Article
Chemistry, Analytical
Raviraj Thakur, Felix P. Aplin, Gene Y. Fridman
Summary: The study developed a silicone-based nerve cuff lead for stimulating and recording nerves, providing greater spatial separation and reversible nerve block through the delivery of direct current. Unlike most metallic electrodes, this cuff was manufactured using consumer-grade equipment, making it a cost-effective solution for neuro modulation experiments.
Article
Otorhinolaryngology
James T. Heaton, James B. Kobler, Mark P. Ottensmeyer, Robert H. Petrillo, Monica A. Tynan, Robert E. Hillman, Steven M. Zeitels
Summary: A new method for tracking recovery after nerve injury was studied, using subcutaneous electrical connection ports to repeatedly connect to nerve cuff or intramuscular electrodes for periodic assessments of nerve and muscle function over long periods.
OTOLARYNGOLOGY-HEAD AND NECK SURGERY
(2021)
Review
Biochemistry & Molecular Biology
Luke Juckett, Tiam Mana Saffari, Benjamin Ormseth, Jenna-Lynn Senger, Amy M. M. Moore
Summary: Peripheral nerve injuries (PNI) often result in lifelong disability with rare complete functional recovery. Intraoperative electrical stimulation (ES) is a promising surgical adjunct that can augment the intrinsic molecular pathways of nerve regeneration. Clinical trials have shown that ES can be an efficacious therapy to improve patient outcomes following PNIs.
Article
Materials Science, Multidisciplinary
Samuel Lienemann, Mary J. Donahue, Johan Zotterman, Simon Farnebo, Klas Tybrandt
Summary: Bioelectronic medicine is a promising approach for treating diseases and disorders by electrically stimulating peripheral nerves. This paper presents the development of a soft and stretchable multielectrode cuff that can achieve selective nerve stimulation. The device is made of silicone with embedded gold nanowire conductors, allowing it to be functional even under strain.
ADVANCED MATERIALS TECHNOLOGIES
(2023)
Review
Engineering, Biomedical
Woo-Youl Maeng, Wan-Ling Tseng, Song Li, Jahyun Koo, Yuan-Yu Hsueh
Summary: This review examines the potential and challenges of using bioelectronic implantable devices for peripheral nerve regeneration. It summarizes modern fabrication methods and integration techniques to deliver effective and controllable electroceuticals.
Article
Multidisciplinary Sciences
Geumbee Lee, Emily Ray, Hong -Joon Yoon, Sabrina Genovese, Yeon Sik Choi, Min-Kyu Lee, Samet Sahin, Ying Yan, Hak-Young Ahn, Amay J. Bandodkar, Joohee Kim, Minsu Park, Hanjun Ryu, Sung Soo Kwak, Yei Hwan Jung, Arman Odabas, Umang Khandpur, Wilson Z. Ray, Matthew R. MacEwan, John A. Rogers
Summary: This study introduces a bioresorbable nerve stimulator that can provide pain relief through electrical nerve block without the need for surgical extraction. The device is designed to minimize adverse effects and disappears harmlessly in the body after use, making it a potential alternative to addictive drugs for pain treatment.
Article
Chemistry, Physical
Runyi Mao, Bin Yu, Jinjie Cui, Zeying Wang, Xintai Huang, Hongbo Yu, Kaili Lin, Steve G. F. Shen
Summary: This study developed a piezoelectric nerve conduit using a composite of PCL/ZnO nanofiber, which demonstrated faster and superior sciatic nerve repair compared to conventional materials. The piezoelectric stimulation from PZNF increased the expression of nerve growth factor/vascular endothelial growth factor and activated downstream pathways, leading to accelerated nerve repair and function recovery. This novel strategy offers potential for rapid peripheral nerve regeneration.
