Article
Multidisciplinary Sciences
Lanxin Li, Inge Verstraeten, Mark Roosjen, Koji Takahashi, Lesia Rodriguez, Jack Merrin, Jian Chen, Lana Shabala, Wouter Smet, Hong Ren, Steffen Vanneste, Sergey Shabala, Bert De Rybel, Dolf Weijers, Toshinori Kinoshita, William M. Gray, Jiri Friml
Summary: Plant growth is regulated by environmental factors, such as how plants respond to gravity by bending shoots up and roots down. Research has shown that the plant hormone auxin affects root growth by regulating cell expansion and contraction in the roots.
Article
Plant Sciences
Nelson B. C. Serre, Dominik Kralik, Ping Yun, Zdenek Slouka, Sergey Shabala, Matyas Fendrych
Summary: The research reveals that rapid auxin-induced membrane depolarization is closely related to rapid growth inhibition, requiring the AFB1 auxin co-receptor. AFB1 is essential for the rapid formation of the membrane depolarization gradient in the gravistimulated root.
Review
Biochemistry & Molecular Biology
Trinh Hua, Melanie Robitaille, Sarah J. Roberts-Thomson, Gregory R. Monteith
Summary: Apoptosis is a complex and regulated cell death pathway, and calcium signaling plays a crucial role in its regulation. The initiation and execution of apoptosis are controlled by different groups of cysteine proteases, including caspases, calpains, and cathepsins. Evading apoptosis is a hallmark of cancer cells, which can be achieved through deregulation of cysteine proteases and remodeling of calcium signaling. This review explores the involvement of calcium in the regulation of cysteine protease activity and its impact on intracellular calcium handling during apoptosis.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
(2023)
Article
Microbiology
Smija M. Kurian, Alexander Lichius, Nick D. Read
Summary: This study investigates the impact of Ca2+ signaling on the early developmental stages of F. oxysporum. The results demonstrate that different drugs and doses have specific and dose-dependent effects on spore germination and CAT-mediated cell fusion. These findings contribute an important first step towards the development of Ca2+ inhibitors with fungus-specific effects.
Article
Chemistry, Physical
Chu Nie, Jun Geng, William H. Marlow
Summary: This study investigated the formation free energy of molecules interacting via Lennard-Jones potential at the critical point, revealing that the critical sizes of Stillinger i-mer and tWF i-mer remain finite, with their formation free energies on the order of k(B)T. This behavior can be explained by Binder's theory, suggesting a gradual transition from nucleation to spinodal decomposition when the Ginzburg criterion is not satisfied.
JOURNAL OF CHEMICAL PHYSICS
(2021)
Article
Biology
Wenzheng Guan, Maosheng Xia, Ming Ji, Beina Chen, Shuai Li, Manman Zhang, Shanshan Liang, Binjie Chen, Wenliang Gong, Chengyi Dong, Gehua Wen, Xiaoni Zhan, Dianjun Zhang, Xinyu Li, Yuefei Zhou, Dawei Guan, Alexei Verkhratsky, Baoman Li
Summary: The study reveals two distinct molecular mechanisms by which iron ions trigger calcium signaling in astrocytes, shedding light on the regulation of intracellular calcium concentration in these cells. These findings contribute to our understanding of the functional role of astrocytes in normal neurodevelopment.
COMMUNICATIONS BIOLOGY
(2021)
Review
Cell Biology
Ranyue Ren, Jiachao Guo, Yangmengfan Chen, Yayun Zhang, Liangxi Chen, Wei Xiong
Summary: The process of bone remodelling is closely related to bone health, with the Ca2+/Calcineurin/NFAT signalling pathway playing a key role. Excessive activation of osteoclasts or lack of function of osteoblasts can lead to the occurrence and development of various bone-related diseases.
CELL PROLIFERATION
(2021)
Article
Multidisciplinary Sciences
Jay Xiaojun Tan, Toren Finkel
Summary: Lysosomal dysfunction, particularly lysosomal membrane permeabilization (LMP), can be resolved rapidly through the phosphoinositide-initiated membrane tethering and lipid transport (PITT) pathway. This pathway involves the accumulation of phosphatidylinositol-4 kinase type 2 alpha (PI4K2A) on damaged lysosomes, resulting in the recruitment of multiple oxysterol-binding protein (ORP) family members and the subsequent transfer of phosphatidylserine and cholesterol from the endoplasmic reticulum to support lysosomal repair. Additionally, the lipid transfer protein ATG2 is recruited to damaged lysosomes and mediates rapid membrane repair through direct lysosomal lipid transfer.
