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Medicine, Research & Experimental
Maolin Zhu, Huiyang Wang, Jiawei Chen, Huang Zhu
Summary: The study showed that sinomenine nanoliposomes have therapeutic effects on nephropathy in diabetic rats by inhibiting oxidative stress, reducing renal cell apoptosis and fibrosis, and regulating the JAK2/STAT3/SOCS1 pathway to protect renal tissues.
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Food Science & Technology
Yujie Zhong, Ruilin Luo, Qi Liu, Jiachang Zhu, Min Lei, Xiaofei Liang, Xin Wang, Xiaoli Peng
Summary: Jujuboside A shows renoprotective effects on type II diabetic nephropathy by inhibiting oxidative stress and apoptosis, while enhancing autophagy and mitophagy.
FOOD AND CHEMICAL TOXICOLOGY
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Biochemistry & Molecular Biology
Prasanta Dey, Amit Kundu, Ha Eun Lee, Babli Kar, Vineet Vishal, Suvakanta Dash, In Su Kim, Tejendra Bhakta, Hyung Sik Kim
Summary: The extract of Molineria recurvata exhibits protective effects on nephropathy in diabetic rats by suppressing inflammation and oxidative stress.
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Food Science & Technology
Bo-sai He, Xiao Wang, Ying Zhang, Cheng Gao, Cheng-kai Wu, Si-rui Guo, Yan-ting Gu, Qing Li, Jia-hong Wang
Summary: The seeds of Moringa oleifera Lam have renal protective effects in diabetic nephropathy by modulating multiple signaling pathways, exerting anti-inflammatory, anti-fibrosis, and anti-oxidative effects.
JOURNAL OF FUNCTIONAL FOODS
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Plant Sciences
Nur Ainina Abd Wahab, Nelli Giribabu, Eswar Kumar Kilari, Naguib Salleh
Summary: Abietic acid helps to mitigate nephropathy development in diabetes mellitus by counteracting oxidative stress, inflammation, and apoptosis.
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Environmental Sciences
Gamal Badr, Leila H. Sayed, Hossam El-Din M. Omar, Sary Khaleel Abd Elghaffar, Medhat M. Menshawy
Summary: Diabetes mellitus causes immune organ alterations and immune system dysregulation, while dietary supplementation of bee gomogenat can improve these conditions.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
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Medicine, Research & Experimental
Nada H. Eisa, Ahmed E. Khodir, Mohamed El-Sherbiny, Nehal M. Elsherbiny, Eman Said
Summary: PEITC showed renal protective effects against DN in rats induced by STZ, improving kidney and liver functions, histopathological features, tissue fibrosis, macrophage infiltration, and blood glucose levels. The mechanisms involved modulation of glycation, oxidative stress, and inflammatory response, including activation of GLO1 and Nrf2 pathways and suppression of NLRP3 inflammasome activation.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
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Biochemistry & Molecular Biology
Xing Wang, Caina Li, Yi Huan, Hui Cao, Sujuan Sun, Lei Lei, Quan Liu, Shuainan Liu, Wenming Ji, Kaixun Huang, Zhufang Shen, Jun Zhou
Summary: DPDS supplementation improved hyperglycemia, glucose intolerance, dyslipidemia, and renal pathological abnormalities in STZ-induced DN rats. It also promoted antioxidant enzyme activities, reduced pro-inflammatory factors levels, and activated the renal Nrf2/Keap1 signaling pathway while attenuating NF kappa B/MAPK signaling pathways, suggesting DPDS as a potential therapeutic approach for DN.
CHEMICO-BIOLOGICAL INTERACTIONS
(2021)
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Food Science & Technology
Tingting Wang, Lin Zheng, Xiaoling Liu, Mouming Zhao
Summary: Sea cucumber hydrolysates (SCH) showed renoprotective effects in diabetic rats by enhancing antioxidant activity and activating Akt/Nrf2 pathway.
JOURNAL OF FUNCTIONAL FOODS
(2023)
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Neurosciences
Zekrayat J. H. Medras, Yasser M. Mostafa, Amal A. M. Ahmed, Norhan M. El-Sayed
Summary: This study found that arctigenin (ARC) can improve diabetic neuropathy (DN) by combating apoptosis and oxidative stress and improving autophagy.
CNS NEUROSCIENCE & THERAPEUTICS
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Environmental Sciences
Ceyhan Hacioglu, Fatih Kar, Yakup Kara, Ersin Yucel, Dilek Burukoglu Donmez, Hakan Senturk, Gungor Kanbak
Summary: The study evaluated the antidiabetic effects of CL aqueous extract on STZ-induced diabetic rats and found that CL treatment significantly improved blood glucose levels, lipid profile, pancreatic markers, and liver and kidney function tests. CL treatment also showed dose-dependent reductions in oxidative, apoptotic, and inflammatory pathways, as well as a greater increase in total antioxidant capacity compared to metformin. Additionally, CL treatment provided histologically more improvement in various tissues compared to metformin, suggesting that CL aqueous extract may have stronger short-term anti-diabetic effects than metformin.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2021)
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Medicine, Research & Experimental
Duojun Qiu, Shan Song, Yuhan Wang, Yawei Bian, Ming Wu, Haijiang Wu, Yonghong Shi, Huijun Duan
Summary: The study demonstrates that NQO1 plays a protective role against oxidative stress and apoptosis in diabetic nephropathy by regulating Sirt1 and increasing intracellular NAD+/NADH levels.
