Article
Neurosciences
Longfei Li, Jin Miao, Dandan Chu, Nana Jin, Yunn Chyn Tung, Chun-Ling Dai, Wen Hu, Cheng-Xin Gong, Khalid Iqbal, Fei Liu
Summary: Findings from this study suggest that the monoclonal tau antibody 77G7 effectively suppresses the seeding activity of AD O-tau and could potentially be developed as an immunotherapeutic drug to inhibit the propagation of tau pathology in AD and related tauopathies.
CNS NEUROSCIENCE & THERAPEUTICS
(2022)
Review
Biochemistry & Molecular Biology
Chun-Ling Dai, Fei Liu, Khalid Iqbal, Cheng-Xin Gong
Summary: The article discusses the interaction between gut microbiota, the immune system, and AD immunotherapy, emphasizing the crucial role of gut microbiota in the pathogenesis and treatment of AD.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Cell Biology
Tanzeel Khan, Rashid Waseem, Mohammad Shahid, Jaoud Ansari, Ishfaq Ahmad Ahanger, Imtaiyaz Hassan, Asimul Islam
Summary: Alzheimer's disease is the most prevalent form of dementia, and there is currently no permanent cure. Stem cell therapy has shown promising results in preclinical studies and is being explored as a potential treatment. This article reviews research from the past decade, discusses hypotheses related to the pathology of Alzheimer's disease, and provides an overview of ongoing clinical trials for immunotherapy and stem cell therapy.
AGEING RESEARCH REVIEWS
(2023)
Article
Neurosciences
Rinie Bajracharya, David Brici, Liviu-Gabriel Bodea, Phillip W. Janowicz, Jurgen Gotz, Rebecca M. Nisbet
Summary: The study compared the efficacy of tau-specific antibodies with different Fc-receptor binding affinities in reducing tau pathology and microgliosis in an AD mouse model. The results showed that the IgG1/kappa isoform had a better ability to reduce tau pathology and microgliosis, while the IgG2a/kappa isoform enhanced extracellular tau phagocytosis in vitro.
ACTA NEUROPATHOLOGICA COMMUNICATIONS
(2021)
Article
Pharmacology & Pharmacy
Valentina Latina, Margherita De Introna, Chiara Caligiuri, Alessia Loviglio, Rita Florio, Federico La Regina, Annabella Pignataro, Martine Ammassari-Teule, Pietro Calissano, Giuseppina Amadoro
Summary: Tau-targeted immunotherapy is a promising approach for Alzheimer's disease (AD) treatment. This study shows that treatment with 12A12mAb significantly reduces the accumulation of tau and A beta pathology in the retina and visual centers of AD animal models, leading to improvement in visual cognitive abilities and synaptic plasticity. These findings have important implications for clinical interventions targeting visual impairments in AD.
Review
Biochemistry & Molecular Biology
Yan Lian, Yu-Juan Jia, Joelyn Wong, Xin-Fu Zhou, Weihong Song, Junhong Guo, Colin L. Masters, Yan-Jiang Wang
Summary: This article analyzes key questions regarding the efficacy of Aβ targeting therapies and provides perspectives on early intervention, adequate Aβ removal, sufficient treatment period, and combinatory therapeutics. The success of recent clinical trials and lessons from previous trials provide critical evidence supporting the role of Aβ in AD pathogenesis.
MOLECULAR PSYCHIATRY
(2023)
Review
Clinical Neurology
Jin Jun Luo, William Wallace, John W. Kusiak
Summary: The search for effective therapy for Alzheimer's disease patients has been challenging, with the recent approval of Aducanumab sparking controversy due to questions surrounding its appropriateness. Various hypotheses including amyloid and tau protein aggregation remain controversial, but Aducanumab did show some benefit in mild AD patients. Understanding these hypotheses and controversies is important to evaluate the limitations and challenges in treating AD patients and exploring more efficacious therapies in the future.
JOURNAL OF THE NEUROLOGICAL SCIENCES
(2022)
Article
Chemistry, Multidisciplinary
Rinie Bajracharya, Esteban Cruz, Jurgen Gotz, Rebecca M. Nisbet
Summary: Tau-specific immunotherapy is a promising treatment strategy for Alzheimer's disease. However, the blood-brain barrier poses a challenge for effective delivery of tau-specific antibodies. Previous research has shown that low-intensity scanning ultrasound combined with microbubbles can increase antibody passage into the brain. This study aimed to assess the therapeutic response of ultrasound-mediated delivery of tau-specific antibodies.
