Article
Behavioral Sciences
Na Ma, Gaixia Li, Xiuxin Fu
Summary: The study examined the mechanism of action of activating transcription factor 3 (ATF3) in cerebral ischemia. Results showed that ATF3 repressed neuronal apoptosis and microglia activation by targeting CCL2 and mediating the TLR4/NF-kappa B signaling, thereby alleviating brain injury.
BRAIN AND BEHAVIOR
(2022)
Article
Plant Sciences
Xinxin Zhang, Zhaowei Xue, Shangjun Zhu, Yuting Guo, Yan Zhang, Jianwei Dou, Jiye Zhang, Yoichiro Ito, Zengjun Guo
Summary: This study identified a novel signaling pathway HIKESHI/HSP70/NF-kappa B associated with DIO-treated I/R, which may serve as therapeutic targets or drugs with potential implications for the treatment of I/R in clinic.
Article
Peripheral Vascular Disease
Danpeng Zhao, Jinming Ji, Shanshan Li, Aimei Wu
Summary: This study found that Skullcapflavone II (SCP) has a protective effect on cerebral ischemia/reperfusion injury by reducing cerebral edema, infarct volume, neurological deficits, oxidative stress, inflammation, and increasing angiogenesis.
MICROVASCULAR RESEARCH
(2022)
Article
Plant Sciences
Junxuan Wu, Sixuan Chen, Peng Wu, Ying Wang, Xiaoxiao Qi, Rong Zhang, Zhongqiu Liu, Dawei Wang, Yuanyuan Cheng
Summary: This study aims to investigate the therapeutic effect of Ilexsaponin I (ISI) on myocardial ischemia/reperfusion injury (MI/RI) and its mechanism. The results of the study demonstrate that ISI suppresses NLRP3 inflammasome activation by promoting the formation of CTSB/HSP70 complex and disrupting CTSB/NLRP3 complex, thus protecting the heart from injury.
Article
Multidisciplinary Sciences
Wanli Ji, Yaoxin Ren, Xiaolian Wei, Xiangxiang Ding, Yihan Dong, Bin Yuan
Summary: The immune mediator MIF is upregulated after brain tissue ischemia and is associated with inflammation. ISO-1, a potent inhibitor of MIF tautomerase, can protect neurons by reducing blood-brain barrier permeability. This study investigated the role of ISO-1 in cerebral ischemia/reperfusion injury using a rat model.
SCIENTIFIC REPORTS
(2023)
Review
Neurosciences
Teresa Jover-Mengual, Jee-Yeon Hwang, Hyae-Ran Byun, Brenda L. Court-Vazquez, Jose M. Centeno, Maria C. Burguete, R. Suzanne Zukin
Summary: This article discusses the impact of inflammatory response triggered by cerebral ischemia on neuronal death and the dual role of NF-κB in that context. NF-κB may play both protective and potentially damaging roles in cerebral ischemia, leading to conflicting observations regarding its function. Further research is needed to clarify the exact role of NF-κB in mediating inflammation and neuronal death in cerebral ischemia.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2021)
Article
Plant Sciences
Tian Xu, Xueqian Wang, Chongyang Ma, Jing Ji, Wenxiu Xu, Qi Shao, Xuejing Liao, Ying Li, Fafeng Cheng, Qingguo Wang
Summary: Baicalin has potential therapeutic effects in preventing cerebral ischemia by reducing neurological injury and inhibiting inflammatory responses through multiple pathways.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Article
Immunology
Chenghong Sun, Ningning Cao, Qingguo Wang, Ning Liu, Tianye Yang, Shirong Li, Lihong Pan, Jingchun Yao, Li Zhang, Mingfei Liu, Guimin Zhang, Xuefeng Xiao, Changxiao Liu
Summary: This study evaluated the therapeutic effects of icaritin against cerebral ischemic stroke injury using a mouse model. The results showed that icaritin reduced cerebral infarction size, brain edema, and improved neurological score in the mice. It also alleviated cerebral ischemia-induced damage and reduced neuronal apoptosis, as well as protected the blood-brain barrier. Furthermore, icaritin inhibited inflammation and targeted cathepsin B, showing potential for anti-neuroinflammation therapy.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Neurosciences
Dong Yuan, Kurt Hu, Chun Mun Loke, Hironori Teramoto, Chunli Liu, Bingren Hu
Summary: The study demonstrates that stroke leads to NSF inactivation, disruption of endolysosomal structures, blockage of endocytic and autophagic pathways, massive release of CTSB, and subsequent neuronal death.