Review
Health Care Sciences & Services
Sophie Hasiba-Pappas, Lars-P. Kamolz, Hanna Luze, Sebastian P. Nischwitz, Judith C. J. Holzer-Geissler, Alexandru Cristian Tuca, Theresa Rienmueller, Mathias Polz, Daniel Ziesel, Raimund Winter
Summary: The combined application of nerve guidance conduits and electrical stimulation can improve peripheral nerve regeneration in rat models, but there is high variation in treatment protocols and further evaluation under standardized conditions is needed.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Article
Nanoscience & Nanotechnology
Mei Yu, Changxian Wang, Huanqing Cui, Jianping Huang, Qianhengyuan Yu, Ping Wang, Chao Huang, Guanglin Li, Yang Zhao, Xuemin Du, Zhiyuan Liu
Summary: We propose a self-closing stretchable cuff electrode that can close onto tissue bundles after dropping water. The curliness is achieved by the mechanical stress mismatch between different layers of the elastic substrate. The material of the substrate can be selected to match the modulus of the target tissue to achieve minimal constraint on the tissue. In vivo testing with rat's sciatic nerve stimulation and electromyographic signal monitoring for 1 month demonstrates the excellent conformity of our proposed electrode to the curved surface of biological tissue.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Biophysics
Rongyu Tang, Chenglin Zhang, Bingxin Liu, Chanyuan Jiang, Lei Wang, Xuerui Zhang, Qiang Huang, Jing Liu, Lei Li
Summary: A fluidic cuff electrode using gallium-based liquid metal conductor has been developed as an artificial peripheral nerve device. The LM cuff electrode has high flexibility and conductivity. It has been shown to maintain long-term effectiveness in transmitting nerve signals and triggering event-related potentials.
BIOSENSORS & BIOELECTRONICS
(2022)
Article
Chemistry, Multidisciplinary
Estelle A. Cuttaz, Christopher A. R. Chapman, Omaer Syed, Josef A. Goding, Rylie A. Green
Summary: This study focuses on the application of conductive elastomers in nerve cuff devices, comparing their performance with traditional metallic electrodes. Results show that conductive elastomer cuffs have advantages in electrical and mechanical stability compared to metallic cuffs. In a biological environment, the conductive elastomer cuffs demonstrate superior charge transfer and electrochemical safety.
Review
Clinical Neurology
Lingmei Ni, Zhao Yao, Yifan Zhao, Tianfang Zhang, Jie Wang, Siyue Li, Zuobing Chen
Summary: Peripheral nerve injury is common in extremity trauma patients and surgical therapeutic approaches may not ensure functional recovery. Rehabilitation plays a vital role in promoting nerve repair and sensorimotor recovery through individualized electrical stimulation therapy. However, the parameters and long-term effectiveness of electrical stimulation need further exploration.
FRONTIERS IN NEUROLOGY
(2023)
Article
Engineering, Biomedical
Samuel Lienemann, Johan Zotterman, Simon Farnebo, Klas Tybrandt
Summary: This study developed a high performance soft and stretchable cuff electrode based on inert materials for low-voltage nerve stimulation. The stretchable cuff electrodes showed excellent stability under strain cycling and one million stimulation pulses, achieving saturated homogeneous stimulation of the sciatic nerve at only 200 mV. The combination of favourable mechanical properties and good electrode performance makes it ideal for low power supply applications within bioelectronic medicine.
JOURNAL OF NEURAL ENGINEERING
(2021)
Article
Chemistry, Physical
Shunyi Lu, Wen Chen, Jiayi Wang, Zilong Guo, Lan Xiao, Lingyu Wei, Jieqin Yu, Ya Yuan, Weisin Chen, Mengxuan Bian, Lei Huang, Yuanyuan Liu, Jian Zhang, Yu-Lin Li, Li-Bo Jiang
Summary: A biodegradable, conductive poly(l-lactide-co-caprolactone)/graphene (PLCL/GN) composite conduit with a micropatterned surface and electrical stimulation capability is developed. It effectively stimulates cell migration, adhesion, and elongation, enhances neuronal expression of SCs, and promotes myelin sheath growth and nerve regeneration in vivo.
