Article
Biochemistry & Molecular Biology
David F. Carrageta, Lais Freire-Brito, Barbara Guerra-Carvalho, Joao C. Ribeiro, Bruno S. Monteiro, Alberto Barros, Pedro F. Oliveira, Mariana P. Monteiro, Marco G. Alves
Summary: UCPs play a crucial role in regulating mitochondrial activity and ROS production. The expression and function of UCPs in human spermatozoa have been investigated, providing valuable insights into the mechanisms of male infertility.
Article
Nutrition & Dietetics
Margalida Torrens-Mas, Cayetano Navas-Enamorado, Devin Wahl, Andres Sanchez-Polo, Anna Picca, Jordi Oliver, Pilar Roca, Marta Gonzalez-Freire
Summary: “Calorie restriction (CR) is the only nutritional strategy proven to extend lifespan, prevent age-related diseases, and delay functional decline. The effects of CR when started early in life are not well understood. This study found that young female rats treated with CR showed similar expression patterns of key genes/pathways associated with healthy aging compared to old animals treated with CR, while in male rats these effects were reduced.”
Article
Geriatrics & Gerontology
Jazmin A. Cole, Mackenzie N. Kehmeier, Bradley R. Bedell, Sahana Krishna Kumaran, Grant D. Henson, Ashley E. Walker
Summary: Vascular endothelial function declines with age, but there is variability in this decline across individuals. Frailty index can be used as a surrogate for biological age, and this study found that frailty is related to age-related decline in vascular function, but the relationship is dependent on sex and the artery examined. Arterial oxidative stress and proinflammatory signaling may mediate the relationship between frailty and endothelial function.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2022)
Article
Neurosciences
Covadonga M. Diaz-Caneja, Clara Alloza, Pedro M. Gordaliza, Alberto Fernandez-Pena, Lucia de Hoyos, Javier Santonja, Elizabeth E. L. Buimer, Neeltje E. M. van Haren, Wiepke Cahn, Celso Arango, Rene S. Kahn, Hilleke E. Hulshoff Pol, Hugo G. Schnack, Joost Janssen
Summary: Sex differences in trajectories of global sulcal morphology were observed, with females having thicker cortex until age 40 and converging trajectories thereafter. Sulcal shortening was faster before age 40, while sulcal shallowing and widening were faster afterwards. Males showed greater variability in cortex volume and lower variability in sulcal width.
Article
Biochemistry & Molecular Biology
Brittney G. Borowiec, Michael P. Wilkie
Summary: This study investigates the interactions between senescence, oxidative stress, and metabolic function in sea lamprey. It reveals that sea lamprey experience greater oxidative stress with age and suggests a possible role of mitochondrial dysfunction in the senescence of sea lamprey.
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY A-MOLECULAR & INTEGRATIVE PHYSIOLOGY
(2023)
Article
Geriatrics & Gerontology
Marianne Chanti-Ketterl, Rebecca C. Stebbins, Hardeep K. Obhi, Daniel W. Belsky, Brenda L. Plassman, Yang Claire Yang
Summary: Metabolic dysregulation is more strongly associated with cognition in women compared with men, and there is heterogeneity in the associations between individual metabolic factors and cognition.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2022)
Article
Geriatrics & Gerontology
Qu Tian, Brendan A. Mitchell, Guray Erus, Christos Davatzikos, Ruin Moaddel, Susan M. Resnick, Luigi Ferrucci
Summary: Lipids are important for brain structure and function, and studies show that men experience greater brain atrophy than women with aging. This study investigated the sex-specific associations between circulating lipids and brain atrophy in a sample of cognitively normal older adults. Results revealed sex differences in the associations between specific lipid profiles and accelerated brain aging. The findings suggest the need for further investigation into the mechanisms underlying these sex-specific lipid profiles.
NEUROBIOLOGY OF AGING
(2023)
Review
Neurosciences
Dmitry B. Zorov, Nadezda Andrianova, Valentina A. Babenko, Irina B. Pevzner, Vasily A. Popkov, Savva D. Zorov, Ljubava D. Zorova, Egor Yu Plotnikov, Gennady T. Sukhikh, Denis N. Silachev
Summary: This review examines the use of mitochondrial uncouplers in the treatment of various pathologies, including neurological disorders. It analyzes the mechanisms and metabolic/signaling cascades associated with uncouplers, highlighting both positive and negative effects that should be considered in experimental and clinical settings.
