Review
Neurosciences
Angela M. Mabb
Summary: Transcription-translation coupling leads to the production of key proteins for controlling essential neuronal processes, while posttranslational signaling pathways, such as ubiquitination, also play a crucial role in regulating these processes. Ubiquitin attaches to its targets and plays a role in multiple signaling pathways, primarily by removing substrates via the proteasome. This review focuses on 40 years of progress on ubiquitination in the nervous system at glutamatergic synapses, highlighting its importance in various neuronal processes.
Review
Neurosciences
Roberta Celli, Francesco Fornai
Summary: The review focuses on the role of ionotropic glutamate receptors in seizures and the clinical development of iGlu receptor antagonists for drug-resistant epilepsy. Antagonists inhibit experimental seizures while agonists worsen them, but clinical development is limited by adverse effects. Perampanel is the only drug specifically targeting iGlu receptors marketed for focal epilepsy.
CURRENT NEUROPHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Denis P. Laryushkin, Sergei A. Maiorov, Valery P. Zinchenko, Valentina N. Mal'tseva, Sergei G. Gaidin, Artem M. Kosenkov
Summary: This study investigates the role of ionotropic glutamate receptors (iGluRs) in the generation of paroxysmal depolarization shift (PDS) and the dependence of PDS pattern on neuronal membrane potential. The results show that external stimuli play a crucial role in PDS induction. AMPA receptors are necessary for PDS generation, while NMDA and kainate receptors modulate paroxysmal activity. Agonists of G(i)-coupled receptors suppress PDS generation, suggesting a potential approach for epilepsy pharmacotherapy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Audiology & Speech-Language Pathology
Dalian Ding, Weidong Qi, Haiyan Jiang, Richard Salvi
Summary: Excessive release of glutamate at the inner hair cell-type I auditory nerve synapse leads to excitotoxicity, with potential damage extending to the spiral ganglion soma. Developmental regulation of glutamate receptors alters the pattern of excitotoxic damage, with different receptor expressions in early postnatal versus adult cochlear cultures impacting the extent of damage. AMPAR and KAR expression on specific structures closely correlates with cochlear excitotoxic damage.
Review
Cell Biology
Marina N. Vukolova, Laura Y. Yen, Margarita I. Khmyz, Alexander I. Sobolevsky, Maria V. Yelshanskaya
Summary: This review discusses the role of AMPA and kainate receptors in the pathogenesis and treatment of Parkinson's disease, epilepsy, and amyotrophic lateral sclerosis. Although these receptors represent promising therapeutic targets, their antagonists often cause adverse side effects. Further research on the factors affecting subunit expression and trafficking, as well as the regulation by novel compounds, holds promise for pharmacological studies.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Deepa Gautam, Ulhas P. Naik, Meghna U. Naik, Santosh K. Yadav, Rameshwar Nath Chaurasia, Debabrata Dash
Summary: This paper explores the role of platelets in neurodegenerative disorders such as Alzheimer's disease and Parkinson's disease, as well as the critical role of glutamate receptors in the pathophysiology of these diseases. By reviewing data from clinical trials, animal models, and cellular studies, it reveals the involvement of glutamate receptor dysfunction in neurodegenerative processes and provides an overview of current treatments, including glutamate receptor antagonists, for AD and PD.
Review
Neurosciences
Jeremy M. Henley, Jithin D. Nair, Richard Seager, Busra P. Yucel, Gavin Woodhall, Benjamin S. Henley, Karolina Talandyte, Hope I. Needs, Kevin A. Wilkinson
Summary: Epilepsy is caused by abnormal neuronal network activity. The review focuses on the role and regulation of kainate and AMPA receptors in seizure activity, discussing the impact of GluK2 and GluA2 subunits on their respective receptors' properties.