JOURNAL OF CONTROLLED RELEASE
(2022)
Article
Cardiac & Cardiovascular Systems
Marco Luciani, Mauro Montalbano, Luca Troncone, Camilla Bacchin, Keita Uchida, Gianlorenzo Daniele, Bethany Jacobs Wolf, Helen M. Butler, Justin Kiel, Stefano Berto, Cortney Gensemer, Kelsey Moore, Jordan Morningstar, Thamonwan Diteepeng, Onder Albayram, Jose F. Abisambra, Russell A. Norris, Thomas G. Di Salvo, Benjamin Prosser, Rakez Kayed, Federica del Monte
Summary: This study found that Tau protein is expressed and aggregates in the heart tissue of patients with heart failure and Alzheimer's disease. Furthermore, monoclonal antibody therapy can improve heart function and clear toxic aggregates, suggesting that Tau may be a potential target for heart failure treatment.
EUROPEAN HEART JOURNAL
(2023)
Article
Pharmacology & Pharmacy
Peter Bloomingdale, Daniela Bumbaca-Yadav, Jonathan Sugam, Steve Grauer, Brad Smith, Svetlana Antonenko, Michael Judo, Glareh Azadi, Ka Lai Yee
Summary: The objective of this study was to develop a mechanistic mathematical model to enhance our understanding of tau antibody pharmacokinetics and pharmacodynamics in animals and humans, supporting the preclinical development and clinical translation of therapeutic antibodies for the treatment of Alzheimer's disease.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Vasileios Papaliagkas, Kallirhoe Kalinderi, Patroklos Vareltzis, Despoina Moraitou, Theodora Papamitsou, Maria Chatzidimitriou
Summary: Alzheimer's disease (AD) is a rapidly growing disease that urgently requires early diagnosis and treatment. Cerebrospinal fluid (CSF), which directly contacts the brain's extracellular space, is the most useful biological fluid for reflecting molecular events in the brain. Proteins and molecules that reflect the pathogenesis of AD, including neurodegeneration, accumulation of Abeta, hyperphosphorylation of tau protein, and apoptosis, can be used as biomarkers. The most commonly used CSF biomarkers for AD are total tau, phospho-tau, and Abeta42.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Filippa Lo Cascio, Paola Marzullo, Rakez Kayed, Antonio Palumbo Piccionello
Summary: This review highlights recent research on modifying the structure of curcumin to search for new effective therapeutic agents against neurodegenerative diseases, with a particular focus on Alzheimer's disease.
Article
Geriatrics & Gerontology
Fei Liu, Ruozhen Wu, Nana Jin, Dandan Chu, Jianlan Gu, Yunn Chyn Tung, Zhihao Hu, Cheng-Xin Gong, Khalid Iqbal
Summary: Two simple assays, capture assay and seeded-tau aggregation assay, were developed to assess tau seeding activity. These assays were proven to be specific and sensitive and can be carried out in a regular biomedical laboratory setting.
FRONTIERS IN AGING NEUROSCIENCE
(2023)
Review
Chemistry, Multidisciplinary
Yuying Li, Tianqing Liu, Mengchao Cui
Summary: This review summarizes the latest development of Tau tracers and analyzes their chemical structures and biological properties. The limitations of current tracers and considerations for the development of new tracers are also discussed.
CHINESE CHEMICAL LETTERS
(2022)
Review
Chemistry, Medicinal
Baofeng Gong, Wenbo Ji, Xiaohan Chen, Peng Li, Wenbin Cheng, Yuchen Zhao, Bin He, Jianhua Zhuang, Jie Gao, You Yin
Summary: Alzheimer's disease is a complex neurodegenerative disease characterized by the accumulation of A beta and tau proteins, leading to an imbalance in clearance and production rates. Current therapeutic strategies have limited effectiveness, but recent advances in immunotherapies and nanomedicines targeting these abnormal proteins may represent a crucial breakthrough.
MINI-REVIEWS IN MEDICINAL CHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Robert F. Hillary, Anna J. Stevenson, Simon R. Cox, Daniel L. McCartney, Sarah E. Harris, Anne Seeboth, Jon Higham, Duncan Sproul, Adele M. Taylor, Paul Redmond, Janie Corley, Alison Pattie, Maria Del C. Valdes Hernandez, Susana Munoz-Maniega, Mark E. Bastin, Joanna M. Wardlaw, Steve Horvath, Craig W. Ritchie, Tara L. Spires-Jones, Andrew M. McIntosh, Kathryn L. Evans, Ian J. Deary, Riccardo E. Marioni
Summary: The study found that higher DNAm GrimAge is associated with lower cognitive ability and brain vascular lesions in older age, independently of early-life cognitive ability.
