Article
Multidisciplinary Sciences
Lynne Chantranupong, Celia C. Beron, Joshua A. Zimmer, Michelle J. Wen, Wengang Wang, Bernardo L. Sabatini
Summary: Experiments in mice provide insight into the dynamic relationship between dopamine and acetylcholine in the ventrolateral striatum and how this signaling circuit affects decision-making and behavior.
Article
Neurosciences
Qiaoling Cui, Xixun Du, Isaac Y. M. Chang, Arin Pamukcu, Varoth Lilascharoen, Brianna L. Berceau, Daniela Garcia, Darius Hong, Uree Chon, Ahana Narayanan, Yongsoo Kim, Byung Kook Lim, C. Savio Chan
Summary: The study reveals that direct-pathway striatal projection neurons not only innervate the external globus pallidus (GPe), but also selectively target Npas1(+) neurons within it. In a Parkinson's disease model, this projection is significantly strengthened, leading to movement suppression. This highlights the critical role of the direct-pathway striatal input to GPe as a circuit mechanism for regulating movement in both healthy and parkinsonian states.
JOURNAL OF NEUROSCIENCE
(2021)
Article
Multidisciplinary Sciences
Jaeeon Lee, Bernardo L. Sabatini
Summary: The study reveals that indirect striatal projection neurons in the basal ganglia contribute to action selection and exploration by modulating the superior colliculus, highlighting a competitive interaction between hemispheres of the superior colliculus in triggering motor actions.
Article
Cell Biology
Wei Wang, Xueyi Xie, Xiaowen Zhuang, Yufei Huang, Tao Tan, Himanshu Gangal, Zhenbo Huang, William Purvines, Xuehua Wang, Alexander Stefanov, Ruifeng Chen, Lucas Rodriggs, Anita Chaiprasert, Emily Yu, Valerie Vierkant, Michelle Hook, Yun Huang, Emmanuel Darcq, Jun Wang
Summary: Withdrawal from chronic opioid use leads to hypodopaminergic states and negative affect, promoting relapse. Activation of MORs in dMSNs in the striatal patch compartment suppresses striatopallidal transmission, and withdrawal potentiated this transmission. Fentanyl self-administration enhances striatonigral transmission and reduces dopaminergic activity, while activated striatal neurons mediate contextual memory retrieval. Inhibition of striatal MOR+ neurons rescues fentanyl withdrawal-induced physical symptoms and anxiety-like behaviors. These findings suggest that chronic opioid use induces GABAergic striatopallidal and striatonigral plasticity, leading to hypodopaminergic states and relapse.
Article
Cell Biology
Thomas Andreska, Patrick Luningschror, Daniel Wolf, Rhonda L. McFleder, Maurilyn Ayon-Olivas, Marta Rattka, Christine Drechsler, Veronika Perschin, Robert Blum, Sarah Aufmkolk, Noelia Granado, Rosario Moratalla, Markus Sauer, Camelia Monoranu, Jens Volkmann, Chi Wang Ip, Christian Stigloher, Michael Sendtner
Summary: Parkinson's disease (PD) is characterized by impaired motor control. Cortico-striatal synapses, along with brain-derived neurotrophic factor (BDNF) and TrkB, play crucial roles in motor learning. Dopamine depletion in PD reduces the responsiveness of striatal medium spiny projection neurons (SPNs) to BDNF, leading to impaired TrkB processing and disturbed motor function. Sortilin related VPS10 domain containing receptor 2 (SORCS-2) may protect intracellular TrkB clusters from lysosomal degradation.
Article
Neurosciences
Zhijun Diao, Yuanyuan Di, Meilin Wu, Chenyang Zhai, Mengsi Kang, Yongfeng Li, Yingxun Liu, Chunling Wei, Qiaohua Zheng, Jing Han, Zhiqiang Liu, Yingfang Tian, Wei Ren
Summary: Plasticity in glutamatergic synapses on striatal medium spiny neurons is crucial for behavioral adaptation and is highly susceptible to drugs of abuse. A single exposure to cocaine can disrupt reinforcement learning by impairing the potentiation required for this type of learning, possibly by potentiating the activity of direct pathway neurons in the dorsomedial striatum.
