Menghua Chen, Philip Kam-Tao Li
Summary: This exploratory study found a connection between malnutrition and intestinal microbiota in peritoneal dialysis patients. Certain bacteria in the gut microbiota of malnourished patients showed higher abundance and were negatively correlated with serum albumin and SGA score. These preliminary findings provide the basis for further research on the interaction between malnutrition and intestinal flora in dialysis patients and potential interventions using probiotics and prebiotics.
SCIENTIFIC REPORTS
(2023)
Article
Veterinary Sciences
Wentong Peng, Mir Zulqarnain Talpur, Yuxian Zeng, Peipei Xie, Jincheng Li, Songbo Wang, Lina Wang, Xiaotong Zhu, Ping Gao, Qingyan Jiang, Gang Shu, Haijun Zhang
Summary: This study found that a solid-state fermented feed additive can improve the growth performance and feed conversion ratio of broilers, and have positive effects on small intestine histology/morphology, immunity, and microbiota.
BMC VETERINARY RESEARCH
(2022)
Article
Microbiology
Melinda A. Engevik, Heather A. Danhof, Anne Hall, Kristen A. Engevik, Thomas D. Horvath, Sigmund J. Haidacher, Kathleen M. Hoch, Bradley T. Endres, Meghna Bajaj, Kevin W. Garey, Robert A. Britton, Jennifer K. Spinler, Anthony M. Haag, James Versalovic
Summary: Bifidobacterium dentium displayed acid resistance, adhered to human mucus, and metabolized various nutrient sources, indicating strong adaptability for colonization in the gastrointestinal tract.
Article
Nutrition & Dietetics
Fangshen Guo, Yanqiang Geng, Waseem Abbas, Wenrui Zhen, Shuiqing Wang, Yuechuan Huang, Yuming Guo, Qiugang Ma, Zhong Wang
Summary: This study investigated the impact and possible mechanisms of vitamin D3 (VD3) nutritional status on the gut health of hens challenged with Salmonella enterica serovar Enteritidis (SE). The results showed that VD3 sufficiency reversed the negative effects of salmonella infection and VD3 deficiency on laying performance of hens, ameliorated gut injury, and restored the balance of gut microbiota.
FRONTIERS IN NUTRITION
(2022)
Article
Physiology
Marina. K. K. Gerstenberg, Daniel. B. B. Andersen, Lola Torz, Carlos. M. M. Castorena, Angie. L. L. Bookout, Bolette Hartmann, Jens. F. F. Rehfeld, Natalia Petersen, Jens. J. J. Holst, Rune. E. E. Kuhre
Summary: After weight loss, the secretion of appetite-inhibiting hormones such as GLP-1 and PYY is still reduced, and other appetite-inhibiting hormones are also decreased. These results suggest that the reduced secretion of gut hormones in individuals with obesity may persist after weight loss and contribute to their susceptibility to weight regain.
Article
Multidisciplinary Sciences
Ingrid S. Surono, Dian Widiyanti, Pratiwi D. Kusumo, Koen Venema
Summary: The study aimed to investigate the difference in gut microbiota composition between stunted Indonesian children and children with normal nutritional status, revealing significantly lower levels of Prevotella 9 in stunted children. It also found differences in the relative abundance of Bacteroidetes and Firmicutes between the two groups. Additionally, stunted children had lower macronutrient intake and potentially higher energy loss in the form of short-chain fatty acids and branched-chain fatty acids.
Article
Multidisciplinary Sciences
Qing Xiao, Li Zhao, Chang Jiang, Yanjin Zhu, Jizhou Zhang, Juan Hu, Guozeng Wang
Summary: Polysaccharides in Pseudostellaria heterophylla (TZS) have been found to modulate the gut microbiota, reduce inflammation, and enhance immune function, thus alleviating spleen deficiency syndrome (SDS).
SCIENTIFIC REPORTS
(2022)
Review
Developmental Biology
Nicolas R. Chevalier
Summary: This review provides an up-to-date survey of the extrinsic and intrinsic mechanical forces acting on the embryonic vertebrate gut during development and their role in various aspects of intestinal morphogenesis, including enteric nervous system formation, epithelium structuring, muscle orientation and differentiation, anisotropic growth, and the development of myogenic and neurogenic motility.
