The science of cerebral ischemia and the quest for neuroprotection: navigating past failure to future success

Forecasting the Future of Cardiovascular Disease in the United States

(2011) Paul A. Heidenreich et al.   CIRCULATION

Age and sex-related changes in rat brain mitochondrial oxidative status

(2011) Rocío Guevara et al.   EXPERIMENTAL GERONTOLOGY

Stem cells and stroke: opportunities, challenges and strategies

(2011) Terry C Burns et al.   EXPERT OPINION ON BIOLOGICAL THERAPY

Matrix Metalloproteinase-9 in an Exploratory Trial of Intravenous Minocycline for Acute Ischemic Stroke

(2011) Jeffrey A. Switzer et al.   STROKE

Minocycline Development for Acute Ischemic Stroke

(2011) Susan C. Fagan et al.   Translational Stroke Research

Biphasic actions of HMGB1 signaling in inflammation and recovery after stroke

(2010) Kazuhide Hayakawa et al.   Annals of the New York Academy of Sciences

Therapeutic Targets for Neuroprotection in Acute Ischemic Stroke: Lost in Translation?

(2010) Jeannette N. Stankowski et al.   ANTIOXIDANTS & REDOX SIGNALING

Spreading depolarizations cycle around and enlarge focal ischaemic brain lesions

(2010) Hajime Nakamura et al.   BRAIN

Inhibition of Reactive Astrocytes with Fluorocitrate Retards Neurovascular Remodeling and Recovery after Focal Cerebral Ischemia in Mice

(2010) Kazuhide Hayakawa et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Inflammatory mechanisms in ischemic stroke: role of inflammatory cells

(2010) Rong Jin et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Cerebrovascular expression of proteins related to inflammation, oxidative stress and neurotoxicity is altered with aging

(2010) Debjani Tripathy et al.   Journal of Neuroinflammation

Molecular insights and therapeutic targets for blood–brain barrier disruption in ischemic stroke: Critical role of matrix metalloproteinases and tissue-type plasminogen activator

(2010) Rong Jin et al.   NEUROBIOLOGY OF DISEASE

Age exaggerates proinflammatory cytokine signaling and truncates signal transducers and activators of transcription 3 signaling following ischemic stroke in the rat

(2010) V.A. DiNapoli et al.   NEUROSCIENCE

Neuroprotective Effect of Bax-Inhibiting Peptide on Neonatal Brain Injury

(2010) Xiaoyang Wang et al.   STROKE

Microglia-aging: Roles of microglial lysosome- and mitochondria-derived reactive oxygen species in brain aging

(2009) Hiroshi Nakanishi et al.   BEHAVIOURAL BRAIN RESEARCH

NOX2 inhibition with apocynin worsens stroke outcome in aged rats

(2009) Kimberly A. Kelly et al.   BRAIN RESEARCH

The contribution of astrocyte signalling to neurovascular coupling

(2009) Giorgio Carmignoto et al.   BRAIN RESEARCH REVIEWS

Ischemia Alters the Expression of Connexins in the Aged Human Brain

(2009) Taizen Nakase et al.   JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY

Changes in Experimental Stroke Outcome across the Life Span

(2009) Fudong Liu et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

The neurovascular unit in the setting of stroke

(2009) G. J. del Zoppo   JOURNAL OF INTERNAL MEDICINE

Apoptotic Mechanisms After Cerebral Ischemia

(2009) Brad R.S. Broughton et al.   STROKE

A Randomized, Double-Blind, Placebo-Controlled Trial to Evaluate the Efficacy, Safety, Tolerability, and Pharmacokinetic/Pharmacodynamic Effects of a Targeted Exposure of Intravenous Repinotan in Patients With Acute Ischemic Stroke

(2009) Philip Teal et al.   STROKE

Update of the Stroke Therapy Academic Industry Roundtable Preclinical Recommendations

(2009) Marc Fisher et al.   STROKE

Tacrolimus (FK506) suppresses rt-PA-induced hemorrhagic transformation in a rat thrombotic ischemia stroke model

(2008) Masashi Maeda et al.   BRAIN RESEARCH

Inflammation as Therapeutic Objective in Stroke

(2008) Joaquin Jordan et al.   CURRENT PHARMACEUTICAL DESIGN

Rodent Models of Ischemic Stroke: A Useful Tool for Stroke Drug Development

(2008) Aysan Durukan et al.   CURRENT PHARMACEUTICAL DESIGN

A new penumbra: transitioning from injury into repair after stroke

(2008) Eng H Lo   NATURE MEDICINE

NXY-059 for the Treatment of Acute Stroke

(2008) Hans-Christoph Diener et al.   STROKE

Delayed Treatment With Minocycline Ameliorates Neurologic Impairment Through Activated Microglia Expressing a High-Mobility Group Box1–Inhibiting Mechanism

(2008) Kazuhide Hayakawa et al.   STROKE

Astrocytes and Ischemic Injury

(2008) T. Takano et al.   STROKE