Article
Neurosciences
Alexandra B. Nelson, Allison E. Girasole, Hsien-Yang Lee, Louis J. Ptacek, Anatol C. Kreitzer
Summary: Abnormal involuntary movements, or dyskinesias, are observed in various neurologic disorders, and may be caused by alterations in neural activity or connectivity. This study shows that dysfunction in the indirect pathway of the striatum contributes to the development of dyskinesia in a mouse model, suggesting that hypoactivity in the indirect pathway may be a key mechanism for involuntary movements in other disorders.
JOURNAL OF NEUROSCIENCE
(2022)
Article
Computer Science, Artificial Intelligence
Jhielson M. Pimentel, Renan C. Moioli, Mariana F. P. De Araujo, Patricia A. Vargas
Summary: This work presents a neurorobotics model that integrates the cerebellum and basal ganglia to coordinate movements in a humanoid robot. The model is capable of predicting and adjusting the robot's hand motion in real time, making it an important tool for brain studies and robot motor control.
INTERNATIONAL JOURNAL OF NEURAL SYSTEMS
(2023)
Article
Biology
Hunter E. Halverson, Jinsook Kim, Andrei Khilkevich, Michael D. Mauk, George J. Augustine, Upinder Singh Bhalla
Summary: The study demonstrates that the feedback inhibitory circuit between cerebellar Purkinje cells and molecular layer interneurons plays a crucial role in regulating neuronal activity during learning processes and learning-related movements.
Article
Clinical Neurology
Ellen T. Koch, Marja D. Sepers, Judy Cheng, Lynn A. Raymond
Summary: This study investigated the correlation between striatal activity and behavior in a Huntington's disease mouse model. Decreased striatal activity was observed during motor learning, with an inverse correlation between latency to fall and striatal activity. At an early stage, the YAC128 mice did not show a deficit in latency to fall but exhibited significant differences in paw kinematics and a weaker correlation between latency to fall and striatal activity. However, at 6 to 7 months, the YAC128 mice showed reduced latency to fall, impaired paw kinematics, and increased striatal activity. In the open field, elevated neuronal activity was observed at rest in the YAC128 mice.
MOVEMENT DISORDERS
(2022)
Article
Multidisciplinary Sciences
Youngcho Kim, Dennis Jung, Mayu Oya, Morgan Kennedy, Tomas Lence, Stephanie L. Alberico, Nandakumar S. Narayanan
Summary: Brain rhythms are linked with behavior, and abnormal rhythms can indicate pathological conditions. However, the relevance of phase in brain stimulation is still unclear. In this study, a phase-adaptive, real-time, closed-loop algorithm was developed to control the instantaneous phase of brain rhythms. The findings provide causal evidence that phase is important for brain stimulation, allowing for more precise and individualized treatments. These findings have implications for preclinical brain stimulation and circuit-specific neuromodulation in human brain disease.
SCIENTIFIC REPORTS
(2022)
Article
Neurosciences
Junichi Yoshida, Maritza Onate, Leila Khatami, Jorge Vera, Farzan Nadim, Kamran Khodakhah
Summary: The cerebellum and basal ganglia are connected through direct pathways, influencing motor coordination and dopamine release, and impacting motor deficits and addictive behavior.
JOURNAL OF NEUROSCIENCE
(2022)
Article
Cell Biology
Violeta G. Lopez-Huerta, Jai A. Denton, Yoko Nakano, Omar Jaidar, Marianela Garcia-Munoz, Gordon W. Arbuthnott
Summary: The research shows that D1 and D2 neurons have different roles in controlling motor behavior, with D1 neurons having a greater impact on overall kinematics results and D2 neurons being more involved in controlling target accuracy. Practice of movements changes synaptic patterns between neurons.
Article
Cell Biology
Ling Guo, Sravani Kondapavulur, Stefan M. Lemke, Seok Joon Won, Karunesh Ganguly
Summary: The study reveals the importance of consistent neural activity patterns across brain structures during recovery poststroke, and suggests that modulation of cross-area coordination can be a therapeutic target for enhancing motor function.
Article
Multidisciplinary Sciences
Ana K. Pimentel-Farfan, Ana S. Baez-Cordero, Teresa M. Pena-Rangel, Pavel E. Rueda-Orozco
Summary: This study investigated the interactions between the cortex and striatum in bilaterally coordinated movements in rats. It found that bilateral actions are initiated by the motor cortex regions, with the striatum influencing movement duration and kinematic parameters.
Article
Clinical Neurology
Hsiao-Ying Kuo, Shih-Yun Chen, Rui-Chi Huang, Hiroshi Takahashi, Yen-Hui Lee, Hao-Yu Pang, Cheng-Hsi Wu, Ann M. Graybiel, Fu-Chin Liu
Summary: Kuo et al. have identified a mechanism by which the KE family mutation in FOXP2 can lead to childhood apraxia of speech. Using a mouse model, they found that the mutation disrupts the formation of vocalization circuits by inhibiting intracellular trafficking. This discovery sheds light on the genetic control of vocal communication in humans and could contribute to understanding speech disorders associated with FOXP2 mutations.
