Article
Biology
Shreya H. Dhume, Steven A. Connor, Fergil Mills, Parisa Karimi Tari, Sarah H. M. Au-Yeung, Benjamin Karimi, Shinichiro Oku, Reiko T. Roppongi, Hiroshi Kawabe, Shernaz X. Bamji, Yu Tian Wang, Nils Brose, Michael F. Jackson, Ann Marie Craig, Tabrez J. Siddiqui, Katalin Toth
Summary: LRRTM1 and LRRTM2 regulate the density and morphological integrity of excitatory synapses in hippocampal circuits, and play a role in long-term potentiation and enduring fear memory, contributing to fine-tuning of hippocampal circuit connectivity and plasticity.
Article
Neurosciences
Paolo Spaiardi, Walter Marcotti, Sergio Masetto, Stuart L. Johnson
Summary: The maintenance of balance and gaze relies on faithful and rapid signaling of head movements to the brain. This study suggests that mature type-I hair cells rely on non-quantal synaptic transmission to sustain high-frequency phasic signal transmission.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2022)
Article
Neurosciences
Mamoru Tanaka, Takeshi Sakaba, Takafumi Miki
Summary: The study revealed that at the hippocampal mossy fibre-CA3 interneuron synapse, there is a high occupancy probability and release probability, which are crucial determinants of short-term synaptic depression.
JOURNAL OF PHYSIOLOGY-LONDON
(2021)
Article
Neurosciences
Nicole F. Wong, Matthew A. Xu-Friedman
Summary: Exposure to nontraumatic noise can cause changes in auditory nerve synapses, potentially affecting hearing. Nitric oxide (NO) plays a crucial role in inducing these synaptic changes, and the activation of auditory nerve fibers leads to the release of NO, causing long-lasting alterations in synaptic function.
JOURNAL OF NEUROSCIENCE
(2022)
Review
Neurosciences
Maria Gurma, Yi-Mei Yang, Lu-Yang Wang
Summary: This article reviews the impact of NMDARs on central synapse function during the early postnatal stage and raises unanswered questions that are crucial for understanding the developing brain in health and diseases.
Review
Cell Biology
Sofiia Reshetniak, Silvio O. Rizzoli
Summary: The synaptic vesicle cluster is not only a storage space for synaptic vesicles, but also potentially regulates protein distribution, cytoskeleton architecture, selective removal of synaptic components, and presynaptic responses to plasticity. It serves as a key organizer of synaptic composition and dynamics.
CURRENT OPINION IN CELL BIOLOGY
(2021)
Article
Neurosciences
Xiaokun Zhou, Wenxiang Yi, Yiqiang Zhi, Jurui Yu, Danping Lu, Zhousong Luo, Ling Yuan, Liyu Chen, Zhiheng Xu, Dan Xu
Summary: Stress is considered a major cause of depression, and recent studies have linked JNK kinase activity to depression. We conducted a study on transgenic mice and found that excessive activation of JNK directly leads to depression-like behavior in mice, accompanied by reduced expression of synaptic-associated genes and abnormal dendritic spine development in hippocampal neurons. These findings provide compelling evidence for targeting JNK activity as a potential therapeutic strategy for depression.
MOLECULAR NEUROBIOLOGY
(2023)
Article
Clinical Neurology
Luka Milosevic, Suneil K. Kalia, Mojgan Hodaie, Andres M. Lozano, Milos R. Popovic, William D. Hutchison, Milad Lankarany
Summary: This study investigates the brain-region-specific and frequency-dependent effects of deep brain stimulation on neuronal activity. The results show that higher stimulation frequencies lead to neuronal suppression, while site-specific responses are influenced by local neuroanatomical properties and short-term synaptic plasticity.
Article
Neurosciences
Pablo San Segundo, Beatrice Terni, Artur Llobet
Summary: Presynaptic terminals in the central nervous system can release neurotransmitters synchronously through either univesicular or multivesicular mechanisms, but the functional implications of one mechanism prevailing over the other remain unresolved. In this study, the liberation of glutamate and its effects on excitatory postsynaptic currents were examined using a glutamate sensor expressed in glial cells in hippocampal neuronal cultures. Optical detection revealed heterogeneous neurotransmitter release probabilities among the studied synaptic boutons, with each neuron exhibiting a predominant release mechanism. Multivesicular release was found to enhance synaptic strength and short-term synaptic depression. These findings indicate that the preference of hippocampal boutons to synchronously release one or more vesicles determines the strength and low pass filtering properties of the synapses formed.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2023)
Article
Biochemistry & Molecular Biology
Congyue Xu, Qi Xiong, Xiang Tian, Wei Liu, Binlian Sun, Qin Ru, Xiji Shu
Summary: This study found that ferroptosis plays an important role in the mediation of alcohol-induced depressive and anxiety-like behaviors. Alcohol exposure led to neuron damage and reduced levels of synapse-related proteins in mice. It also increased the number of iron-positive staining cells. The ferroptosis inhibitor prevented alcohol-induced neuron damage and enhanced the expression of certain proteins.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Clinical Neurology
Keita Kinoshita, Gen Hamanaka, Ryo Ohtomo, Hajime Takase, Kelly K. Chung, Josephine Lok, Eng H. Lo, Hiroshi Katsuki, Ken Arai
Summary: Exercise preconditioning in mature adult mice has been shown to promote recovery from intracerebral hemorrhage-induced neurological deficits, reduce lesion volumes, increase phagocytotic microglial numbers, and elevate levels of several soluble factors in the plasma. This suggests that exercise preconditioning may offer neuroprotection and improve brain health even in middle adulthood.