EXPERIMENTAL NEUROLOGY
(2021)
Article
Biochemistry & Molecular Biology
Shanshan Li, Yaoshuai Zhang, Lili Fei, Yuhan Zhang, Jinlong Pang, Wei Gao, Fangtian Fan, Yadong Xing, Xian Li
Summary: Baicalein, a natural ingredient derived from Scutellaria baicalensis Georgi, has shown neuroprotective effects by reducing neurological deficits and cell death induced by cerebral ischemia reperfusion (CIR). It inhibits the activity of calpain 1 and prevents AIF nuclear translocation, leading to the protection against CIR injury.
BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Dae Ki Hong, Jae-Won Eom, A. Ra Kho, Song Hee Lee, Beom Seok Kang, Si Hyun Lee, Jae-Young Koh, Yang-Hee Kim, Bo Young Choi, Sang Won Suh
Summary: The compound 2G11 has been found to have neuroprotective effects by blocking zinc translocation and AMPK phosphorylation, thus protecting hippocampal neurons from ischemia-induced damage.
Article
Immunology
Changchang Meng, Shiyu Chen, Qi He, Junyi Tan, Jingxian Wu, Jing Zhao
Summary: This study found that the expression of IKZF3 gene peaked in both the ischemia-reperfusion injury model in rats and the oxygen-glucose deprivation/reoxygenation model in cells. By regulating the production of inflammatory factors, IKZF3 affected the extent of cellular and brain tissue damage, and it may be associated with the phosphorylation and nuclear transfer of NF-kappa B.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Immunology
Yue Dong, Hanqiao Yu, Xueqi Li, Kelong Bian, Yayuan Zheng, Mingrui Dai, Xuejian Feng, Yao Sun, Yu He, Bin Yu, Haihong Zhang, Jiaxin Wu, Xianghui Yu, Hui Wu, Wei Kong
Summary: This study revealed, for the first time, that hyperphosphorylated tau (pTau) induces necroptosis and inflammation in Alzheimer's disease (AD) by activating the RIPK1/RIPK3/MLKL and NF-kappa B pathways, thereby contributing to neuronal death.
JOURNAL OF NEUROINFLAMMATION
(2022)
Article
Biochemistry & Molecular Biology
A. Ra Kho, Dae Ki Hong, Beom Seok Kang, Woo-Jung Park, Kyung Chan Choi, Kyoung-Ha Park, Sang Won Suh
Summary: The study shows that atorvastatin can reduce neuronal death, oxidative stress, inflammation, and blood-brain barrier disruption in global cerebral ischemia, improving cognitive function. Additionally, atorvastatin can also reduce endothelial cell damage and VV proliferation. These results suggest that atorvastatin may be an effective option in managing global cerebral ischemia.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Peripheral Vascular Disease
Chih-Chieh Tsao, Julia Baumann, Sheng-Fu Huang, Diana Kindler, Aileen Schroeter, Nicole Kachappilly, Max Gassmann, Markus Rudin, Omolara O. Ogunshola
Summary: Pericyte HIF-1 loss of function reduces ischemic damage and barrier permeability at 3 days reperfusion, preserving barrier integrity by reducing pericyte death and improving vascular functionality post stroke.
Article
Biochemistry & Molecular Biology
Pei-Yang Gao, Ya-Nan Ou, Yi-Ming Huang, Zhi-Bo Wang, Yan Fu, Ya-Hui Ma, Qiong-Yao Li, Li-Yun Ma, Rui-Ping Cui, Yin-Chu Mi, Lan Tan, Jin-Tai Yu
Summary: Liver function may play a role in the progression of Alzheimer's disease. The study found that as AD progressed, certain liver function markers increased while others decreased. The relationship between liver function and CSF AD biomarkers indicates a potential mediation effect on cognition.
JOURNAL OF NEUROCHEMISTRY
(2024)