Review
Neurosciences
Martine Hoogman, Daan van Rooij, Marieke Klein, Premika Boedhoe, Iva Ilioska, Ting Li, Yash Patel, Merel C. Postema, Yanli Zhang-James, Evdokia Anagnostou, Celso Arango, Guillaume Auzias, Tobias Banaschewski, Claiton H. D. Bau, Marlene Behrmann, Mark A. Bellgrove, Daniel Brandeis, Silvia Brem, Geraldo F. Busatto, Sara Calderoni, Rosa Calvo, Francisco X. Castellanos, David Coghill, Annette Conzelmann, Eileen Daly, Christine Deruelle, Ilan Dinstein, Sarah Durston, Christine Ecker, Stefan Ehrlich, Jeffery N. Epstein, Damien A. Fair, Jacqueline Fitzgerald, Christine M. Freitag, Thomas Frodl, Louise Gallagher, Eugenio H. Grevet, Jan Haavik, Pieter J. Hoekstra, Joost Janssen, Georgii Karkashadze, Joseph A. King, Kerstin Konrad, Jonna Kuntsi, Luisa Lazaro, Jason P. Lerch, Klaus-Peter Lesch, Mario R. Louza, Beatriz Luna, Paulo Mattos, Jane McGrath, Filippo Muratori, Clodagh Murphy, Joel T. Nigg, Eileen Oberwelland-Weiss, Ruth L. O'Gorman Tuura, Kirsten O'Hearn, Jaap Oosterlaan, Mara Parellada, Paul Pauli, Kerstin J. Plessen, J. Antoni Ramos-Quiroga, Andreas Reif, Liesbeth Reneman, Alessandra Retico, Pedro G. P. Rosa, Katya Rubia, Philip Shaw, Tim J. Silk, Leanne Tamm, Oscar Vilarroya, Susanne Walitza, Neda Jahanshad, Stephen Faraone, Clyde Francks, Odile A. van den Heuvel, Tomas Paus, Paul M. Thompson, Jan K. Buitelaar, Barbara Franke
Summary: Neuroimaging has been extensively used to study brain structure and function in individuals with ADHD and ASD. However, there have been limitations in the current literature, such as small sample sizes and heterogeneous methods. To address these limitations, the ENIGMA-ADHD and ENIGMA-ASD working groups were established to collaborate on large-scale neuroimaging projects. The findings so far have shown overlap and unique differences in cortical structures between ASD and ADHD. Ongoing work is exploring other research questions.
HUMAN BRAIN MAPPING
(2022)
Review
Clinical Neurology
Francesca A. Cupaioli, Fabio A. Zucca, Cinzia Caporale, Klaus-Peter Lesch, Luca Passamonti, Luigi Zecca
Summary: In modern societies, efforts are being made to improve the quality of life by better understanding the brain's influence on aggression. Neurobiological research shows that changes in specific brain regions are related to aggression, and genetic and environmental factors also play a significant role in aggressiveness.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2021)
Article
Psychiatry
Yash Patel, Nadine Parker, Jean Shin, Derek Howard, Leon French, Sophia I. Thomopoulos, Elena Pozzi, Yoshinari Abe, Christoph Abe, Alan Anticevic, Martin Alda, Andre Aleman, Clara Alloza, Silvia Alonso-Lana, Stephanie H. Ameis, Evdokia Anagnostou, Andrew A. McIntosh, Celso Arango, Paul D. Arnold, Philip Asherson, Francesca Assogna, Guillaume Auzias, Rosa Ayesa-Arriola, Geor Bakker, Nerisa Banaj, Tobias Banaschewski, Cibele E. Bandeira, Alexandr Baranov, Nuria Bargallo, Claiton H. D. Bau, Sarah Baumeister, Bernhard T. Baune, Mark A. Bellgrove, Francesco Benedetti, Alessandro Bertolino, Premika S. W. Boedhoe, Marco Boks, Irene Bollettini, Caterina del Mar Bonnin, Tiana Borgers, Stefan Borgwardt, Daniel Brandeis, Brian P. Brennan, Jason M. Bruggemann, Robin Bulow, Geraldo F. Busatto, Sara Calderoni, Vince D. Calhoun, Rosa Calvo, Erick J. Canales-Rodriguez, Dara M. Cannon, Vaughan J. Carr, Nicola Cascella, Mara