Article
Obstetrics & Gynecology
Min Xia, Jie Zheng
Summary: In normal ovarian responders, the GnRH antagonist protocol showed lower clinical pregnancy rates and lower incidences of moderate and severe ovarian hyperstimulation syndrome in fresh transfer cycles compared to the depot GnRH agonist protocol. However, in frozen-thawed transfer cycles, both protocols had similar clinical pregnancy rates. Further large-sample, prospective, randomized, and controlled studies are needed to confirm these results.
BMC PREGNANCY AND CHILDBIRTH
(2021)
Article
Pediatrics
Seung Ah Chung, Hae Sang Lee, Seung Woo Kim, Jin Soon Hwang
Summary: In this one-year study, patients with CPP receiving treatments showed less myopic progression compared to the controls.
Article
Cell Biology
Matteo Spaziani, Chiara Tarantino, Natascia Tahani, Daniele Gianfrilli, Emilia Sbardella, Andrea Lenzi, Antonio F. Radicioni
Summary: Puberty is a complex process that involves a delicate balance of neuroendocrine mechanisms and hormones to achieve psychophysical maturity and reproductive capacity. The onset of puberty is triggered by interactions between the hypothalamus, pituitary gland, and gonads, with significant variations between genders and individuals, as well as possible pathological variations such as precocious and delayed puberty.
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2021)
Article
Medicine, General & Internal
Rihwa Choi, Aerin Kwon, Youngju Oh, Sang Gon Lee, Eun Hee Lee
Summary: The study investigated laboratory data for GnRH stimulation testing in Korean children and found that the time points of 45 minutes and 60 minutes after stimulation showed the best performance in identifying pubertal responses.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Obstetrics & Gynecology
Jacques Donnez, Olivier Donnez, Michel Brethous, Elke Bestel, Elizabeth Garner, Sebastien Charpentier, Andrew Humberstone, Ernest Loumaye
Summary: A once-daily regimen of linzagolix at a fully suppressive dose of 200 mg for 12 weeks, followed by a partially suppressive dose of 100 mg for another 12 weeks, reduced adenomyotic uterine size and improved associated symptoms.
REPRODUCTIVE BIOMEDICINE ONLINE
(2022)
Article
Obstetrics & Gynecology
Ernesto Bosch, Elena Labarta, Jose Zuzuarregui, Stamatina Iliodromiti, Scott M. Nelson
Summary: The capability of serum AMH measured with the Elecsys AMH immunoassay to determine ovarian response after fertility treatment was evaluated in a retrospective cohort study. AMH concentration showed a strong positive correlation with oocyte yield, and the accuracy of predicting ovarian response using AMH was high. A single determination of serum AMH before stimulation can be used to predict ovarian response and oocyte yield with high accuracy.
REPRODUCTIVE BIOMEDICINE ONLINE
(2023)
Article
Agriculture, Dairy & Animal Science
H. E. Flay, C. B. Reed, B. Kuhn-Sherlock, C. V. C. Phyn, C. R. Burke, S. Meier, I. J. Clarke
Summary: Previous research has found that Holstein-Friesian dairy heifers with positive genetic merit for fertility traits reach puberty earlier than those with negative genetic merit. This study investigated the functionality of the hypothalamus-pituitary-gonadal (HPG) axis in peripubertal heifers with divergent genetic merit, finding that the earlier onset of puberty in positive heifers is associated with earlier activation of the HPG axis.
JOURNAL OF DAIRY SCIENCE
(2022)
Article
Reproductive Biology
Hanna K. L. Johansson, Sofie Christiansen, Monica Kam Draskau, Terje Svingen, Julie Boberg
Summary: Developmental exposure to endocrine disrupting chemicals can have negative effects on reproductive health in rats, with males being more affected than females. More sensitive test methods are needed to protect the reproductive health of females from harmful chemicals.
