Article
Infectious Diseases
Abdullahi Temitope Jamiu, Jacobus Albertyn, Olihile Sebolai, Onele Gcilitshana, Carolina H. Pohl
Summary: The incidence of infections caused by non-albicans Candida species, including Candida krusei, is increasing, and these infections show resistance to fluconazole and can form biofilms. This study found that linoleic acid (LA) and gamma-linolenic acid (GLA) can inhibit C. krusei biofilms and increase their susceptibility to fluconazole by inducing oxidative stress, cell membrane damage, and disrupting efflux pump activity. These PUFAs also prolonged the lifespan of infected nematodes and showed a synergistic effect with fluconazole, suggesting a potential new treatment strategy for combating infections caused by C. krusei.
Article
Agronomy
Remus Sebastian Sipos, Simona Szasz, Radu Fechete, Eliana Coman, Florina Ruta
Summary: This study highlights the comparative nutritional properties of eggs from different breeds of laying hens using innovative methods like FT-IR spectra. The results show that there is a significant difference in the micronutrient composition of eggs depending on the breed of the laying hen.
Article
Biochemistry & Molecular Biology
Balasubramanian Chellammal Muthubharathi, Boopathi Balasubramaniam, Dilawar Ahmad Mir, Velayutham Ravichandiran, Krishnaswamy Balamurugan
Summary: Metabolomic reprogramming was found to play a crucial role in the activation of regulatory mechanisms during C. sakazakii infection in C. elegans, leading to disordered neurotransmitter transmission and decreased antioxidant levels. This study revealed the impact of pathogen infection on behavior, physiology, and biochemistry of the nematode host, indicating potential neuroprotective and cytotoxic responses mediated by serotonin and other metabolites. The findings suggest a complex interplay between pathogen-induced metabolic changes and neuronal damage in the host organism.
ACS CHEMICAL NEUROSCIENCE
(2021)
Article
Biochemistry & Molecular Biology
Yaping Shao, Zhenfa Fu, Yanfeng Wang, Zhaofei Yang, Yushan Lin, Song Li, Cheng Cheng, Min Wei, Zheyi Liu, Guowang Xu, Weidong Le
Summary: By using metabolomics and lipidomics analysis, this study investigated the effects of fasting on brain metabolism in mice. The results showed that fasting induced triacylglycerol degradation and lipolysis to meet energy demands, and led to changes in amino acid profiles that may play crucial roles in energy metabolism, neurotransmitter signaling, and anti-inflammatory and antioxidant responses. Additionally, the study reported a significant elevation of neuroprotective lipids called N-acylethanolamines in the brain and liver during fasting. These findings provide novel insights into the molecular basis and mechanisms of calorie restriction and offer a comprehensive resource for further investigation.
SIGNAL TRANSDUCTION AND TARGETED THERAPY
(2023)
Article
Multidisciplinary Sciences
Helena Rawsthorne, Fernando Calahorro, Lindy Holden-Dye, Vincent O'Connor, James Dillon
Summary: Autism spectrum disorder (ASD) is a neurodevelopmental disorder characterized by disruptions in social behavior, with a clear genetic basis. However, the specific mechanisms of how genes affect neural circuits leading to behavioral impairments are still not fully understood.
Article
Multidisciplinary Sciences
Shaojie Cui, Glenn Simmons, Goncalo Vale, Yaqin Deng, Jungyeon Kim, Hyeonwoo Kim, Ruihui Zhang, Jeffrey G. McDonald, Jin Ye
Summary: This study reveals that Fas-associated factor 1 (FAF1) interacts directly with free polyunsaturated fatty acids (PUFAs) and this interaction is crucial for protecting cells from ferroptosis. FAF1 assembles a globular structure that sequesters free PUFAs into a hydrophobic core, preventing PUFA peroxidation and ultimately inhibiting ferroptosis initiation.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Environmental Sciences
Marua Abu Risha, Asghar Ali, Puntita Siengdee, Nares Trakooljul, Dirk Dannenberger, Klaus Wimmers, Siriluck Ponsuksili
Summary: Climate change-induced temperature fluctuations have detrimental effects on the health and productivity of farm animals. This study investigates the impact of temperature stress on muscle cell differentiation, growth, and membrane fatty acid composition, revealing changes in molecular pathways related to lipid metabolism and fatty acid elongation.
