Brain insulin resistance accelerates Aβ fibrillogenesis by inducing GM1 ganglioside clustering in the presynaptic membranes

Physiopathological function of hematoside (GM3 ganglioside)

(2011) Jin-ichi INOKUCHI   PROCEEDINGS OF THE JAPAN ACADEMY SERIES B-PHYSICAL AND BIOLOGICAL SCIENCES

Insulin inhibits Aβ fibrillogenesis through a decrease of the GM1 ganglioside-rich microdomain in neuronal membranes

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Glycosphingolipids and insulin resistance

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Age-dependent high-density clustering of GM1 ganglioside at presynaptic neuritic terminals promotes amyloid β-protein fibrillogenesis

(2008) Naoki Yamamoto et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Defects in IGF-1 receptor, insulin receptor and IRS-1/2 in Alzheimer's disease indicate possible resistance to IGF-1 and insulin signalling

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Phosphatidylinositol-3-kinase activation blocks amyloid beta-induced neurotoxicity

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