Developmental vulnerability of synapses and circuits associated with neuropsychiatric disorders

Tau phosphorylation is exaggerated in Alzheimer disease with psychosis

(2013) Patrick S. Murray et al.   AMERICAN JOURNAL OF GERIATRIC PSYCHIATRY

Intramembranous Valine Linked to Schizophrenia Is Required for Neuregulin 1 Regulation of the Morphological Development of Cortical Neurons

(2013) Y. Chen et al.   JOURNAL OF NEUROSCIENCE

SHANK1 Deletions in Males with Autism Spectrum Disorder

(2012) Daisuke Sato et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Effect of Alzheimer’s Disease Risk Genes on Trajectories of Cognitive Function in the Cardiovascular Health Study

(2012) Robert A. Sweet et al.   AMERICAN JOURNAL OF PSYCHIATRY

SCN1A Affects Brain Structure and the Neural Activity of the Aging Brain

(2012) Sandra Meier et al.   BIOLOGICAL PSYCHIATRY

NAAG, NMDA Receptor and Psychosis

(2012) Richard Bergeron et al.   CURRENT MEDICINAL CHEMISTRY

Neuregulin Directly Decreases Voltage-Gated Sodium Current in Hippocampal ErbB4-Expressing Interneurons

(2012) M. J. Janssen et al.   JOURNAL OF NEUROSCIENCE

The Importance of the NRG-1/ErbB4 Pathway for Synaptic Plasticity and Behaviors Associated with Psychiatric Disorders

(2012) A. Shamir et al.   JOURNAL OF NEUROSCIENCE

Autistic-like social behaviour in Shank2-mutant mice improved by restoring NMDA receptor function

(2012) Hyejung Won et al.   NATURE

β-Amyloid 42/40 ratio and kalirin expression in Alzheimer disease with psychosis

(2012) Patrick S. Murray et al.   NEUROBIOLOGY OF AGING

The X-Linked Intellectual Disability Protein TSPAN7 Regulates Excitatory Synapse Development and AMPAR Trafficking

(2012) Silvia Bassani et al.   NEURON

Association Analysis of 94 Candidate Genes and Schizophrenia-Related Endophenotypes

(2012) Tiffany A. Greenwood et al.   PLoS One

Neuregulin and dopamine modulation of hippocampal gamma oscillations is dependent on dopamine D4 receptors

(2012) R. H. Andersson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

CACNA1C (Cav1.2) in the pathophysiology of psychiatric disease

(2012) Shambhu Bhat et al.   PROGRESS IN NEUROBIOLOGY

NMDA Receptor Hypofunction, Parvalbumin-Positive Neurons, and Cortical Gamma Oscillations in Schizophrenia

(2012) G. Gonzalez-Burgos et al.   SCHIZOPHRENIA BULLETIN

Schizophrenia-associated HapICE haplotype is associated with increased NRG1 type III expression and high nucleotide diversity

(2012) C S Weickert et al.   Translational Psychiatry

GABAergic Circuit Dysfunctions in Neurodevelopmental Disorders

(2012) Bidisha Chattopadhyaya et al.   Frontiers in Psychiatry

Deletion of the immunoglobulin domain of IL1RAPL1 results in nonsyndromic X-linked intellectual disability associated with behavioral problems and mild dysmorphism

(2011) Karl J. Franek et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART A

Analysis of 94 Candidate Genes and 12 Endophenotypes for Schizophrenia From the Consortium on the Genetics of Schizophrenia

(2011) Tiffany A. Greenwood et al.   AMERICAN JOURNAL OF PSYCHIATRY

Conserved Interneuron-Specific ErbB4 Expression in Frontal Cortex of Rodents, Monkeys, and Humans: Implications for Schizophrenia

(2011) Jörg Neddens et al.   BIOLOGICAL PSYCHIATRY

Disentangling the Myriad Genomics of Complex Disorders, Specifically Focusing on Autism, Epilepsy, and Schizophrenia

(2011) M. Poot et al.   CYTOGENETIC AND GENOME RESEARCH

The X-linked intellectual disability protein IL1RAPL1 regulates excitatory synapse formation by binding PTPδ and RhoGAP2

(2011) Pamela Valnegri et al.   HUMAN MOLECULAR GENETICS

Synaptic dysfunction and abnormal behaviors in mice lacking major isoforms of Shank3

(2011) Xiaoming Wang et al.   HUMAN MOLECULAR GENETICS

Importance of Shank3 Protein in Regulating Metabotropic Glutamate Receptor 5 (mGluR5) Expression and Signaling at Synapses