Article
Multidisciplinary Sciences
Qifei Gao, Chao Wang, Yasheng Xi, Qiaolin Shao, Legong Li, Sheng Luan
Summary: Precise signaling between pollen tubes and synergid cells is crucial in fertilization of flowering plants. The interaction between the pollen tube and the ovule leads to calcium spiking in the synergids, which results in pollen tube rupture and sperm release. Three proteins, FER, LRE, and NTA, play important roles in this process. FER acts as a receptor-like kinase, LRE is a glycosylphosphatidylinositol-anchored protein, and NTA is a transmembrane protein with an unknown function. It has been previously unknown how these proteins work together to enable communication between the synergid and the pollen tube. This study identifies two small peptides derived from the pollen tube as ligands for the FER-LRE co-receptor, which recruits NTA to the plasma membrane. NTA functions as a calcium channel required for calcium spiking in the synergid, initiating the fertilization process. The FER-LRE-NTA trio forms an unexpected receptor-channel complex in the female cell to recognize male signals and trigger fertilization.
Article
Plant Sciences
Yoshiharu Mimata, Shintaro Munemasa, Toshiyuki Nakamura, Yoshimasa Nakamura, Yoshiyuki Murata
Summary: This study reveals that malate can induce stomatal closure by directly activating SLAC1 and stimulating Ca2+ signaling. It provides insights into the molecular mechanism of malate-induced stomatal closure.
Article
Oncology
Yuyang Sun, Viviane Nascimento Da Conceicao, Arun Chauhan, Pramod Sukumaran, Pooja Chauhan, Julian L. Ambrus, Arjan Vissink, Frans G. M. Kroese, Madesh Muniswamy, Bibhuti B. Mishra, Brij B. Singh
Summary: The study aimed to understand the mechanisms and identify key factors leading to the development and progression of primary Sjogren's syndrome (pSS). The results showed that loss of calcium signaling is one of the initial factors that induces salivary gland dysfunction and immune cell infiltration in pSS. Inhibition of TRPC1 channels leads to loss of salivary acinar cells and release of immune mediators, exacerbating the pSS phenotype. Treatment with paquinimod restores calcium signaling and inhibits immune mediator release, reversing the pSS phenotype and halting disease progression.
CLINICAL AND TRANSLATIONAL MEDICINE
(2023)
Review
Biochemistry & Molecular Biology
Ran Ding, Ya-Ling Yin, Lin-Hua Jiang
Summary: The article discusses the importance of endothelial cell function in physiological and pathological processes, with a focus on the role of the TRPM2 channel in mediating ROS-induced calcium signaling in endothelial cells.
Article
Cell Biology
Srimanta Patra, Kewal Kumar Mahapatra, Prakash Priyadarshi Praharaj, Debasna Pritimanjari Panigrahi, Chandra Sekhar Bhol, Soumya Ranjan Mishra, Bishnu Prasad Behera, Amruta Singh, Mrutyunjay Jena, Sujit Kumar Bhutia
Summary: Mitochondrial Ca2+ plays a crucial role in maintaining cellular homeostasis by regulating mitochondrial dynamics, mitophagy, and mitochondrial biogenesis, while dysregulation of mitochondrial Ca2+ can lead to various pathological conditions, including cancer. This review discusses the interaction between mitochondrial Ca2+ and quality control, highlighting their importance in governing mitochondrial health and coordination in cancer development.
Review
Biochemistry & Molecular Biology
Madelaine Magali Audero, Natalia Prevarskaya, Alessandra Fiorio Pla
Summary: This review presents the impact of hypoxia and acidosis in the tumor microenvironment (TME) on cancer progression, and focuses on the role of Ca2+ channels in this process.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Sandeep Kumar Barodia, Tuithung Sophronea, Pratibha Mehta Luthra
Summary: The study demonstrated that A(2A) receptors modulate IP3 levels to release cytoplasmic calcium via cAMP-dependent PKA, potentially opening new avenues in the therapy of neurodegenerative disorders.
BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS
(2022)