Article
Biochemistry & Molecular Biology
Lisa L. Wilson, Shainnel O. Eans, Insitar Ramadan-Siraj, Maria N. Modica, Giuseppe Romeo, Sebastiano Intagliata, Jay P. McLaughlin
Summary: SI 1/28 is an effective treatment for acute inflammatory pain and chronic neuropathy, without adverse effects at therapeutic doses. This supports the development of S1R antagonists as therapeutics for chronic pain.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Pharmacology & Pharmacy
Hichem Bouchenaki, Aurore Danigo, Amandine Bernard, Flavien Bessaguet, Laurence Richard, Franck Sturtz, David Balayssac, Laurent Magy, Claire Demiot
Summary: The study evaluated the effect of the ACE inhibitor ramipril in a mouse model of oxaliplatin-induced acute pain syndrome, showing that ramipril can prevent cold sensitivity and improve tactile sensitivity in treated mice.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Anesthesiology
James C. Eisenach, Regina S. Curry, Timothy T. Houle
Summary: This study compared the effects of intrathecal oxytocin and placebo on neuropathic pain and mechanical hyperalgesia. The results showed that oxytocin reduced pain intensity more than placebo, but also increased the hyperalgesic area. Although limited by the small sample size, further research on spinal oxytocin in this population is warranted.
Article
Neurosciences
Sang-Min Jeon, Dennis Chang, Aleksander Geske, David D. Ginty, Michael J. Caterina
Summary: The study identified that Merkel cell-A beta afferent complexes partially contribute to mechanical allodynia produced by peripheral nerve injury, with this effect being sex-dependent in mice. This finding will help in understanding the mechanisms underlying neuropathic pain.
JOURNAL OF NEUROSCIENCE
(2021)
Article
Pharmacology & Pharmacy
Gabriela Becker, Maria Fernanda Pessano Fialho, Indiara Brusco, Sara Marchesan Oliveira
Summary: Cisplatin is a commonly used chemotherapy drug for solid tumors, but its effectiveness is limited by neurotoxic side effects such as peripheral neuropathy. This study investigates the role of kinin B-1 and B-2 receptors in cisplatin-induced peripheral neuropathy in mice. The results suggest that targeting these receptors may be a potential strategy for treating the painful symptoms caused by cisplatin treatment.
Article
Plant Sciences
Nari Kim, Geehoon Chung, So-Ri Son, Jae Hyun Park, Young Hyun Lee, Keon-Tae Park, Ik-Hyun Cho, Dae Sik Jang, Sun Kwang Kim
Summary: This study aimed to investigate the suppressive effects of magnolin, an ERK inhibitor substance derived from Magnolia denudata seeds, on the symptoms of chemotherapy-induced peripheral neuropathy (CIPN). The results showed that magnolin administration exerted an analgesic effect on CIPN-induced cold allodynia and inhibited ERK phosphorylation in the dorsal root ganglion (DRG). These results suggest that magnolin could be developed as an alternative treatment to suppress paclitaxel-induced neuropathic pain symptoms.
Article
Chemistry, Medicinal
Youyi Peng, Qiang Zhang, William J. Welsh
Summary: Through structure- and drug design strategies, novel triazole-based S1R antagonists were synthesized and biologically evaluated. Compound 10 showed potent binding affinity for S1R, indicating its potential for pain treatment.
JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Article
Cell Biology
Huixing Wang, Xiaodong Huo, Chenyang Han, Jiang Ning, Hongguang Chen, Bo Li, Jingzhi Liu, Wenting Ma, Quanbo Li, Yonghao Yu, Kemei Shi
Summary: The study in rats indicated that ferroptosis is involved in the development of neuropathic pain by blocking neuron and astrocyte activation in the spinal dorsal horn.
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2021)
Article
Clinical Neurology
Donald Iain MacDonald, Ana P. Luiz, Federico Iseppon, Queensta Millet, Edward C. Emery, John N. Wood
Summary: Neuropathic pain leads to innocuous cooling being perceived as excruciating pain, yet the cell and molecular basis of this cold allodynia remains poorly understood. Research has found that in neuropathic pain states, normally silent large diameter cold-sensing neurons become sensitive to cooling, with many of them responding to noxious mechanical stimuli.