Article
Medicine, General & Internal
Francesca Veronesi, Deyanira Contartese, Veronica Borsari, Stefania Pagani, Milena Fini, Monica De Mattei, Matilde Tschon
Summary: This study developed an in vitro model to mimic the microenvironment of aging and osteoarthritis and evaluated the differences between male and female fibroblast-like synoviocytes (FLSs). The results showed that FLSs from female donors demonstrated a better response capacity in unfavorable conditions of inflammation and oxidative stress.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Health Care Sciences & Services
Matheus Almeida Souza, Daniel Goble, Paige Arney, Edgar Ramos Vieira, Gabriela Silveira-Nunes, Leonardo Intelangelo, Michelle Almeida Barbosa, Alexandre Carvalho Barbosa
Summary: This study aimed to characterize the risk of falling in older adults from South and North America using a portable force-plate. South American women showed better balance compared to other groups. No significant differences were found between North vs. South Americans, nor between males and females.
Article
Cell Biology
Michael Kolland, Edith Hofer, Lukas Pirpamer, Daniela Eibl, Christian Enzinger, Alexander R. Rosenkranz, Reinhold Schmidt
Summary: Impaired kidney function is associated with brain volume loss and cognitive dysfunction, particularly in men.
Review
Geriatrics & Gerontology
Mitchell Ng, Lili-Naz Hazrati
Summary: Biological sex plays an important role in many diseases, with distinct differences between men and women in disease development. Cellular senescence may underlie these sex differences and could be a driver of sex-specific disease outcomes. Further research is needed to investigate sex differences in cellular senescence and validate findings from animal studies in human contexts.
NEUROBIOLOGY OF AGING
(2022)
Review
Medicine, Research & Experimental
Rahul Kumar, T. Amruthanjali, Siva Singothu, Shashi Bala Singh, Vasundhra Bhandari
Summary: Mitochondrial uncoupling proteins (UCP) play a critical role in regulating mitochondrial function and preventing neuronal loss and death, making them a potential therapeutic target for neurodegenerative diseases.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Biochemistry & Molecular Biology
Maliha Islam, Monica Strawn, Susanta K. Behura
Summary: The sex differences in brain aging are programmed at the fetal stage and epigenetically linked to the placenta.
Review
Biochemistry & Molecular Biology
Jonathan Hirschenson, Emiliano Melgar-Bermudez, Ryan J. Mailloux
Summary: Mitochondrial uncoupling proteins (UCP) 1-3 have multiple physiological functions, and most studies suggest that they play a role in preventing oxidative stress. The exact mechanism is still unclear, but it may involve proton return to the matrix and other functions such as Ca2+ transport.
Letter
Gastroenterology & Hepatology
Marita Grimanesa Trelles Guzman, Maria Teresa Novell Duran, M. Luisa Heredia Centeno, Monica Florido Garcia, Maria del Carmen Sanchez-Contador Escudero, Eduardo Yun Iyo Miyashiro, Silvia Patricia Ortega Moya, Elisa Miro Viamonte, Guillem Artigues Vives, Joan Gelabert Zornoza, Paul David Garcia Cortez, Juan Antonio Lucero Pizones, Carolina Rodriguez Hidalgo, Alicia Ruiz Rubi, Maria del Pilar Roca Salom, Jorge Sastre-Serrae, Jose Reyes Moreno
GASTROENTEROLOGIA Y HEPATOLOGIA
(2022)
Article
Food Science & Technology
Margalida Torrens-Mas, Marina Alorda-Clara, Maria Martinez-Vigara, Pilar Roca, Jorge Sastre-Serra, Jordi Oliver, Daniel Gabriel Pons
Summary: The study found that low doses of XN treatment did not significantly affect cell viability, but led to a general decrease in pro-inflammatory, antioxidant and mitochondrial biogenesis gene expression. Additionally, glucose and oxidative metabolism enzymes were also reduced.
