Article
Pharmacology & Pharmacy
Mauricio dos Santos Pereira, Glauce Crivelaro do Nascimento, Mariza Bortolanza, Patrick Pierre Michel, Rita Raisman-Vozari, Elaine Del Bel
Summary: Doxy has the potential to alleviate l-DOPA-induced dyskinesia in Parkinson's disease regardless of the intensity of dopaminergic lesioning. Its anti-inflammatory effects account for the reduction in LID, rather than neurorestorative effects.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Shih-Yi Lin, Ya-Yu Wang, Cheng-Yi Chang, Chih-Cheng Wu, Wen-Ying Chen, Su-Lan Liao, Chun-Jung Chen
Summary: The emerging molecule TNF-alpha is reported to have inflammatory and metabolic roles. Studies have shown that the TNF-alpha receptor inhibitor R-7050 has neuroprotective, antihyperglycemic, and anti-inflammatory effects in stroke cases. This highlights a feasible way to combat stroke disease based on an anti-TNF therapy involving anti-inflammatory and metabolic mechanisms.
Review
Biochemistry & Molecular Biology
Yi-Wen Duan, Shao-Xia Chen, Qiao-Yun Li, Ying Zang
Summary: This review focuses on the neuroimmune mechanism of neuropathic pain. TNF-alpha plays a crucial role in inducing and modulating neuropathic pain by facilitating peripheral and central sensitization. It controls cell survival and death through an inflammatory response and programmed cell death mechanisms. Overproduction of TNF-alpha in certain brain structures has an important role in pain-associated emotional disorders and memory deficits. The review also highlights the research prospects of the TNF-alpha-necroptosis pathway in pain modulation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Immunology
Joanna K. Winstone, Khyatiben Pathak, Wendy Winslow, Ignazio S. Piras, Jennifer White, Ritin Sharma, Matthew J. Huentelman, Patrick Pirrotte, Ramon Velazquez
Summary: This study provides the first evidence that glyphosate infiltrates the brain, upregulates the expression of TNF alpha and soluble A beta, and disrupts the transcriptome in a dose-dependent manner. These findings suggest that exposure to this herbicide may have detrimental effects on the health of the general population.
JOURNAL OF NEUROINFLAMMATION
(2022)
Article
Biochemistry & Molecular Biology
Bhagyeswari Behera, Rajesh Kumar Meher, Showkat Ahmad Mir, Binata Nayak, Kunja Bihari Satapathy
Summary: The present study evaluated the anti-inflammatory and immunomodulatory activities of Hydrilla verticillata (L.f.) Royle. Potential therapeutic compounds were identified through analysis, and the inhibitory effects on inflammatory responses were examined using macrophage cells. Molecular docking and simulation were used to investigate the underlying mechanisms. The results suggest that Hydrilla verticillata extract has the potential to reduce inflammation without causing toxicity to normal cells.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2023)
Article
Biochemistry & Molecular Biology
Nobutomo Ikarashi, Nanaho Mizukami, Chenchen Pei, Ryogo Uchino, Izumi Fujisawa, Natsuko Fukuda, Risako Kon, Hiroyasu Sakai, Junzo Kamei
Summary: In type 2 diabetes, the level of skin water channel protein AQP3 decreases, potentially leading to xeroderma, while anti-inflammatory drugs may be beneficial for diabetic xerosis.
Article
Chemistry, Physical
Ningqiang Gong, Xuexiang Han, Lulu Xue, Rakan El-Mayta, Ann E. Metzloff, Margaret M. Billingsley, Alex G. Hamilton, Michael J. Mitchell
Summary: In situ PEGylation of CAR T cells provides a materials-based strategy for safer cellular immunotherapy by blocking cell-to-cell interactions and decreasing toxic cytokine secretion. It also allows for controlled tumor killing and immune response stimulation, mitigating cytokine release syndrome and reducing neurotoxicity.
Article
Biochemistry & Molecular Biology
Timea Teglas, Emoke Mihok, Zoltan Cziaky, Neli-Kinga Olah, Csaba Nyakas, Endre Mathe
Summary: Many plant-derived flavonoids found in black currant have anti-neuroinflammatory and anti-neurodegenerative effects. A standardized black currant gemmotherapy extract (BC-GTE) made from fresh buds contains approximately 133 phytonutrients, including significant flavonoids such as luteolin, quercetin, apigenin, and kaempferol. Experimental results suggest that BC-GTE possesses anti-neuroinflammatory/neuroprotective properties and has the potential to be used as a complementary therapeutic approach.
