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Cardiac & Cardiovascular Systems
Hao-Lin Ren, Ruiping Cai, Ruize Xue, Yaoxia Zhang, Qian Xu, Xianyang Zhang, RenZhi Cai, Wei Sha, Andrew V. V. Schally, Ming-Sheng Zhou
Summary: GHRH-A MR409 has been shown to effectively attenuate vascular calcification and heart valve calcification in diabetic mice, while protecting against endothelial dysfunction and vascular injury. This may be achieved through upregulation of anti-calcifying protein Klotho and reduction in vascular reactive oxygen species (ROS) generation, as well as the expression of redox sensitive osteogenic genes Runx2 and ALP. GHRH-A could represent a new pharmacological strategy for the treatment of vascular calcification and diabetes-associated cardiovascular complications.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
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Medicine, Research & Experimental
Lucia Recinella, Annalisa Chiavaroli, Serena Veschi, Valentina Di Valerio, Rossano Lattanzio, Giustino Orlando, Claudio Ferrante, Iacopo Gesmundo, Riccarda Granata, Renzhi Cai, Wei Sha, Andrew V. Schally, Luigi Brunetti, Sheila Leone
Summary: The MIAMI class GHRH antagonist MIA-690 was shown to suppress the progression and growth of colorectal cancer (CRC) by reducing inflammatory and oxidative markers, modulating apoptotic and oncogenic pathways, and improving survival rates in mice. Further research is needed to explore the translation of these findings into clinical applications.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
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Medicine, Research & Experimental
Seung Yeon Park, Hyun Jung Lee, Jin-Ho Song, Yong Kyoo Shin, A. M. Abd El-Aty, Amer Ramadan, A. Hacimuftuoglu, Ji Hoon Jeong, Tae Woo Jung
Summary: In summary, DITA treatment attenuated palmitate-induced impairment of insulin signaling and inflammation in C2C12 myocytes by enhancing AMPK phosphorylation, PPAR delta expression, and FGF21 secretion. This study suggests that targeting the AMPK/FGF21/PPAR delta pathway may alleviate insulin resistance in skeletal muscle cells.
Review
Oncology
Yen-Shen Lu, Andrea Wong, Hee-Jeong Kim
Summary: Combining ovarian function suppression (OFS) with endocrine therapy has been shown to significantly increase survival rates in some premenopausal patients with HR+ breast cancer, providing a new potential treatment option.
FRONTIERS IN ONCOLOGY
(2021)
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Biochemistry & Molecular Biology
Mohammad S. Akhter, Nektarios Barabutis
Summary: GHRH is a hypothalamic hormone that regulates growth hormone secretion, and GHRHAnt can counteract the pathological effects of GHRH while also exhibiting anti-inflammatory and antioxidative properties. Research shows that GHRHAnt has antioxidative effects in cells expressing GHRH receptors.
JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY
(2021)
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Biochemistry & Molecular Biology
Hua Zhang, Zhao-Fu Sheng, Jingxiong Wang, PeiRu Zheng, XunLei Kang, Hui-Ming Chang, Edward T. H. Yeh, De-Pei Li
Summary: This study reveals that transient activation of NMDA receptors suppresses M-currents through the Ca2+-dependent PI3K-PIP2 signaling pathway, while sustained activation of NMDA receptors reduces Kv7.3 protein expression and suppresses M-currents through a PKC-dependent pathway.
JOURNAL OF NEUROCHEMISTRY
(2022)
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Obstetrics & Gynecology
Xin Mu, He Cai, Juan-zi Shi
Summary: This study compares the outcomes of two different hormonal protocols for IVF in young patients with low BMI. The prolonged protocol required more medication and stimulation time, but the live birth rate was similar to that of the long protocol. However, the prolonged protocol had a higher incidence of ovarian hyperstimulation syndrome.
INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS
(2023)
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Endocrinology & Metabolism
Takuya Murata, Shuichi Chiba, Mitsumori Kawaminami
Summary: The study shows that activin A can downregulate the expression of Anxa5 but not Anxa1 in L beta T2 cells, while also increasing Nr4a3 expression and slightly reducing GnRHa-induced Nr4a3 increase. This suggests a differential regulation mechanism in gonadotrope cells for Anxa1 and Anxa5 expression in response to activin A signaling.
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Endocrinology & Metabolism
Takuya Murata, Shuichi Chiba, Mitsumori Kawaminami
Summary: In this study, the researchers found that activin A has differential effects on the expression of Anxa1 and a5 in L beta T2 cells. Activin A suppresses Anxa5 expression while increasing Nr4a3 expression, whereas activin A and GnRH synergistically stimulate Anxa1 expression. These findings suggest that the mechanism regulating Anxa1 and a5 expression is differentially coupled with activin A signal transduction in gonadotrope cells.
