Article
Endocrinology & Metabolism
Martin Werdermann, Ilona Berger, Laura D. Scriba, Alice Santambrogio, Pia Schlinkert, Heike Brendel, Henning Morawietz, Andreas Schedl, Mirko Peitzsch, Aileen J. F. King, Cynthia L. Andoniadou, Stefan R. Bornstein, Charlotte Steenblock
Summary: This study investigated the impact of metabolic diseases on progenitor cells in the hypothalamic-pituitary-adrenal axis, showing that insulin enhances proliferation and differentiation of these cells, while chronic metabolic stress leads to hyperactivation of the axis. This suggests a potential link between early life stress and the development of metabolic syndrome in adulthood.
MOLECULAR METABOLISM
(2021)
Review
Neurosciences
Tabia Volqvartz, Helena Hordum Breum Andersen, Lars Henning Pedersen, Agnete Larsen
Summary: Obesity in pregnant women has a negative impact on both the mother and the offspring, affecting neurodevelopment and the HPA axis of the offspring, and increasing the risk of diabetes and cardiovascular disease.
EUROPEAN JOURNAL OF NEUROSCIENCE
(2023)
Article
Dermatology
Minghan Chen, Jie Cai, Xiaofeng Zhang, Zixian Liao, Min Zhong, Jing Shang, Yunyun Yue
Summary: This study demonstrates that the release of SP under chronic psychological stress interferes with melanogenesis through keratinocytes, leading to skin depigmentation disorders such as vitiligo. The study also reveals the important role of the HPA axis in mediating the effects of SP on melanogenesis.
JOURNAL OF DERMATOLOGICAL SCIENCE
(2022)
Article
Endocrinology & Metabolism
Yannuo Li, Ioannis P. Androulakis
Summary: The suprachiasmatic nucleus (SCN) synchronizes physiological rhythms and adapts to changes in photoperiod, affecting the phase distribution of neuron activities. Elevated glucocorticoid levels in short photoperiods are associated with peak disease incidence. Topological changes in the SCN network may influence seasonal variations in disease incidence.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Environmental Sciences
Bin Pan, Minjie Chen, Xuan Zhang, Shuai Liang, Xiaobo Qin, Lianglin Qiu, Qi Cao, Renzhen Peng, Shimin Tao, Zhouzhou Li, Yaning Zhu, Haidong Kan, Yanyi Xu, Zhekang Ying
Summary: This study found that ambient PM2.5 exposure can activate the HPA axis and mediate PM2.5-induced pulmonary inflammation, providing insights into the contribution of central neurohormonal mechanisms in modulating adverse health effects caused by exposure to PM2.5.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2021)
Article
Pharmacology & Pharmacy
Min Xiao, Kaiyong Xie, Li Yuan, Jun Wang, Xing Liu, Zhonghua Chen
Summary: This study explored the antidepressive effect and mechanism of Huolisu oral solution (HLS) using a rat model of depression. HLS was found to alleviate depression-like behavior by regulating neurotransmitters, the HPA axis, and beta-EP. These findings suggest that HLS may be a potentially effective agent for treating depression.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Endocrinology & Metabolism
Pauline S. Effenberger, Tabea S. Send, Maria Gilles, Josef Frank, Stephan Bongard, Robert Kumsta, Stephanie H. Witt, Marcella Rietschel, Michael Deuschle, Fabian Streit, Isabell A. C. Wolf
Summary: There is no strong association between urbanicity and behavior problems or HPA axis regulation in preschool age, and urinary cortisol and salivary cortisol response after stress exposure are not identified as mediators of this relationship.
PSYCHONEUROENDOCRINOLOGY
(2022)
Review
Medicine, Research & Experimental
Lin Zhou, Tian Wang, Yawen Yu, Mingan Li, Xiaohui Sun, Wenhao Song, Yunjie Wang, Ce Zhang, Fenghua Fu
Summary: Approximately one in three ischemic stroke survivors suffer from post-stroke depression (PSD), which affects functional rehabilitation and quality of life. This study focuses on the stroke-induced hyperactivity of the hypothalamic-pituitary-adrenal (HPA) axis and its role in PSD. The review summarizes possible etiologies of PSD, including stress and proinflammatory cytokines release, and discusses the effects of HPA axis hyperactivity on specific brain structures, enzymes expression, excitotoxicity, intestinal permeability, microglial activation, neuroendocrine regulation, inflammation, and therapy options.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Review
Microbiology
Ousman Bajinka, Lucette Simbilyabo, Yurong Tan, John Jabang, Shakeel Ahmed Saleem
Summary: The appreciation of human microbiome is gaining strong grounds in biomedical research, focusing on the lung-brain axis in addition to the gut-brain axis. Interdisciplinary approaches based on emerging studies are recommended to develop effective treatments for lung induced neurodegenerative diseases. In-depth understanding of the bi-directional communication between host and microbiome in the lung could confer treatment to respiratory infections, alleviate stress, anxiety, and enhance neurological effects.
