Article
Physiology
Chloe G. Henderson, Damian L. Turner, Steven J. Swoap
Summary: Alternate day fasting (ADF), pair-feeding (PF), and low-fat (LF) diets each lead to improved markers of health relative to high-fat diet-induced obese mice, with caloric restriction associated with ADF being the major factor for the noted improvements.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Oncology
Dan Shi, Jingjing Wu, Youqile Wu, Xiaojing Lin, Cai Xu, Xuemei Lian
Summary: Obesity induced by high-fat diet was found to promote lung tumorigenesis in C57BL/6J mice, with leptin-mediated activation of the PI3K/Akt/mTOR/STAT3 pathway likely playing a key role in this mechanism.
FRONTIERS IN ONCOLOGY
(2021)
Article
Chemistry, Medicinal
Sowmya Shree Gopal, Shinde Vijay Sukhdeo, Baskaran Vallikannan, Ganesan Ponesakki
Summary: Lutein has antiobesity effects in a high-fat diet-induced obese mouse model, reducing adipose tissue weight, serum cholesterol, triglycerides, and blood glucose levels, as well as downregulating genes and proteins associated with obesity.
PHYTOTHERAPY RESEARCH
(2023)
Article
Microbiology
Carmen P. Ortega-Santos, Layla Al-Nakkash, Corrie M. Whisner
Summary: This study aimed to investigate the effects of genistein, exercise, and their combined effect on gut microbiota changes and obesity. The results showed that exercise and genistein could reduce weight gain and gut microbiota richness, but switching from a high-fat, high-sugar diet to chow had the greatest potential to revert these characteristics.
Article
Food Science & Technology
Chia-Chien Hsieh, Yen-Fang Wang, Pin-Yu Lin, Shih-Han Peng, Mei-Jia Chou
Summary: The study revealed that lunasin can reduce inflammation levels in obese mice, decrease macrophage infiltration in adipose tissue, and regulate spleen size and cell numbers. Additionally, lunasin promotes the production of interferon gamma and interleukin-2 in splenocytes, thus modulating immune responses.
FOOD AND CHEMICAL TOXICOLOGY
(2021)
Article
Multidisciplinary Sciences
Shino Nemoto, Tetsuya Kubota, Hiroshi Ohno
Summary: This study investigates the genetic cause of phenotypic differences between B6J and B6N mice, identifying candidate genes with differential expression in metabolic tissues and providing comparative data on body weight, tissue weight, blood components, and energy balance. These findings have important implications for future research in related fields.
Article
Endocrinology & Metabolism
Katherine Veras, Camila Ferraz Lucena, Julia Goedcke, Fabiana S. Evangelista, Angelo Carpinelli, Carla Roberta de Oliveira Carvalho
Summary: This study evaluated the effects of moderated aerobic treadmill exercise training on pancreatic islet cell viability and function in mice consuming a high-fat and sucrose diet. The results showed that exercise training can slow down and prevent adverse metabolic effects associated with consuming a westernized diet.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Cong Liang, Xiao-Hong Zhou, Pi-Min Gong, Hai-Yue Niu, Lin-Zheng Lyu, Yi-Fan Wu, Xue Han, Lan-Wei Zhang
Summary: The novel strain Lactiplantibacillus plantarum H-87 exhibited excellent anti-obesity effects by altering the bile acid enterohepatic circulation to alleviate HFD-induced obesity.
Article
Pharmacology & Pharmacy
Kenneth Alper, Janelle Cange, Ria Sah, Deanna Schreiber-Gregory, Henry Sershen, K. Yaragudri Vinod
Summary: This study investigated the effects of psilocybin on voluntary ethanol consumption in adult male and female C57BL/6J mice. The results showed that psilocybin reduced ethanol consumption and preference in male mice, but had no significant effect in female mice.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Nutrition & Dietetics
Hye-Lin Kim, You Mee Ahn, So Min Lee, Chang-Seob Seo, Seong-Hwan Park, Ok-Sun Bang, Jeeyoun Jung
Summary: This study investigated the anti-obesity effects of an aqueous extract of Sunbanghwalmyung-eum (SBH) in high-fat and high-cholesterol diet-induced obese mice. The results showed that SBH reduced body weight gain and fat accumulation, improved plasma lipid levels, inhibited inflammation, and regulated adipogenic factors, ultimately alleviating obesity symptoms.
