Article
Biochemistry & Molecular Biology
Carolina G. Ferroni, Davide Albertini, Marco Lanzilotto, Alessandro Livi, Monica Maranesi, Luca Bonini
Summary: This research investigated the neural activity in the action observation network (AON) during self and others' action encoding, revealing temporal and tuning specificities of distinct brain areas and neuronal classes. Different areas within AON showed varied prevalence of facilitated and suppressed neurons during task execution and observation, with distinct cell classes carrying specific visuomotor signals. The findings elucidated the firing properties and time course of activity at both system and local levels in the AON.
Article
Biology
Zhenni Wang, Shihao Lou, Xiao Ma, Hui Guo, Yan Liu, Wenjing Chen, Dating Lin, Yupeng Yang
Summary: This study found that the medial prefrontal cortex (mPFC) plays a crucial role in both the training and maintenance processes of visual perceptual learning (VPL). By recording the calcium activity of mPFC pyramidal neurons, distinct ON and OFF neural ensembles were identified, which may encode different cognitive information. Additionally, the mPFC was found to recruit more reward-related components during VPL.
Article
Multidisciplinary Sciences
Jim Berg, Staci A. Sorensen, Jonathan T. Ting, Jeremy A. Miller, Thomas Chartrand, Anatoly Buchin, Trygve E. Bakken, Agata Budzillo, Nick Dee, Song-Lin Ding, Nathan W. Gouwens, Rebecca D. Hodge, Brian Kalmbach, Changkyu Lee, Brian R. Lee, Lauren Alfiler, Katherine Baker, Eliza Barkan, Allison Beller, Kyla Berry, Darren Bertagnolli, Kris Bickley, Jasmine Bomben, Thomas Braun, Krissy Brouner, Tamara Casper, Peter Chong, Kirsten Crichton, Rachel Dalley, Rebecca de Frates, Tsega Desta, Samuel Dingman Lee, Florence D'Orazi, Nadezhda Dotson, Tom Egdorf, Rachel Enstrom, Colin Farrell, David Feng, Olivia Fong, Szabina Furdan, Anna A. Galakhova, Clare Gamlin, Amanda Gary, Alexandra Glandon, Jeff Goldy, Melissa Gorham, Natalia A. Goriounova, Sergey Gratiy, Lucas Graybuck, Hong Gu, Kristen Hadley, Nathan Hansen, Tim S. Heistek, Alex M. Henry, Djai B. Heyer, DiJon Hill, Chris Hill, Madie Hupp, Tim Jarsky, Sara Kebede, Lisa Keene, Lisa Kim, Mean-Hwan Kim, Matthew Kroll, Caitlin Latimer, Boaz P. Levi, Katherine E. Link, Matthew Mallory, Rusty Mann, Desiree Marshall, Michelle Maxwell, Medea McGraw, Delissa McMillen, Erica Melief, Eline J. Mertens, Leona Mezei, Norbert Mihut, Stephanie Mok, Gabor Molnar, Alice Mukora, Lindsay Ng, Kiet Ngo, Philip R. Nicovich, Julie Nyhus, Gaspar Olah, Aaron Oldre, Victoria Omstead, Attila Ozsvar, Daniel Park, Hanchuan Peng, Trangthanh Pham, Christina A. Pom, Lydia Potekhina, Ramkumar Rajanbabu, Shea Ransford, David Reid, Christine Rimorin, Augustin Ruiz, David Sandman, Josef Sulc, Susan M. Sunkin, Aaron Szafer, Viktor Szemenyei, Elliot R. Thomsen, Michael Tieu, Amy Torkelson, Jessica Trinh, Herman Tung, Wayne Wakeman, Femke Waleboer, Katelyn Ward, Rene Wilbers, Grace Williams, Zizhen Yao, Jae-Geun Yoon, Costas Anastassiou, Anton Arkhipov, Pal Barzo, Amy Bernard, Charles Cobbs, Philip C. de Witt Hamer, Richard G. Ellenbogen, Luke Esposito, Manuel Ferreira, Ryder P. Gwinn, Michael J. Hawrylycz, Patrick R. Hof, Sander Idema, Allan R. Jones, C. Dirk Keene, Andrew L. Ko, Gabe J. Murphy, Lydia Ng, Jeffrey G. Ojemann, Anoop P. Patel, John W. Phillips, Daniel L. Silbergeld, Kimberly Smith, Bosiljka Tasic, Rafael Yuste, Idan Segev, Christiaan P. J. de Kock, Huibert D. Mansvelder, Gabor Tamas, Hongkui Zeng, Christof Koch, Ed S. Lein
Summary: By studying neurosurgically resected human tissues, researchers have identified diverse glutamatergic neuron types in the neocortex and demonstrated strong correlations between morphological, physiological, and transcriptomic phenotypes. The results provide insight into the increased complexity of cortical function in humans and suggest certain transcriptomic neuron types are selectively vulnerable in diseases like Alzheimer's.