CRITICAL REVIEWS IN MICROBIOLOGY
(2022)
Article
Endocrinology & Metabolism
Aleksandra S. S. Stojiljkovic, Zeljko Cupic, Stevan Macesic, Ana Ivanovic-Sasic, Ljiljana Kolar-Anic
Summary: This study investigates the mechanisms underlying the effects of arginine vasopressin (AVP) on the Hypothalamic-Pituitary-Adrenal (HPA) axis and reveals the influence of the synergistic action between AVP and corticotrophin-releasing hormone (CRH) on the ultradian dynamics of the HPA axis. The extended nonlinear network reaction model incorporates AVP into the HPA axis model and explores the conditions under which the HPA system transitions between oscillatory and stable states. The results demonstrate the importance of the synergy reaction rate constant and highlight the superior stimulatory effect of CRH compared to AVP on ACTH secretion in humans.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Immunology
Sehee Kim, Eun S. Park, Peng R. Chen, Eunhee Kim
Summary: Diabetic patients have worse outcomes after ischemic stroke due to dysregulated stress response and increased inflammation. Maintaining an optimal level of stress response by regulating the hypothalamic-pituitary-adrenal (HPA) axis may improve stroke outcomes in patients with diabetes.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Endocrinology & Metabolism
L. Barrea, L. Verde, E. Camajani, A. S. Sojat, L. Marina, S. Savastano, A. Colao, M. Caprio, G. Muscogiuri
Summary: This narrative review aims to provide further insights into the effects of Very Low-Calorie Ketogenic Diet (VLCKD) on the HPA axis and RAAS in different phases of weight loss and in different clinical settings.
JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION
(2023)
Article
Immunology
Dongfeng Cai, Jing Zhang, Jin Yang, Qi Lv, Chao Zhong
Summary: This study reveals that FTO is involved in the alleviation of osteoarthritis (OA) through the regulation of the miR-515-5p/TLR4/MyD88/NF-Kappa B axis, which reduces inflammation and cell injury.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Clinical Neurology
Jelena Bakusic, Manosij Ghosh, Andrea Polli, Bram Bekaert, Wilmar Schaufeli, Stephan Claes, Lode Godderis
Summary: The study revealed that job stress was associated with increased levels of cortisol and cortisone in burnout participants. Changes in DNA methylation of the NR3C1 and SLC6A4 genes were observed in burnout individuals, and some of these methylation changes correlated with burnout symptoms. Increased methylation in a specific CpG in the SLC6A4 gene moderated the association between job stress and burnout, while DNA methylation in this CpG was also associated with increased cortisol levels. Furthermore, average methylation of NR3C1 was negatively associated with cortisone levels.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Article
Nutrition & Dietetics
Yuming Lan, Junjie Lu, Guohong Qiao, Xuhua Mao, Jianxin Zhao, Gang Wang, Peijun Tian, Wei Chen
Summary: Psychobiotics, a type of probiotics targeting the gut-brain axis, show great potential in improving sleep quality. A clinical trial with 40 participants diagnosed with stress-induced insomnia found that the group treated with CCFM1025 showed a significant decrease in sleep quality index scores compared to the placebo group. The administration of CCFM1025 was also associated with a more pronounced reduction in stress marker concentrations.
Editorial Material
Immunology
Alana K. Ribarovska, Mark R. Hutchinson, Quentin J. Pittman, Carmine Pariante, Sarah J. Spencer
BRAIN BEHAVIOR AND IMMUNITY
(2021)
Article
Biochemistry & Molecular Biology
Luba Sominsky, Tamara Dangel, Sajida Malik, Simone N. De Luca, Nicolas Singewald, Sarah J. Spencer
Summary: Microglia play essential roles not only in immune defense but also in regulating satiety, memory, and pain responses. These functions are significantly influenced by circadian rhythmicity, impacting various physiological processes throughout the day.
Article
Nutrition & Dietetics
Soniya Xavier, Jasmine Gili, Peter McGowan, Simin Younesi, Paul F. A. Wright, David W. Walker, Sarah J. Spencer, Luba Sominsky
Summary: The study findings indicate that a maternal diet high in fat and sugar had minimal negative effects on newborn pups, while consuming a diet rich in omega-3 fatty acids during pregnancy may be detrimental for some metabolic developmental outcomes in the offspring.
Article
Reproductive Biology
Luba Sominsky, Simin Younesi, Simone N. De Luca, Sophie M. Loone, Kylie M. Quinn, Sarah J. Spencer
Summary: The study reveals that ovarian follicles are resilient against short-term disturbances in circulating and ovarian monocytes, making them able to withstand acute changes in immune balance.
BIOLOGY OF REPRODUCTION
(2021)
Review
Gastroenterology & Hepatology
Jackson L. K. Yip, Gayathri K. Balasuriya, Sarah J. Spencer, Elisa L. Hill-Yardin
Summary: Intestinal macrophages play a crucial role in the gut immune system and gastrointestinal physiology, but their heterogeneity hinders the understanding of their specific functions; subsets of intestinal macrophages play diverse roles in various gastrointestinal diseases, with a complex interplay between cytokine production and enteric nervous system activation.
CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY
(2021)
Article
Immunology
Soniya Xavier, Alita Soch, Simin Younesi, Sajida Malik, Sarah J. Spencer, Luba Sominsky
Summary: Maternal obesity and poor diet have been found to increase the risk of postpartum mood disorders. Experimental studies using a high-fat-high-sugar diet showed that it can lead to elevated levels of circulating cytokines, activated microglia, and altered neurogenesis, while a diet high in omega-3 PUFAs can mitigate these effects.
BRAIN BEHAVIOR AND IMMUNITY
(2021)
Article
Cell Biology
Simin Younesi, Sarah J. Spencer, Luba Sominsky
Summary: Acute depletion of monocytes does not have sustained effects on ovarian follicle health, but it may exacerbate the impact of lipopolysaccharide (LPS) and transiently suppress ovulatory capacity, which is likely to be restored with resolution of the inflammatory environment.
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2021)
Review
Pharmacology & Pharmacy
Aleksandar Dobric, Simone N. De Luca, Sarah J. Spencer, Steven Bozinovski, Michael M. Saling, Christine F. McDonald, Ross Vlahos
Summary: Chronic obstructive pulmonary disease (COPD) is a major incurable global health burden and a leading cause of death worldwide. Cognitive dysfunction is highly prevalent in COPD and has significant impacts on quality of life and survival. Understanding the mechanisms underlying cognitive dysfunction in COPD could lead to novel therapeutic opportunities.
PHARMACOLOGY & THERAPEUTICS
(2022)
Review
Endocrinology & Metabolism
Eva Guerrero-Hreins, Claire J. Foldi, Brian J. Oldfield, Aneta Stefanidis, Priya Sumithran, Robyn M. Brown
Summary: Bariatric surgery leads to long-term weight loss and improved metabolic phenotype by affecting the gut-brain axis. However, the impact of the surgery on disordered eating behaviors is not well understood, and understanding this is crucial for improving treatment outcomes for people with obesity.
REVIEWS IN ENDOCRINE & METABOLIC DISORDERS
(2022)
Review
Clinical Neurology
Fei-Yi Zhao, Qiang-Qiang Fu, Sarah J. Spencer, Gerard A. Kennedy, Russell Conduit, Wen-Jing Zhang, Zhen Zheng
Summary: Acupuncture has shown promising therapeutic effects on comorbid depression and insomnia during perimenopause, ameliorating symptoms and regulating hormone levels with minimal adverse events. However, high-quality trials are needed to further validate its effectiveness, as most studies have methodological flaws. Neuroendocrine modulation is likely a major mechanism mediating these effects.
NATURE AND SCIENCE OF SLEEP
(2021)
Article
Immunology
Sajida Malik, Hao Wang, Soniya Xavier, Mary Slayo, Steve Bozinovski, Luba Sominsky, Sarah J. Spencer
Summary: The study shows that immune response can still occur in the absence of microglia and monocytes, but it is exacerbated and prolonged due to excessive neutrophil response in peripheral organs.
BRAIN BEHAVIOR AND IMMUNITY
(2023)
Editorial Material
Immunology
Elisa L. Hill-Yardin, Mark R. Hutchinson, Robin Laycock, Sarah J. Spencer
BRAIN BEHAVIOR AND IMMUNITY
(2023)
Article
Immunology
R. A. Ankeny, A. L. Whittaker, M. Ryan, J. Boer, M. Plebanski, J. Tuke, S. J. Spencer
Summary: One advantage of using highly standardised biological models, such as model organisms, is the ability to control multiple variables precisely, making it easier to study the variable of interest. However, this approach often hides effects in sub-populations due to natural population heterogeneity. Efforts to understand these sub-populations are underway, but require fundamental modifications to traditional study designs in BBI research.
BRAIN BEHAVIOR AND IMMUNITY
(2023)
Article
Endocrinology & Metabolism
A. Stefanidis, C. M. C. Lee, E. Greaves, M. K. Montgomery, M. Arnold, S. Newn, A. J. Budin, M. B. Lemus, C. J. Foldi, P. R. Burton, W. . A. Brown, T. A. Lutz, M. J. Watt, B. J. Oldfield
Summary: This study aimed to investigate the role of brown adipose tissue (BAT) in the efficacy of Vertical Sleeve Gastrectomy (VSG) surgery. The results showed that VSG surgery can activate BAT, thereby improving glucose regulation and promoting weight loss.
MOLECULAR METABOLISM
(2023)
Article
Zoology
Danielle L. Eastick, Amy M. Edwards, Stephen R. Griffiths, Sarah J. Spencer, Kylie A. Robert
Summary: The study validated quantitative magnetic resonance (QMR) as a non-invasive measure of body composition by comparing it with chemical carcass analysis (CCA). It also found that the body condition index could accurately predict lean and water mass but was a poor predictor of fat mass in Gould's wattled bats. Using accurate, non-invasive, repeatable measures of body composition may have important implications for ecological research in changing environments.
AUSTRALIAN MAMMALOGY
(2021)