Article
Nutrition & Dietetics
Sophie B. Chehade, George B. H. Green, Christopher D. Graham, Ayanabha Chakraborti, Bijal Vashai, Amber Moon, Michael B. Williams, Benjamin Vickers, Taylor Berryhill, William van der Pol, Landon Wilson, Mickie L. Powell, Daniel L. Smith, Stephen Barnes, Casey Morrow, M. Shahid Mukhtar, Gregory D. Kennedy, James A. Bibb, Stephen A. Watts
Summary: Investigations have shown that western dietary patterns play a causative role in obesity and disease pathogenesis, and the quality and quantity of dietary fats and carbohydrates can predict the development of these disorders. Traditional rodent diets do not reflect modern human dietary habits, and high-fat diets used in previous studies did not accurately represent human fat intake levels. Recent research focuses on developing pre-clinical diets that resemble human diets. This study emphasizes the importance of diet quality in maintaining metabolic homeostasis and highlights the need for relevant pre-clinical diets to study chronic diseases affected by western dietary consumption patterns.
FRONTIERS IN NUTRITION
(2022)
Article
Multidisciplinary Sciences
Brenda Kick, Laura Anderson, Rosalinda Doty, Christine Wooley, Meaghan Dyer, Torrian Green, Veronica Knickerbocker, Zoe Brown, Samantha Loeber, Janine Wotton, Bonnie Lyons, Linda Waterman, Zoe Bichler
Summary: Tarsal joint abnormalities, including calcaneal displacement, inflammation, and proliferation of cartilage and connective tissue, have been observed in aged male mice of the C57BL/6J lineage. These abnormalities lead to decreased body weight, increased frailty, heightened touch sensitivity, and reduced running ability. This study emphasizes the importance of further characterizing inbred mouse mutations.
Article
Nutrition & Dietetics
Ling Liu, Songfeng Yu, Tingting Bu, Guoqing He, Shanshan Li, Jianping Wu
Summary: This study found that the components VPP and IPP derived from bovine casein hydrolysates can alleviate chronic inflammation caused by obesity and improve adipocyte dysfunction. The results showed that 4% casein hydrolysates could mitigate high fat diet-induced chronic inflammation and prevent obesity-related inflammation and adipocyte dysfunction.
Article
Nutrition & Dietetics
Tsun-Li Cheng, Zi-Yun Lin, Keng-Ying Liao, Wei-Chi Huang, Cian-Fen Jhuo, Pin-Ho Pan, Chun-Jung Chen, Yu-Hsiang Kuan, Wen-Ying Chen
Summary: This study investigated the potential of Magnesium lithospermate B (MLB) in combating muscle atrophy in mice with high-fat diet (HFD)-induced obesity. The results showed that MLB supplementation alleviated metabolic abnormalities and prevented muscle loss caused by obesity, likely through inhibiting muscle degradation pathways. This study also revealed changes in inflammatory markers and signaling pathways associated with muscle atrophy.
Article
Nutrition & Dietetics
Dean S. Ross, Tzu-Hsuan Yeh, Shalinie King, Julia Mathers, Mark S. Rybchyn, Elysia Neist, Melissa Cameron, Alexander Tacey, Christian M. Girgis, Itamar Levinger, Rebecca S. Mason, Tara C. Brennan-Speranza
Summary: This study explored the effects of a high fat diet on glucose metabolism and bone density in developing and mature male C57BL/6J mice. The results showed that high fat diet significantly impaired glucose tolerance and reduced bone density in both age groups, with more pronounced effects in the mature mice. This mature HFD mouse model accurately represents late-onset impaired glucose tolerance/pre-T2DM cases in humans and provides insights into the mechanisms of skeletal fragility in these patients.
Letter
Rheumatology
Maja Skov Kragsnaes, Jens Kjeldsen, Hans Christian Horn, Heidi Lausten Munk, Jens Kristian Pedersen, Soren Andreas Just, Palle Ahlquist, Jesper Romhild Davidsen, Anna Christine Nilsson, Richard Rottger, Mogens Kruhoffer, Julian R. Marchesi, Karsten Kristiansen, Robin Christensen, Torkell Ellingsen
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Article
Nutrition & Dietetics
Jin-Gang Wang, Si-Han Zhao, Yu-Cheng Qian, Yi-Fan Qian, Yi-Chan Liu, Fang Qiao, Yuan Luo, Mei-Ling Zhang, Zhen-Yu Du
Summary: Hormone-sensitive lipase (HSL) is a key enzyme in lipid metabolism, and its dysfunction affects nutrient homeostasis and energy balance. In this study, hsla-deficient and HSL-inhibited zebrafish models were established, revealing retardation in growth, altered gene expression related to inflammation and apoptosis, and severe fat deposition. Hsl dysfunction also disrupted lipid catabolism, glycogen breakdown, and protein metabolism, leading to energy compensation. These findings highlight the important role of Hsl in maintaining energy homeostasis.