REPRODUCTIVE TOXICOLOGY
(2021)
Article
Obstetrics & Gynecology
Li Chen, Qianwen Xi, Shutian Jiang, Yining Gao, Hui Long, Yao Wang, Yanping Kuang
Summary: This study compared the pregnancy and neonatal outcomes of patients triggered with GnRHa, hCG, and dual trigger in LE-IUI cycles. The study found that there was no significant difference in the clinical pregnancy rate between GnRHa and dual trigger compared to hCG trigger in LE-HMG IUI cycles. However, the miscarriage rate was lower in the GnRHa trigger group and higher in the dual trigger group compared to the hCG group. There were no significant differences in neonatal outcomes. Therefore, both GnRHa and dual trigger can be used to trigger ovulation in LE-HMG IUI cycles, but dual trigger must be used with caution.
BMC PREGNANCY AND CHILDBIRTH
(2023)
Article
Public, Environmental & Occupational Health
Vicente Mustieles, Juan-Pedro Arrebola, Miquel Porta
Summary: Citizens should have access to regulatory changes and policies that prioritize the needs of humans, the climate, and nature. We draw on past experiences of preventable human suffering and economic losses caused by delayed regulation of both old and new pollutants. It is crucial for health professionals, the media, and citizens' organizations to increase awareness of environmental health issues. Improving the translation of research into clinical practices and policies is necessary to reduce the burden of diseases caused by exposure to environmental chemicals. There are valuable lessons to be learned from previous science-to-policy processes and current trends in regulating pollutants.
PREVENTIVE MEDICINE
(2023)
Article
Public, Environmental & Occupational Health
Margot Guth, Tyler Pollock, Mandy Fisher, Tye E. Arbuckle, Maryse F. Bouchard
Summary: A study found a negative correlation between urinary paraben concentrations and serum hormone levels in girls, particularly estradiol, LH, and FSH. This suggests that parabens may impact the development and function of the endocrine system in females.
INTERNATIONAL JOURNAL OF HYGIENE AND ENVIRONMENTAL HEALTH
(2021)
Article
Environmental Sciences
Emily S. Barrett, Matthew Corsetti, Drew Day, Sally W. Thurston, Christine T. Loftus, Catherine J. Karr, Kurunthachalam Kannan, Kaja Z. LeWinn, Alicia K. Smith, Roger Smith, Frances A. Tylavsky, Nicole R. Bush, Sheela Sathyanarayana
Summary: Phthalates may disrupt the endocrine pathways in pregnant women, impacting pregnancy outcomes and fetal development. This study found associations between phthalate mixtures and changes in plasma pCRH levels, with differing effects observed among women with gestational diabetes and gestational hypertension.
ENVIRONMENT INTERNATIONAL
(2022)
Article
Endocrinology & Metabolism
Bo Zhou, Shufang Liu, Jianhong Wang, Ting Zhang, Yuan Yuan, Wenquan Niu, Zhixin Zhang, Lin Wang
Summary: The combination therapy with GnRHa and rhGH can slightly increase the final height of children with idiopathic short stature and normal timed puberty, but the effect is not significant, therefore not recommended as a routine treatment for idiopathic short stature.
Review
Pediatrics
Natalie G. Allen, Kanthi Bangalore Krishna, Peter A. Lee
Summary: GnRHas have shown significant efficacy in treating conditions such as central precocious puberty, with beneficial effects also seen in gender incongruent individuals. While use in those with DSDs remains experimental, it has become a standard of care in the treatment of adolescent transgender individuals.
CURRENT OPINION IN PEDIATRICS
(2021)
Article
Endocrinology & Metabolism
Yuzhen Shi, Ziyi Ma, Xi Yang, Yanqin Ying, Xiaoping Luo, Ling Hou
Summary: This study investigated the effectiveness and safety of combining GnRHa with rhGH in the treatment of girls with CPP. The results showed that the combination therapy produced better height gains, suppressed the gonadal axis, delayed bone age progression, and had good safety and efficacy.
FRONTIERS IN ENDOCRINOLOGY
(2022)