Article
Pharmacology & Pharmacy
Xingxing Hu, Menglin Zou, Lan Ni, Mingyang Zhang, Weishuai Zheng, Bing Liu, Zhenshun Cheng
Summary: DEC1 plays a significant role in pulmonary fibrosis by promoting epithelial-mesenchymal transition (EMT) through the PI3K/AKT/GSK-3 beta/beta-catenin integrated signaling pathway, leading to the accumulation of fibroblasts and myofibroblasts and excessive collagen deposition. Targeting DEC1 may be a potential novel therapeutic approach for idiopathic pulmonary fibrosis (IPF).
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Oncology
Alberto M. Martelli, Camilla Evangelisti, Francesca Paganelli, Francesca Chiarini, James A. McCubrey
Summary: GSK-3 consists of two isoforms, alpha and beta, that are constitutively active but can be inactivated through phosphorylation by upstream kinases. It was initially considered a tumor suppressor, but it has also been found to have oncogenic properties in promoting pathways critical for cancer cell proliferation, survival, and drug-resistance.
Article
Medicine, Research & Experimental
Nora O. Abdel Rasheed, Weam W. Ibrahim
Summary: This study demonstrates that telmisartan has neuroprotective effects in a rat model of Huntington's disease, improving motor and cognitive dysfunction and reducing oxidative stress, neuro-inflammation, and apoptosis. These effects may be achieved through the activation of peroxisome proliferator activated receptor-gamma and blockade of angiotensin-II receptor type 1.
Article
Biochemistry & Molecular Biology
Yuko Nagao, Kikuko Amo-Shiinoki, Hiroko Nakabayashi, Masayuki Hatanaka, Manabu Kondo, Kimie Matsunaga, Masahiro Emoto, Shigeru Okuya, Yukio Tanizawa, Katsuya Tanabe
Summary: Endoplasmic reticulum stress is a key pathogenic factor in type 1 and 2 diabetes. Gsk-3 inhibition prevents proteasomal degradation of ATF4 and alleviates apoptosis by regulating phosphorylation of ATF4-S214. Mechanistically, Gsk-3 inhibition modulates transcription targets of ATF4 and facilitates dephosphorylation of eIF2 alpha under ER stress.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Hsuan-Yeh Pan, Mallika Valapala
Summary: Autophagy is a vital cellular mechanism that ensures cellular maintenance and survival. The GSK-3 signaling pathway regulates autophagy by modulating TFEB and other signaling molecules.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Plant Sciences
Xiang-wen Meng, Can-xia He, Xiao Chen, Xiao-song Yang, Chao Liu
Summary: This study found that the extract of Gnaphalium affine D. Don significantly improved cardiomyocyte viability and exhibited antioxidant effects by regulating various proteins and genes to alleviate oxidative stress and reduce cell apoptosis.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Article
Chemistry, Medicinal
Jeong-Hyun Yoon, Nayoung Lee, Kumju Youn, Mi Ra Jo, Hyeung-Rak Kim, Dong-Seok Lee, Chi-Tang Ho, Mira Jun
Summary: In this study, dieckol was found to inhibit the processing of amyloid precursor protein and regulate the enzymes related to APP processing, while also activating the PI3K/Akt signaling pathway to reduce the accumulation of amyloid-beta peptide. These findings suggest that dieckol may have potential therapeutic effects for Alzheimer's disease through its modulation of APP processing and associated signaling pathways.
Article
Neurosciences
Xue-Hua Wang, Zhong-Fu Zuo, Lu Meng, Qi Yang, Pan Lv, Li-Pan Zhao, Xiao-Bai Wang, Yu-Fei Wang, Ying Huang, Cong Fu, Wen-Qiang Liu, Xue-Zheng Liu, De-Yu Zheng
Summary: The study aimed to investigate the effects and mechanisms of salidroside on hippocampal neurons in streptozotocin-induced diabetic mice. The results showed that salidroside could improve cognitive function, increase the number of hippocampal neurons, and promote the activation of the PI3K/Akt/GSK-3 beta signaling pathway in diabetic mice. This study revealed a partial mechanism by which salidroside exerts neuroprotective effects in diabetic cognitive dysfunction.