(2011) Chiara Verpelli et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Tau Protein Is Required for Amyloid  -Induced Impairment of Hippocampal Long-Term Potentiation

(2011) O. A. Shipton et al.   JOURNAL OF NEUROSCIENCE

IL-1 Receptor Accessory Protein-Like 1 Associated with Mental Retardation and Autism Mediates Synapse Formation by Trans-Synaptic Interaction with Protein Tyrosine Phosphatase  

(2011) T. Yoshida et al.   JOURNAL OF NEUROSCIENCE

Rapid reversal of impaired inhibitory and excitatory transmission but not spine dysgenesis in a mouse model of mental retardation

(2011) Andrew D. Powell et al.   JOURNAL OF PHYSIOLOGY-LONDON

Regulation of Long-Term Plasticity Induction by the Channel and C-Terminal Domains of GluN2 Subunits

(2011) Frank Fetterolf et al.   MOLECULAR NEUROBIOLOGY

Alzheimer's disease: synapses gone cold

(2011) Robert M Koffie et al.   Molecular Neurodegeneration

Rare structural variation of synapse and neurotransmission genes in autism

(2011) X Gai et al.   MOLECULAR PSYCHIATRY

Genome-wide association study of Alzheimer's disease with psychotic symptoms

(2011) P Hollingworth et al.   MOLECULAR PSYCHIATRY

De novo CNV analysis implicates specific abnormalities of postsynaptic signalling complexes in the pathogenesis of schizophrenia

(2011) G Kirov et al.   MOLECULAR PSYCHIATRY

Neocortical excitation/inhibition balance in information processing and social dysfunction

(2011) Ofer Yizhar et al.   NATURE

Shank3 mutant mice display autistic-like behaviours and striatal dysfunction

(2011) João Peça et al.   NATURE

A circadian clock in hippocampus is regulated by interaction between oligophrenin-1 and Rev-erbα

(2011) Pamela Valnegri et al.   NATURE NEUROSCIENCE

Neuregulin 1 regulates excitability of fast-spiking neurons through Kv1.1 and acts in epilepsy

(2011) Ke-Xin Li et al.   NATURE NEUROSCIENCE

Dendritic spine pathology in neuropsychiatric disorders

(2011) Peter Penzes et al.   NATURE NEUROSCIENCE

TOMM40 poly-T repeat lengths, age of onset and psychosis risk in Alzheimer disease

(2011) Su Hee Chu et al.   NEUROBIOLOGY OF AGING

Increased expression of Kalirin-9 in the auditory cortex of schizophrenia subjects: Its role in dendritic pathology

(2011) Anthony J. Deo et al.   NEUROBIOLOGY OF DISEASE

Rare De Novo Variants Associated with Autism Implicate a Large Functional Network of Genes Involved in Formation and Function of Synapses

(2011) Sarah R. Gilman et al.   NEURON

Communication Impairments in Mice Lacking Shank1: Reduced Levels of Ultrasonic Vocalizations and Scent Marking Behavior

(2011) Markus Wöhr et al.   PLoS One

Expression of the Neuregulin Receptor ErbB4 in the Brain of the Rhesus Monkey (Macaca mulatta)

(2011) Jörg Neddens et al.   PLoS One

Haploinsufficiency of the autism-associated Shank3 gene leads to deficits in synaptic function, social interaction, and social communication

(2011) Ozlem Bozdagi et al.   Molecular Autism

Trajectory of Cognitive Decline as a Predictor of Psychosis in Early Alzheimer Disease in the Cardiovascular Health Study

(2010) James E. Emanuel et al.   AMERICAN JOURNAL OF GERIATRIC PSYCHIATRY

L-type calcium channels and psychiatric disorders: A brief review

(2010) Francesco Casamassima et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS

Biological Validation of Increased Schizophrenia Risk With NRG1, ERBB4, and AKT1 Epistasis via Functional Neuroimaging in Healthy Controls

(2010) Kristin K. Nicodemus et al.   ARCHIVES OF GENERAL PSYCHIATRY

Altered Cortical CDC42 Signaling Pathways in Schizophrenia: Implications for Dendritic Spine Deficits

(2010) Masayuki Ide et al.   BIOLOGICAL PSYCHIATRY

Assessment and familial aggregation of psychosis in Alzheimer's disease from the National Institute on Aging Late Onset Alzheimer's Disease Family Study

(2010) R. A. Sweet et al.   BRAIN

The neuregulin signaling pathway and schizophrenia: From genes to synapses and neural circuits

(2010) Andrés Buonanno   BRAIN RESEARCH BULLETIN

N-methyl-d-aspartate (NMDA) receptor dysfunction or dysregulation: The final common pathway on the road to schizophrenia?