Article
Multidisciplinary Sciences
William E. Medendorp, Andreas Bjorefeldt, Emmanuel L. Crespo, Mansi Prakash, Akash Pal, Madison L. Waddell, Christopher Moore, Ute Hochgeschwender
Summary: In genetic and pharmacological models, neural activity changes in developing neocortical network were observed. Excessive excitation of cortical pyramidal neurons during early postnatal period led to decreased social interaction and increased grooming behavior in adult animals. These findings suggest that enhanced pyramidal firing during development may selectively drive altered adult circuit function and maladaptive changes in behavior.
Article
Neurosciences
Antoine Carton-Leclercq, Sofia Carrion-Falgarona, Paul Baudin, Pierre Lemaire, Sarah Lecas, Thomas Topilko, Stephane Charpier, Severine Mahon
Summary: The study investigates the laminar expression of cortical activities induced by transient anoxia in the rat primary somatosensory cortex. It reveals a well-organized sequence of activity patterns across cortical layers after the interruption of brain oxygenation. The onset and propagation of anoxic depolarization (AD) show layer-dependent variations, while the repolarization of cortical neurons upon reoxygenation does not exhibit a specific spatio-temporal profile.
NEUROBIOLOGY OF DISEASE
(2023)
Article
Multidisciplinary Sciences
Xiaocen Fan, Jiachen Song, Chaonan Ma, Yanbo Lv, Feifei Wang, Lan Ma, Xing Liu
Summary: This study found that increased norepinephrine release from the locus coeruleus to the medial prefrontal cortex during contextual fear conditioning is crucial for memory tagging and remote memory storage. It is regulated by the ventrolateral periaqueductal grey and can be promoted by activating beta1-adrenergic receptor signaling in juvenile mice.
NATURE COMMUNICATIONS
(2022)
Article
Cell Biology
J. Julius Zhu
Summary: This study developed a recording system that enables the reconstruction of complex cortical neuronal circuits. The method revealed the disinhibitory neuronal circuits across different cortices in mice. The modular circuits optimize cortical complexity and exhibit age-dependent deficits in an animal model of Alzheimer's disease, correlating with cognitive impairments.
Article
Neurosciences
Zhaoyang Li, Wenhao Dong, Xinyuan Zhang, Jun-Mei Lu, Yan-Ai Mei, Changlong Hu
Summary: The study demonstrates that PKC activation inhibits Kv2.2 channel currents and alters their steady-state activation, showing that the function of Kv2.2 is dependent on its phosphorylation state. In cortical slices, PKC activation reduces the frequency of action potentials by regulating Kv2.2 channels.
NEUROSCIENCE BULLETIN
(2022)
Article
Biochemical Research Methods
Reem Khalil, Sadok Kallel, Ahmad Farhat, Pawel Dlotko
Summary: Neuronal morphology is crucial for information processing in neurons and networks. Current computational methods for analyzing neurons are limited. This study introduces a novel technique using Sholl descriptors to quantitatively describe dendritic morphology and perform clustering and classification of neurons.
PLOS COMPUTATIONAL BIOLOGY
(2022)
Article
Multidisciplinary Sciences
Maya Zhe Wang, Benjamin Y. Hayden, Sarah R. Heilbronner
Summary: Economic choice involves multiple cognitive subprocesses associated with the central orbitofrontal cortex (cOFC). This study challenges the assumption that cOFC is a single region with a single function, showing anatomical and physiological evidence for subdivision into cOFCm and cOFCl subregions. These subregions differ in functional connectivity and the relaying of choice signals.
