Article
Biochemistry & Molecular Biology
Muhammad Afzal, Sami Alzarea, Khalid Saad Alharbi, Abdulaziz Alzarea, Sattam Khulaif Alenezi, Mohammed Salem Alshammari, Ali H. Alquraini, Imran Kazmi
Summary: The aim of this study was to determine whether rosiridin, a bioactive component of Rhodiola rosea, could protect rats from neurocognitive problems induced by scopolamine. The results showed that rosiridin improved behavioral parameters, reduced oxidative stress and inflammation markers, restored acetylcholine esterase and choline acetyltransferase activities, and normalized other biochemical parameters. These findings suggest that rosiridin may limit the effects of scopolamine on rat cognitive function.
Article
Multidisciplinary Sciences
Amal F. F. Soliman, Mohamed A. A. Sabry, Gehad Abdelwahab
Summary: The essential oil isolated from Araucaria heterophylla resin was analyzed, and 24 components were identified, accounting for 99.89% of the total detected constituents. The oil exhibited inhibitory activity against aldose reductase and BuCHE enzymes, possibly due to compounds containing epoxide and hydroxyl groups. This study provides preliminary screening for the oil as potential therapeutic agents for antidiabetic cataract and Alzheimer's disease.
SCIENTIFIC REPORTS
(2023)
Article
Biochemistry & Molecular Biology
Rongbo Zhang, Jin Liu, Bin Xu, You Wu, Shunli Liang, Qiang Yuan
Summary: The study investigated the therapeutic effects of cornuside on EAE and its impact on Th17 and Treg cell infiltration. Cornuside showed anti-inflammatory and immunosuppressive effects, alleviating neurological deficits in EAE rats with Th17 cells possibly being one of its therapeutic targets.
JOURNAL OF ZHEJIANG UNIVERSITY-SCIENCE B
(2021)
Article
Immunology
Guo-Guo Chu, Jing Wang, Zhi-Bin Ding, Jin-Zhu Yin, Li-Juan Song, Qing Wang, Jian-Jun Huang, Bao-Guo Xiao, Cun-Gen Ma
Summary: The study demonstrated that Hydroxyfasudil could alleviate the symptoms and pathological damage of experimental autoimmune encephalomyelitis (EAE), regulate the balance of peripheral T cells, inhibit inflammatory signaling cascades, promote anti-inflammatory factors in the central nervous system, and protect the blood-brain barrier. These findings suggest that Hydroxyfasudil may be a promising treatment for multiple sclerosis (MS).
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Immunology
Leon Islas-Weinstein, Brenda Marquina-Castillo, Dulce Mata-Espinosa, Iris S. Paredes-Gonzalez, Jaime Chavez, Luciana Balboa, Jose Luis Marin Franco, Daniel Guerrero-Romero, Jorge Alberto Barrios-Payan, Rogelio Hernandez-Pando
Summary: The cholinergic system is involved in regulating inflammation during bacterial respiratory infections, and studies have shown its presence and role in the immunopathogenesis of pulmonary tuberculosis. Upregulation of the cholinergic system, particularly during late progressive TB, can aid in bacterial growth and immunomodulation within the lung. Manipulating this system therapeutically may offer potential for treating the disease.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Jong Hee Choi, Jinhee Oh, Min Jung Lee, Seong-Gyu Ko, Seung-Yeol Nah, Ik-Hyun Cho
Summary: The study revealed that Gintonin has neuroprotective effects in models of multiple sclerosis, alleviating inflammatory lesions. The mechanism of action may involve inhibiting various signaling pathways, enhancing antioxidant activity, and modulating immune cell activity through LPARs, providing a new therapeutic approach for autoimmune disorders.
