Article
Biochemistry & Molecular Biology
Xina Dou, Lei Qiao, Xiaofan Song, Jiajing Chang, Shanyao Pi, Xinyi Zhang, Xiaonan Zeng, Lixu Zhu, Chunlan Xu
Summary: This study reveals that the protective effects of selenium nanoparticles (SeNPs) against intestinal epithelial barrier dysfunction are associated with mitochondria-lysosomal crosstalk. SeNPs can alleviate intestinal epithelial barrier injury through regulating mitochondrial autophagy. These findings suggest that the protective effect of SeNPs on intestinal epithelial barrier injury is closely associated with the TBC1D15/Rab7-mediated mitochondria-lysosome crosstalk signaling pathway.
Article
Agriculture, Dairy & Animal Science
Xiao Xu, Yu Wei, Hongwei Hua, Huiling Zhu, Kan Xiao, Jiangchao Zhao, Yulan Liu
Summary: This study showed that glycine supplementation in the diet can alleviate intestinal damage caused by oxidative stress in weanling piglets. Glycine reduces intestinal oxidative stress and inhibits ferroptosis in intestinal epithelial cells. The findings suggest that dietary glycine supplementation improves the morphology and function of the intestinal mucosa by regulating antioxidant capacity and ferroptosis.
Article
Biochemistry & Molecular Biology
Jung-Ha Park, In Kyo Jung, Yongjun Lee, Soojung Jin, Hee Jung Yun, Byung Woo Kim, Hyun Ju Kwon
Summary: Drinking alcohol can stimulate the proliferation of small intestinal epithelial cells, potentially through activating the Wnt signaling pathway. This study's findings demonstrate the effects of alcohol consumption on small intestinal epithelial cells.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Article
Agriculture, Dairy & Animal Science
Jung Woong Yoon, Sang In Lee
Summary: This study used the porcine intestinal epithelial cell line IPEC-J2 as an in vitro model to investigate the molecular mechanisms and adverse effects of Ochratoxin A (OTA) exposure. The results revealed that OTA alters various molecular mechanisms and has detrimental effects on the cells.
JOURNAL OF ANIMAL SCIENCE AND TECHNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Zaozao Pan, Jiaqiang Huang, Ting Hu, Yonghong Zhang, Lingyu Zhang, Jiaxi Zhang, Defeng Cui, Lu Li, Jing Wang, Qiong Wu
Summary: In this study, the protective effects of chitosan-coated selenium nanoparticles (SeNPs) and inorganic selenium (Na2SeO3) on bisphenol A (BPA)-induced toxicity in porcine intestinal epithelial cells (IPEC-J2) were compared. The results showed that SeNPs and Na2SeO3 both attenuated the cellular damage caused by BPA. SeNPs were more effective than Na2SeO3 in protecting against BPA-induced tight junction function injury, proinflammatory response, oxidative stress, apoptosis, and endoplasmic reticulum stress. These findings suggest that selenium nanoparticles may be an effective tool for preventing BPA toxicity in animals and humans.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Ning Zhou, Yong Tian, Hongzhi Wu, Yongqing Cao, Ruiqing Li, Kang Zou, Wenwu Xu, Lizhi Lu
Summary: Resveratrol has antioxidant effects on duck intestinal epithelial cells, potentially alleviating oxidative stress and inhibiting cell apoptosis through the PI3K/AKT and P38 MAPK signaling pathways. These findings have important implications for studying the health benefits of resveratrol.
Article
Nutrition & Dietetics
Jaeeun Lee, Joo Weon Lim, Hyeyoung Kim
Summary: Oxidative stress induces DNA damage and apoptosis, while astaxanthin protects against oxidative stress-induced damage by preventing Ku protein degradation and suppressing apoptosis. The study found that oxidative stress decreases Ku70/80 expression through the ubiquitin-proteasome pathway, leading to DNA fragmentation and apoptotic cell death. However, astaxanthin inhibits oxidative stress-mediated apoptosis by reducing ROS levels and inhibiting Ku protein degradation. Overall, dietary astaxanthin supplementation or consumption of astaxanthin-rich food may be effective in preventing or delaying oxidative stress-induced cell damage by suppressing Ku protein loss and apoptosis in gastric epithelial cells.