NEUROSCIENCE BULLETIN
(2021)
Article
Cell Biology
Zhaorong Chen, Zhi-Yu Zhang, Wen Zhang, Taorong Xie, Yaping Li, Xiao-Hong Xu, Haishan Yao
Summary: The study revealed that in rodents, inactivation of D1 and D2 receptor-expressing medium spiny neurons (MSNs) in the ventrolateral striatum (VLS) oppositely alters the number of licks in a bout. D1-MSNs and D2-MSNs exhibit different patterns of activity related to licking sequences and have different phases of oscillation time-locked to the lick cycle. Distinct roles of D1-MSNs and D2-MSNs in regulating licking behavior at both coarse and fine timescales were demonstrated.
Article
Multidisciplinary Sciences
Allen P. F. Chen, Lu Chen, Kaiyo W. Shi, Eileen Cheng, Shaoyu Ge, Qiaojie Xiong
Summary: The auditory striatum plays an important role in auditory-conditioned fear memory formation and expression through the striatal-amygdala pathway. Neuronal responses in the auditory striatum to conditioned tones are potentiated during memory acquisition and expression. Nigrostriatal dopaminergic projections are crucial in modulating striatal potentiation.
NATURE COMMUNICATIONS
(2023)
Article
Neurosciences
Chang Li, Osama F. Elabi, Tim Fieblinger, M. Angela Cenci
Summary: The dendritic arbour of striatal projection neurons undergoes atrophic changes in Parkinson's disease. In a mouse model of dopamine denervation, spiny projection neurons in the direct pathway show coordinated changes in dendritic morphology, intrinsic excitability, and Kir conductances at 28 days post-lesion, which may interfere with their normal movement-related output.
EUROPEAN JOURNAL OF NEUROSCIENCE
(2023)
Review
Neurosciences
Lisa Z. Fang, Meaghan C. Creed
Summary: This article provides an overview of the neurochemical and molecular diversity of striatal and pallidal neurons, as well as recent studies on circuit connectivity in rodents. The authors highlight the anatomical organizational principles of the dorsal and ventral basal ganglia pathways. Future research integrating the molecular and anatomical properties of specific subpopulations may help resolve controversies related to the function of basal ganglia networks.
NATURE NEUROSCIENCE
(2023)
Article
Neurosciences
Nicole L. Jenni, Griffin Rutledge, Stan B. Floresco
Summary: The medial orbitofrontal cortex (mOFC) plays a role in regulating risk/reward decision-making through different projection pathways. The mOFC -> NAc circuit helps establish and stabilize decision biases, while the mOFC -> DMS circuit facilitates adjustments in decision biases based on changes in profitability.
JOURNAL OF NEUROSCIENCE
(2022)
Article
Clinical Neurology
Felix Brandl, Franziska Knolle, Mihai Avram, Claudia Leucht, Igor Yakushev, Josef Priller, Stefan Leucht, Sibylle Ziegler, Klaus Wunderlich, Christian Sorg
Summary: Negative symptoms in patients with schizophrenia are highly prevalent and debilitating. This study found that impaired model-free reward prediction influence is a mechanism for negative symptoms in schizophrenia, and it is associated with reduced associative striatum dopamine and executive dysfunction.
Article
Medicine, Research & Experimental
Tingting Dong, Leon Tejwani, Youngseob Jung, Hiroshi Kokubu, Kimberly Luttik, Terri M. Driessen, Janghoo Lim
Summary: Reduction of Nemo-like kinase (Nlk) in microglia, but not in neurons, can alter total brain Pgrn levels in mice, revealing a mechanism for Pgrn level regulation in the brain through the active catabolism by microglia and providing insights into the pathophysiology of PGRN-associated diseases.
Article
Multidisciplinary Sciences
Bo Liang, Lifeng Zhang, Yan Zhang, Craig T. Werner, Nicholas J. Beacher, Alex J. Denman, Yun Li, Rong Chen, Charles R. Gerfen, Giovanni Barbera, Da-Ting Lin
Summary: The dorsal striatum plays a crucial role in movement control and motor skill learning. This study explores how the medium spiny neurons (MSNs) in the direct and indirect pathways of the striatum encode motor skill learning. By combining miniature fluorescence microscopy and an accelerating rotarod procedure, the researchers identified two distinct subpopulations of MSNs involved in accelerating rotarod learning. They found that early-stage neurons in both the D1 and D2 MSNs displayed activity tuned to acceleration during early stages of trials and movement speed during late stages of trials. The evolution of D1 MSNs correlated strongly with performance improvement, and inhibiting early-stage neural activity in D1 MSNs impaired accelerating rotarod learning.