MOLECULAR PSYCHIATRY
(2021)
Article
Neurosciences
Jane Tulloch, Olga Netsyk, Eleanor K. Pickett, Abigail G. Herrmann, Pooja Jain, Anna J. Stevenson, Iris Oren, Oliver Hardt, Tara L. Spires-Jones
Summary: The lack of understanding on how amyloid beta and tau cooperate to cause neurodegeneration is a key knowledge gap in Alzheimer's disease research. A mouse model (APP/PS1 + Tau) developed with amyloid plaque pathology and human tau expression without endogenous murine tau shows differences in behavioral hyperactivity phenotype and transcriptional deficits from mice with endogenous tau. The data highlight potential functional differences between mouse and human tau, emphasizing the need to use multiple models to fully understand Alzheimer's disease pathogenesis and develop effective therapeutic strategies.
EUROPEAN JOURNAL OF NEUROSCIENCE
(2021)
Article
Geriatrics & Gerontology
Anna J. Stevenson, Danni A. Gadd, Robert F. Hillary, Daniel L. McCartney, Archie Campbell, Rosie M. Walker, Kathryn L. Evans, Sarah E. Harris, Tara L. Spires-Jones, Allan F. McRae, Peter M. Visscher, Andrew M. McIntosh, Ian J. Deary, Riccardo E. Marioni
Summary: The study developed a DNAm-based predictor for IL-6 and successfully used it to predict IL-6 levels in an independent test cohort. Results indicated a negative association between the DNAm score and cognitive functioning, offering new insights into the relationship between inflammation and health outcomes.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2021)
Article
Clinical Neurology
Hatice Kurucu, Marti Colom-Cadena, Caitlin Davies, Lewis Wilkins, Declan King, Jamie Rose, Makis Tzioras, Jane H. Tulloch, Colin Smith, Tara L. Spires-Jones
Summary: In Alzheimer's disease, loss of inhibitory neurons and synapses may contribute to disrupted excitatory/inhibitory balance and cognitive decline.
EUROPEAN JOURNAL OF NEUROLOGY
(2022)
Review
Neurosciences
Elizabeth Drinkwater, Caitlin Davies, Tara L. Spires-Jones
Summary: Social isolation is a potentially modifiable lifestyle factor associated with Alzheimer's disease. Research suggests that social isolation may be linked to the development of Alzheimer's disease.
EUROPEAN JOURNAL OF NEUROSCIENCE
(2022)
Review
Neurosciences
Tyler S. Saunders, Danni A. Gadd, Tara L. Spires-Jones, Declan King, Craig Ritchie, Graciela Muniz-Terrera
Summary: This systematic review evaluates the association between cerebrospinal fluid protein markers and cognition in neurodegenerative dementias. Some evidence suggests a correlation between certain markers and worse cognition in Alzheimer's disease, frontotemporal dementia, and typical cognitive ageing. However, due to the substantial heterogeneity between studies, no firm conclusions can be drawn. Future research should focus on improving standardization and reporting, as well as investigating the significance of novel markers.
EUROPEAN JOURNAL OF NEUROSCIENCE
(2022)
Editorial Material
Neurosciences
Anton P. Porsteinsson, Srikant Rangaraju, Tara L. Spires-Jones, M. Kerry O'Banion
EUROPEAN JOURNAL OF NEUROSCIENCE
(2022)
Article
Neurosciences
Zsofia Laszlo, Nicole Hindley, Anna Sanchez Avila, Rachel A. Kline, Samantha L. Eaton, Douglas J. Lamont, Colin Smith, Tara L. Spires-Jones, Thomas M. Wishart, Christopher M. Henstridge
Summary: Increasing evidence suggests that synaptic dysfunction is a central and possibly triggering factor in Amyotrophic Lateral Sclerosis (ALS). This study aimed to assess the molecular profile of ALS synapses using an unbiased synaptic proteomics experiment. The researchers identified ALS-associated proteins and alterations in synaptic protein expression levels, as well as the influence of cognitive decline and a specific genetic mutation on synaptic composition. This study provides novel insights into the role of synaptic dysfunction in ALS pathophysiology.
ACTA NEUROPATHOLOGICA COMMUNICATIONS
(2022)
Article
Clinical Neurology
Declan King, Kris Holt, Jamie Toombs, Xin He, Owen Dando, Judith A. Okely, Makis Tzioras, Jamie Rose, Ciaran Gunn, Adele Correia, Carmen Montero, Hannah McAlister, Jane Tulloch, Douglas Lamont, Adele M. Taylor, Sarah E. Harris, Paul Redmond, Simon R. Cox, Christopher M. Henstridge, Ian J. Deary, Colin Smith, Tara L. Spires-Jones
Summary: This study examines the contribution of synaptic molecular changes to age-related cognitive decline and finds that synaptic pathology and gene expression related to synaptic signaling are associated with Alzheimer's disease.
