A phosphoinositide signalling pathway mediates rapid lysosomal repair

Highly accurate protein structure prediction with AlphaFold

(2021) John Jumper et al.   NATURE

PI4P/PS countertransport by ORP10 at ER–endosome membrane contact sites regulates endosome fission

(2021) Asami Kawasaki et al.   JOURNAL OF CELL BIOLOGY

AlphaFold Protein Structure Database: massively expanding the structural coverage of protein-sequence space with high-accuracy models

(2021) Mihaly Varadi et al.   NUCLEIC ACIDS RESEARCH

Cryo-EM reconstruction of a VPS13 fragment reveals a long groove to channel lipids between membranes

(2020) PeiQi Li et al.   JOURNAL OF CELL BIOLOGY

ORF3a of the COVID-19 virus SARS-CoV-2 blocks HOPS complex-mediated assembly of the SNARE complex required for autolysosome formation

(2020) Guangyan Miao et al.   DEVELOPMENTAL CELL

The ESCRT and autophagy machineries cooperate to repair ESX-1-dependent damage at the Mycobacterium-containing vacuole but have opposite impact on containing the infection

(2019) Ana T. López-Jiménez et al.   PLoS Pathogens

Atg2 mediates direct lipid transfer between membranes for autophagosome formation

(2019) Takuo Osawa et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

ATG2 transports lipids to promote autophagosome biogenesis

(2019) Diana P. Valverde et al.   JOURNAL OF CELL BIOLOGY

The autophagic membrane tether ATG2A transfers lipids between membranes

(2019) Shintaro Maeda et al.   eLife

ER–lysosome contacts enable cholesterol sensing by mTORC1 and drive aberrant growth signalling in Niemann–Pick type C

(2019) Chun-Yan Lim et al.   NATURE CELL BIOLOGY

The CLN3 gene and protein: What we know

(2019) Myriam Mirza et al.   Molecular Genetics & Genomic Medicine

Rapid affinity purification of intracellular organelles using a twin strep tag

(2019) Jian Xiong et al.   JOURNAL OF CELL SCIENCE

Human ATG2B possesses a lipid transfer activity which is accelerated by negatively charged lipids and WIPI4

(2019) Takuo Osawa et al.   GENES TO CELLS

The Oxysterol-Binding Protein Cycle: Burning Off PI(4)P to Transport Cholesterol

(2018) Bruno Antonny et al.   Annual Review of Biochemistry

Triggered recruitment of ESCRT machinery promotes endolysosomal repair

(2018) Michael L. Skowyra et al.   SCIENCE

Efficient proximity labeling in living cells and organisms with TurboID

(2018) Tess C Branon et al.   NATURE BIOTECHNOLOGY

Mechanisms of Cell-to-Cell Transmission of Pathological Tau

(2018) Garrett S. Gibbons et al.   JAMA Neurology

ESCRT‐mediated lysosome repair precedes lysophagy and promotes cell survival

(2018) Maja Radulovic et al.   EMBO JOURNAL

The PRIDE database and related tools and resources in 2019: improving support for quantification data

(2018) Yasset Perez-Riverol et al.   NUCLEIC ACIDS RESEARCH

Lysosomal storage diseases

(2018) Frances M. Platt et al.   Nature Reviews Disease Primers

Lysosomal cell death mechanisms in aging

(2016) Raquel Gómez-Sintes et al.   AGEING RESEARCH REVIEWS

Endosome-ER Contacts Control Actin Nucleation and Retromer Function through VAP-Dependent Regulation of PI4P

(2016) Rui Dong et al.   CELL

Polyphosphoinositide binding domains: Key to inositol lipid biology

(2015) Gerald R.V. Hammond et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

A Kinase-Independent Role for EGF Receptor in Autophagy Initiation

(2015) Xiaojun Tan et al.   CELL

Optogenetic acidification of synaptic vesicles and lysosomes

(2015) Benjamin R Rost et al.   NATURE NEUROSCIENCE

Phosphatidylserine transport by ORP/Osh proteins is driven by phosphatidylinositol 4-phosphate

(2015) J. Moser von Filseck et al.   SCIENCE

PI4P/phosphatidylserine countertransport at ORP5- and ORP8-mediated ER-plasma membrane contacts

(2015) J. Chung et al.   SCIENCE

The crystal structure of the phosphatidylinositol 4-kinase II 

(2014) A. Baumlova et al.   EMBO REPORTS

A novel probe for phosphatidylinositol 4-phosphate reveals multiple pools beyond the Golgi

(2014) Gerald R.V. Hammond et al.   JOURNAL OF CELL BIOLOGY

Improved vectors and genome-wide libraries for CRISPR screening

(2014) Neville E Sanjana et al.   NATURE METHODS

Characterization of the Sterol and Phosphatidylinositol 4-Phosphate Binding Properties of Golgi-Associated OSBP-Related Protein 9 (ORP9)

(2014) Xinwei Liu et al.   PLoS One

Molecular insights into the membrane-associated phosphatidylinositol 4-kinase IIα

(2014) Qiangjun Zhou et al.   Nature Communications

A Four-Step Cycle Driven by PI(4)P Hydrolysis Directs Sterol/PI(4)P Exchange by the ER-Golgi Tether OSBP

(2013) Bruno Mesmin et al.   CELL

Autophagy sequesters damaged lysosomes to control lysosomal biogenesis and kidney injury

(2013) Ikuko Maejima et al.   EMBO JOURNAL

Interactome map uncovers phosphatidylserine transport by oxysterol-binding proteins

(2013) Kenji Maeda et al.   NATURE

Spatiotemporally controlled induction of autophagy-mediated lysosome turnover

(2013) Yu-Hsien Hung et al.   Nature Communications

A promiscuous biotin ligase fusion protein identifies proximal and interacting proteins in mammalian cells

(2012) Kyle J. Roux et al.   JOURNAL OF CELL BIOLOGY

α-Synuclein and ALPS motifs are membrane curvature sensors whose contrasting chemistry mediates selective vesicle binding

(2011) Iwona M. Pranke et al.   JOURNAL OF CELL BIOLOGY

Membrane curvature during peroxisome fission requires Pex11

(2010) Łukasz Opaliński et al.   EMBO JOURNAL

OSBP-related protein 11 (ORP11) dimerizes with ORP9 and localizes at the Golgi–late endosome interface

(2010) You Zhou et al.   EXPERIMENTAL CELL RESEARCH

Mucolipins: Intracellular TRPML1-3 channels

(2010) Xiping Cheng et al.   FEBS LETTERS

Galectin-3, a marker for vacuole lysis by invasive pathogens

(2009) Irit Paz et al.   CELLULAR MICROBIOLOGY

Amphipathic helices and membrane curvature

(2009) Guillaume Drin et al.   FEBS LETTERS

Oxysterol Binding Protein–related Protein 9 (ORP9) Is a Cholesterol Transfer Protein That Regulates Golgi Structure and Function

(2009) Mike Ngo et al.   MOLECULAR BIOLOGY OF THE CELL

Loss of phosphatidylinositol 4-kinase 2α activity causes late onset degeneration of spinal cord axons

(2009) J. Paul Simons et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

HELIQUEST: a web server to screen sequences with specific  -helical properties

(2008) R. Gautier et al.   BIOINFORMATICS

Lipid extraction by methyl-tert-butyl ether for high-throughput lipidomics

(2008) Vitali Matyash et al.   JOURNAL OF LIPID RESEARCH

Membrane Phosphatidylserine Regulates Surface Charge and Protein Localization

(2008) T. Yeung et al.   SCIENCE