INTERNATIONAL JOURNAL OF FOOD SCIENCES AND NUTRITION
(2022)
Review
Oncology
Marina Alorda-Clara, Margalida Torrens-Mas, Pere Miquel Morla-Barcelo, Toni Martinez-Bernabe, Jorge Sastre-Serra, Pilar Roca, Daniel Gabriel Pons, Jordi Oliver, Jose Reyes
Summary: Colorectal cancer (CRC) is a highly diagnosed cancer with significant mortality rates, and early detection is crucial for improving patient survival. Current CRC screening programs involve stool tests and colonoscopies, but the use of new biomarkers could enhance screening effectiveness. Omics technologies offer promise in detecting novel biomarkers for CRC across different sample types.
Article
Gastroenterology & Hepatology
Carme Loras, Xavier Andujar, Joan B. Gornals, Vicente Sanchiz, Enric Brullet, Beatriz Sicilia, Maria Dolores Martin-Arranz, Antonio Naranjo, Jesus Barrio, Carmen Duenas, Jose Ramon Foruny, David Busquets, David Monfort, Juan Ramon Pineda, Ferran Gonzalez-Huix, Francisco Perez-Roldan, Vicente Pons, Begona Gonzalez, Jose Reyes Moreno, Empar Sainz, Jordi Guardiola, Marta Maia Bosca-Watts, Fernando Fernandez-Banares, Vicenc Mayor, Maria Esteve
Summary: This study compares the efficacy and safety of endoscopic balloon dilation (EBD) and fully covered self-expandable metal stents (FCSEMS) in the treatment of Crohn's disease strictures, and compares the mean cost of both treatments. The results show that EBD is more effective than FCSEMS for Crohn's disease strictures and both treatments have a good safety profile.
LANCET GASTROENTEROLOGY & HEPATOLOGY
(2022)
Article
Biology
Reyniel Hernandez-Lopez, Margalida Torrens-Mas, Daniel G. Pons, Maria M. Company, Esther Falco, Teresa Fernandez, Javier M. Ibarra de la Rosa, Pilar Roca, Jordi Oliver, Jorge Sastre-Serra
Summary: Metastasis is a crucial factor in the mortality of colorectal cancer (CRC) patients. This study explores the changes in mitochondrial function associated with the metastatic stage of CRC and investigates whether they could be utilized as therapeutic targets. The findings indicate notable differences in mitochondrial functionality between tumor tissue and normal adjacent tissue in metastatic CRC patients. These alterations contribute to the promotion and maintenance of the metastatic phenotype, highlighting the impairment of mitochondrial function in tumor tissue during the metastatic stage.
Article
Oncology
Mar Giner-Calabuig, Seila De Leon, Julian Wang, Tara D. Fehlmann, Chinedu Ukaegbu, Joanna Gibson, Miren Alustiza-Fernandez, Maria-Dolores Pico, Cristina Alenda, Maite Herraiz, Marta Carrillo-Palau, Inmaculada Salces, Josep Reyes, Silvia P. Ortega, Antonia Obrador-Hevia, Michael Cecchini, Sapna Syngal, Elena Stoffel, Nathan A. Ellis, Joann Sweasy, Rodrigo Jover, Xavier Llor, Rosa M. Xicola
Summary: This study provides a molecular characterization of MMR-deficient tumors, revealing the variability in their mutational profiles and highlighting the importance of accurate diagnosis and treatment for personalized medicine.
BRITISH JOURNAL OF CANCER
(2022)
Article
Biochemistry & Molecular Biology
Marina Alorda-Clara, Margalida Torrens-Mas, Pere Miquel Morla-Barcelo, Pilar Roca, Jorge Sastre-Serra, Daniel Gabriel Pons, Jordi Oliver
Summary: Genistein may increase oxidative stress and inflammation in colon cancer cells, ultimately decreasing cell viability.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Nutrition & Dietetics
Margalida Torrens-Mas, Cayetano Navas-Enamorado, Devin Wahl, Andres Sanchez-Polo, Anna Picca, Jordi Oliver, Pilar Roca, Marta Gonzalez-Freire
Summary: “Calorie restriction (CR) is the only nutritional strategy proven to extend lifespan, prevent age-related diseases, and delay functional decline. The effects of CR when started early in life are not well understood. This study found that young female rats treated with CR showed similar expression patterns of key genes/pathways associated with healthy aging compared to old animals treated with CR, while in male rats these effects were reduced.”