Cercignani, Tiffany M. Chaim-Avancini, Anastasia Christakou, David Coghill, Annette Conzelmann, Benedicto Crespo-Facorro, Ana I. Cubillo, Kathryn R. Cullen, Renata B. Cupertino, Eileen Daly, Udo Dannlowski, Christopher G. Davey, Damiaan Denys, Christine Deruelle, Annabella Di Giorgio, Erin W. Dickie, Danai Dima, Katharina Dohm, Stefan Ehrlich, Benjamin A. Ely, Tracy Erwin-Grabner, Thomas Ethofer, Damien A. Fair, Andreas J. Fallgatter, Stephen V. Faraone, Mar Fatjo-Vilas, Jennifer M. Fedor, Kate D. Fitzgerald, Judith M. Ford, Thomas Frodl, Cynthia H. Y. Fu, Janice M. Fullerton, Matt C. Gabel, David C. Glahn, Gloria Roberts, Tinatin Gogberashvili, Jose M. Goikolea, Ian H. Gotlib, Roberto Goya-Maldonado, Hans J. Grabe, Melissa J. Green, Eugenio H. Grevet, Nynke A. Groenewold, Dominik Grotegerd, Oliver Gruber, Patricia Gruner, Amalia Guerrero-Pedraza, Raquel E. Gur, Ruben C. Gur, Shlomi Haar, Bartholomeus C. M. Haarman, Jan Haavik, Tim Hahn, Tomas Hajek, Benjamin J. Harrison, Neil A. Harrison, Catharina A. Hartman, Heather C. Whalley, Dirk J. Heslenfeld, Derrek P. Hibar, Eva Hilland, Yoshiyuki Hirano, Tiffany C. Ho, Pieter J. Hoekstra, Liesbeth Hoekstra, Sarah Hohmann, L. E. Hong, Cyril Hoschl, Marie F. Hovik, Fleur M. Howells, Igor Nenadic, Maria Jalbrzikowski, Anthony C. James, Joost Janssen, Fern Jaspers-Fayer, Jian Xu, Rune Jonassen, Georgii Karkashadze, Joseph A. King, Tilo Kircher, Matthias Kirschner, Kathrin Koch, Peter Kochunov, Gregor Kohls, Kerstin Konrad, Bernd Kramer, Axel Krug, Jonna Kuntsi, Jun Soo Kwon, Mikael Landen, Nils I. Landro, Luisa Lazaro, Irina S. Lebedeva, Elisabeth J. Leehr, Sara Lera-Miguel, Klaus-Peter Lesch, Christine Lochner, Mario R. Louza, Beatriz Luna, Astri J. Lundervold, Frank P. MacMaster, Luigi A. Maglanoc, Charles B. Malpas, Maria J. Portella, Rachel Marsh, Fiona M. Martyn, David Mataix-Cols, Daniel H. Mathalon, Hazel McCarthy, Colm McDonald, Genevieve McPhilemy, Susanne Meinert, Jose M. Menchon, Luciano Minuzzi, Philip B. Mitchell, Carmen Moreno, Pedro Morgado, Filippo Muratori, Clodagh M. Murphy, Declan Murphy, Benson Mwangi, Leila Nabulsi, Akiko Nakagawa, Takashi Nakamae, Leyla Namazova, Janardhanan Narayanaswamy, Neda Jahanshad, Danai D. Nguyen, Rosa Nicolau, Ruth L. O'Gorman Tuura, Kirsten O'Hearn, Jaap Oosterlaan, Nils Opel, Roel A. Ophoff, Bob Oranje, Victor Ortiz Garcia de la Foz, Bronwyn J. Overs, Yannis Paloyelis, Christos Pantelis, Mara Parellada, Paul Pauli, Maria Pico-Perez, Felipe A. Picon, Fabrizio Piras, Federica Piras, Kerstin J. Plessen, Edith Pomarol-Clotet, Adrian Preda, Olga Puig, Yann Quide, Joaquim Radua, J. Antoni Ramos-Quiroga, Paul E. Rasser, Lisa Rauer, Janardhan Reddy, Ronny Redlich, Andreas Reif, Liesbeth Reneman, Jonathan Repple, Alessandra Retico, Vanesa Richarte, Anja Richter, Pedro G. P. Rosa, Katya K. Rubia, Ryota Hashimoto, Matthew D. Sacchet, Raymond Salvador, Javier Santonja, Kelvin Sarink, Salvador Sarro, Theodore D. Satterthwaite, Akira Sawa, Ulrich Schall, Peter R. Schofield, Anouk Schrantee, Jochen Seitz, Mauricio H. Serpa, Esther Setien-Suero, Philip Shaw, Devon Shook, Tim J. Silk, Kang Sim, Schmitt Simon, Helen Blair Simpson, Aditya Singh, Antonin Skoch, Norbert Skokauskas, Jair C. Soares, Noam Soreni, Carles Soriano-Mas, Gianfranco Spalletta, Filip Spaniel, Stephen M. Lawrie, Emily R. Stern, S. Evelyn Stewart, Yoichiro Takayanagi, Henk S. Temmingh, David