Article
Pharmacology & Pharmacy
Myrna Deciga-Campos, Rodrigo Villafan-Gutierrez, Josue Vidal Espinosa-Juarez, Osmar Antonio Jaramillo-Morales, Francisco Javier Lopez-Munoz
Summary: The study found that specific combinations of gabapentin and haloperidol can synergistically reduce nerve injury-induced allodynia and hyperalgesia, demonstrating an antiallodynic and antihyperalgesic effect.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Review
Clinical Neurology
Amirmohammad Toloui, Hamzah Adel Ramawad, Pantea Gharin, Alexander R. Vaccaro, Hamed Zarei, Mostafa Hosseini, Mahmoud Yousefifard, Vafa Rahimi-Movaghar
Summary: This systematic review and meta-analysis assessed the efficacy of exercise in reducing neuropathic pain following traumatic spinal cord injuries. The results showed that exercise significantly improved mechanical allodynia, thermal hyperalgesia, and cold allodynia. The study also found that voluntary, continuous training initiated in the subacute phase of mild spinal cord injury had a more prominent effect size.
Article
Dermatology
Sara Moradi Tuchayi, Ying Wang, Alla Khodorova, Isaac J. Pence, Conor L. Evans, R. Rox Anderson, Ethan A. Lerner, Clifford J. Woolf, Lilit Garibyan
Summary: We developed a neural selective and injectable cryoneurolysis method using ice slurry, which effectively reduces cutaneous pain caused by skin disease. This method shows comparable effects on nerve structure and function compared to an FDA-approved cryoneurolysis device. The decrease in mechanical pain from slurry injection, although less profound than that of the FDA-approved device, lasts longer without inducing dysesthesia.
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Lisa L. Wilson, Amy R. Alleyne, Shainnel O. Eans, Thomas J. Cirino, Heather M. Stacy, Marco Mottinelli, Sebastiano Intagliata, Christopher R. McCurdy, Jay P. McLaughlin
Summary: The study demonstrates that the S2R selective antagonist CM-398 produces antinociception and anti-allodynia with fewer side effects, suggesting its potential as a treatment for chronic pain.
Review
Anesthesiology
Marc A. Russo, Ralf Baron, Anthony H. Dickenson, Kai-Uwe Kern, Danielle M. Santarelli
Summary: Ambroxol is a versatile drug with multiple therapeutic actions, including mucoactive, secretolytic, anti-inflammatory, antioxidant, and local anesthetic properties. It has a long history of use in respiratory diseases and has shown efficacy in relieving sore throat. Recent research has focused on its potential for neuropathic pain treatment, despite slow progress. Ambroxol is an inhibitor of Na(v)1.8, an important player in neuropathic pain, and Na(v)1.7, a promising target for chronic pain treatment. This review discusses its analgesic mechanisms, synergistic properties, preclinical and clinical results in managing persistent pain and neuropathic pain symptoms. It is a safe drug with extensive data, encouraging further investigation for repurposing, and urging the pharmaceutical industry to develop optimized formulations for neuropathic pain.
Article
Pharmacology & Pharmacy
Moses M. Kasembeli, Pooja Singhmar, Jiacheng Ma, Jules Edralin, Yongfu Tang, Clydell Adams, Cobi J. Heijnen, Annemieke Kavelaars, David J. Tweardy
Summary: TTI-101, a competitive inhibitor of STAT3, shows target engagement, no toxicity, and clinical benefit in patients with solid tumors. Unexpectedly, TTI-101 also suppresses neuropathic pain induced by chemotherapy, providing additional benefits beyond its direct anti-tumor effect.