PSYCHOPHARMACOLOGY
(2023)
Article
Medicine, Research & Experimental
Chung-Yuh Tzeng, Wei-Shan Lee, Keng-Fan Liu, Hsi-Kai Tsou, Chun-Jung Chen, Wen-Huang Peng, Jen-Chieh Tsai
Summary: This study investigated the effect and mechanism of action of allantoin on AD-related memory impairment. The results showed that allantoin could improve cognitive impairment in A beta(1-42)-induced rats by activating the PI3K/Akt/GSK-3 beta signaling pathway to reduce abnormal hyperphosphorylation of Tau. These findings suggest that allantoin may be a potential therapeutic agent for neurodegenerative diseases.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Pharmacology & Pharmacy
Zoe Gonzalez-Carnicero, Raquel Hernanz, Marta Martinez-Casales, Maria Teresa Barrus, Angela Martin, Maria Jesus Alonso
Summary: Toll-like receptor 4 pathway is involved in the prooxidant and proinflammatory effects of Interleukin-1 beta. Furthermore, activation of nuclear factor-erythroid 2-related factor 2 prevents the deleterious effects of Interleukin-1 beta, likely by reducing Toll-like receptor 4-dependent pathway. Although further research is needed, the results are promising as they suggest that nuclear factor-erythroid 2-related factor 2 activators might protect against the oxidative stress and inflammation characteristic of cardiovascular diseases.
FRONTIERS IN PHARMACOLOGY
(2023)
Review
Immunology
Zhi Chen, Qinyue Lu, Jiacheng Wang, Xiang Cao, Kun Wang, Yuhao Wang, Yanni Wu, Zhangping Yang
Summary: This article summarizes the impact of cadmium exposure on health and highlights the positive role of omega-3 polyunsaturated fatty acids (PUFAs) in preventing and treating cadmium exposure.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Oncology
Fabiana Pani, Yoshinori Yasuda, Sylvie T. Rousseau, Kevin C. Bermea, Solmaz Roshanmehr, Rulin Wang, Srinivasan Yegnasubramanian, Patrizio Caturegli, Luigi Adamo
Summary: The pre-conditioning of the immune system can modulate the therapeutic effect of immune checkpoint inhibitors (ICI); however, the mechanisms behind this phenomenon are still unclear. This study showed that the simultaneous induction of immune-mediated thyroiditis (IET) and papillary thyroid cancer (PTC) in mice resulted in a decreased incidence of PTC in response to ICI treatment.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2022)
Article
Medicine, Research & Experimental
Chunhua Bai, Jiaqi Zhao, Jielin Su, Jiaxin Chen, Xinmu Cui, Manqing Sun, Xuewu Zhang
Summary: The study demonstrated that curcumin triggers mitochondrial apoptosis in HCC by inhibiting the PI3K/AKT/GSK-3 beta signaling pathway and downregulating BCLAF1 expression, thereby inhibiting tumor growth. This highlights a potential therapeutic strategy leveraging the antitumor effects of curcumin against HCC.
Article
Microbiology
Luiz Henrique Agra Cavalcante-Silva, Ericka Garcia Leite, Fernanda Silva Almeida, Arthur Gomes de Andrade, Fernando Cezar Comberlang, Cintya Karina Rolim Lucena, Anna Stella Cysneiros Pacha, Barbara Guimaraes Csordas, Tatjana S. L. Keesen
Summary: This study compared the T cell response of COVID-19-non-vaccinated and -vaccinated patients with active tuberculosis exposed to SARS-CoV-2 antigens. The results showed that CD8+ T cells from non-vaccinated TB patients had a stronger response to viral challenge, while CD4+ T cells from vaccinated TB patients produced more IL-10 after spike peptide stimulus. These findings suggest that the reduced immune balance in coinfected individuals may affect pathogen control.
Article
Biochemistry & Molecular Biology
Sebastian Foersch, Christina Glasner, Ann-Christin Woerl, Markus Eckstein, Daniel-Christoph Wagner, Stefan Schulz, Franziska Kellers, Aurelie Fernandez, Konstantina Tserea, Michael Kloth, Arndt Hartmann, Achim Heintz, Wilko Weichert, Wilfried Roth, Carol Geppert, Jakob Nikolas Kather, Moritz Jesinghaus
Summary: Researchers developed a multistain deep learning model utilizing artificial intelligence to determine the immunoscore and predict response to neoadjuvant therapy in colorectal cancer patients. The model outperformed other clinical, molecular, and immune cell-based parameters and can serve as a valuable decision-making tool for clinicians.