Review
Biochemistry & Molecular Biology
Armita Mahdavi Gorabi, Saeed Aslani, George E. Barreto, Eliana Baez-Jurado, Nasim Kiaie, Tannaz Jamialahmadi, Amirhossein Sahebkar
Summary: Neuroglobin, identified in 2000 in neurons of human and mouse nervous systems, is an oxygen-binding globin that provides protective effects against hypoxic/ischemic damage by promoting oxygen availability within the mitochondria. Impaired neuroglobin functioning has been linked to the pathogenesis of multiple neurodegenerative disorders. Studies have shown the potential of neuroglobin upregulation in improving neuroprotection through modulation of mitochondrial functions.
FREE RADICAL BIOLOGY AND MEDICINE
(2021)
Article
Cardiac & Cardiovascular Systems
Dino A. Giussani
Summary: The article explores the impact of chronic fetal hypoxia during pregnancy on the development of cardiovascular disease in offspring and potential therapeutic approaches, with a focus on molecular-level research and potential targets for clinical intervention.
Review
Nanoscience & Nanotechnology
Yue Zhang, Meiyan Sun, Hongxiang Zhao, Zhengyan Wang, Yanan Shi, Jianxin Dong, Kaifang Wang, Xi Wang, Xingyue Li, Haiyan Qi, Xiaoyong Zhao
Summary: This review discusses the multiple pharmacological activities of DCA in neuroprotection and its therapeutic effects on different diseases. The causes and solutions of DCA's adverse effects are also explored.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Ioannis Tsialtas, Achilleas Georgantopoulos, Maria E. Karipidou, Foteini D. Kalousi, Aikaterini G. Karra, Demetrios D. Leonidas, Anna-Maria G. Psarra
Summary: Estrogens play a crucial role in regulating both reproductive and non-reproductive system physiology, with a particular impact on the nervous system. The presence of mitochondrial estrogen receptor beta (mtER beta) has been shown to directly participate in neuronal physiology maintenance. Overexpression of mtER beta in N2A cells enhances resistance to apoptotic stimuli, suggesting its potential as a therapeutic target for degenerative diseases associated with mitochondrial dysfunction.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Cecile Exertier, Linda Celeste Montemiglio, Ida Freda, Elena Gugole, Giacomo Parisi, Carmelinda Savino, Beatrice Vallone
Summary: Neuroglobin plays an important role in the nervous system, but its specific functions are still unclear. Recent studies have provided new findings and hypotheses about the biochemistry and structure of neuroglobin, making it a challenging task to unravel its mechanisms and roles.
MOLECULAR ASPECTS OF MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Sumit Jamwal, Jennifer K. Blackburn, John D. Elsworth
Summary: This study reveals sex-based and region-based variations in PON2 protein expression in the brain of African green monkeys. Female monkeys exhibit significant differences in PON2 expression levels among different brain regions, while male monkeys do not. The highest expression of PON2 protein is found in the striatum compared to other brain regions in both male and female monkeys.
FREE RADICAL BIOLOGY AND MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Ana-Mishel Spiroski, Youguo Niu, Lisa M. Nicholas, Shani Austin-Williams, Emily J. Camm, Megan R. Sutherland, Thomas J. Ashmore, Katie. L. Skeffington, Angela Logan, Susan E. Ozanne, Michael P. Murphy, Dino A. Giussani
Summary: The study demonstrates that chronic fetal hypoxia during pregnancy leads to mitochondrial-derived oxidative stress, increasing cardiovascular risk in adult offspring. Treatment with the mitochondria-targeted antioxidant MitoQ can help prevent cardiovascular dysfunction in adult offspring exposed to gestational hypoxia.
Article
Biochemistry & Molecular Biology
Ewelina Bratek-Gerej, Apolonia Ziembowicz, Jakub Godlewski, Elzbieta Salinska
Summary: The study established the neuroprotective and antioxidant potential of KYNA in an experimental model of neonatal hypoxia-ischemia, showing significant reduction in brain damage and oxidative stress.
