Article
Biochemistry & Molecular Biology
Miriana Scordino, Monica Frinchi, Giulia Urone, Domenico Nuzzo, Giuseppa Mudo, Valentina Di Liberto
Summary: The differentiation of neural progenitors involves complex regulatory mechanisms that can be modulated by signals such as HSP70 and SOD1. These regulatory mechanisms are crucial for understanding stem cell and cancer research and therapy. In this study, the expression of HSP70 and SOD1 was found to play a role in promoting cell survival and protecting against oxidative stress-induced damage during the differentiation process of SH-SY5Y cells.
Article
Biochemistry & Molecular Biology
Larissa Smulders, Rachel Altman, Carolina Briseno, Alireza Saatchi, Leslie Wallace, Maha AlSebaye, Robert Stahelin, Nikolas Nikolaidis
Summary: HSPA1A is a molecular chaperone that regulates the survival of stressed and cancer cells. It localizes to the plasma membrane of stressed and tumor cells and interacts with specific lipids, playing a role in immunomodulatory functions and rendering tumors resistant to treatment. This study reveals that the surface presentation of HSPA1A is a multifaceted lipid-driven phenomenon controlled by binding to endosomal and plasma membrane lipids.
Article
Cell Biology
Xiang Zhou, Qiankun Ji, Qin Li, Peng Wang, Guowen Hu, Feng Xiao, Minhua Ye, Li Lin, Min Luo, Yun Guo, Weijun Wu, Kai Huang, Hua Guo
Summary: HSPA6 protein, expressed at high levels in patients with glioblastoma, is negatively correlated with clinical prognosis and closely associated with immunity, invasion, and angiogenesis. It may represent a new therapeutic target to improve the prognosis of patients with gliomas.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Binghui Song, Shiyi Shen, Shangyi Fu, Junjiang Fu
Summary: HSPA6, a member of the HSP70 family, plays a role in tumorigenesis, tumor progression, and non-tumor-related diseases. Its exact roles and mechanisms are still unclear. This article reviews the structure, expression, function, research progress, and potential role of HSPA6 in cancers and other diseases.
MOLECULAR BIOLOGY REPORTS
(2022)
Article
Biology
Yin-Sir Chung, Pervaiz Khalid Ahmed, Iekhsan Othman, Mohd. Farooq Shaikh
Summary: The study demonstrated the neuroprotective potential of Orthosiphon stamineus leaf proteins (OSLPs) in SH-SY5Y cells challenged by hydrogen peroxide. OSLPs were found to be safe and significantly increased cell survival and improved cell architecture in a concentration-dependent manner. OSLPs may exert their neuroprotective effects through modulating interleukin-4 and interleukin-13 pathways, regulating inflammation, and modulating HSP-regulated estrogen receptor pathways to counteract cellular damage induced by heat shock proteins under stress conditions.
Article
Cell & Tissue Engineering
Ju-Fang Liu, Po-Chun Chen, Thai-Yen Ling, Chun-Han Hou
Summary: This study demonstrates that heat shock induces the expression of HSPs in hPDMCs through the activation of ROS, p38 MAPK, Akt signaling, and HSF1, which plays a protective role.
STEM CELL RESEARCH & THERAPY
(2022)
Article
Biochemistry & Molecular Biology
Assou El-Battari, Lea Rodriguez, Henri Chahinian, Olivier Delezay, Jacques Fantini, Nouara Yahi, Coralie Di Scala
Summary: The study introduces a gene therapy approach to prevent the formation of neurotoxic oligomers by targeting brain gangliosides, representing a new strategy for treating Alzheimer's and Parkinson's diseases. By genetically modifying brain cells to secrete a therapeutic peptide inhibitor, the therapy effectively blocks the initial steps of neurodegeneration cascade and provides specific protection against oligomer formation. The results demonstrate the potential of this unique gene therapy approach in treating major neurodegenerative disorders.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Cell Biology
Ariadni Androvitsanea, Kostas Stylianou, Eleni Drosataki, Ioannis Petrakis
Summary: Research has shown that heat-shock proteins can have varying effects on the immune system, either triggering immune responses or alleviating them, which is important for studying and treating autoimmune diseases.
Article
Biochemistry & Molecular Biology
Lucie Valek, Irmgard Tegeder
Summary: Knockdown of nucleoredoxin (NXN) in neuronal cells leads to increased proliferation, elevated basal respiratory rates, and a similar relative change in oxygen consumption compared to control cells under mitochondrial stressors. Moreover, NXN-deficient cells show increased expression of redox-sensitive heat shock proteins and autophagy markers, indicating higher levels of self-renewal and autophagy.