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Neurosciences
Eden M. Anderson, Steven Loke, Benjamin Wrucke, Annabel Engelhardt, Skyler Demis, Kevin O'Reilly, Evan Hess, Kevin Wickman, Matthew C. Hearing
Summary: GIRK1-dependent signaling is critical for maintaining optimal PrL function and behavioral control in male mice, but not in females. Stress-induced deficits in affect regulation and cognition are associated with disruption of this signaling pathway, providing a potential therapeutic target for improving quality of life.
NEUROPSYCHOPHARMACOLOGY
(2021)
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Endocrinology & Metabolism
Liat Perl, Erella Elkon-Tamir, Anat Segev-Becker, Galit Israeli, Avivit Brener, Asaf Oren
Summary: The study aimed to analyze the blood pressure changes in transgender female adolescents before and after receiving GnRHa and after adding estrogen treatment. The research found that neither GnRHa nor GnRHa + estrogen treatment had a significant impact on the blood pressure of the adolescents. Further larger studies are needed to confirm these findings.
JOURNAL OF PEDIATRIC ENDOCRINOLOGY & METABOLISM
(2021)
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Biochemistry & Molecular Biology
Kristoffer Sahlholm, Fan Liao, David M. Holtzman, Jinbin Xu, Robert H. Mach
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(2015)
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Immunology
Fan Liao, Tony J. Zhang, Thomas E. Mahan, Hong Jiang, David M. Holtzman
BRAIN BEHAVIOR AND IMMUNITY
(2015)
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Neurosciences
Fan Liao, Hong Jiang, Subhashini Srivatsan, Qingli Xiao, Katheryn B. Lefton, Kaoru Yamada, Thomas E. Mahan, Jin-Moo Lee, Andrey S. Shaw, David M. Holtzman
MOLECULAR NEURODEGENERATION
(2015)
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Multidisciplinary Sciences
Byung Hee Han, Meng-Liang Zhou, Andrew W. Johnson, Itender Singh, Fan Liao, Ananth K. Vellimana, James W. Nelson, Eric Milner, John R. Cirrito, Jacob Basak, Min Yoo, Hans H. Dietrich, David M. Holtzman, Gregory Joseph Zipfel
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
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Clinical Neurology
Ping Yan, Alec Zhu, Fan Liao, Qingli Xiao, Andrew W. Kraft, Ernie Gonzales, Ron Perez, Steven M. Greenberg, David M. Holtzman, Jin-Moo Lee
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Neurosciences
Fan Liao, Tony J. Zhang, Hong Jiang, Katheryn B. Lefton, Grace O. Robinson, Robert Vassar, Patrick M. Sullivan, David M. Holtzman
ACTA NEUROPATHOLOGICA COMMUNICATIONS
(2015)
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Biochemistry & Molecular Biology
Alaina T. Baker-Nigh, Kwasi G. Mawuenyega, James G. Bollinger, Vitaliy Ovod, Tom Kasten, Erin E. Franklin, Fan Liao, Hong Jiang, David Holtzman, Nigel J. Cairns, John C. Morris, Randall J. Bateman
JOURNAL OF BIOLOGICAL CHEMISTRY
(2016)
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Physiology
Ping Taishi, Christopher J. Davis, Omar Bayomy, Mark R. Zielinski, Fan Liao, James M. Clinton, Dirk E. Smith, James M. Krueger
JOURNAL OF APPLIED PHYSIOLOGY
(2012)
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Immunology
Jungsu Kim, Adam E. M. Eltorai, Hong Jiang, Fan Liao, Philip B. Verghese, Jaekwang Kim, Floy R. Stewart, Jacob M. Basak, David M. Holtzman
JOURNAL OF EXPERIMENTAL MEDICINE
(2012)
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Immunology
Kaoru Yamada, Jerrah K. Holth, Fan Liao, Floy R. Stewart, Thomas E. Mahan, Hong Jiang, John R. Cirrito, Tirth K. Patel, Katja Hochgraefe, Eva-Maria Mandelkow, David M. Holtzman
JOURNAL OF EXPERIMENTAL MEDICINE
(2014)
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Neurosciences
Fan Liao, Yukiko Hori, Eloise Hudry, Adam Q. Bauer, Hong Jiang, Thomas E. Mahan, Katheryn B. Lefton, Tony J. Zhang, Joshua T. Dearborn, Jungsu Kim, Joseph P. Culver, Rebecca Betensky, David F. Wozniak, Bradley T. Hyman, David M. Holtzman
JOURNAL OF NEUROSCIENCE
(2014)
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Cell Biology
Safak Caglayan, Shizuka Takagi-Niidome, Fan Liao, Anne-Sophie Carlo, Vanessa Schmidt, Tilman Burgert, Yu Kitago, Ernst-Martin Fuechtbauer, Annette Fuechtbauer, David M. Holtzman, Junichi Takagi, Thomas E. Willnow
SCIENCE TRANSLATIONAL MEDICINE
(2014)
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Clinical Neurology
Fan Liao, David M. Holtzman
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Neurosciences
Ping Taishi, Lynn Churchill, Mingxiang Wang, Daniel Kay, Christopher J. Davis, Xin Guan, Alok De, Tadanobu Yasuda, Fan Liao, James M. Krueger