SCIENCE OF THE TOTAL ENVIRONMENT
(2022)
Article
Agricultural Engineering
Anil Kumar Patel, Ajeet Singh Chauhan, Prashant Kumar, Philippe Michaud, Vijai Kumar Gupta, Jo-Shu Chang, Chiu-Wen Chen, Cheng-Di Dong, Reeta Rani Singhania
Summary: This article provides an update on the production of essential fatty acids from potential microbes and explores novel strategies to promote the accumulation of omega-3 and omega-6 through engineering and omics approaches.
BIORESOURCE TECHNOLOGY
(2022)
Article
Chemistry, Applied
Pengkai Wang, Jingna Liu, Yuanhong Zhuang, Peng Fei
Summary: In this study, the acylation modification of blueberry anthocyanins with fatty acid side chains significantly improved the lipid solubility and antioxidant activities, demonstrating potential applications in the food and pharmaceutical industries.
Article
Nutrition & Dietetics
Michael Fridden, Andrdes Martinez Mora, Lars Lind, Ulf Riserus, Joel Kullberg, Fredrik Rosqvist
Summary: In this study conducted on participants of UK Biobank, it was found that intake of saturated and animal fat is positively associated with liver fat, visceral fat, and intermuscular fat, whereas biomarkers of polyunsaturated fat are inversely associated with these fat deposits. This suggests that the type of dietary fat is an important determinant of ectopic fat in the human body.
CLINICAL NUTRITION
(2023)
Article
Biochemistry & Molecular Biology
Haruhiko Jimbo, Koki Yuasa, Kensuke Takagi, Takashi Hirashima, Sumie Keta, Makiko Aichi, Hajime Wada
Summary: Our study showed that PUFAs accelerate the photodamage to PSII in Synechocystis cells, while monounsaturated fatty acids do not have this effect. PUFAs are specifically incorporated into the sn-2 position of PG molecules, a process that requires the involvement of acyl-ACP synthetase.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biodiversity Conservation
Ana M. M. Goncalves, Carolina P. Rocha, Joao C. Marques, Fernando J. M. Goncalves
Summary: The toxic effects of pesticides, especially in aquatic ecosystems, have been a major concern for environmental and human safety. Biomarkers, such as antioxidant enzymes and fatty acids, are crucial in assessing the impacts of pesticides on organisms. Fatty acids have been identified as potential biomarkers due to their sensitivity to alterations in organism homeostasis, particularly in freshwater communities.
ECOLOGICAL INDICATORS
(2021)
Editorial Material
Medicine, Research & Experimental
Philip C. Calder, Nicolaas E. P. Deutz
Summary: This article summarizes two highly cited papers published in Clinical Science in 1982 and 2011, which investigated the effects of stable isotope-labeled amino acids infusion and high-dose omega-3 fatty acid intake on skeletal muscle protein synthesis. These papers provide experimental approaches to study human physiology, novel insights into the impact of nutritional state and specific nutrients on muscle protein synthesis, and potential interventions for preventing and reversing muscle mass decline.
Article
Multidisciplinary Sciences
Jorge Ivan Castillo-Quan, Michael J. Steinbaugh, Laura Paulette Fernandez-Cardenas, Nancy K. Pohl, Ziyu Wu, Feime Zhu, Natali Moroz, Veronic Teixeira, Monet S. Bland, Nicolas J. Lehrbach, Lorenz Moronetti, Magdalen Teufi, T. Keith Blackwell
Summary: This study reveals that oleic acid (OA) can promote lipid homeostasis, reduce steatosis, and mediate longevity in C. elegans through activation of the ER-resident transcription factor SKN-1A. This unexpected mechanism of FA signal transduction and lipid homeostasis pathway may provide strategies for opposing obesity-related pathologies and aging, and explain the benefits of the OA-rich Mediterranean diet.
Article
Biochemistry & Molecular Biology
Nidhi Hans, Shreya Gupta, Falguni Pattnaik, Ashok Kumar Patel, Satyanarayan Naik, Anushree Malik
Summary: This study recovers maximum value-added products from Kappaphycus alvarezii using emerging green extraction technologies and evaluates their bio-functional properties. Supercritical fluid extraction (SFE) and ultrasonication assisted approach are used to extract lipids and κ-carrageenan from the biomass, while subcritical water hydrolysis is used to recover total protein. The effectiveness of κ-carrageenan in inhibiting the main protease of SARS-CoV-2 is investigated using in vitro and in silico approaches.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)