Review
Biochemistry & Molecular Biology
Ivan M. Veselov, Daria V. Vinogradova, Andrey V. Maltsev, Pavel N. Shevtsov, Elena A. Spirkova, Sergey O. Bachurin, Elena F. Shevtsova
Summary: This review focuses on the common features connecting metabolic disorders and type 2 diabetes with the development of Alzheimer's disease. The pathogenesis of Alzheimer's disease overlaps with the mechanisms of type 2 diabetes, and aging is an important risk factor for both diseases. Common pathological mechanisms include oxidative stress, neuroinflammation, insulin resistance, and amyloidosis, as well as mitochondrial dysfunctions and cell death. The available drugs for type 2 diabetes and Alzheimer's disease have limited efficacy, highlighting the need for new treatment strategies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Celia Salazar, Miriam Barros, Alvaro A. Elorza, Lina Maria Ruiz
Summary: HIG2A protein is essential for the formation of mitochondrial respiratory supercomplexes and is associated with cell proliferation, survival, and cancer biology. Its levels increase under oxidative stress, and its distribution between mitochondria and nucleus varies depending on stress factors and cell type.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Endocrinology & Metabolism
Miled Bourourou, Elsa Gouix, Nicolas Melis, Jonas Friard, Catherine Heurteaux, Michel Tauc, Nicolas Blondeau
Summary: Targeting the polyamine-eIF5A-hypusine axis represents a new therapeutic opportunity for stroke and ischemic diseases, with GC7 showing potential in protecting neurons and improving post-stroke motor and cognitive deficits.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2021)
Article
Biochemistry & Molecular Biology
Lucia Viejo, Marcos Rubio-Alarcon, Raquel L. Arribas, Manuel Moreno-Castro, Raquel Perez-Marin, Maria Braun-Cornejo, Martin Estrada-Valencia, Cristobal de los Rios
Summary: Mitochondria play a key role in regulating cytosolic Ca2+ levels in excitable cells. Dysregulation of mitochondrial Ca2+ buffering can lead to serious pathologies, such as neurodegenerative diseases. Research has identified new synthesized NCLX blockers with improved neuroprotective activity and drug-likeness.
Article
Cell Biology
Satomi Hirose, Julie Hesnard, Nasser Ghazi, Damien Roussel, Yann Voituron, Oliver Cochet-Escartin, Jean-Paul Rieu, Christophe Anjard, Kenichi Funamoto
Summary: Spatial and temporal variations of oxygen environments affect cell behaviors, and the aerotaxis of Dictyostelium discoideum seems to be an effective strategy for survival. Flavohemoglobins, potential oxygen sensors and oxidative stress modulators, play a role in this phenomenon.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Article
Pharmacology & Pharmacy
Weiping Li, Zhe Zhang, Jiawen Li, Jun Mu, Meng Sun, Xue Wu, Xiaochen Niu, Yang Yang, Huanle Yan, Xiaoling Xu, Chengxu Xue, Lu Qian, Ye Tian
Summary: This study aimed to investigate the protective effects of silibinin against cerebral ischemia-reperfusion injury in neuroblastoma N2a cells, as well as the mechanisms involved. The results showed that silibinin significantly reduced cell death, apoptotic rate, LDH, and ROS generation, and inhibited mitochondrial dysfunction and oxidative stress. However, the protective effects of silibinin were weakened when GAS6 was silenced.
Article
Biochemistry & Molecular Biology
Diana Pintye, Reka Eszter Sziva, Maxim Mastyugin, Marianna Torok, Sonako Jacas, Agnes Lo, Saira Salahuddin, Zsuzsanna K. Zsengeller
Summary: Preeclampsia (PE), a syndrome specific to pregnancy, affects 5-7% of patients and currently has no effective treatment. Early abnormal placental development leads to oxidative stress and release of reactive oxygen species (ROS) in the placenta, resulting in downstream signaling, stabilization of Hypoxia Inducible Factor 1A (HIF1A), and transcription of anti-angiogenic factors sFLT1 and sEng. This study found that the nitroxide-type antioxidant molecule HMP could reduce placental oxidative stress and alleviate PE symptoms in vitro.