BRAIN BEHAVIOR AND IMMUNITY
(2021)
Article
Plant Sciences
Joon-Il Lee, Jong-Hee Choi, Tae-Woo Kwon, Hyo-Sung Jo, Do-Geun Kim, Seong-Gyu Ko, Gyun Jee Song, Ik-Hyun Cho
Summary: Bornyl acetate (BA) extracted from pine oil has been found to have anti-inflammatory and blood-spinal cord barrier protective effects, which can effectively alleviate behavioral dysfunction and demyelination in an animal model of multiple sclerosis (MS) and may be a potential therapeutic agent for treating autoimmune demyelinating diseases.
Article
Immunology
Alba Sanchez-Fernandez, Stephanie Zandee, Mauricio Mastrogiovanni, Marc Charabati, Homero Rubbo, Alexandre Prat, Ruben Lopez-Vales
Summary: This study reveals that there is an imbalance in the production of specialized pro-resolving mediators (SPMs) in patients with multiple sclerosis (MS) and in mice with experimental autoimmune encephalomyelitis (EAE), and increasing the bioavailability of SPMs, such as Maresin-1 (MaR1), can reduce inflammation and mediate therapeutic effects. These findings suggest that immunoresolvent therapies could be a novel approach for the treatment of MS.
JOURNAL OF NEUROINFLAMMATION
(2022)
Article
Neurosciences
Reza Nasrnezhad, Sohrab Halalkhor, Farzin Sadeghi, Fereshteh Pourabdolhossein
Summary: Piperine shows anti-inflammatory, neuroprotective effects in EAE models by reducing inflammation and oxidative damage, promoting myelin repair, and could be a potential therapeutic target for multiple sclerosis treatment.
MOLECULAR NEUROBIOLOGY
(2021)
Article
Biology
Rudra Palash Mukherjee, Geok-Yong Yow, Samuel Sarakbi, Stefano Menegatti, Patrick V. Gurgel, Ruben G. Carbonell, Benjamin G. Bobay
Summary: This study reports the rational design and screening of trimeric peptides as ligands for the purification of butyrylcholinesterase (BChE). The selected peptides exhibited high affinity for BChE and achieved a significant purification factor. The study also revealed the correlation between conformational changes of BChE and the ionic strength and pH of the aqueous environment, providing insights for ligand design and affinity maturation.
COMPUTATIONAL BIOLOGY AND CHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Muhammad Taha, Fazal Rahim, Nizam Uddin, Ihsan Ullah Khan, Naveed Iqbal, El Hassane Anouar, Mohammed Salahuddin, Rai Khalid Farooq, Mohammed Gollapalli, Khalid Mohammed Khan, Ameeduzzafar Zafar
Summary: Indole-based thiadiazole derivatives were synthesized and evaluated for their inhibition of AChE and BChE. Compounds with para, ortho, and meta-fluoro substitutions on the phenyl ring attached to thiadiazole showed the highest activity. Characterization was done using NMR, MS, and molecular docking studies were conducted.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Multidisciplinary Sciences
Katharina Robichon, Sven Sondhauss, T. William Jordan, Robert A. Keyzers, Bronwen Connor, Anne C. La Flamme
Summary: This study investigated the tissue distribution and localization of clozapine in the brain using mass spectrometry techniques and found that clozapine was enriched in specific brain regions and significantly elevated in serum during EAE. Additionally, changes in dopamine receptor expression on brain-resident and infiltrating immune cells during EAE were observed, providing insights into how neuroinflammation alters the distribution and downstream effects of clozapine.