Article
Psychiatry
Derek Van Booven, Mengying Li, J. Sunil Rao, Ilya O. Blokhin, R. Dayne Mayfield, Estelle Barbier, Markus Heilig, Claes Wahlestedt
Summary: Alcohol is associated with genome-wide changes in splicing in multiple human brain regions, likely due to dysregulation of splicing factor(s) and/or altered expression of splicing-related lncRNAs.
TRANSLATIONAL PSYCHIATRY
(2021)
Article
Neurosciences
Xuegang He, Xudong Guo, Bo Deng, Jihe Kang, Wenzhao Liu, Guangzhi Zhang, Yonggang Wang, Yong Yang, Xuewen Kang
Summary: In this study, the researchers established in vivo and in vitro models of traumatic spinal cord injury (TSCI) and manipulated the expression of Heat Shock Protein Family A Member 1A (HSPA1A). They found that upregulation of HSPA1A promoted recovery and inhibited apoptosis in TSCI rats, as well as suppressed H2O2-induced apoptosis in vitro. They also discovered that HSPA1A overexpression activated the Wnt/beta-catenin signaling pathway, which played a role in the inhibition of apoptosis.
EXPERIMENTAL NEUROLOGY
(2023)
Article
Plant Sciences
Anthony Guihur, Bruno Fauvet, Andrija Finka, Manfredo Quadroni, Pierre Goloubinoff
Summary: In the scorching summer dawn, land plants establish molecular defenses to prepare for extreme midday temperatures, inducing heat-shock proteins for acquired thermotolerance. Despite high protein crowding, heat priming did not accumulate HSP chaperones in chloroplasts, while HSP20s accumulated in the cytosol, suggesting their role in preventing heat-labile protein aggregation.
PLANT CELL AND ENVIRONMENT
(2021)
Article
Multidisciplinary Sciences
Ahmed Barakat, Even Birkeland, Melissa D. Jorstad, Magalie El Hajj, Msafiri Marijani, Anne Doskeland, Olav Mjaavatten, Frode S. Berven, Tehmina Mustafa
Summary: This study investigated the proteomic profile of PBMCs in pulmonary tuberculosis (PTB) patients to predict treatment response. Blood samples were collected from 8 adult PTB patients in Tanzania at baseline, 2 months of treatment, and treatment completion. Proteins extracted from PBMCs were quantified and analyzed using LC-MS/MS. The results identified differentially expressed proteins involved in cellular processes, metabolic processes, binding, and catalytic activity, suggesting that proteome analysis of PBMCs can be used as a novel technique to monitor anti-tuberculosis treatment response and gain insights into PTB.
Article
Multidisciplinary Sciences
Gabriela Boufelli de Freitas, Laura Penteado, Mila Meneguelli Miranda, Jose Roberto Filassi, Edmund Chada Baracat, Iara Moreno Linhares
Summary: The serum concentration of the 70 kDa heat shock protein (HSPA1A) is elevated in Brazilian women with breast cancer. Elevated HSPA1A levels are associated with advanced histological tumor grade and cell proliferation index. Further investigation on larger and more varied populations is needed to confirm the potential value of HSPA1A detection in breast cancer diagnosis and progression.
SCIENTIFIC REPORTS
(2022)
Article
Plant Sciences
Tung-Yi Lin, Wei-Jyun Hua, Hsin Yeh, Ai-Jung Tseng
Summary: The study demonstrates that FIPs LZ-8 and GMI induce changes in the proteomic profile of tumor lesions in LLC1 cell-bearing mouse, potentially regulating heat shock proteins (HSPs)-related cell viability and inhibiting cell migration and inducing apoptosis. Inhibition of HSPs may contribute to the anti-lung cancer activity of FIPs.
Article
Biochemistry & Molecular Biology
Pei-Yang Gao, Ya-Nan Ou, Yi-Ming Huang, Zhi-Bo Wang, Yan Fu, Ya-Hui Ma, Qiong-Yao Li, Li-Yun Ma, Rui-Ping Cui, Yin-Chu Mi, Lan Tan, Jin-Tai Yu
Summary: Liver function may play a role in the progression of Alzheimer's disease. The study found that as AD progressed, certain liver function markers increased while others decreased. The relationship between liver function and CSF AD biomarkers indicates a potential mediation effect on cognition.
JOURNAL OF NEUROCHEMISTRY
(2024)