Article
Biochemistry & Molecular Biology
Paulina Chalupnik, Alina Vialko, Darryl S. Pickering, Markus Hinkkanen, Stephanie Donbosco, Thor C. Moller, Anders A. Jensen, Birgitte Nielsen, Yasmin Bay, Anders S. Kristensen, Tommy N. Johansen, Kamil Latka, Marek Bajda, Ewa Szymanska
Summary: A new selective antagonist for GluK3 receptors with high affinity and selectivity has been discovered. This antagonist shows a 400-fold preference for GluK3 over other homomeric receptors and does not exhibit agonist or antagonist activity in functional assays.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Anatomy & Morphology
S. Serter Kocoglu, C. Cakir, Z. Minbay, O. Eyigor
Summary: This study demonstrated the expression of glutamate receptor subunits in neuronostatin neurons, suggesting the formation of functional receptor complexes. These findings provide important clues for further research on the function and regulation mechanisms of neuronostatin neurons.
FOLIA MORPHOLOGICA
(2022)
Article
Cell Biology
Niccolo P. Pampaloni, Irene Riva, Anna L. Carbone, Andrew J. R. Plested
Summary: The study shows that in addition to the previously known fast-acting AMPA receptors, slow AMPA receptors with prolonged activity are also expressed in the hippocampal CA1 region. These slow AMPA receptors may play a significant role in synaptic transmission, short-term potentiation, and triggering of action potentials.
Article
Immunology
Md Abdul Alim, Mirjana Grujic, Paul W. Ackerman, Per Kristiansson, Pernilla Eliasson, Magnus Peterson, Gunnar Pejler
Summary: Mast cells play a role in communication between peripheral nerves and immune cells, expressing glutamate receptors and being sensitive to glutamate signaling. Glutamate induces upregulation of various glutamate receptors and gene expression in mast cells, including pro-inflammatory components and transcription factors. The presence of a functional glutamate-glutamate receptor axis in mast cells is supported by in vitro and in vivo evidence, revealing a novel principle of communication between immune cells and nerve cells.
CELLULAR & MOLECULAR IMMUNOLOGY
(2021)
Article
Health Care Sciences & Services
Andrea Salmaggi, Cristina Corno, Marta Maschio, Sara Donzelli, Annachiara D'Urso, Paola Perego, Emilio Ciusani
Summary: Perampanel alone exhibits pro-apoptotic effects on glioblastoma cell lines, possibly through increased GluR2/3 expression, while a strong synergistic effect is observed when combined with temozolomide in certain cell lines. Further investigation into the impact of this combination on oncologic outcomes in glioblastoma is warranted.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Article
Neurosciences
Jeffrey C. Watkins, Richard H. Evans, Alex Bayes, Sam A. Booker, Alasdair Gibb, Angela M. Mabb, Mark Mayer, Jack R. Mellor, Elek Molnar, Li Niu, Arturo Ortega, Yuriy Pankratov, David Ramos-Vicente, Ada Rodriguez-Campuzano, Antonio Rodriguez-Moreno, Lu-Yang Wang, Yu Tian Wang, Lonnie Wollmuth, David J. A. Wyllie, Min Zhuo, Bruno G. Frenguelli
Summary: The excerpt discusses a seminal review written by Jeff Watkins and Dick Evans in 1981 on excitatory amino acids and their receptors, providing compelling evidence for the role of EAAs as neurotransmitters in the nervous system. The research on EAAs has continued to thrive into the 21st Century, with EAAs and their receptors flourishing in various disciplines and clinical conditions.
Article
Neurosciences
Natalia A. Quijano Carde, Erika E. Perez, Richard Feinn, Henry R. Kranzler, Mariella De Biasi
Summary: Selective inhibition of GluK1*KAR has been shown to reduce ethanol intake and preference, alleviate physical manifestations of ethanol withdrawal, and influence the rewarding properties of ethanol. Additionally, this study reveals that the effects of GluK1*KAR are influenced by ethanol-dependent state.
Article
Neurosciences
Sebastiano A. Torrisi, Silvia Rizzo, Samuele Laudani, Alessandro Ieraci, Filippo Drago, Gian Marco Leggio
Summary: Several studies have shown that chronic stress has a negative effect on recognition memory, but the effects of acute stress on this cognitive ability have not been well studied. This study aimed to investigate the impact of acute stress on recognition memory consolidation in a sex-dependent manner. The results showed that acute stress did not affect memory performance in male and female mice immediately after training, but it altered memory performance after a 24-hour delay, with sex-dependent effects.
