Involvement of interleukin-1β in the autophagic process of microglia: relevance to Alzheimer’s disease

Inhibition of Double-Stranded RNA-Dependent Protein Kinase Strongly Decreases Cytokine Production and Release in Peripheral Blood Mononuclear Cells from Patients with Alzheimer's Disease

(2017) Julien Couturier et al.   JOURNAL OF ALZHEIMERS DISEASE

Neuroinflammation in Alzheimer's Disease: Are NSAIDs and Selective COX-2 Inhibitors the Next Line of Therapy?

(2017) Catherine H. Trepanier et al.   JOURNAL OF ALZHEIMERS DISEASE

Autophagy regulates inflammation following oxidative injury in diabetes

(2013) Yang Wang et al.   Autophagy

Astrocyte-Microglia Cooperation in the Expression of a Pro-Inflammatory Phenotype

(2013) Massimo Barbierato et al.   CNS & Neurological Disorders-Drug Targets

Inflammatory Bowel Disease: Dysfunction of Autophagy?

(2013) Michael Scharl et al.   DIGESTIVE DISEASES

Sustained Interleukin-1  Overexpression Exacerbates Tau Pathology Despite Reduced Amyloid Burden in an Alzheimer's Mouse Model

(2013) S. Ghosh et al.   JOURNAL OF NEUROSCIENCE

Promotion of autophagy at the maturation step by IL-6 is associated with the sustained mitogen-activated protein kinase/extracellular signal-regulated kinase activity

(2013) Xue-zhong Li et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Reciprocal Modulation Between Microglia and Astrocyte in Reactive Gliosis Following the CNS Injury

(2013) Zhongwen Gao et al.   MOLECULAR NEUROBIOLOGY

Autophagy in Human Health and Disease

(2013) Augustine M.K. Choi et al.   NEW ENGLAND JOURNAL OF MEDICINE

RNA-Dependent Protein Kinase Is Essential for 2-Methoxyestradiol-Induced Autophagy in Osteosarcoma Cells

(2013) Caihong Yang et al.   PLoS One

Autophagy in axonal and dendritic degeneration

(2013) Yi Yang et al.   TRENDS IN NEUROSCIENCES

The Protein Kinase Double-Stranded RNA-Dependent (PKR) Enhances Protection against Disease Cause by a Non-Viral Pathogen

(2013) Pauline Sebby Ogolla et al.   PLoS Pathogens

Autophagy and IL-1 Family Cytokines

(2013) James Harris   Frontiers in Immunology

Regulation of Immune Responses by mTOR

(2012) Jonathan D. Powell et al.   Annual Review of Immunology

Autophagy in astrocytes

(2012) Chiara Di Malta et al.   Autophagy

Autophagic flux, supported by toll-like receptor 2 activity, defends against the carcinogenesis of hepatocellular carcinoma

(2012) Heng Lin et al.   Autophagy

Methylthioninium chloride (methylene blue) induces autophagy and attenuates tauopathy in vitro and in vivo

(2012) Erin E. Congdon et al.   Autophagy

Guidelines for the use and interpretation of assays for monitoring autophagy

(2012) Daniel J. Klionsky et al.   Autophagy

Autophagy in regulation of Toll-like receptor signaling

(2012) Takeshi Into et al.   CELLULAR SIGNALLING

Mechanisms mediating propofol protection of pulmonary epithelial cells against lipopolysaccharide-induced cell death

(2012) Xiaoxia Gu et al.   CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY

Pharmacological Inhibition of PKR in APPswePS1dE9 Mice Transiently Prevents Inflammation at 12 Months of Age but Increases Aβ42 Levels in the Late Stages of the Alzheimer’s Disease

(2012) Julien Couturier et al.   Current Alzheimer Research

Astrocytes: Conductors of the Alzheimer disease neuroinflammatory symphony

(2012) Rodrigo Medeiros et al.   EXPERIMENTAL NEUROLOGY

Inhibition of Glycogen Synthase Kinase-3 Ameliorates β-Amyloid Pathology and Restores Lysosomal Acidification and Mammalian Target of Rapamycin Activity in the Alzheimer Disease Mouse Model

(2012) Limor Avrahami et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Herpes Simplex Virus 1 Us11 Protein Inhibits Autophagy through Its Interaction with the Protein Kinase PKR

(2012) M. Lussignol et al.   JOURNAL OF VIROLOGY

Cytoplasmic STAT3 Represses Autophagy by Inhibiting PKR Activity

(2012) Shensi Shen et al.   MOLECULAR CELL

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(2012) Yinzhong Zhang et al.   MOLECULAR MEDICINE

NLRP3 is activated in Alzheimer’s disease and contributes to pathology in APP/PS1 mice

(2012) Michael T. Heneka et al.   NATURE

Novel role of PKR in inflammasome activation and HMGB1 release

(2012) Ben Lu et al.   NATURE

Activation of autophagy by inflammatory signals limits IL-1β production by targeting ubiquitinated inflammasomes for destruction

(2012) Chong-Shan Shi et al.   NATURE IMMUNOLOGY

Functions of microglia in the central nervous system – beyond the immune response