Review
Cell Biology
Joseph Jose Thottacherry, Jia Chen, Daniel St Johnston
Summary: Apical-basal polarity is crucial for the form and function of intestinal epithelial cells, which form a single layer in the gut and have distinct apical, lateral, and basal domains. The occluding junctions at the apical side of the lateral domains play a crucial role in maintaining tissue homeostasis, protecting against gastrointestinal pathogens, and supporting immune response. While most epithelial cells establish apical-basal polarity through conserved polarity factors, recent studies suggest novel mechanisms in gut epithelium polarization. This review discusses the advances in understanding polarity factors, focusing on studies in C. elegans, Drosophila, Zebrafish, and Mouse.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Caroline Moser, Katherine A. Gossele, Miroslav Balaz, Lucia Balazova, Carla Horvath, Patricia Kuenzle, Katarzyna Maria Okreglicka, Fengqi Li, Matthias Blueher, Birgit Stierstorfer, Eva Hess, Thorsten Lamla, Bradford Hamilton, Holger Klein, Heike Neubauer, Christian Wolfrum, Susanne Wolfrum
Summary: The number of diabetic patients is increasing globally, leading to a rise in diabetes associated complications. The gut secretes various proteins that control blood glucose levels and food intake. In this study, a previously unexplored gut secreted protein called FAM3D was found to improve fasting blood glucose levels and insulin sensitivity, and reduce liver lipid deposition in obese mice.
Article
Nutrition & Dietetics
Chandrasekhar Balasubramaniam, Rashmi Hogarehalli Mallappa, Devendra Kumar Singh, Pankaj Chaudhary, Bhavneet Bharti, Santhosh Kumar Muniyappa, Sunita Grover
Summary: This study investigated the association of a dysbiotic gut with childhood malnutrition by assessing the abundance of major gut bacterial phyla and specific bacteria. The results showed higher abundance of Actinobacteria and Bifidobacterium in healthy children compared to those with severe acute malnutrition, while Lactobacillus showed higher abundance in malnourished children.
EUROPEAN JOURNAL OF NUTRITION
(2021)
Review
Gastroenterology & Hepatology
Vivienne Woo, Theresa Alenghat
Summary: The complex relationship between the gastrointestinal tract and microbiota is regulated by epigenetic modifications, including modifications to DNA or histones and regulation of non-coding RNAs. Further research is needed to fully understand the mechanisms of epigenetic regulation.
Review
Medicine, Research & Experimental
Jaqueline Barbosa de Souza, Maria Carolina Accioly Brelaz-de-Castro, Isabella Macario Ferro Cavalcanti
Summary: This review examines the current research on the microorganisms present in the gut microbiota that can influence the development of CRC, as well as possible treatment options to prevent the initiation and spread of the disease. Despite promising alternatives, further improvement and development are needed for new therapeutic approaches targeting the microorganisms that cause CRC.
Article
Environmental Sciences
Wenting Lin, Kan Li, Yingjun Qin, Xing Han, Xiaohui Chen, Yuan Ren
Summary: In this study, zebrafish were exposed to the benzodiazepine drug flunitrazepam (FLZ) for 30 days, and the results showed that FLZ disrupted the balance of gut microbiota, leading to pathological damage to the intestine and increased intestinal permeability. FLZ also interfered with nucleotide metabolism and amino acid biosynthesis in the brain, causing pathological changes. This study elucidated the molecular mechanisms of FLZ on the microbiota-gut-brain axis and provided a theoretical basis for the ecological environmental risk assessment of psychoactive substances.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Article
Geosciences, Multidisciplinary
Sietze J. de Graaff, Pim Kaskes, Thomas Dehais, Steven Goderis, Vinciane Debaille, Catherine H. Ross, Sean P. S. Gulick, Jean-Guillaume Feignon, Ludovic Ferriere, Christian Koeberl, Jan Smit, Nadine Mattielli, Philippe Claeys
Summary: This study characterizes the petrography and geochemistry of rocks and impactites from the Chicxulub impact structure in Mexico, aiming to investigate the components involved in impact melt formation and the emplacement processes at Chicxulub. The different impactite units are interpreted as different stages of impact melt rock injection and surface deposition during crater formation. The geochemical characterization of pre-impact lithologies provides insights into the composition of the impact melt rock units.