NEUROBIOLOGY OF STRESS
(2023)
Article
Neurosciences
Bing Ye, Hui Shen, Jing Zhang, Yuan-Gui Zhu, Bruce R. Ransom, Xiao-Chun Chen, Zu-Cheng Ye
Article
Neurosciences
Margaret A. Hamner, Zucheng Ye, Richard V. Lee, Jamie R. Colman, Thu Le, Davin C. Gong, Bruce R. Ransom, Jonathan R. Weinstein
JOURNAL OF NEUROSCIENCE
(2015)
Editorial Material
Neurosciences
Bruce R. Ransom
Review
Immunology
Xin Yang, Bruce R. Ransom, Jian-Fang Ma
JOURNAL OF NEUROIMMUNOLOGY
(2016)
Article
Biochemistry & Molecular Biology
Brian Skriver Nielsen, Daniel Bloch Hansen, Bruce R. Ransom, Morten Schak Nielsen, Nanna MacAulay
NEUROCHEMICAL RESEARCH
(2017)
Review
Neurosciences
Alice E. Waitt, Liam Reed, Bruce R. Ransom, Angus M. Brown
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2017)
Article
Biochemistry & Molecular Biology
Daniel Bloch Hansen, Zu-Cheng Ye, Kirstine Calloe, Thomas Hartig Braunstein, Johannes Pauli Hofgaard, Bruce R. Ransom, Morten Schak Nielsen, Nanna MacAulay
JOURNAL OF BIOLOGICAL CHEMISTRY
(2014)
Article
Endocrinology & Metabolism
Angus M. Brown, Bruce R. Ransom
METABOLIC BRAIN DISEASE
(2015)
Editorial Material
Neurosciences
Bruce R. Ransom, Helmut Kettenmann
Article
Biochemistry & Molecular Biology
Ying Yu, Xiang Luo, Chunyu Li, Fengfei Ding, Minghuan Wang, Minjie Xie, Zhiyuan Yu, Bruce R. Ransom, Wei Wang
JOURNAL OF NEUROCHEMISTRY
(2020)
Article
Neurosciences
Margaret A. Hamner, Ashley McDonough, Davin C. Gong, Levi J. Todd, German Rojas, Sibylle Hodecker, Christopher B. Ransom, Thomas A. Reh, Bruce R. Ransom, Jonathan R. Weinstein
Summary: Ischemic preconditioning (IPC) is a phenomenon where exposure to non-injurious ischemia enhances tolerance to subsequent ischemic challenges. In a study testing the hypothesis that microglia are necessary for IPC in white matter (WM), researchers found that depletion of microglia eliminated IPC-mediated protection, highlighting the critical role of preconditioned microglia in WM IPC.
Article
Biochemistry & Molecular Biology
Laura R. Rich, Bruce R. Ransom, Angus M. Brown
Summary: The conduction of action potentials in sciatic nerve A fibers relies on an adequate supply of glucose as an energy substrate, and lactate can also support nerve metabolism. Functional Schwann cells are essential for the recovery of compound action potentials (CAP) after CAP failure caused by glucose depletion or high-frequency stimulation (HFS).
Review
Biochemistry & Molecular Biology
Butian Zhou, Zhongqun Zhu, Bruce R. Ransom, Xiaoping Tong
Summary: Depression is a common mental illness affecting over 300 million people worldwide. Various theories exist regarding its pathogenesis, including the monoamine hypothesis, changes in the hypothalamic-pituitary-adrenal axis, inflammation, immune system alterations, and abnormalities of neurogenesis. In addition to well-known theories, there are also less widely recognized theories of depression causation.
MOLECULAR PSYCHIATRY
(2021)
Article
Multidisciplinary Sciences
Laura R. Rich, Jonathan A. Patrick, Margaret A. Hamner, Bruce R. Ransom, Angus M. Brown
Article
Physiology
Angus M. Brown, Richard D. Evans, Paul A. Smith, Laura R. Rich, Bruce R. Ransom
PHYSIOLOGICAL REPORTS
(2019)