Article
Microbiology
April S. Gislason, Matthew Choy, Ruhi A. M. Bloodworth, Wubin Qu, Maria S. Stietz, Xuan Li, Chenggang Zhang, Silvia T. Cardona
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2017)
Article
Biochemistry & Molecular Biology
Yiming Lu, Cheng Quan, Hebing Chen, Xiaochen Bo, Chenggang Zhang
NUCLEIC ACIDS RESEARCH
(2017)
Article
Medicine, General & Internal
Jiguo Xue, Cheng Quan, Chunyong Li, Jingwei Yue, Chenggang Zhang
Article
Oncology
Xiaohui Zhu, Yangdong Sun, Chenggang Zhang, Haifeng Liu
MOLECULAR MEDICINE REPORTS
(2017)
Article
Oncology
Jibin Sha, Bo Sui, Xiaoqing Su, Qingfang Meng, Chenggang Zhang
MOLECULAR MEDICINE REPORTS
(2017)
Article
Multidisciplinary Sciences
Chunyong Li, Jiguo Xue, Cheng Quan, Jingwei Yue, Chenggang Zhang
Article
Oncology
Zenghua Deng, Zhihui Li, Changqing Sun, Hui Xie, Zhengang Chen, Jinbo Liu, Hui Wang, Chenggang Zhang, Guangshun Wang
Article
Multidisciplinary Sciences
Cheng Quan, Chunyong Li, Jiguo Xue, Jingwei Yue, Chenggang Zhang
Article
Multidisciplinary Sciences
Jiguo Xue, Chunyong Li, Cheng Quan, Yiming Lu, Jingwei Yue, Chenggang Zhang
SCIENTIFIC REPORTS
(2017)
Article
Biochemistry & Molecular Biology
Kun Wang, Haiwei Li, Yue Xu, Qianzhi Shao, Jianming Yi, Ruichao Wang, Wanshi Cai, Xingyi Hang, Chenggang Zhang, Haoyang Cai, Wubin Qu
NUCLEIC ACIDS RESEARCH
(2019)
Article
Biochemistry & Molecular Biology
Alexander Pilozzi, Zhanyang Yu, Isabel Carreras, Kerry Cormier, Dean Hartley, Jack Rogers, Alpaslan Dedeoglu, Xudong Huang
Article
Genetics & Heredity
Hao Lu, Luyu Ma, Cheng Quan, Lei Li, Yiming Lu, Gangqiao Zhou, Chenggang Zhang
Summary: This study introduces a computational framework called RegVar, based on deep neural networks, which accurately predicts the tissue-specific impact of non-coding regulatory variants on target genes. RegVar outperforms current methods in predicting regulatory variants and is capable of assessing the regulatory impact of any variant on its putative target genes in various tissues.
GENOMICS PROTEOMICS & BIOINFORMATICS
(2023)
Article
Food Science & Technology
Chenggang Zhang, Wenjing Gong, Zhihui Li, Dawen Gao, Yan Gao
FOOD SCIENCE AND HUMAN WELLNESS
(2019)
Article
Medicine, Research & Experimental
Ji-Bin Sha, Shuang-Shuang Zhang, Yi-Ming Lu, Wen-Jing Gong, Xiao-Ping Jiang, Jian-Jun Wang, Tong-Ling Qiao, Hong-Hong Zhang, Min-Qian Zhao, Da-Peng Wang, Hua Xia, Zhong-Wei Li, Jian-Liang Chen, Lin Zhang, Cheng-Gang Zhang
MEDICAL GAS RESEARCH
(2018)
Article
Oncology
Yu Wang, Wei Chen, Bin Hou, Yan Gao, Zhihui Li, Xu Li, Chenggang Zhang
INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL PATHOLOGY
(2018)