Article
Radiology, Nuclear Medicine & Medical Imaging
Bruny V. Kenou, Lester S. Manly, Sara B. Rubovits, Somachukwu A. Umeozulu, Maia G. Van Buskirk, Andrea S. Zhang, Victor W. Pike, Paolo Zanotti-Fregonara, Ioline D. Henter, Robert B. Innis
Summary: This article reviews the development of PET radioligands for cyclooxygenase (COX) subtypes 1 and 2 as biomarkers of neuroinflammation. COX-1 is primarily located in microglia, while COX-2 is primarily located in neurons. The functions of COX-1 and COX-2 in neuroinflammation are still not fully understood, but recent research has focused on developing radioligands to image them in animals and humans.
JOURNAL OF NUCLEAR MEDICINE
(2022)
Article
Immunology
Shuo Cheng, Hong-Ning Wang, Lin-Jie Xu, Fang Li, Yanying Miao, Bo Lei, Xinghuai Sun, Zhongfeng Wang
Summary: The study found that TNF-alpha induces hyperexcitability in RGCs by selectively upregulating Nav1.6 sodium channels, leading to RGC apoptosis in glaucoma.
JOURNAL OF NEUROINFLAMMATION
(2021)
Article
Medicine, Research & Experimental
Luise Schlotterose, Francois Cossais, Ralph Lucius, Kirsten Hattermann
Summary: Neuroinflammation is both a cause and an effect of neurodegenerative disorders. Activation of astrocytes and microglia leads to the release of cytokines and reactive oxygen species, causing blood-brain barrier leakage and neurotoxicity. This study focuses on cytokine-induced neuroinflammation in human microglia and astrocytes, and demonstrates how resveratrol can inhibit proinflammatory activation and promote returning to resting conditions. These findings contribute to understanding the mechanisms of neuroinflammation and potential treatment options.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Pharmacology & Pharmacy
Mauricio dos Santos Pereira, Gabriel Henrique Dias Abreu, Jeremy Rocca, Sabah Hamadat, Rita Raisman-Vozari, Patrick Pierre Michel, Elaine Del Bel
Summary: The study aimed to characterize mechanisms regulating neuroinflammation in L-DOPA-induced dyskinesia in mice, finding that astrocytic and microglial responses, as well as increased pro-inflammatory cytokine levels, were associated with LID development. Treatment with cannabidiol and capsazepine reduced LID severity and TNF-alpha levels, suggesting a potential therapeutic approach. Glutamate-induced TNF-alpha release from astrocytes may contribute to LID by modulating corticostriatal glutamatergic inputs, with cannabidiol + capsazepine attenuating this effect.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Geriatrics & Gerontology
Min Cao, Jing Liu, Xiaomin Zhang, Yaqi Wang, Yuli Hou, Qiao Song, Yuting Cui, Yue Zhao, Peichang Wang
Summary: IL-17A promotes the progression of AD by inducing the secretion of TNF-α and exacerbating neuroinflammation through the TLR4/NF-κB signaling pathway and microglial activation. In addition, injection of IL-17A antibody significantly improves cognitive function in APP/PS1 mice.
Article
Immunology
Chuen-Mao Yang, Chien-Chung Yang, Li-Der Hsiao, Chia-Ying Yu, Hui-Ching Tseng, Chih-Kai Hsu, Jiro Hasegawa Situmorang
Summary: The study found that TNF-α induces upregulation of COX-2 and PGE(2) through a TNFR1-dependent MitoROS/PKCα/p38 MAPK and JNK1/2 cascade to activate FoxO1 binding with the COX-2 promoter in HCFs. This sheds new light on the mechanisms of TNF-α in cardiac fibrosis and heart failure.
JOURNAL OF INFLAMMATION RESEARCH
(2021)
Article
Multidisciplinary Sciences
Yuji Gao, Dat T. Nguyen, Trifanny Yeo, Su Bin Lim, Wei Xian Tan, Leigh Edward Madden, Lin Jin, Ji Yong Kenan Long, Fazila Abu Bakar Aloweni, Yi Jia Angela Liew, Mandy Li Ling Tan, Shin Yuh Ang, Sivagame D. O. Maniya, Ibrahim Abdelwahab, Kian Ping Loh, Chia-Hung Chen, David Laurence Becker, David Leavesley, John S. Ho, Chwee Teck Lim
Summary: A new flexible biosensing platform has been developed for multiplexed profiling of wound microenvironment, inflammation, and infection state in wound management. This platform integrates sensor array for measuring inflammatory mediators, microbial burden, and physicochemical parameters with microfluidic wound exudate collector and flexible electronics for wireless data readout via smartphones. This technology may improve chronic wound healing outcomes by facilitating timely and personalized wound management.
