期刊
NEURON
卷 89, 期 2, 页码 300-307出版社
CELL PRESS
DOI: 10.1016/j.neuron.2015.12.025
关键词
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资金
- Tourette Association of America
- Korea Brain Research Institute basic research program - Ministry of Science, ICT and Future Planning [2231-415]
- Funding Program for Next Generation World-Leading Researchers from Cabinet Office, Government of Japan [LS074]
- Ministry of Science, ICT & Future Planning, Republic of Korea [16-BR-03] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
- Grants-in-Aid for Scientific Research [16K06995, 15H04262] Funding Source: KAKEN
Inappropriate vocal expressions, e.g., vocal tics in Tourette syndrome, severely impact quality of life. Neural mechanisms underlying vocal tics remain unexplored because no established animal model representing the condition exists. We report that unilateral disinhibition of the nucleus accumbens (NAc) generates vocal tics in monkeys. Whole-brain PET imaging identified prominent, bilateral limbic cortico-subcortical activation. Local field potentials (LFPs) developed abnormal spikes in the NAc and the anterior cingulate cortex (ACC). Vocalization could occur without obvious LFP spikes, however, when phase-phase coupling of alpha oscillations were accentuated between the NAc, ACC, and the primary motor cortex. These findings contrasted with myoclonic motor tics induced by disinhibition of the dorsolateral putamen, where PET activity was confined to the ipsilateral sensorimotor system and LFP spikes always preceded motor tics. We propose that vocal tics emerge as a consequence of dysrhythmic alpha coupling between critical nodes in the limbic and motor networks.
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