Article
Psychology, Multidisciplinary
Henrich R. Greve
Summary: The passage discusses the difference between organizational goals and goals adopted by individuals voluntarily. It highlights the lack of understanding about individual-level mechanisms in response to goals and the need to resolve research questions to elucidate organizational responses. Further investigation on the role of construal in guiding these processes is crucial.
FRONTIERS IN PSYCHOLOGY
(2023)
Article
Multidisciplinary Sciences
Reed M. Stein, Hye Jin Kang, John D. McCorvy, Grant C. Glatfelter, Anthony J. Jones, Tao Che, Samuel Slocum, Xi-Ping Huang, Olena Savych, Yurii S. Moroz, Benjamin Stauch, Linda C. Johansson, Vadim Cherezov, Terry Kenakin, John J. Irwin, Brian K. Shoichet, Bryan L. Roth, Margarita L. Dubocovich
Editorial Material
Multidisciplinary Sciences
Brian Krumm, Bryan L. Roth
Editorial Material
Biochemistry & Molecular Biology
Brian Krumm, Bryan L. Roth
Article
Multidisciplinary Sciences
Tao Che, Justin English, Brian E. Krumm, Kuglae Kim, Els Pardon, Reid H. J. Olsen, Sheng Wang, Shicheng Zhang, Jeffrey F. Diberto, Noah Sciaky, F. Ivy Carroll, Jan Steyaert, Daniel Wacker, Bryan L. Roth
NATURE COMMUNICATIONS
(2020)
Article
Biochemical Research Methods
May Fern Toh, Julie M. Brooks, Tim Strassmaier, Rodolfo J. Haedo, Corey B. Puryear, Bruce L. Roth, Kosalvisal Ouk, Sokhom S. Pin
Meeting Abstract
Biochemistry & Molecular Biology
Abdelfattah Faouzi, Saheem Zaidi, Tao Che, Chad Kormos, Tiffany Zhang, Manish Madasu, Shainnel Eans, Chloe Simons, Ying-Xian Pan, Jay McLaughlin, Ivy Carroll, Ream Al Hassani, Bryan Roth, Vsevolod Katritch, Susruta Majumdar
Meeting Abstract
Biochemistry & Molecular Biology
Grant Glatfelter, Reed Stein, Hye Kang, Anthony Jones, John Irwin, Bryan Roth, Brian Shoichet, Margarita Dubocovich
Article
Multidisciplinary Sciences
David E. Gordon, Gwendolyn M. Jang, Mehdi Bouhaddou, Jiewei Xu, Kirsten Obernier, Kris M. White, Matthew J. O'Meara, Veronica V. Rezelj, Jeffrey Z. Guo, Danielle L. Swaney, Tia A. Tummino, Ruth Huttenhain, Robyn M. Kaake, Alicia L. Richards, Beril Tutuncuoglu, Helene Foussard, Jyoti Batra, Kelsey Haas, Maya Modak, Minkyu Kim, Paige Haas, Benjamin J. Polacco, Hannes Braberg, Jacqueline M. Fabius, Manon Eckhardt, Margaret Soucheray, Melanie J. Bennett, Merve Cakir, Michael J. McGregor, Qiongyu Li, Bjoern Meyer, Ferdinand Roesch, Thomas Vallet, Alice Mac Kain, Lisa Miorin, Elena Moreno, Zun Zar Chi Naing, Yuan Zhou, Shiming Peng, Ying Shi, Ziyang Zhang, Wenqi Shen, Ilsa T. Kirby, James E. Melnyk, John S. Chorba, Kevin Lou, Shizhong A. Dai, Inigo Barrio-Hernandez, Danish Memon, Claudia Hernandez-Armenta, Jiankun Lyu, Christopher J. P. Mathy, Tina Perica, Kala Bharath Pilla, Sai J. Ganesan, Daniel J. Saltzberg, Ramachandran Rakesh, Xi Liu, Sara B. Rosenthal, Lorenzo Calviello, Srivats Venkataramanan, Jose Liboy-Lugo, Yizhu Lin, Xi-Ping Huang, YongFeng Liu, Stephanie A. Wankowicz, Markus Bohn, Maliheh Safari, Fatima S. Ugur, Cassandra Koh, Nastaran Sadat Savar, Quang Dinh Tran, Djoshkun Shengjuler, Sabrina J. Fletcher, Michael