Review
Biochemistry & Molecular Biology
Guadalupe Mengod, Jose M. Palacios, Roser Cortes
ACS CHEMICAL NEUROSCIENCE
(2015)
Article
Neurosciences
C. Marin, M. Bonastre, G. Mengod, R. Cortes, M. C. Rodriguez-Oroz
Article
Multidisciplinary Sciences
Emily M. Johansson, Maria S. Garcia-Gutierrez, Maria Moscoso-Castro, Jorge Manzanares, Olga Valverde
Article
Endocrinology & Metabolism
Elena Alvarez-Salas, Guadalupe Mengod, Cinthia Garcia-Luna, Paulina Soberanes-Chavez, Gilberto Matamoros-Trejo, Patricia de Gortari
Article
Biochemistry & Molecular Biology
R. Martin-Alvarez, N. Paul-Fernandez, V. Palomo, C. Gil, A. Martinez, G. Mengod
JOURNAL OF CHEMICAL NEUROANATOMY
(2017)
Article
Neurosciences
Antonio Flores-Burgess, Carmelo Millon, Belen Gago, Manuel Narvaez, Dasiel O. Borroto-Escuela, Guadalupe Mengod, Jose Angel Narvaez, Kjell Fuxe, Luis Santin, Zaida Diaz-Cabiale
Article
Multidisciplinary Sciences
Julie Jezequel, Emily M. Johansson, Julien P. Dupuis, Veronique Rogemond, Helene Grea, Blanka Kellermayer, Nora Hamdani, Emmanuel Le Guen, Corentin Rabu, Marilyn Lepleux, Marianna Spatola, Elodie Mathias, Delphine Bouchet, Amy J. Ramsey, Robert H. Yolken, Ryad Tamouza, Josep Dalmau, Jerome Honnorat, Marion Leboyer, Laurent Groc
NATURE COMMUNICATIONS
(2017)
Review
Biochemistry & Molecular Biology
J. M. Palacios, G. Mengod
JOURNAL OF CHEMICAL NEUROANATOMY
(2018)
Review
Neurosciences
J. Jezequel, E. M. Johansson, M. Leboyer, L. Groc
TRENDS IN NEUROSCIENCES
(2018)
Article
Anatomy & Morphology
Raul Penas-Cazorla, M. Teresa Vilaro
BRAIN STRUCTURE & FUNCTION
(2015)
Article
Neurosciences
Giovanni Di Pinto, Maria Di Bari, Rocio Martin-Alvarez, Samantha Sperduti, Silvia Serrano-Acedo, Valentina Gatta, Ada M. Tata, Guadalupe Mengod
EUROPEAN JOURNAL OF NEUROSCIENCE
(2018)
Article
Multidisciplinary Sciences
E. M. Johansson, D. Bouchet, R. Tamouza, P. Ellul, A. S. Morr, E. Avignone, R. Germi, M. Leboyer, H. Perron, L. Groc
Article
Biochemistry & Molecular Biology
Catharine A. Mielnik, Mary A. Binko, Yuxiao Chen, Adam J. Funk, Emily M. Johansson, Katheron Intson, Nirun Sivananthan, Rehnuma Islam, Marija Milenkovic, Wendy Horsfall, Ruth A. Ross, Laurent Groc, Ali Salahpour, Robert E. McCullumsmith, Shreejoy Tripathy, Evelyn K. Lambe, Amy J. Ramsey
Summary: NMDARs play a crucial role in brain development and connectivity, with dysfunction leading to various neurodevelopmental disorders. Restoring NMDAR function through gene editing in adulthood significantly improves cognitive functions, providing a new approach for the treatment of neurodevelopmental disorders.
MOLECULAR PSYCHIATRY
(2021)
Article
Behavioral Sciences
M. I. Valdes-Moreno, V. Alcantara-Alonso, E. Estrada-Camarena, G. Mengod, M. I. Amaya, G. Matamoros-Trejo, P. de Gortari
BEHAVIOURAL BRAIN RESEARCH
(2017)