Article
Immunology
Jingxia Gao, Guanzhong Song, Haibo Shen, Yiming Wu, Chongqi Zhao, Zhuo Zhang, Qian Jiang, Xilong Li, Xiaokang Ma, Bie Tan, Yulong Yin
Summary: This study found that allicin improves intestinal barrier function and prevents damage caused by bacteria. It increases cell viability and enhances the integrity of cell monolayers.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Food Science & Technology
Zheng Cao, Jinsong Gao, Wanyue Huang, Juli Yan, Anshan Shan, Xiang Gao
Summary: Curcumin protects against Deoxynivalenol-induced disruption of intestinal epithelial barrier by regulating apoptotic pathway and TJs pathway.
FOOD AND CHEMICAL TOXICOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Dongbin Zou, Yun Yang, Fengjie Ji, Renlong Lv, Tieshan Xu, Chengjun Hu
Summary: Intestinal vessels play a critical role in nutrient absorption, and low birth weight (LBW) has been found to inhibit intestinal angiogenesis through oxidative stress and DUOX2.
Article
Reproductive Biology
Kai Wang, Zhaojian Li, Yansen Li, Xiaotong Li, Yunpeng Suo, Chunmei Li
Summary: This study investigated the effects of high temperature on the morphology, oxidative stress levels, and testosterone synthesis in porcine testicular tissue. The results showed that high temperature exposure disrupted testicular morphology, induced oxidative stress, and inhibited testosterone synthesis.
Article
Immunology
Huan Qu, Qiufang Zong, Ping Hu, Zhaojian Li, Haifei Wang, Shenglong Wu, Hao-Yu Liu, Wenbin Bao, Demin Cai
Summary: The serum levels of cholesterol and its intermediates are important indicators of metabolism-related disorders. In this study, it was found that desmosterol (DES), the most abundant intermediate in cholesterol biosynthesis and highly enriched in red/brown algae, plays a crucial role in modulating genes related to oxidative stress and inflammatory response in ileum epithelial cells. DES treatment resulted in down-regulation of genes involved in oxidative and cholesterol homeostasis pathways, decreased cellular ROS levels, and upregulation of key inflammatory genes. DES also elevated the expression of nuclear receptor ROR-gamma, suggesting its potential role as a mediator. These findings highlight the physiological actions of DES in inflammatory and oxidative processes, and its potential applications in anti-oxidation treatment and immunotherapy in the future.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Gastroenterology & Hepatology
Xiaoming Hu, Fuxin Jiao, Jiali Deng, Ziheng Zhou, Shanghai Chen, Changqin Liu, Zhanju Liu, Feifan Guo
Summary: The incidence of inflammatory bowel disease (IBD) in the elderly has increased. Cytokine-inducible SH2-containing protein (CISH) is involved in the susceptibility of ageing-related colitis. CISH expression is increased in the colons of ageing mice and older ulcerative colitis patients. Targeted therapy against CISH may provide a novel strategy for treating ageing-related IBD.
JOURNAL OF CROHNS & COLITIS
(2023)
Article
Food Science & Technology
Z. Pardo, I Seiquer
Summary: Zinc supplementation was found to reduce cell membrane damage, alleviate oxidative stress, promote antioxidant enzyme activity, and protect intestinal barrier function under heat stress conditions, which may be a beneficial nutritional strategy against intestinal damage caused by high temperatures.
JOURNAL OF FUNCTIONAL FOODS
(2021)
Article
Agriculture, Dairy & Animal Science
Yun Ji, Yu He, Ying Yang, Zhaolai Dai, Zhenlong Wu
Summary: This study evaluated the protective effects of hydroxyproline (Hyp) on 4-hydroxy-2-nonenal (4-HNE)-induced oxidative stress in pig intestinal epithelial cells. The results showed that Hyp could attenuate cell apoptosis, DNA damage, and changes in oxidative stress-related molecules. Furthermore, the enhanced expression of Kruppel-like factor 4 (KLF4) may be involved in the protective effects of Hyp.