Article
Computer Science, Information Systems
Dongyeon Kang, Wonjung Kim, Jun Tae Jang, Changwook Kim, Jung Nam Kim, Sung-Jin Choi, Jong-Ho Bae, Dong Myong Kim, Yoon Kim, Dae Hwan Kim
Summary: In this paper, a synaptic transistor with a floating-gate (FG) node and an amorphous InGaZnO (IGZO) channel layer is proposed. The device emulates the neuroplasticity functions of both short-term memory (STM) and long-term memory (LTM) through the control of the amplitude and the number of input pulses. The STM occurs when the input amplitude is relatively small (< 9 V) by ion movement in the gate dielectrics, and the LTM occurs when the input amplitude is relatively large (> 10 V) by storing electrons in the FG. Increasing the number of input pulses allows for longer information storage. The FG IGZO synaptic transistor could be a promising device solution for brain-inspired computing systems.
Article
Biology
Reetu Daswani, Carlotta Gilardi, Michael Soutschek, Prakruti Nanda, Kerstin Weiss, Silvia Bicker, Roberto Fiore, Christoph Dieterich, Pierre-Luc Germain, Jochen Winterer, Gerhard Schratt
Summary: This study identifies miR138-5p as a critical regulator of PV interneuron function in the mouse hippocampus. Inactivation of miR138-5p impairs spatial recognition memory and enhances GABAergic synaptic input onto pyramidal neurons. The upregulation of the schizophrenia-associated Erbb4 gene is validated as a direct target of miR138-5p.
Article
Pharmacology & Pharmacy
Zhujin Song, Zhijuan Bian, Zhengrong Zhang, Xuncui Wang, Aisong Zhu, Guoqi Zhu
Summary: Memantine reduces LPS-induced depression-like behaviors, NLRP3 inflammasome activation, and astrocyte activation by modulating the NMDAR/calpain-1 signaling axis. Additionally, astrocytic Kir4.1 may regulate NLRP3 inflammasome activation and contribute to depression-like behaviors.
TOXICOLOGY AND APPLIED PHARMACOLOGY
(2021)
Review
Neurosciences
Ileana Fuentes, Yoshikazu Morishita, Sofia Gonzalez-Salinas, Frances A. Champagne, Shusaku Uchida, Gleb P. Shumyatsky
Summary: Maternal behavior is influenced by developmental needs and environmental factors, and the maternal brain exhibits a high degree of plasticity that overlaps with mechanisms involved in memory formation. The role of activity- and experience-dependent processes in maternal behavior is still unclear, despite the identification of various molecules and intracellular processes.
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2022)
Article
Audiology & Speech-Language Pathology
Paul B. Manis, Luke Campagnola
Article
Neurosciences
Leann H. Brennaman, Xuying Zhang, Hanjun Guan, Jason W. Triplett, Arthur Brown, Galina P. Demyanenko, Paul B. Manis, Lynn Landmesser, Patricia F. Maness
Article
Neurosciences
Seth D. Koehler, Shashwati Pradhan, Paul B. Manis, Susan E. Shore
EUROPEAN JOURNAL OF NEUROSCIENCE
(2011)
Article
Audiology & Speech-Language Pathology
Yong Wang, Chongyu Ren, Paul B. Manis
Article
Audiology & Speech-Language Pathology
Yong Wang, Heather O'Donohue, Paul Manis
Article
Neurosciences
Qing Liu, Paul B. Manis, Robin L. Davis
JARO-JOURNAL OF THE ASSOCIATION FOR RESEARCH IN OTOLARYNGOLOGY
(2014)
Article
Neurosciences
Deepti Rao, Gregory J. Basura, Joseph Roche, Scott Daniels, Jaime G. Mancilla, Paul B. Manis
JOURNAL OF NEUROPHYSIOLOGY
(2010)
Article
Neurosciences
Ruili Xie, Paul B. Manis
JOURNAL OF NEUROPHYSIOLOGY
(2013)
Article
Neurosciences
Ruili Xie, Paul B. Manis
JOURNAL OF NEUROSCIENCE
(2013)
Article
Neurosciences
Galina P. Demyanenko, Vishwa Mohan, Xuying Zhang, Leann H. Brennaman, Katherine E. S. Dharbal, Tracy S. Tran, Paul B. Manis, Patricia F. Maness
JOURNAL OF NEUROSCIENCE
(2014)
Article
Neurosciences
Luke Campagnola, Paul B. Manis
JOURNAL OF NEUROSCIENCE
(2014)
Article
Medicine, Research & Experimental
Alexander W. Rich, Ruili Xie, Paul B. Manis
Article
Neurosciences
Ruili Xie, Paul B. Manis
FRONTIERS IN NEURAL CIRCUITS
(2014)
Article
Mathematical & Computational Biology
Luke Campagnola, Megan B. Kratz, Paul B. Manis
FRONTIERS IN NEUROINFORMATICS
(2014)
Article
Biology
George A. Spirou, Matthew Kersting, Sean Carr, Bayan Razzaq, Carolyna Yamamoto Alves Pinto, Mariah Dawson, Mark H. Ellisman, Paul B. Manis
Summary: This study used volume electron microscopy to investigate the cochlear nucleus in mice, constructing accurate synaptic maps and revealing the relationship between synaptic inputs and cellular morphology in globular bushy cells. The study proposes hypotheses regarding how these cells integrate synaptic inputs and suggests mechanisms for adjusting their excitability. The research also discovered new dendritic structures and dendrites lacking synaptic innervation. This framework provides a template for further research on the role of cellular features in sound encoding and highlights the need for new experimental measurements to fill in missing cellular parameters.