NATURE COMMUNICATIONS
(2022)
Article
Neurosciences
Dominique Arion, John F. Enwright, Guillermo Gonzalez-Burgos, David A. Lewis
Summary: Reciprocal connections between primate dorsolateral prefrontal and posterior parietal cortices play a crucial role in cognitive processes, and the transcriptomes of layer 3 pyramidal neurons in different regions exhibit regional and projection type specificity.
Article
Biology
Moustafa Algamal, Alyssa N. N. Russ, Morgan R. R. Miller, Steven S. S. Hou, Megi Maci, Leon P. P. Munting, Qiuchen Zhao, Dmitry Gerashchenko, Brian J. J. Bacskai, Ksenia V. V. Kastanenka
Summary: This study used in vivo calcium imaging with multiphoton microscopy to compare the activity of excitatory and inhibitory interneurons in APP/PS1 and control mice. The results showed that inhibitory interneurons were hyperactive in APP/PS1 mice, while excitatory neuron activity was decreased. These findings highlight the complexity of neuron-specific deficits in Alzheimer's disease.
COMMUNICATIONS BIOLOGY
(2022)
Article
Multidisciplinary Sciences
Sahil Loomba, Jakob Straehle, Vijayan Gangadharan, Natalie Heike, Abdelrahman Khalifa, Alessandro Motta, Niansheng Ju, Meike Sievers, Jens Gempt, Hanno S. Meyer, Moritz Helmstaedter
Summary: The possible differences in synaptic circuits between the human cerebral cortex and that of a mouse are still poorly understood. This study reveals key neuronal network alterations in the human cortex, including an increase in interneuron density, changes in inhibitory-versus-excitatory input balance, and expansion of interneuron networks.
Article
Neurosciences
Guillermo Gonzalez-Burgos, Takeaki Miyamae, Nita Reddy, Sidney Dawkins, Chloe Chen, Avyi Hill, John Enwright, Bard Ermentrout, David A. Lewis
Summary: In primates, the DLPFC and PPC cortices play crucial roles in the working memory network, with higher frequency oscillations observed in DLPFC. The higher frequency in DLPFC may be attributed to a greater quantity of synapses in the basal dendrites, leading to stronger synaptically evoked excitation and subsequently, increased oscillation frequency and power. These findings provide insights into the mechanisms underlying regional differences in oscillation properties between brain regions.
Article
Neurosciences
Jing Zhang, Shu-Jing Li, Wanying Miao, Xiaodi Zhang, Jing-Jing Zheng, Chen Wang, Xiang Yu
Summary: The study shows that oxytocin can affect the frequency of synaptic transmission in neurons, with effects varying by age and reaching a critical period around P18. Both sensory experience and oxytocin peak in their effects on pyramidal neurons around P14 and stabilize by P18. Oxtr expression shifts from glutamatergic neurons to GABAergic neurons as mice age.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2021)
Article
Neurosciences
Alexander Hsu, Jennifer I. Luebke, Maria Medalla
JOURNAL OF COMPARATIVE NEUROLOGY
(2017)
Article
Cell Biology
Larissa I. Estrada, Amy A. Robinson, Ana C. Amaral, Eustathia L. Giannaris, Nadine C. Heyworth, Farzad Mortazavi, Laura B. Ngwenya, Debra E. Roberts, Howard J. Cabral, Ronald J. Killiany, Douglas L. Rosene
JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY
(2017)
Article
Neurosciences
Daniel J. Apicco, Peter E. A. Ash, Brandon Maziuk, Chelsey LeBlang, Maria Medalla, Ali Al Abdullatif, Antonio Ferragud, Emily Botelho, Heather I. Ballance, Uma Dhawan, Samantha Boudeau, Anna Lourdes Cruz, Daniel Kashy, Aria Wong, Lisa R. Goldberg, Neema Yazdani, Cheng Zhang, Choong Y. Ung, Yorghos Tripodis, Nicholas M. Kanaan, Tsuneya Ikezu, Pietro Cottone, John Leszyk, Hu Li, Jennifer Luebke, Camron D. Bryant, Benjamin Wolozin
