Combination fluconazole/paroxetine treatment is neuroprotective despite ongoing neuroinflammation and viral replication in an SIV model of HIV neurological disease

Antiretroviral drugs induce oxidative stress and neuronal damage in the central nervous system

(2014) Cagla Akay et al.   JOURNAL OF NEUROVIROLOGY

Fluoxetine Pretreatment Promotes Neuronal Survival and Maturation after Auditory Fear Conditioning in the Rat Amygdala

(2014) Lizhu Jiang et al.   PLoS One

Biomarker Evidence of Axonal Injury in Neuroasymptomatic HIV-1 Patients

(2014) Jan Jessen Krut et al.   PLoS One

Effects of Chronic Fluoxetine Treatment on Neurogenesis and Tryptophan Hydroxylase Expression in Adolescent and Adult Rats

(2014) Anne Klomp et al.   PLoS One

How Might We Cure HIV?

(2014) David M. Margolis   Current Infectious Disease Reports

Implementing Neuronal Plasticity in NeuroAIDS: the Experience of Brain-derived Neurotrophic Factor and other Neurotrophic Factors

(2013) Italo Mocchetti et al.   Journal of Neuroimmune Pharmacology

Targeting the Glutamatergic System for the Treatment of HIV-Associated Neurocognitive Disorders

(2013) Michelle C. Potter et al.   Journal of Neuroimmune Pharmacology

Pharmacotherapy with Fluoxetine Restores Functional Connectivity from the Dentate Gyrus to Field CA3 in the Ts65Dn Mouse Model of Down Syndrome

(2013) Fiorenza Stagni et al.   PLoS One

Role of nonsynaptic GluN2B-containing NMDA receptors in excitotoxicity: Evidence that fluoxetine selectively inhibits these receptors and may have neuroprotective effects

(2012) E.S. Vizi et al.   BRAIN RESEARCH BULLETIN

Targeting HIV latency: pharmacologic strategies toward eradication

(2012) Sifei Xing et al.   DRUG DISCOVERY TODAY

Catechins protect neurons against mitochondrial toxins and HIV proteins via activation of the BDNF pathway

(2012) Samir Nath et al.   JOURNAL OF NEUROVIROLOGY

CaMKII regulation in information processing and storage

(2012) Steven J. Coultrap et al.   TRENDS IN NEUROSCIENCES

Early Minocycline Treatment Prevents a Decrease in Striatal Dopamine in an SIV Model of HIV-Associated Neurological Disease

(2011) Kelly A. Meulendyke et al.   Journal of Neuroimmune Pharmacology

Fluoxetine prevents MPTP-induced loss of dopaminergic neurons by inhibiting microglial activation

(2011) Young C. Chung et al.   NEUROPHARMACOLOGY

Fluoxetine protects neurons against microglial activation-mediated neurotoxicity

(2011) Feng Zhang et al.   PARKINSONISM & RELATED DISORDERS

HIV and SIV Induce Alterations in CNS CaMKII Expression and Activation

(2010) Ravi G. Gupta et al.   AMERICAN JOURNAL OF PATHOLOGY

Paroxetine Prevents Loss of Nigrostriatal Dopaminergic Neurons by Inhibiting Brain Inflammation and Oxidative Stress in an Experimental Model of Parkinson's Disease

(2010) Y. C. Chung et al.   JOURNAL OF IMMUNOLOGY

Simian Immunodeficiency Virus–Infected Macaques Treated with Highly Active Antiretroviral Therapy Have Reduced Central Nervous System Viral Replication and Inflammation but Persistence of Viral DNA

(2010) M. Christine Zink et al.   JOURNAL OF INFECTIOUS DISEASES

HIV-Associated Neurocognitive Disorder: Pathogenesis and Therapeutic Opportunities

(2010) Kathryn A. Lindl et al.   Journal of Neuroimmune Pharmacology

Rescue of adult hippocampal neurogenesis in a mouse model of HIV neurologic disease

(2010) Myoung-Hwa Lee et al.   NEUROBIOLOGY OF DISEASE

HIV-associated neurocognitive disorders persist in the era of potent antiretroviral therapy: CHARTER Study

(2010) R. K. Heaton et al.   NEUROLOGY

Selective Serotonin Reuptake Inhibitor Suppression of HIV Infectivity and Replication

(2010) Tami Benton et al.   PSYCHOSOMATIC MEDICINE

Cerebrospinal fluid neopterin: an informative biomarker of central nervous system immune activation in HIV-1 infection

(2010) Lars Hagberg et al.   AIDS Research and Therapy

MPTP-induced neuroblast apoptosis in the subventricular zone is not regulated by dopamine or other monoamine transporters

(2009) Yusuke Shibui et al.   NEUROTOXICOLOGY

Validation of the CNS Penetration-Effectiveness Rank for Quantifying Antiretroviral Penetration Into the Central Nervous System

(2008) Scott Letendre   ARCHIVES OF NEUROLOGY

Serotonin decreases HIV-1 replication in primary cultures of human macrophages through 5-HT1Areceptors

(2008) B Manéglier et al.   BRITISH JOURNAL OF PHARMACOLOGY

Fluoxetine affords robust neuroprotection in the postischemic brain via its anti-inflammatory effect

(2008) Chae-Moon Lim et al.   JOURNAL OF NEUROSCIENCE RESEARCH

The accelerated simian immunodeficiency virus macaque model of human immunodeficiency virus–associated neurological disease: From mechanism to treatment

(2008) Janice E Clements et al.   JOURNAL OF NEUROVIROLOGY

The antidepressant sertraline improves the phenotype, promotes neurogenesis and increases BDNF levels in the R6/2 Huntington's disease mouse model

(2007) Qi Peng et al.   EXPERIMENTAL NEUROLOGY