BRITISH JOURNAL OF NUTRITION
(2023)
Review
Biochemistry & Molecular Biology
Finn E. von Eyben, Karsten Kristiansen, Daniel S. Kapp, Rong Hu, Ovidiu Preda, Francisco F. Nogales
Summary: This review summarizes the literature on the gene expression and epigenetic regulation of germ cell tumors of the testis type II (TGCT). The seminoma subtype of TGCT expresses a panel of induced pluripotent stem cell (iPSC) with four upregulated genes, while the embryonal carcinoma (EC) subtype has a different set of four upregulated genes. The epigenetic mechanisms, such as DNA methylation and histone modifications, regulate the expression of these driver genes and contribute to the clinical characteristics of TGCT.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Ecology
Jacob A. Rasmussen, Pia Kiilerich, Abdullah S. Madhun, Rune Waagbo, Erik-Jan R. Lock, Lise Madsen, M. Thomas P. Gilbert, Karsten Kristiansen, Morten T. Limborg
Summary: Understanding the evolutionary relationships between a host and its intestinal resident bacteria can transform our understanding of adaptive phenotypic traits. This study reveals a strong co-evolution between the population structure of Atlantic salmon and nucleotide variability of the intestinal Mycoplasma populations, indicating an interplay between the host and its resident bacteria.
Article
Immunology
Daniel Andersen, Janne Marie Moll, Pankaj Arora, Niels Banhos Danneskiold-Samsoe, Si Brask Sonne, Christopher Thomas Workman, Andrew Richard Williams, Karsten Kristiansen, Susanne Brix
Summary: Intestinal tuft cells and immune responses were examined in mice fed a high-fat diet and gavaged with helminth PCF. Helminth PCF upregulated gene expression in tuft cells and increased levels of innate lymphoid cells and eosinophils. Network analyses revealed immunometabolic cues linking tuft cell response to fat mass ratio and eosinophils in eWAT to body fat mass regulation.
PARASITE IMMUNOLOGY
(2023)
Article
Multidisciplinary Sciences
Xiaoqian Lin, Tongyuan Hu, Jianwei Chen, Hewei Liang, Jianwei Zhou, Zhinan Wu, Chen Ye, Xin Jin, Xun Xu, Wenwei Zhang, Xiaohuan Jing, Tao Yang, Jian Wang, Huanming Yang, Karsten Kristiansen, Liang Xiao, Yuanqiang Zou
Summary: The authors present an expanded version of the Cultivated Genome Reference (CGR), termed CGR2, which includes 3324 high-quality draft genomes based on gut bacterial isolates from Chinese individuals. They classify 527 species from 8 phyla, including 179 previously unidentified species, and provide information on secondary metabolite biosynthetic gene clusters and gut phage-bacteria interactions.
NATURE COMMUNICATIONS
(2023)
Article
Cell Biology
Valdemar Brimnes Ingemann Johansen, Daisy Faero, Karsten Buschard, Karsten Kristiansen, Flemming Pociot, Pia Kiilerich, Knud Josefsen, Martin Haupt-Jorgensen, Julie Christine Antvorskov
Summary: The incidence of type 1 diabetes is increasing and environmental factors are believed to contribute to it. A gluten-free diet has been shown to improve autoimmune diabetes in non-obese diabetic (NOD) mice and humans. This study conducted analysis of gut microbiota and pancreatic immune environment in NOD mice fed a gluten-free (GF) diet and a gluten-containing standard (STD) diet. The results revealed distinct microbiota compositions and reduced insulitis in GF mice, suggesting a protective effect of a GF diet in humans.
Article
Fisheries
An -Hui Jin, Yi-Fan Qian, Jiong Ren, Jin-Gang Wang, Fang Qiao, Mei-Ling Zhang, Zhen-Yu Du, Yuan Luo
Summary: Inhibition of PDKs promotes glucose utilization, reduces hepatic lipid deposition, and improves oxidative stress in carnivorous fish. This finding contributes to the understanding of the role of the PDKs-PDHE1a axis in glucose metabolism and improves the utilization of dietary carbohydrates in farmed carnivorous fish.