(2010) Joshua T. Kantrowitz et al.   BRAIN RESEARCH BULLETIN

A Postsynaptic Signaling Pathway that May Account for the Cognitive Defect Due to IL1RAPL1 Mutation

(2010) Alice Pavlowsky et al.   CURRENT BIOLOGY

Synapse Pathology in Psychiatric and Neurologic Disease

(2010) Myrrhe van Spronsen et al.   Current Neurology and Neuroscience Reports

Phenotypic variability and genetic susceptibility to genomic disorders

(2010) S. Girirajan et al.   HUMAN MOLECULAR GENETICS

A  Oligomers Cause Localized Ca2+ Elevation, Missorting of Endogenous Tau into Dendrites, Tau Phosphorylation, and Destruction of Microtubules and Spines

(2010) H. Zempel et al.   JOURNAL OF NEUROSCIENCE

Kinetic Properties and Functional Dynamics of Sodium Channels during Repetitive Spiking in a Slow Pacemaker Neuron

(2010) L. S. Milescu et al.   JOURNAL OF NEUROSCIENCE

Differential effects of prenatal and postnatal expressions of mutant human DISC1 on neurobehavioral phenotypes in transgenic mice: evidence for neurodevelopmental origin of major psychiatric disorders

(2010) Y Ayhan et al.   MOLECULAR PSYCHIATRY

Control of cortical GABA circuitry development by Nrg1 and ErbB4 signalling

(2010) Pietro Fazzari et al.   NATURE

Functional impact of global rare copy number variation in autism spectrum disorders

(2010) Dalila Pinto et al.   NATURE

Mutations in the SHANK2 synaptic scaffolding gene in autism spectrum disorder and mental retardation

(2010) Simone Berkel et al.   NATURE GENETICS

Disrupted-in-Schizophrenia 1 (DISC1) regulates spines of the glutamate synapse via Rac1

(2010) Akiko Hayashi-Takagi et al.   NATURE NEUROSCIENCE

No association of psychosis in Alzheimer disease with neurodegenerative pathway genes

(2010) Mary Ann A. DeMichele-Sweet et al.   NEUROBIOLOGY OF AGING

Dopamine enhances the excitability of somatosensory thalamocortical neurons

(2010) G. Govindaiah et al.   NEUROSCIENCE

Molecular Cloning and Characterization of the Human ErbB4 Gene: Identification of Novel Splice Isoforms in the Developing and Adult Brain

(2010) Wei Tan et al.   PLoS One

Multiple Events Lead to Dendritic Spine Loss in Triple Transgenic Alzheimer's Disease Mice

(2010) Tobias Bittner et al.   PLoS One

Recurrent Rearrangements in Synaptic and Neurodevelopmental Genes and Shared Biologic Pathways in Schizophrenia, Autism, and Mental Retardation

(2009) Audrey Guilmatre et al.   ARCHIVES OF GENERAL PSYCHIATRY

Chromosome 22q13.3 deletion syndrome with a de novo interstitial 22q13.3 cryptic deletion disrupting SHANK3

(2009) A. Delahaye et al.   European Journal of Medical Genetics

The functional consequences of cortical circuit abnormalities on gamma oscillations in schizophrenia: insights from computational modeling

(2009) Kevin Spencer   Frontiers in Human Neuroscience

Genome-wide association studies in ADHD

(2009) Barbara Franke et al.   HUMAN GENETICS

The DISC locus and schizophrenia: evidence from an association study in a central European sample and from a meta-analysis across different European populations

(2009) Johannes Schumacher et al.   HUMAN MOLECULAR GENETICS

Common circuit defect of excitatory-inhibitory balance in mouse models of autism

(2009) Nadine Gogolla et al.   Journal of Neurodevelopmental Disorders

Selective Expression of ErbB4 in Interneurons, But Not Pyramidal Cells, of the Rodent Hippocampus

(2009) D. Vullhorst et al.   JOURNAL OF NEUROSCIENCE

Amyloid β Protein: Aβ40 Inhibits Aβ42 Oligomerization

(2009) Megan M. Murray et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Kalirin loss results in cortical morphological alterations