Review
Medicine, General & Internal
Agustin Garcia-Collado, Juan A. Valera-Calero, Cesar Fernandez-de-las-Penas, Jose L. Arias-Buria
Summary: This paper assesses the effects of percutaneous electrical nerve stimulation (PENS) on pain- and function-related outcomes. The study found that PENS had positive effects on nerve tissue, but due to heterogeneity in populations, interventions, and follow-up periods, pooling analyses were not possible. Further research is needed to determine the application of PENS in clinical practice.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Engineering, Biomedical
Tina Vrabec, Niloy Bhadra, Gustaf Van Acker, Narendra Bhadra, Kevin Kilgore
IEEE TRANSACTIONS ON NEURAL SYSTEMS AND REHABILITATION ENGINEERING
(2017)
Article
Engineering, Biomedical
Doe W. Kumsa, Narendra Bhadra, Eric M. Hudak, J. Thomas Mortimer
JOURNAL OF NEURAL ENGINEERING
(2017)
Article
Engineering, Biomedical
Narendra Bhadra, Emily Foldes, Tina Vrabec, Kevin Kilgore, Niloy Bhadra
JOURNAL OF NEURAL ENGINEERING
(2018)
Article
Engineering, Biomedical
Doe W. Kumsa, Eric M. Hudak, Narendra Bhadra, J. Thomas Mortimer
JOURNAL OF NEURAL ENGINEERING
(2019)
Article
Biochemical Research Methods
Leah Marie Roldan, Thomas E. Eggers, Kevin L. Kilgore, Narendra Bhadra, Tina Vrabec, Niloy Bhadra
JOURNAL OF NEUROSCIENCE METHODS
(2019)
Article
Engineering, Biomedical
Tina L. Vrabec, Jesse S. Wainright, Narendra Bhadra, Laura Shaw, Kevin L. Kilgore, Niloy Bhadra
IEEE TRANSACTIONS ON NEURAL SYSTEMS AND REHABILITATION ENGINEERING
(2019)
Article
Biochemical Research Methods
N. Bhadra, E. L. Foldes, M. R. Gerges, D. M. Ackermann, N. Bhadra, K. L. Kilgore
JOURNAL OF NEUROSCIENCE METHODS
(2020)
Article
Engineering, Biomedical
Thomas Eggers, Joseph Kilgore, David Green, Tina Vrabec, Kevin Kilgore, Niloy Bhadra
Summary: The study successfully combined DC and KHFAC into a waveform named CROW, which can reduce the onset response and achieve effective nerve block, providing broader possibilities for clinical application of electrical nerve block.
JOURNAL OF NEURAL ENGINEERING
(2021)
Article
Chemistry, Analytical
Andrew Goh, David Roberts, Jesse Wainright, Narendra Bhadra, Kevin Kilgore, Niloy Bhadra, Tina Vrabec
Summary: The application of direct current (DC) can produce rapid and reversible nerve conduction block, but prolonged charge injection may cause damage to nervous tissue. This study evaluates the surface stability of activated carbon and platinum black electrodes in vitro, providing insights for future development of HCM electrodes for in vivo nerve conduction block.
Article
Engineering, Biomedical
Shane A. Bender, David B. Green, Robert J. Daniels, Stephen P. Ganocy, Niloy Bhadra, Tina L. Vrabec
Summary: Electrical conduction block of the vagus nerve was studied to characterize its effects on heart rate dynamics. The results show that complete block and partial block can be achieved using direct current (DC) at different amplitudes. The amplitude of DC was found to significantly predict the induction time for complete block, and the blocking duration and injected charge were significant in predicting the recovery time.
JOURNAL OF NEURAL ENGINEERING
(2023)
Proceedings Paper
Engineering, Biomedical
Tina L. Vrabec, Kevin L. Kilgore, Jesse S. Wainright, Niloy Bhadra
2019 9TH INTERNATIONAL IEEE/EMBS CONFERENCE ON NEURAL ENGINEERING (NER)
(2019)
Article
Biochemical Research Methods
Aline Silva da Cruz, Maria Margarida Drehmer, Wagner Baetas-da-Cruz, Joao Carlos Machado
Summary: This study quantified microcirculation cerebral blood flow in a rat model of ischemic stroke using ultrasound biomicroscopy and ultrasound contrast agents. The results showed high sensitivity and specificity of this method, making it a valuable tool for preclinical studies.