C. O'Neal, Yiming Cai, Jason C. J. Chang, David J. Broadhurst, Saker Klippsten, Phillip P. Sharp, Nicole A. Wenzell, Duygu Kuzuoglu-Ozturk, Hao-Yuan Wang, Raphael Trenker, Janet M. Young, Devin A. Cavero, Joseph Hiatt, Theodore L. Roth, Ujjwal Rathore, Advait Subramanian, Julia Noack, Mathieu Hubert, Robert M. Stroud, Alan D. Frankel, Oren S. Rosenberg, Kliment A. Verba, David A. Agard, Melanie Ott, Michael Emerman, Natalia Jura, Mark von Zastrow, Eric Verdin, Alan Ashworth, Olivier Schwartz, Christophe D'Enfert, Shaeri Mukherjee, Matt Jacobson, Harmit S. Malik, Danica G. Fujimori, Trey Ideker, Charles S. Craik, Stephen N. Floor, James S. Fraser, John D. Gross, Andrej Sali, Bryan L. Roth, Davide Ruggero, Jack Taunton, Tanja Kortemme, Pedro Beltrao, Marco Vignuzzi, Adolfo Garcia-Sastre, Kevan M. Shokat, Brian K. Shoichet, Nevan J. Krogan
Article
Biochemistry & Molecular Biology
Reid H. J. Olsen, Jeffrey F. DiBerto, Justin G. English, Alexis M. Glaudin, Brian E. Krumm, Samuel T. Slocum, Tao Che, Ariana C. Gavin, John D. McCorvy, Bryan L. Roth, Ryan T. Strachan
NATURE CHEMICAL BIOLOGY
(2020)
Article
Neurosciences
Yuji Nagai, Naohisa Miyakawa, Hiroyuki Takuwa, Yukiko Hori, Kei Oyama, Bin Ji, Manami Takahashi, Xi-Ping Huang, Samuel T. Slocum, Jeffrey F. DiBerto, Yan Xiong, Takuya Urushihata, Toshiyuki Hirabayashi, Atsushi Fujimoto, Koki Mimura, Justin G. English, Jing Liu, Ken-ichi Inoue, Katsushi Kumata, Chie Seki, Maiko Ono, Masafumi Shimojo, Ming-Rong Zhang, Yutaka Tomita, Jin Nakahara, Tetsuya Suhara, Masahiko Takada, Makoto Higuchi, Jian Jin, Bryan L. Roth, Takafumi Minamimoto
NATURE NEUROSCIENCE
(2020)
Article
Neurosciences
A. F. Garcia, I. G. Webb, L. M. Yager, M. B. Seo, S. M. Ferguson
PSYCHOPHARMACOLOGY
(2020)
Article
Biochemistry & Molecular Biology
Xi-Ping Huang, Terrence P. Kenakin, Shuo Gu, Brian K. Shoichet, Bryan L. Roth
Article
Biochemistry & Molecular Biology
Kuglae Kim, Tao Che, Ouliana Panova, Jeffrey F. DiBerto, Jiankun Lyu, Brian E. Krumm, Daniel Wacker, Michael J. Robertson, Alpay B. Seven, David E. Nichols, Brian K. Shoichet, Georgios Skiniotis, Bryan L. Roth
Article
Medicine, Research & Experimental
Gabriel D. Bosse, Roberto Cadeddu, Gabriele Floris, Ryan D. Farero, Eva Vigato, Suhjung J. Lee, Tejia Zhang, Nilesh W. Gaikwad, Kristen A. Keefe, Paul E. M. Phillips, Marco Bortolato, Randall T. Peterson
Summary: Research has shown that finasteride reduces self-administration of multiple opioids and physical signs of opioid withdrawal in zebrafish and rat models. Steroidogenic pathways are highlighted as important therapeutic targets for opioid use disorder, with finasteride potentially offering a new treatment option.
JOURNAL OF CLINICAL INVESTIGATION
(2021)
Article
Multidisciplinary Sciences
Joshua Pottel, Duncan Armstrong, Ling Zou, Alexander Fekete, Xi-Ping Huang, Hayarpi Torosyan, Dallas Bednarczyk, Steven Whitebread, Barun Bhhatarai, Guiqing Liang, Hong Jin, S. Nassir Ghaemi, Samuel Slocum, Katalin V. Lukacs, John J. Irwin, Ellen L. Berg, Kathleen M. Giacomini, Bryan L. Roth, Brian K. Shoichet, Laszlo Urban