(2009) Zhong Xie et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Postnatal NMDA receptor ablation in corticolimbic interneurons confers schizophrenia-like phenotypes

(2009) Juan E Belforte et al.   NATURE NEUROSCIENCE

Experience-dependent structural synaptic plasticity in the mammalian brain

(2009) Anthony Holtmaat et al.   NATURE REVIEWS NEUROSCIENCE

Neuregulin 1 regulates pyramidal neuron activity via ErbB4 in parvalbumin-positive interneurons

(2009) L. Wen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Kalirin regulates cortical spine morphogenesis and disease-related behavioral phenotypes

(2009) M. E. Cahill et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Impaired maturation of dendritic spines without disorganization of cortical cell layers in mice lacking NRG1/ErbB signaling in the central nervous system

(2009) C. S. Barros et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Oligomeric amyloid   associates with postsynaptic densities and correlates with excitatory synapse loss near senile plaques

(2009) R. M. Koffie et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Contact in the genetics of autism and schizophrenia

(2009) J. Peter H. Burbach et al.   TRENDS IN NEUROSCIENCES

Novel de novo SHANK3 mutation in autistic patients

(2008) Julie Gauthier et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS

Autism genetics: strategies, challenges, and opportunities

(2008) Brian J. O'Roak et al.   Autism Research

Soluble oligomers of the amyloid β-protein impair synaptic plasticity and behavior

(2008) Dennis J. Selkoe   BEHAVIOURAL BRAIN RESEARCH

Neural basis of psychosis-related behaviour in the infection model of schizophrenia

(2008) Urs Meyer et al.   BEHAVIOURAL BRAIN RESEARCH

Neuroanatomical correlates of neuropsychiatric symptoms in Alzheimer's disease

(2008) P. D. Bruen et al.   BRAIN

Neuregulin-1 Modulates Hippocampal Gamma Oscillations: Implications for Schizophrenia

(2008) André Fisahn et al.   CEREBRAL CORTEX

Mutations in the calcium-related gene IL1RAPL1 are associated with autism

(2008) A. Piton et al.   HUMAN MOLECULAR GENETICS

Smaller Dendritic Spines, Weaker Synaptic Transmission, but Enhanced Spatial Learning in Mice Lacking Shank1

(2008) A. Y. Hung et al.   JOURNAL OF NEUROSCIENCE

Type III Neuregulin-1 Is Required for Normal Sensorimotor Gating, Memory-Related Behaviors, and Corticostriatal Circuit Components

(2008) Y.-J. J. Chen et al.   JOURNAL OF NEUROSCIENCE

Kalirin-7 Is Required for Synaptic Structure and Function

(2008) X.-M. Ma et al.   JOURNAL OF NEUROSCIENCE

Altered brain microRNA biogenesis contributes to phenotypic deficits in a 22q11-deletion mouse model

(2008) Kimberly L Stark et al.   NATURE GENETICS

Palmitoylation-dependent neurodevelopmental deficits in a mouse model of 22q11 microdeletion

(2008) Jun Mukai et al.   NATURE NEUROSCIENCE

Neuregulin 1 in neural development, synaptic plasticity and schizophrenia

(2008) Lin Mei et al.   NATURE REVIEWS NEUROSCIENCE

Reduced Dendritic Spine Density in Auditory Cortex of Subjects with Schizophrenia

(2008) Robert A Sweet et al.   NEUROPSYCHOPHARMACOLOGY

Neuregulin-1 regulates LTP at CA1 hippocampal synapses through activation of dopamine D4 receptors

(2008) O. B. Kwon et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A mutation in mouse Disc1 that models a schizophrenia risk allele leads to specific alterations in neuronal architecture and cognition

(2008) M. Kvajo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

GABA Neurons and the Mechanisms of Network Oscillations: Implications for Understanding Cortical Dysfunction in Schizophrenia

(2008) G. Gonzalez-Burgos et al.   SCHIZOPHRENIA BULLETIN

Convergent CaMK and RacGEF signals control dendritic structure and function

(2008) Peter Penzes et al.   TRENDS IN CELL BIOLOGY

Dendritic spine dynamics – a key role for kalirin-7

(2008) Peter Penzes et al.   TRENDS IN NEUROSCIENCES

Circuit-based framework for understanding neurotransmitter and risk gene interactions in schizophrenia

(2008) John E. Lisman et al.   TRENDS IN NEUROSCIENCES

Psychosis of Alzheimer's disease: Gender differences in regional perfusion

(2007) E.K. Moran et al.   NEUROBIOLOGY OF AGING