JOURNAL OF NEUROSCIENCE METHODS
(2024)
Article
Biochemical Research Methods
Christina Dalla, Ivana Jaric, Pavlina Pavlidi, Georgia E. Hodes, Nikolaos Kokras, Anton Bespalov, Martien J. Kas, Thomas Steckler, Mohamed Kabbaj, Hanno Wuerbel, Jordan Marrocco, Jessica Tollkuhn, Rebecca Shansky, Debra Bangasser, Jill B. Becker, Margaret McCarthy, Chantelle Ferland-Beckham
Summary: Many funding agencies have emphasized the importance of considering sex as a biological variable in experimental design to improve the reproducibility and translational relevance of preclinical research. Omitting the female sex from experimental designs in neuroscience and pharmacology can result in biased or limited understanding of disease mechanisms. This article provides methodological considerations for incorporating sex as a biological variable in in vitro and in vivo experiments, including the influence of age and hormone levels, and proposes strategies to enhance methodological rigor and translational relevance in preclinical research.
JOURNAL OF NEUROSCIENCE METHODS
(2024)
Article
Biochemical Research Methods
Wenyu Gu, Dongxu Li, Jia-Hong Gao
Summary: We developed a precise and rapid method for positioning and labelling triaxial OPMs on a wearable magnetoencephalography (MEG) system, improving the efficiency of OPM positioning and labelling.
JOURNAL OF NEUROSCIENCE METHODS
(2024)
Article
Biochemical Research Methods
Kai Lin, Linhang Zhang, Jing Cai, Jiaqi Sun, Wenjie Cui, Guangda Liu
Summary: The article introduces an EEG feature map processing model for emotion recognition, which achieves significantly improved accuracy by fusing EEG information at different spatial scales and introducing a channel attention mechanism.
JOURNAL OF NEUROSCIENCE METHODS
(2024)
Article
Biochemical Research Methods
John E. Parker, Asier Aristieta, Aryn H. Gittis, Jonathan E. Rubin
Summary: This work presents a toolbox that implements a methodology for automated classification of neural responses based on spike train recordings. The toolbox provides a user-friendly and efficient approach to detect various types of neuronal responses that may not be identified by traditional methods.
JOURNAL OF NEUROSCIENCE METHODS
(2024)
Article
Biochemical Research Methods
Yun Liang, Ke Bo, Sreenivasan Meyyappan, Mingzhou Ding
Summary: This study compared the performance of SVM and CNN on the same datasets and found that CNN achieved consistently higher classification accuracies. The classification accuracies of SVM and CNN were generally not correlated, and the heatmaps derived from them did not overlap significantly.
JOURNAL OF NEUROSCIENCE METHODS
(2024)
Article
Biochemical Research Methods
Antonino Visalli, Maria Montefinese, Giada Viviani, Livio Finos, Antonino Vallesi, Ettore Ambrosini
Summary: This study introduces an analytical strategy that allows the use of mixed-effects models (LMM) in mass univariate analyses of EEG data. The proposed method overcomes the computational costs and shows excellent performance properties, making it increasingly important in the field of neuroscience.
JOURNAL OF NEUROSCIENCE METHODS
(2024)
Article
Biochemical Research Methods
Xavier Cano-Ferrer, Alexandra Tran -Van -Minh, Ede Rancz
Summary: This study developed a novel rotation platform for studying neural processes and spatial navigation. The platform is modular, affordable, and easy to build, and can be driven by the experimenter or animal movement. The research demonstrated the utility of the platform, which combines the benefits of head fixation and intact vestibular activity.
JOURNAL OF NEUROSCIENCE METHODS
(2024)