FISH & SHELLFISH IMMUNOLOGY
(2023)
Article
Food Science & Technology
Atabak M. Azad, Annette Bernhard, Anne Shen, Lene Secher Myrmel, Anne-Katrine Lundebye, Laurene Alicia Lecaudey, Even Fjaere, Quang Tri Ho, Harald Sveier, Karsten Kristiansen, Morten Tonsberg Limborg, Lise Madsen
Summary: Alternative feed ingredients, such as blue mussel meal, can replace fish meal in farmed salmon feed without adversely affecting the fatty acid content of the fish. This study also found that including blue mussel meal in a meat-based diet led to a dose-dependent increase in the fatty acid ratios in mice livers.
FOOD RESEARCH INTERNATIONAL
(2023)
Article
Engineering, Environmental
Quang Tri Ho, Sylvia Frantzen, Bente M. Nilsen, Ole Jakob Nostbakken, Atabak M. Azad, Arne Duinker, Lise Madsen, Michael S. Bank
Summary: This study investigated the bioaccumulation of persistent organic pollutants (POPs) in marine fish from the North-East Atlantic Ocean (NEAO). It was found that POPs congener composition profiles were mainly influenced by fish species rather than geographical location. The study also revealed that factors such as fat content, fish size, trophic position, and latitude had an impact on POPs concentrations in fish. Additionally, a non-linear relationship between POPs concentrations and fat content was observed, with concentrations reaching saturation when fat content exceeded 10%.
JOURNAL OF HAZARDOUS MATERIALS
(2023)
Review
Fisheries
Zhe Wang, Fang Qiao, Wen-Bing Zhang, Giuliana Parisi, Zhen-Yu Du, Mei-Ling Zhang
Summary: With the increasing demand for high-quality aquatic products, controlling the harvest quality of farmed fish is crucial in aquaculture industry. Texture is a key sensory property that greatly affects consumers' perception and satisfaction. Extensive research has been conducted on texture quality, focusing on its related theories, influencing factors, and intervention strategies. Texture is mainly determined by muscle fibres, intramuscular connective tissue, and intramuscular fat, which can be modified through nutritional and management factors. This article provides an overview of these muscle components and discusses promising methods for manipulating fish texture, such as dietary intervention, feed restriction, and exercise training. The specific considerations for their applications in large-scale aquaculture facilities are also highlighted.
REVIEWS IN AQUACULTURE
(2023)
Article
Rheumatology
Maja Skov Kragsnaes, Jesus Miguens Blanco, Benjamin H. Mullish, Jose Ivan Contreras-Serrano, Jens Kjeldsen, Hans Christian Horn, Jens Kristian Pedersen, Heidi Lausten Munk, Anna Christine Nilsson, Ash Salam, Matthew R. Lewis, Elena Chekmeneva, Karsten Kristiansen, Julian R. Marchesi, Torkell Ellingsen
Summary: This study investigated the intestinal permeability and metabolomic profiles in methotrexate-treated psoriatic arthritis patients, and their relationship with clinical response. The results showed that intestinal permeability and metabolomic profiles were associated with the primary clinical trial end point.
ACR OPEN RHEUMATOLOGY
(2023)
Article
Cell Biology
Liang Sun, Zhiming Li, Caiyou Hu, Jiahong Ding, Qi Zhou, Guofang Pang, Zhu Wu, Ruiyue Yang, Shenghui Li, Jian Li, Jianping Cai, Yuzhe Sun, Rui Li, Hefu Zhen, Shuqin Sun, Jianmin Zhang, Mingyan Fang, Zhihua Chen, Yuan Lv, Qizhi Cao, Yanan Sun, Ranhui Gong, Zezhi Huang, Yong Duan, Hengshuo Liu, Jun Dong, Junchun Li, Jie Ruan, Haorong Lu, Benjin He, Ninghu Li, Tao Li, Wenbin Xue, Yan Li, Juan Shen, Fan Yang, Cheng Zhao, Qinghua Liang, Mingrong Zhang, Chen Chen, Huan Gong, Yong Hou, Jian Wang, Ying Zhang, Huanming Yang, Shida Zhu, Liang Xiao, Zhen Jin, Haiyun Guo, Peng Zhao, Susanne Brix, Xun Xu, Huijue Jia, Karsten Kristiansen, Ze Yang, Chao Nie
Summary: This study analyzed the gut microbiota and serum metabolome of individuals from a Chinese longevity cohort, as well as two other aging cohorts, and discovered age-dependent differences in both microbiota and serum metabolome. They also found potential causal relationships between specific gut microbes and serum metabolite markers related to impaired renal function and aging. The findings provide valuable insights into the effects of microbiota-metabolite interplay on renal function and healthy aging.