Article
Neurosciences
Paige N. McKeon, Garrett W. Bunce, Mary H. Patton, Rong Chen, Brian N. Mathur
Summary: Fast-spiking interneurons in the dorsal striatum regulate actions and action strategies, with synchronization arising from electrical synapses or convergent cortical input. In adult mice, the primary source of functional coordination of fast-spiking interneuron activity is the convergence of corticostriatal input, with electrical synapses providing only minor enhancement of synchronization.
JOURNAL OF PHYSIOLOGY-LONDON
(2022)
Review
Psychology, Multidisciplinary
Samuel A. Nordli, Peter M. Todd
Summary: The neural circuitry underlying motor control in vertebrates has remained virtually unchanged over time, despite the diverse species-level differences. This article reviews how this circuitry facilitates motor control, procedural learning, and habit formation and proposes a model to explain how it works to build and refine goal-directed actions. The model suggests that this same circuitry also regulates cognitive control in humans and operates analogously in both cognitive and motor domains.
FRONTIERS IN PSYCHOLOGY
(2022)
Article
Multidisciplinary Sciences
Bruno F. Cruz, Goncalo Guiomar, Sofia Soares, Asma Motiwala, Christian K. Machens, Joseph J. Paton
Summary: The direct and indirect pathways of the basal ganglia play opposite roles in action suppression. Co-activation of neurons in the movement center and dorsolateral striatum is observed during action suppression. Optogenetic inhibition experiments demonstrate that the dorsolateral striatum is primarily involved in suppressing actions, while other striatal circuits promote contralateral actions. These findings highlight the importance of opponent interactions between region-specific basal ganglia processes in behavioral control, and emphasize the critical role of the sensorimotor indirect pathway in the proactive suppression of tempting actions.
Article
Multidisciplinary Sciences
Lei Ma, Julian Day-Cooney, Omar Jaidar Benavides, Michael A. Muniak, Maozhen Qin, Jun B. Ding, Tianyi Mao, Haining Zhong
Summary: PKA activity is essential for normal locomotion in both direct and indirect pathway striatal spiny projection neurons. Dopamine activates PKA activity in direct pathway SPNs, while adenosine accumulation largely affects PKA activity in indirect pathway SPNs.
Article
Biology
Guang-Heng Dong, Haohao Dong, Min Wang, Jialin Zhang, Weiran Zhou, Xiaoxia Du, Marc N. Potenza
Summary: The study found that individuals with internet gaming disorder (IGD) showed shifts in functional connectivity between the ventral and dorsal striatum, similar to traditional addictions, suggesting a potential mechanistic role as proposed by Dong et al.
COMMUNICATIONS BIOLOGY
(2021)
Review
Neurosciences
Kevin W. McCairn, Atsushi Iriki, Masaki Isoda
JOURNAL OF NEUROPHYSIOLOGY
(2015)
Article
Neurosciences
Kevin W. McCairn, Robert S. Turner
JOURNAL OF NEUROPHYSIOLOGY
(2015)
Article
Neurosciences
Kevin W. McCairn, Yuji Nagai, Yukiko Hori, Taihei Ninomiya, Erika Kikuchi, Ju-Young Lee, Tetsuya Suhara, Atsushi Iriki, Takafumi Minamimoto, Masahiko Takada, Masaki Isoda, Masayuki Matsumoto
Article
Neuroimaging
Hang Joon Jo, Kevin W. McCairn, William S. Gibson, Paola Testini, Cong Zhi Zhao, Krzysztof R. Gorny, Joel P. Felmlee, Kirk M. Welker, Charles D. Blaha, Bryan T. Klassen, Hoon-Ki Min, Kendall H. Lee
NEUROIMAGE-CLINICAL
(2018)
Article
Clinical Neurology
Kevin W. McCairn, Maya Bronfeld, Katya Belelovsky, Izhar Bar-Gad
Article
Neurosciences
Yulia Worbe, Nicolas Baup, David Grabli, Marion Chaigneau, Stephanie Mounayar, Kevin McCairn, Jean Feger, Leon Tremblay
Article
Neurosciences
Kevin W. McCairn, Robert S. Turner
JOURNAL OF NEUROPHYSIOLOGY
(2009)
Article
Neurosciences
Yaara Erez, Hadass Czitron, Kevin McCairn, Katya Belelovsky, Izhar Bar-Gad
JOURNAL OF NEUROSCIENCE
(2009)
Article
Neurosciences
Kevin W. McCairn, Atsushi Iriki, Masaki Isoda
JOURNAL OF NEUROSCIENCE
(2013)
Article
Neurosciences
Kevin W. McCairn, Atsushi Iriki, Masaki Isoda
Article
Multidisciplinary Sciences
Hye Ran Park, In Hyang Kim, Hyejin Kang, Kevin W. McCairn, Dong Soo Lee, Bung-Nyun Kim, Dong Gyu Kim, Sun Ha Paek
Article
Clinical Neurology
D Grabli, K McCairn, EC Hirsch, Y Agid, J Féger, C Francois, L Tremblay
Article
Clinical Neurology
C François, D Grabli, K McCairn, C Jan, C Karachi, EC Hirsch, J Féger, L Tremblay
Article
Clinical Neurology
Alex K. Wu, Kevin W. McCairn, Gabriel Zada, Tiffany Wu, Robert S. Turner
JOURNAL OF NEUROSURGERY
(2007)