(2012) Hiroaki Wake et al.   Neuron Glia Biology

Lipopolysaccaride induces autophagic signaling in macrophages via a TLR4, heme oxygenase-1 dependent pathway

(2011) Paul Waltz et al.   Autophagy

The Beclin 1 network regulates autophagy and apoptosis

(2011) R Kang et al.   CELL DEATH AND DIFFERENTIATION

TOR in the immune system

(2011) Koichi Araki et al.   CURRENT OPINION IN CELL BIOLOGY

Autophagy-based unconventional secretory pathway for extracellular delivery of IL-1β

(2011) Nicolas Dupont et al.   EMBO JOURNAL

Autophagy Controls IL-1β Secretion by Targeting Pro-IL-1β for Degradation

(2011) James Harris et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Blocking IL-1 Signaling Rescues Cognition, Attenuates Tau Pathology, and Restores Neuronal  -Catenin Pathway Function in an Alzheimer's Disease Model

(2011) M. Kitazawa et al.   JOURNAL OF IMMUNOLOGY

Chronic IL-1β-Mediated Neuroinflammation Mitigates Amyloid Pathology in a Mouse Model of Alzheimer’s Disease without Inducing Overt Neurodegeneration

(2011) Sarah B. Matousek et al.   Journal of Neuroimmune Pharmacology

Prevention of the β-amyloid peptide-induced inflammatory process by inhibition of double-stranded RNA-dependent protein kinase in primary murine mixed co-cultures

(2011) J Couturier et al.   Journal of Neuroinflammation

AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1

(2011) Joungmok Kim et al.   NATURE CELL BIOLOGY

Autophagy failure in Alzheimer's disease—locating the primary defect

(2011) Ralph A. Nixon et al.   NEUROBIOLOGY OF DISEASE

Mammalian Target of Rapamycin: Hitting the Bull's-Eye for Neurological Disorders

(2011) Zhao Zhong Chong et al.   Oxidative Medicine and Cellular Longevity

Emerging role of p62/sequestosome-1 in the pathogenesis of Alzheimer's disease

(2011) Antero Salminen et al.   PROGRESS IN NEUROBIOLOGY

Stimulation of autophagy in the liver by lipopolysaccharide-induced systemic inflammation in a rat model of diabetes mellitus

(2010) Satoshi Hagiwara et al.   BIOMEDICAL RESEARCH-TOKYO

Systemic administration of lipopolysaccharide induces molecular and morphological alterations in the hippocampus

(2010) Grzegorz A. Czapski et al.   BRAIN RESEARCH

Protein synthesis in plasma cells is regulated by crosstalk between endoplasmic reticulum stress and mTOR signaling

(2010) Meidan Goldfinger et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Knockdown of autophagy enhances the innate immune response in hepatitis C virus-infected hepatocytes

(2010) Shubham Shrivastava et al.   HEPATOLOGY

Functions and regulation of the 70kDa ribosomal S6 kinases

(2010) Tim R. Fenton et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Autophagy Negatively Regulates Keratinocyte Inflammatory Responses via Scaffolding Protein p62/SQSTM1

(2010) H.-M. Lee et al.   JOURNAL OF IMMUNOLOGY

Neuroinflammatory processes in Alzheimer’s disease

(2010) Michael T. Heneka et al.   JOURNAL OF NEURAL TRANSMISSION

Role of the mTOR Pathway in LPS-Activated Monocytes: Influence of Hypertonic Saline

(2010) Valérie Schaeffer et al.   JOURNAL OF SURGICAL RESEARCH

Autophagy proteins regulate innate immune responses by inhibiting the release of mitochondrial DNA mediated by the NALP3 inflammasome

(2010) Kiichi Nakahira et al.   NATURE IMMUNOLOGY

Regulation of Mammalian Autophagy in Physiology and Pathophysiology

(2010) Brinda Ravikumar et al.   PHYSIOLOGICAL REVIEWS

Inhibition of mTOR by Rapamycin Abolishes Cognitive Deficits and Reduces Amyloid-β Levels in a Mouse Model of Alzheimer's Disease

(2010) Patricia Spilman et al.   PLoS One

Involvement of mTOR kinase in cytokine-dependent microglial activation and cell proliferation

(2009) Cinzia Dello Russo et al.   BIOCHEMICAL PHARMACOLOGY

p62 at the Crossroads of Autophagy, Apoptosis, and Cancer

(2009) Jorge Moscat et al.   CELL

PKR, the double stranded RNA-dependent protein kinase as a critical target in Alzheimer's disease

(2009) Milena Morel et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Evidence of molecular links between PKR and mTOR signalling pathways in Aβ neurotoxicity: Role of p53, Redd1 and TSC2

(2009) Milena Morel et al.   NEUROBIOLOGY OF DISEASE

Anti-inflammatory effects of daidzein on primary astroglial cell culture

(2009) Man-Hai Liu et al.   NUTRITIONAL NEUROSCIENCE

Loss of the autophagy protein Atg16L1 enhances endotoxin-induced IL-1β production

(2008) Tatsuya Saitoh et al.   NATURE