Article
Oncology
Marina Alorda-Clara, Margalida Torrens-Mas, Reyniel Hernandez-Lopez, Javier M. Ibarra de la Rosa, Esther Falco, Teresa Fernandez, Maria Margarita Company, Jorge Sastre-Serra, Jordi Oliver, Daniel Gabriel Pons, Pilar Roca
Summary: Non-tumor adjacent tissue has an important role in the development and inflammatory process of colorectal cancer. This study analyzed the expression of inflammatory, epithelial-mesenchymal transition (EMT), and metastasis-related proteins in tumor and non-tumor adjacent tissues from colorectal cancer patients. The results showed that tumor tissue had increased levels of metastasis and EMT-related proteins compared to non-tumor adjacent tissue, particularly in stage II. Tumor tissue from stage II also had increased levels of inflammatory-related proteins, which was also observed in non-tumor adjacent tissue from stage II. Additionally, higher expression levels of Vimentin and VEGF-B were associated with lower relapse-free survival in stage II patients. These findings suggest that these proteins could be potential biomarkers for early diagnosis of colorectal cancer.
Article
Biochemistry & Molecular Biology
Toni Martinez-Bernabe, Jordi Oliver, Jorge Sastre-Serra, Daniel Gabriel Pons
Summary: This study analyzed the effect of oxaliplatin on tumor spheres formation efficiency, cell viability, cancer stem cells, and inflammation in primary- and metastatic-derived colorectal tumor spheres. The results showed that primary-derived spheres responded to oxaliplatin by modulating cancer stem cells and stemness properties, while metastatic-derived spheres exhibited an inflammatory response. In addition, the expression of inflammatory markers after oxaliplatin treatment correlated with poor prognosis and a metastatic phenotype. These findings highlight the importance of drug testing and personalized medicine in early-stage colorectal cancer.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Marina Alorda-Clara, Jose Reyes, Marita Grimanesa Trelles-Guzman, Monica Florido, Pilar Roca, Daniel Gabriel Pons, Jordi Oliver
Summary: Colorectal cancer is the third most common cancer worldwide, and the lack of early and specific biomarkers leads to late-stage detection. Tumors release extracellular vesicles (EVs) that have various functions and can be used as a source of biomarkers. Bowel lavage fluid (BLF) obtained during colonoscopy is an underutilized sample that represents EVs from tumor cells and has the potential to be a useful research tool. In this study, EVs from BLF were isolated and characterized, confirming their suitability for CRC study and potential as biomarkers for diagnosis and monitoring.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Ecology
Facundo Luna, Jorge Sastre-Serra, Jordi Oliver, C. Daniel Antenucci
Summary: In mammals, the integrated requirements of all activities must conform to a sustained rate of metabolism for the pup's development and adult life. Partitioning available energy according to short-term priorities allows animals to optimize long-term reproductive success. In this study, the development of thermogenic capacity in altricial rodent pups, specifically Ctenomys talarum, was evaluated. The results showed that non-shivering thermogenesis was absent in the pups until day 60, despite the presence of molecular markers for thermogenesis in brown adipose tissue deposits. However, the total thermogenic capacity became fixed at an early age, indicating an improvement in shivering thermogenesis efficiency after day 10.
FRONTIERS IN ECOLOGY AND EVOLUTION
(2023)
Article
Pharmacology & Pharmacy
Silvia P. Ortega-Moya, Ileana Martinez-Cabrera, Marita Telles Guzman, Eduardo Iyo Miyashiro, Jose Reyes Moreno
Summary: This study evaluated the reliability, reproducibility, and effectiveness of simethicone pre-treatment before endoscopic exploration. The results showed that using simethicone as a pre-preparation drink improved image quality and reduced operation time.
JOURNAL OF PHARMACY & PHARMACOGNOSY RESEARCH
(2022)
