Leptin inhibits amyloid β-protein fibrillogenesis by decreasing GM1 gangliosides on the neuronal cell surface through PI3K/Akt/mTOR pathway

Propofol and Thiopental Suppress Amyloid Fibril Formation and GM1 Ganglioside Expression through the γ-Aminobutyric Acid A Receptor

(2013) Naoki Yamamoto et al.   ANESTHESIOLOGY

Brain insulin resistance accelerates Aβ fibrillogenesis by inducing GM1 ganglioside clustering in the presynaptic membranes

(2012) Naoki Yamamoto et al.   JOURNAL OF NEUROCHEMISTRY

Control of proliferation in astrocytoma cells by the receptor tyrosine kinase/PI3K/AKT signaling axis and the use of PI-103 and TCN as potential anti-astrocytoma therapies

(2011) D. B. Gursel et al.   NEURO-ONCOLOGY

Insulin inhibits Aβ fibrillogenesis through a decrease of the GM1 ganglioside-rich microdomain in neuronal membranes

(2010) Naoki Yamamoto et al.   JOURNAL OF NEUROCHEMISTRY

Recent advances in understanding leptin signaling and leptin resistance

(2009) David L. Morris et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Constitutively Active Akt Inhibits Trafficking of Amyloid Precursor Protein and Amyloid Precursor Protein Metabolites through Feedback Inhibition of Phosphoinositide 3-Kinase†

(2009) Diana W. Shineman et al.   BIOCHEMISTRY

Association of Plasma Leptin Levels With Incident Alzheimer Disease and MRI Measures of Brain Aging

(2009) Wolfgang Lieb   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Age-dependent high-density clustering of GM1 ganglioside at presynaptic neuritic terminals promotes amyloid β-protein fibrillogenesis

(2008) Naoki Yamamoto et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Leptin signaling in brain: A link between nutrition and cognition?

(2008) Christopher D. Morrison   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

JNK and ERK1/2 pathways have a dual opposite effect on the expression of BACE1

(2008) Elena Tamagno et al.   NEUROBIOLOGY OF AGING

Defects in IGF-1 receptor, insulin receptor and IRS-1/2 in Alzheimer's disease indicate possible resistance to IGF-1 and insulin signalling

(2008) Aileen M. Moloney et al.   NEUROBIOLOGY OF AGING

Transcriptional Regulation of β-Secretase by p25/cdk5 Leads to Enhanced Amyloidogenic Processing

(2008) Yi Wen et al.   NEURON