GEOLOGICAL SOCIETY OF AMERICA BULLETIN
(2022)
Article
Food Science & Technology
Rui Guo, Ai-min Shi, Lei Deng, Lei Li, Lie-chen Wang, Antwi-Boasiako Oteng, Meng-ping Wei, Zhi-hao Zhao, Guido Hooiveld, Chen Zhang, Qiang Wang
Summary: The active components DMN and MIL in PSL extract improve sleep quality by regulating neuronal excitability, indicating a potential mechanism for the traditional Chinese medicine's effects on sleep.
MOLECULAR NUTRITION & FOOD RESEARCH
(2022)
Article
Multidisciplinary Sciences
Melanie A. D. During, Jan Smit, Dennis F. A. E. Voeten, Camille Berruyer, Paul Tafforeau, Sophie Sanchez, Koen H. W. Stein, Suzan J. A. Verdegaal-Warmerdam, Jeroen H. J. L. van der Lubbe
Summary: This study examines the timing of the asteroid impact that caused the Cretaceous-Palaeogene mass extinction and reveals that it occurred during spring. Analysis of fish fossils indicates that the timing of the impact played a significant role in the survival and reproduction of organisms.
Article
Nutrition & Dietetics
Anna M. Malinowska, Dieuwertje E. Kok, Wilma T. Steegenga, Guido J. E. J. Hooiveld, Agata Chmurzynska
Summary: This study aimed to evaluate differences in gut microbiota composition and predicted functional properties between people with healthy and western dietary patterns. The results showed that dietary pattern was associated with beta-diversity of the microbiota, and individuals with a healthy dietary pattern had different levels of certain bacterial groups compared to those with a western dietary pattern. However, dietary intake and stool transit characteristics only explained a small proportion of the variance in microbiota composition and functional properties.
EUROPEAN JOURNAL OF NUTRITION
(2022)
Review
Neurosciences
Emily Connell, Gwenaelle Le Gall, Matthew G. Pontifex, Saber Sami, John F. Cryan, Gerard Clarke, Michael Mueller, David Vauzour
Summary: The increasing prevalence of age-related cognitive decline and dementia is a consequence of our ageing global population. The microbiota-gut-brain axis, a dynamic bidirectional communication system between the gut, its microbiome, and the central nervous system, may play a role in cognitive health and disease. Microbial-derived metabolites have been identified as potential risk factors for cognitive decline, impacting cognition through cytotoxic metabolite production, neuroinflammation, and other mechanisms.
MOLECULAR NEURODEGENERATION
(2022)
Article
Multidisciplinary Sciences
Francisco J. Rodriguez-Tovar, Pim Kaskes, Jens Ormo, Sean P. S. Gulick, Michael T. Whalen, Heather L. Jones, Christopher M. Lowery, Timothy J. Bralower, Jan Smit, David T. King, Steven Goderis, Philippe Claeys
Summary: Researchers have reconstructed the macrobenthic tracemaker community and marine paleoenvironment in the Chicxulub impact area prior to the large impact event using paleoichnology and micropaleontology. The study shows that the K-Pg impact event did not have significant effects on the composition of the macroinvertebrate tracemaker community in the Chicxulub region.
SCIENTIFIC REPORTS
(2022)
Article
Multidisciplinary Sciences
Menno Grouls, Aafke W. F. Janssen, Loes P. M. Duivenvoorde, Guido J. E. J. Hooiveld, Hans Bouwmeester, Meike van der Zande
Summary: This study investigates the effects of short-chain fatty acids (SCFAs) on gene expression in induced pluripotent stem cell derived intestinal epithelial cells. The findings show that each SCFA has a unique impact on gene expression, with butyrate having the largest effect followed by propionate and then acetate. The study also confirms the known effects of SCFAs on metabolism and immune responses.