JOURNAL OF TRANSLATIONAL MEDICINE
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Pharmacology & Pharmacy
Yang Liu, Jin-Yan Zheng, Zhi-Tao Wei, Shu-Kun Liu, Ji-Lei Sun, Yin-Hui Mao, Yong-De Xu, Yong Yang
Summary: This study investigates the therapeutic effect of the combination of ursolic acid and insulin on diabetic nephropathy. The results show that the combined treatment has better outcomes compared to insulin-only treatment. The combination therapy improves renal function and pathological damage, reduces apoptosis and oxidative stress, and inhibits renal fibrosis and epithelial-mesenchymal transition (EMT).
FRONTIERS IN PHARMACOLOGY
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Biochemistry & Molecular Biology
Victor Udo Nna, Ainul Bahiyah Abu Bakar, Zaida Zakaria, Zaidatul Akmal Othman, Nur Asyilla Che Jalil, Mahaneem Mohamed
Summary: Diabetic nephropathy is ameliorated by Malaysian propolis, which possesses anti-hyperglycemic, antioxidant, and anti-inflammatory properties. When combined with metformin, the beneficial effects are enhanced, improving renal function and ameliorating nephropathy symptoms.
Review
Biochemistry & Molecular Biology
Kiyoung Kim, Eun-Young Lee
Summary: Diabetic nephropathy is a serious complication of diabetes which is poorly understood in terms of pathogenic mechanisms. Impaired mitochondrial function and abnormal mitochondrial dynamics play crucial roles in the development and progression of DN. Studies suggest that both aberrant mitochondrial fission and excessively enlarged mitochondria are involved in the pathogenesis of DN.
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Microbiology
April S. Gislason, Matthew Choy, Ruhi A. M. Bloodworth, Wubin Qu, Maria S. Stietz, Xuan Li, Chenggang Zhang, Silvia T. Cardona
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
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Yiming Lu, Cheng Quan, Hebing Chen, Xiaochen Bo, Chenggang Zhang
NUCLEIC ACIDS RESEARCH
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Medicine, General & Internal
Jiguo Xue, Cheng Quan, Chunyong Li, Jingwei Yue, Chenggang Zhang
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Oncology
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MOLECULAR MEDICINE REPORTS
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Multidisciplinary Sciences
Chunyong Li, Jiguo Xue, Cheng Quan, Jingwei Yue, Chenggang Zhang
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Oncology
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Multidisciplinary Sciences
Cheng Quan, Chunyong Li, Jiguo Xue, Jingwei Yue, Chenggang Zhang
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Multidisciplinary Sciences
Jiguo Xue, Chunyong Li, Cheng Quan, Yiming Lu, Jingwei Yue, Chenggang Zhang
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Biochemistry & Molecular Biology
Kun Wang, Haiwei Li, Yue Xu, Qianzhi Shao, Jianming Yi, Ruichao Wang, Wanshi Cai, Xingyi Hang, Chenggang Zhang, Haoyang Cai, Wubin Qu
NUCLEIC ACIDS RESEARCH
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Genetics & Heredity
Hao Lu, Luyu Ma, Cheng Quan, Lei Li, Yiming Lu, Gangqiao Zhou, Chenggang Zhang
Summary: This study introduces a computational framework called RegVar, based on deep neural networks, which accurately predicts the tissue-specific impact of non-coding regulatory variants on target genes. RegVar outperforms current methods in predicting regulatory variants and is capable of assessing the regulatory impact of any variant on its putative target genes in various tissues.
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Food Science & Technology
Chenggang Zhang, Wenjing Gong, Zhihui Li, Dawen Gao, Yan Gao
FOOD SCIENCE AND HUMAN WELLNESS
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Medicine, Research & Experimental
Ji-Bin Sha, Shuang-Shuang Zhang, Yi-Ming Lu, Wen-Jing Gong, Xiao-Ping Jiang, Jian-Jun Wang, Tong-Ling Qiao, Hong-Hong Zhang, Min-Qian Zhao, Da-Peng Wang, Hua Xia, Zhong-Wei Li, Jian-Liang Chen, Lin Zhang, Cheng-Gang Zhang
MEDICAL GAS RESEARCH
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Yu Wang, Wei Chen, Bin Hou, Yan Gao, Zhihui Li, Xu Li, Chenggang Zhang
INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL PATHOLOGY
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Oncology
Yang Xu, Hongxia Dong, Changhui Ge, Yan Gao, Haifeng Liu, Weiguang Li, Chenggang Zhang
ANNALS OF TRANSLATIONAL MEDICINE
(2016)