NATURE NEUROSCIENCE
(2018)
Article
Clinical Neurology
Constantinos D. Paspalas, Becky C. Carlyle, Shannon Leslie, Todd M. Preuss, Johanna L. Crimins, Anita J. Huttner, Christopher H. van Dyck, Douglas L. Rosene, Angus C. Nairn, Amy F. T. Arnsten
ALZHEIMERS & DEMENTIA
(2018)
Article
Neurosciences
Teresa Guillamon-Vivancos, William A. Tyler, Maria Medalla, Wayne Wei-en Chang, Mayumi Okamoto, Tarik F. Haydar, Jennifer I. Luebke
Article
Neurosciences
Mary E. Orczykowski, Kevin R. Arndt, Lauren E. Palitz, Brian C. Kramer, Monica A. Pessina, Adrian L. Oblak, Seth P. Finklestein, Farzad Mortazavi, Douglas L. Rosene, Tara L. Moore
EXPERIMENTAL NEUROLOGY
(2018)
Article
Neurosciences
Tara L. Moore, Bethany G. E. Bowley, Penny L. Shultz, Samantha M. Calderazzo, Eli J. Shobin, Ajay R. Uprety, Douglas L. Rosene, Mark B. Moss
SOMATOSENSORY AND MOTOR RESEARCH
(2018)
Article
Geriatrics & Gerontology
Amy A. Robinson, Carmela R. Abraham, Douglas L. Rosene
Article
Multidisciplinary Sciences
Joseph W. Goodliffe, Hanbing Song, Anastasia Rubakovic, Wayne Chang, Maria Medalla, Christina M. Weaver, Jennifer Luebke
Article
Cell Biology
Jean-Christophe Delpech, Dhruba Pathak, Merina Varghese, Srinidhi Venkatesan Kalavai, Emma C. Hays, Patrick R. Hof, W. Evan Johnson, Seiko Ikezu, Maria Medalla, Jennifer Luebke, Tsuneya Ikezu
Summary: The study shows that in early stages of Alzheimer's disease, Wfs1(+) neurons in the ECII region are associated with abnormally phosphorylated tau, leading to the spread of tau and potential functional abnormalities in CA1 pyramidal neurons.
SCIENCE TRANSLATIONAL MEDICINE
(2021)
Article
Behavioral Sciences
Nicholas T. Church, Wendy Weissner, Janina R. Galler, Ana C. Amaral, Douglas L. Rosene, Jill A. McGaughy, Richard J. Rushmore, Eben Larrabee, David J. Mokler
Summary: The study found that prenatal protein malnutrition may alter the levels of neurotransmitters in the brain, especially norepinephrine. Acute stress may increase serotonin levels, while norepinephrine and dopamine levels remain relatively stable.
BEHAVIORAL NEUROSCIENCE
(2021)
Article
Behavioral Sciences
Ajay Uprety, Mark B. Moss, Douglas L. Rosene, Ronald J. Killiany, Tara L. Moore
Summary: Studies suggest that curcumin (CUR) may improve specific aspects of executive function in rhesus monkeys, but has minimal impact on spatial reversal learning.
BEHAVIORAL NEUROSCIENCE
(2022)
Article
Anatomy & Morphology
Carolin Nieder, Douglas L. Rosene, Farzad Mortazavi, Adrian L. Oblak, Darlene R. Ketten
Summary: The superior olivary complex (SOC) in mammals plays a crucial role in sound localization, with toothed whales relying heavily on hearing and echolocation. A study on the SOC in odontocetes provides insights into their adaptations to underwater hearing and echolocation. The investigation on the lateral superior olive (LSO) in common dolphins reveals unique anatomical characteristics that contribute to their superb sensitivity to ultra-high frequencies for underwater spatial localization and echolocation tasks.
JOURNAL OF MORPHOLOGY
(2022)
Article
Veterinary Sciences
Nitin Seth, Heather A. Simmons, Farah Masood, William A. Graham, Douglas L. Rosene, Susan Westmoreland, Sheila M. Cummings, Basia Gwardjan, Ervin Sejdic, Amber F. Hoggatt, Dane R. Schalk, Hussein A. Abdullah, John B. Sledge, Shanker Nesathurai
COMPARATIVE MEDICINE
(2018)
Article
Neurosciences
Farzad Mortazavi, Adrian L. Oblak, Will Z. Morrison, Jeremy D. Schmahmann, H. Eugene Stanley, Van J. Wedeen, Douglas L. Rosene