SCIENTIFIC REPORTS
(2022)
Article
Endocrinology & Metabolism
Maartje A. J. Rops, Simone J. C. F. M. Moorlag, Rosanne C. van Deuren, Martin Jaeger, Leo A. B. Joosten, Marco Medici, Mihai G. Netea, Jan W. A. Smit, Romana T. Netea-Maier
Summary: This study aimed to evaluate the incidence, severity, and presence of symptoms of respiratory tract infections and COVID-19 in patients with pre-existing thyroid dysfunction. Results showed that patients with thyroid dysfunction did not have a higher risk of self-reported sickness or microbiologically confirmed SARS-CoV-2 infections. However, clinical diagnosis of COVID-19 was more frequent in patients with thyroid diseases, despite a lower incidence of self-reported respiratory-related symptoms compared to controls.
ARCHIVES OF ENDOCRINOLOGY METABOLISM
(2022)
Article
Biochemistry & Molecular Biology
Lei Deng, Frank Vrieling, Rinke Stienstra, Guido J. Hooiveld, Anouk L. Feitsma, Sander Kersten
Summary: Macrophages uptake and process triglyceride-rich lipoproteins through lipoprotein lipase and caveolae-mediated endocytosis. Triglyceride hydrolysis and storage in macrophages depend on lysosomal acid lipase and STARD3. These findings provide new insights into how macrophages process lipoproteins and suggest their remarkable capacity to excrete part of the internalized triglycerides as fatty acids.
Article
Toxicology
Janneke Elzinga, Menno Grouls, Guido J. E. J. Hooiveld, Meike van der Zande, Hauke Smidt, Hans Bouwmeester
Summary: There is a need for standardized in vitro models of the human intestinal tract to study intestinal health without using animals. The Caco-2 cell line is a widely accepted and characterized model for studying intestinal drug transport, host-microbe interactions, and toxicity. We investigated the effect of different experimental variables on gene expression using transcriptome analysis of Caco-2 cells grown on permeable membranes. Our analysis revealed a weak association between experimental variables and gene expression, possibly due to heterogeneity in cell culture practice and inadequate reporting. This highlights the need for improved reporting protocols and serves as a template for future comparative studies.
ARCHIVES OF TOXICOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Jiye Kang, Ziwei Wang, Eleonora Cremonini, Gwenaelle Le Gall, Matthew G. Pontifex, Michael Muller, David Vauzour, Patricia I. Oteiza
Summary: Mounting evidence shows that consuming a high-fat diet (HFD) and developing obesity can lead to changes in cognition and mood. However, certain dietary bioactives, such as (-)-epicatechin (EC), may help prevent obesity-related cognitive decline. This study investigated the effects of EC supplementation on HFD-induced obesity-associated alterations in memory and mood. The results demonstrate that EC can mitigate anxiety-related behaviors and impact BDNF and glucocorticoids-mediated signaling.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2022)
Article
Nutrition & Dietetics
Anna M. Malinowska, Malgorzata Majcher, Guido JEJ. Hooiveld, Hanna Przydatek, Marta Szaban, Agata Kurowiecka, Marcin Schmidt
Summary: This study aimed to evaluate the capacity of human fecal microbiota to produce SCFAs and metabolize soluble and insoluble fiber, and to study their associations with diet, anthropometric parameters, and carbohydrate and lipid metabolism. Results showed that high intake of vegetables, fruits, nuts, and seeds was associated with high fiber metabolism capacity. Additionally, the capacity to produce propionic acid was negatively associated with hip circumference, especially in individuals with a healthy diet.
JOURNAL OF NUTRITION
(2023)
Article
Nutrition & Dietetics
Matthew G. Pontifex, David Vauzour, Michael Muller
Summary: Diets and dietary constituents have an impact on disease risk, and this impact may be modulated by sex. Current evidence suggests that sex differences in disease risk are disease-specific, highlighting the importance of sex stratification in nutritional research.