BIOCHEMICAL PHARMACOLOGY
(2021)
Article
Critical Care Medicine
Elizabeth A. Dugan, Jacqueline Sagen
JOURNAL OF NEUROTRAUMA
(2015)
Article
Neurosciences
Farinaz Nasirinezhad, Shyam Gajavelli, Blake Priddy, Stanislava Jergova, James Zadina, Jacqueline Sagen
Article
Neurosciences
Farinaz Nasirinezhad, Stanislava Jergova, James P. Pearson, Jacqueline Sagen
Article
Cell & Tissue Engineering
Stanislava Jergova, Shyam Gajavelli, Mathew S. Varghese, Paul Shekane, Jacqueline Sagen
CELL TRANSPLANTATION
(2016)
Article
Anesthesiology
Stanislava Jergova, Shyam Gajavelli, Nirmal Pathak, Jacqueline Sagen
Article
Clinical Neurology
Jacqueline Sagen, Daniel A. Castellanos, Aldric T. Hama
JOURNAL OF PAIN RESEARCH
(2016)
Article
Neurosciences
Stanislava Jergova, Catherine E. Gordon, Shyam Gajavelli, Jacqueline Sagen
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2017)
Article
Anesthesiology
E. A. Dugan, J. Sagen
EUROPEAN JOURNAL OF PAIN
(2018)
Article
Multidisciplinary Sciences
Anthony M. Cirrincione, Adriana D. Pellegrini, Jessica R. Dominy, Marisa E. Benjamin, Irina Utkina-Sosunova, Francesco Lotti, Stanislava Jergova, Jacqueline Sagen, Sandra Rieger
SCIENTIFIC REPORTS
(2020)
Article
Neurosciences
Elizabeth A. Dugan, Stanislava Jergova, Jacqueline Sagen
EXPERIMENTAL NEUROLOGY
(2020)
Article
Critical Care Medicine
Elizabeth A. Dugan, Benjamin Schachner, Stanislava Jergova, Jacqueline Sagen
Summary: Research shows that high-intensity locomotor training can significantly reduce neuropathic pain after spinal cord injury and maintain the reduction effect for at least two years, while improving gait outcomes and prolonging lifespan for rats.
JOURNAL OF NEUROTRAUMA
(2021)
Article
Behavioral Sciences
Stanislava Jergova, Cecilia Perez, Julita S. Imperial, Shyam Gajavelli, Aakangsha Jain, Adam Abin, Baldomero M. Olivera, Jacqueline Sagen
Summary: This study found that two venom extracts from Conus showed potential in interacting with the CB1 receptor, demonstrating effectiveness in analgesia and impact on nerve injury models. Further research revealed the presence of potential components in these venoms for the treatment of chronic pain, with mild side effects in the CB tetrad assessment.
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
(2021)
Article
Biotechnology & Applied Microbiology
Stanislava Jergova, Elizabeth A. Dugan, Jacqueline Sagen
Summary: This study found that chronic pain caused by spinal cord injury is related to dysfunctional GABAergic signaling and enhanced NMDA signaling. In a rat model, grafting recombinant rat GABAergic cells into the spinal cord and intensive locomotor training can reduce pain sensitivity. These treatments can attenuate tactile, heat, and cold hypersensitivity and reduce levels of proinflammatory cytokines. The analgesic effects of cell therapy and locomotor training persist even after the training is discontinued. Therefore, intermittent training combined with cell therapy may be an effective approach to manage chronic pain in spinal cord injury patients.
BIOENGINEERING-BASEL
(2023)
Article
Neurosciences
Stanislava Jergova, Melissa Hernandez, Jacqueline Sagen
Summary: This study demonstrates the feasibility of using transplantable recombinant GABAergic cells releasing conopeptide MVIIA to treat chronic pain, with beneficial effects observed in reducing hypersensitivity and pain-related cytokine levels.
Article
Clinical Neurology
Stanislava Jergova, Heidy Martinez, Melissa Hernandez, Benjamin Schachner, Suzanne Gross, Jacqueline Sagen
Summary: This study used Sprague-Dawley male rats to mimic neuropathic and inflammatory pain scenarios in a pre-amputation setting, finding that injuries prior to axotomy resulted in more severe PLP behavior directed towards the pretreatment insult origin. The study also observed changes in biomarkers related to the severity of PLP outcomes.
FRONTIERS IN PAIN RESEARCH
(2021)