SCIENTIFIC REPORTS
(2021)
Article
Biochemistry & Molecular Biology
Luiza Ayumi Nishiyama Mimura, Thais Fernanda de Campos Fraga-Silva, Larissa Ragozzo Cardoso de Oliveira, Larissa Lumi Watanabe Ishikawa, Patricia Aparecida Borim, Carla de Moraes Machado, Jose de Anchieta de Castro e Horta Junior, Denise Morais da Fonseca, Alexandrina Sartori
Summary: The study revealed that Vitamin D3 (VitD) has the potential to control multiple sclerosis (MS) severity, but may trigger hypercalcemia, which led researchers to compare the therapeutic effects of VitD with a non-hypercalcemic vitamin D analog called paricalcitol (Pari). The results showed that VitD had downmodulatory ability to reduce inflammation and demyelination, while Pari did not have this effect.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Neurosciences
Donald A. Godfrey, Lissette Carlson, Jami L. Park, C. David Ross
Summary: This study investigated the distribution of choline acetyltransferase (ChAT) and acetylcholinesterase (AChE) activities in the rat inferior colliculus, revealing differences in their distributions and relatively low levels of ChAT activity compared to other central auditory regions. The results suggest a modest role for cholinergic neurotransmission in modulating the activity of major neuronal types in the inferior colliculus.
Article
Endocrinology & Metabolism
Juliet N. Olayinka, Anthony Eduviere, Olusegun Adeoluwa, Elizabeth Akinluyi, Abiola Obisesan, Oluwole Akawa, Adeshina Adebanjo
Summary: The study demonstrates that quercetin improves memory function, reduces oxidative stress, and decreases acetylcholinesterase activity. Additionally, quercetin enhances choline acetyltransferase activity, thereby improving memory performance.
METABOLIC BRAIN DISEASE
(2022)
Review
Biochemistry & Molecular Biology
Guadalupe Mengod, Jose M. Palacios, Roser Cortes
ACS CHEMICAL NEUROSCIENCE
(2015)
Article
Neurosciences
C. Marin, M. Bonastre, G. Mengod, R. Cortes, M. C. Rodriguez-Oroz
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Endocrinology & Metabolism
Elena Alvarez-Salas, Guadalupe Mengod, Cinthia Garcia-Luna, Paulina Soberanes-Chavez, Gilberto Matamoros-Trejo, Patricia de Gortari
Article
Biochemistry & Molecular Biology
R. Martin-Alvarez, N. Paul-Fernandez, V. Palomo, C. Gil, A. Martinez, G. Mengod
JOURNAL OF CHEMICAL NEUROANATOMY
(2017)
Article
Neurosciences
Antonio Flores-Burgess, Carmelo Millon, Belen Gago, Manuel Narvaez, Dasiel O. Borroto-Escuela, Guadalupe Mengod, Jose Angel Narvaez, Kjell Fuxe, Luis Santin, Zaida Diaz-Cabiale
Review
Biochemistry & Molecular Biology
J. M. Palacios, G. Mengod
JOURNAL OF CHEMICAL NEUROANATOMY
(2018)
Article
Clinical Neurology
Laura Saenz del Burgo, Roser Cortes, Guadalupe Mengod, Mario Montana, Gontzal Garcia del Cano, Joan Salles
EUROPEAN NEUROPSYCHOPHARMACOLOGY
(2013)
Article
Neurosciences
C. Marin, M. Bonastre, G. Mengod, R. Cortes, M. C. Rodriguez-Oroz, J. A. Obeso
EXPERIMENTAL NEUROLOGY
(2013)
Article
Clinical Neurology
Noemi Santana, Guadalupe Mengod, Francesc Artigas
INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY
(2013)
Article
Biochemistry & Molecular Biology
Cristina Sanabra, Emily M. Johansson, Guadalupe Mengod
JOURNAL OF CHEMICAL NEUROANATOMY
(2013)
Article
Neurosciences
C. Marin, M. Bonastre, G. Mengod, R. Cortes, A. Giralt, J. A. Obeso, A. H. Schapira
NEUROBIOLOGY OF DISEASE
(2014)
Review
Oncology
Carla Sole, Erika Larrea, Giovanni Di Pinto, Maitena Tellaetxe, Charles Henderson Lawrie
Article
Behavioral Sciences
M. I. Valdes-Moreno, V. Alcantara-Alonso, E. Estrada-Camarena, G. Mengod, M. I. Amaya, G. Matamoros-Trejo, P. de Gortari
BEHAVIOURAL BRAIN RESEARCH
(2017)