PROCEEDINGS OF THE NUTRITION SOCIETY
(2023)
Article
Food Science & Technology
Shangxin Song, Yulin Gao, Tianlan Xia, Yefei Zhou, Guido J. E. J. Hooiveld, Michael Muller, Chunbao Li
Summary: This study investigated the impact of high or normal dietary chicken protein levels on obesity development in rats fed high-fat diets. The high chicken protein diet significantly reduced body weight gain, adipose tissue mass, and adipocyte size in comparison to the normal diet, without affecting food intake. It also reduced blood insulin and glycosylated serum protein, but had no effect on OGTT and HOMA-IR results. Additionally, the high chicken protein diet downregulated EAT transcriptomics related to lipid biosynthesis.
JOURNAL OF FUNCTIONAL FOODS
(2023)
Article
Biochemistry & Molecular Biology
Xinyu Wang, Jun Huang, Huan Li, Yanlong Li, Shuang Cai, Bangxin Xue, Zhekun Zhu, Xiangzhou Zeng, Xiangfang Zeng
Summary: Embryo development plays a crucial role in pregnancy outcome and lifelong health. A high throughput screening cell model was established to select nutrients that can enhance embryonic development. Resveratrol was identified as a potential candidate for promoting embryo development.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Ren Yoshitomi, Motofumi Kumazoe, Kwan-Woo Lee, Yuki Marugame, Yoshinori Fujimura, Hirofumi Tachibana
Summary: This study investigated the connection between food components and circular RNA (circRNA), as well as the regulatory effect of (-)-Epigallocatechin-3-O-gallate (EGCG) on circRNA expression in the liver. The results showed that EGCG treatment altered the expression of circRNAs in mice livers, and one upregulated circRNA (mmu_circRNA_011775) affected the expression of genes related to liver fibrosis and the cardiovascular system.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
ViVi Tang Kang Wee, Hitoshi Shirakawa, Sung-Ling Yeh, Chiu-Li Yeh
Summary: This study investigated the effects of fermented rice bran (FRB) on modulating intestinal aryl hydrocarbon receptor (AhR) expression, innate lymphoid cell (ILC)3 populations, the fecal microbiota distribution, and their associations with dextran sodium sulfate (DSS)-induced acute colitis. The results showed that FRB supplementation can improve gut health, alleviate colitis symptoms, and have anti-colitis effects by enhancing ILC3 and AhR functions.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Xinzhuang Ma, Xijuan Ren, Xuemin Zhang, Guangyin Wang, Hui Liu, Li Wang
Summary: The study demonstrates that rutin can ameliorate kidney damage caused by PFOA exposure by improving oxidative stress and regulating lipid metabolism.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Ya-Jie Ding, Xue-Ning Li, Zhe Xiao, Chen-Yang Li, Li-Hong Jia
Summary: This study investigates the impact of maternal vitamin D levels during pregnancy on infantile eczema. The findings suggest that lower prenatal maternal vitamin D levels increase the risk of eczema in infants aged 0-1 year. Furthermore, the study indicates that infants with eczema have lower expression of the Foxp3 gene in cord blood and decreased placental FOXP3 protein expression. These results suggest that vitamin D may affect the development of infantile eczema through the regulation of gene and protein expression in cord blood and placenta.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Shujing Liu, Shiyu Song, Shuan Wang, Tonghui Cai, Lian Qin, Xinzhuang Wang, Guangming Zhu, Haibo Wang, Wenqi Yang, Chunlu Fang, Yuan Wei, Fu Zhou, Yang Yu, Shaozhang Lin, Shuang Peng, Liangming Li
Summary: Long-term consumption of a high-fat diet disrupts energy balance and leads to weight gain. The fat mass and obesity-associated (FTO) gene is involved in high-fat diet-induced obesity. The hypothalamus plays a crucial role in regulating energy balance, and high-fat diet-induced hypothalamic leptin resistance contributes to obesity. The study reveals that FTO is associated with hypothalamic leptin resistance and provides new insight into its role in obesity.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Shuang Liu, Xiaoling Chen, Jun He, Yuheng Luo, Ping Zheng, Bing Yu, Daiwen Chen, Zhiqing Huang