ALZHEIMERS & DEMENTIA
(2022)
Article
Neurosciences
Marissa C. Vacher, Claire S. Durrant, Jamie Rose, Ailsa J. Hall, Tara L. Spires-Jones, Frank Gunn-Moore, Mark P. Dagleish
Summary: Toothed whales, such as odontocetes, develop neuropathology similar to Alzheimer's disease, including amyloid plaques and hyperphosphorylated tau accumulation, suggesting that they may be affected by AD-like neurodegeneration.
EUROPEAN JOURNAL OF NEUROSCIENCE
(2023)
Article
Multidisciplinary Sciences
Niamh B. B. McNamara, David A. D. Munro, Nadine Bestard-Cuche, Akiko Uyeda, Jeroen F. J. Bogie, Alana Hoffmann, Rebecca K. K. Holloway, Irene Molina-Gonzalez, Katharine E. E. Askew, Stephen Mitchell, William Mungall, Michael Dodds, Carsten Dittmayer, Jonathan Moss, Jamie Rose, Stefan Szymkowiak, Lukas Amann, Barry W. W. McColl, Marco Prinz, Tara L. L. Spires-Jones, Werner Stenzel, Karen Horsburgh, Jerome J. A. Hendriks, Clare Pridans, Rieko Muramatsu, Anna Williams, Josef Priller, Veronique E. E. Miron
Summary: This study reveals the crucial role of resident microglia in maintaining myelin health in the central nervous system. Microglia are involved in regulating myelin growth, preserving myelin integrity, and influencing cognitive function. Disruption of the TGF beta 1-TGF beta R1 axis is implicated in the mechanism underlying the loss of myelin health. The findings suggest that targeting microglia could be a potential therapeutic approach for conditions with dysregulated myelin growth and integrity.
Review
Clinical Neurology
Makis Tzioras, Robert I. McGeachan, Claire S. Durrant, Tara L. Spires-Jones
Summary: Alzheimer's disease is a neurodegenerative disorder characterized by cognitive decline and the presence of amyloid-beta and tau protein aggregates in the brain. Synaptic loss plays a crucial role in cognitive decline, and the spread of pathology is mediated by soluble forms of amyloid-beta and tau. Understanding the mechanisms of synaptic degeneration is essential for developing new therapeutic approaches for Alzheimer's disease.
NATURE REVIEWS NEUROLOGY
(2023)
Editorial Material
Clinical Neurology
Tara L. Spires-Jones
Summary: Our editor discusses the necessity for standardizing neuroscience PhD training in the UK.
BRAIN COMMUNICATIONS
(2023)
Article
Clinical Neurology
Tyler S. Saunders, Francesca E. Pozzolo, Amanda Heslegrave, Declan King, Robert McGeachan, Maxwell P. Spires-Jones, Sarah E. Harris, Craig Ritchie, Graciela Muniz-Terrera, Ian J. Deary, Simon R. Cox, Henrik Zetterberg, Tara L. Spires-Jones
Summary: Growing evidence supports the use of blood biomarkers including tau phosphorylated at threonine 181, amyloid-beta, neurofilament light and glial fibrillary acidic protein as promising indicators for Alzheimer's disease. However, their predictive validity for age-related cognitive decline without dementia remains unclear. This study investigated the potential of plasma biomarkers and the distribution of tau phosphorylated at threonine 181 in the brain to predict cognitive decline in older adults.
BRAIN COMMUNICATIONS
(2023)
Article
Clinical Neurology
Manuela Marescotti, Flavia Loreto, Tara L. Spires-Jones
Summary: The persistently low representation of women in STEM fields calls for continuous efforts to raise awareness and understanding of this issue. This study analyzed the gender ratios of authors and reviewers in a neuroscience, neurology, and psychiatry journal and found no evidence of gender bias in the peer-review and editorial decision-making processes.
BRAIN COMMUNICATIONS
(2022)
Article
Biochemistry & Molecular Biology
Pei-Yang Gao, Ya-Nan Ou, Yi-Ming Huang, Zhi-Bo Wang, Yan Fu, Ya-Hui Ma, Qiong-Yao Li, Li-Yun Ma, Rui-Ping Cui, Yin-Chu Mi, Lan Tan, Jin-Tai Yu
Summary: Liver function may play a role in the progression of Alzheimer's disease. The study found that as AD progressed, certain liver function markers increased while others decreased. The relationship between liver function and CSF AD biomarkers indicates a potential mediation effect on cognition.
JOURNAL OF NEUROCHEMISTRY
(2024)