Summary: This study found that oleanolic acid promotes the transformation of fast muscle fibers to slow muscle fibers through the TGR5-mediated CaN/NFATc1 signaling pathway.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Huijuan Hu, Fan Li, Shaoli Cheng, Tingting Qu, Fanqi Shen, Jie Cheng, Lina Chen, Zhenghang Zhao, Hao Hu
Summary: Long-term alternate-day fasting can ameliorate obesity-induced anxiety-like behavior and hippocampal damage, but it can cause anxiety in normal-weight mice. Short-term alternate-day fasting does not produce adverse emotional reactions in normal-weight mice.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Jannis Ulke, Christian Schwedler, Janine Krueger, Vanessa Stein, Peter Geserick, Andre Kleinridders, Kai Kappert
Summary: This study characterized the glycosylation pattern of PTPRJ in the liver and found that high-fat diet-induced obesity altered the glycosylation pattern of PTPRJ. These findings provide new insights into the role of glycosylation in metabolic disorders.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Shuang Liu, Marii Mochizuki, Yasuyuki Suzuki, Erika Takemasa, Akiko Yano, Matome Imai, Masaki Mogi
Summary: This study evaluated the feasibility and efficacy of leucine supplementation in offsetting immune dysfunction in sarcopenia. The results showed that leucine supplementation not only improved muscle mass and restored mitochondrial respiratory function, but also reduced inflammation levels. These findings are important for the rational design and optimization of leucine supplementation in patients with sarcopenia and autoimmune diseases.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Review
Biochemistry & Molecular Biology
Zhan Su, Jun Fang, Bin Yao, Gang Liu
Summary: Osteoporosis is a serious skeletal disorder that can be prevented and treated by polyphenols, which have antioxidant and anti-allergy properties. Polyphenols affect bone metabolism and density by inhibiting oxidative stress and exhibiting antibacterial effects. This article provides an overview of the preventive and therapeutic effects of polyphenols on osteoporosis and discusses the mechanisms involved.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Qian Zhang, Xinhua Xiao, Jia Zheng, Ming Li, Miao Yu, Fan Ping, Tong Wang, Xiaojing Wang
Summary: Maternal high-fat diet can affect the structure and function of offspring's pancreas, leading to weight gain, glucose metabolism disorders, and insulin secretion defects. The study found that this may be related to DNA methylation of specific genes in the pancreas.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Hanaa Mousa, Aisha Al Saei, Rozaimi Mohamad Razali, Susu M. Zughaier
Summary: Vitamin D deficiency and dyslipidemia have significant implications for human health. This study investigates the proteomic profiles of individuals with and without these conditions, revealing decreased HDL-associated apolipoproteins and increased acute-phase proteins. Pathway analysis highlights inflammatory and cancer pathways associated with vitamin D deficiency and dyslipidemia.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Qi-Lan Jiang, Tao Li, Qin Xu, Yang Zeng, Wei Wang, Bo-Tao Zhang, Qing-Ping Yao, Rui Jiang, Jun Jiang
Summary: Environmental factors, especially dietary habits, play a significant role in the susceptibility and progression of cardiovascular diseases through epigenetic modification. This study found that a methyl donor diet can attenuate balloon injury-induced intimal hyperplasia in rat carotid arteries, potentially by influencing the composition and function of the extracellular matrix.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Review
Biochemistry & Molecular Biology
Jiayi Cai, Yajie Qiao, Lingbin Chen, Youguang Lu, Dali Zheng
Summary: The Notch signaling pathway plays a regulatory role in normal biological processes such as cellular differentiation, apoptosis, and stem cell self-renewal. Dysregulation of this pathway is associated with various types of cancer. Natural products targeting the Notch pathway have shown potential as chemopreventive and anti-cancer agents, providing a feasible solution to fight against cancer by either alone or in combination with current therapeutic agents.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