F. Tolin, David Tomecek, Diana Tordesillas-Gutierrez, Michela Tosetti, Anne Uhlmann, Therese van Amelsvoort, Nic J. A. van der Wee, Steven J. A. van der Werff, Neeltje E. M. van Haren, Guido A. van Wingen, Alasdair Vance, Javier Vazquez-Bourgon, Daniela Vecchio, Ganesan Venkatasubramanian, Eduard Vieta, Oscar Vilarroya, Yolanda Vives-Gilabert, Aristotle N. Voineskos, Henry Volzke, Georg G. von Polier, Esther Walton, Thomas W. Weickert, Cynthia Shannon Weickert, Andrea S. Weideman, Katharina Wittfeld, Daniel H. Wolf, Mon-Ju Wu, T. T. Yang, Kun Yang, Yuliya Yoncheva, Je-Yeon Yun, Yuqi Cheng, Marcus V. Zanetti, Georg C. Ziegler, Barbara Franke, Martine Hoogman, Jan K. Buitelaar, Daan van Rooij, Ole A. Andreassen, Christopher R. K. Ching, Dick J. Veltman, Lianne Schmaal, Dan J. Stein, Odile A. van den Heuvel, Jessica A. Turner, Theo G. M. van Erp, Zdenka Pausova, Paul M. Thompson, Tomas Paus
Summary: The study identified shared neurobiological processes associated with differences in cortical thickness among multiple psychiatric disorders, suggesting a common role of prenatal development and postnatal functioning of the cerebral cortex. The analysis of data from 145 cohorts revealed that greater expression of genes specific to pyramidal cells was associated with greater group differences in cortical thickness across all 6 disorders.
Article
Neurosciences
Danai Dima, Amirhossein Modabbernia, Efstathios Papachristou, Gaelle E. Doucet, Ingrid Agartz, Moji Aghajani, Theophilus N. Akudjedu, Anton Albajes-Eizagirre, Dag Alnaes, Kathryn Alpert, Micael Andersson, Nancy C. Andreasen, Ole A. Andreassen, Philip Asherson, Tobias Banaschewski, Nuria Bargallo, Sarah Baumeister, Ramona Baur-Streubel, Alessandro Bertolino, Aurora Bonvino, Dorret Boomsma, Stefan Borgwardt, Josiane Bourque, Daniel Brandeis, Alan Breier, Henry Brodaty, Rachel M. Brouwer, Jan K. Buitelaar, Geraldo F. Busatto, Randy L. Buckner, Vincent Calhoun, Erick J. Canales-Rodriguez, Dara M. Cannon, Xavier Caseras, Francisco X. Castellanos, Simon Cervenka, Tiffany M. Chaim-Avancini, Christopher R. K. Ching, Victoria Chubar, Vincent P. Clark, Patricia Conrod, Annette Conzelmann, Benedicto Crespo-Facorro, Fabrice Crivello, Eveline A. Crone, Anders M. Dale, Cristopher Davey, Eco J. C. de Geus, Lieuwe de Haan, Greig de Zubicaray, Anouk den Braber, Erin W. Dickie, Annabella Di Giorgio, Nhat Trung Doan, Erlend S. Dorum, Stefan Ehrlich, Susanne Erk, Thomas Espeseth, Helena Fatouros-Bergman, Simon E. Fisher, Jean-Paul Fouche, Barbara Franke, Thomas Frodl, Paola Fuentes-Claramonte, David C. Glahn, Ian H. Gotlib, Hans-Joergen Grabe, Oliver Grimm, Nynke A. Groenewold, Dominik Grotegerd, Oliver Gruber, Patricia Gruner, Rachel E. Gur, Ruben C. Gur, Ben J. Harrison, Catharine A. Hartman, Sean N. Hatton, Andreas Heinz, Dirk J. Heslenfeld, Derrek P. Hibar, Ian B. Hickie, Beng-Choon Ho, Pieter J. Hoekstra, Sarah Hohmann, Avram J. Holmes, Martine Hoogman, Norbert Hosten, Fleur M. Howells, Hilleke E. Hulshoff Pol, Chaim Huyser, Neda Jahanshad, Anthony James, Terry L. Jernigan, Jiyang Jiang, Erik G. Jonsson, John A. Joska, Rene Kahn, Andrew Kalnin, Ryota Kanai, Marieke Klein, Tatyana P. Klyushnik, Laura Koenders, Sanne Koops, Bernd Kraemer, Jonna Kuntsi, Jim Lagopoulos, Luisa Lazaro, Irina Lebedeva, Won Hee Lee, Klaus-Peter Lesch, Christine Lochner, Marise W. J. Machielsen, Sophie Maingault, Nicholas G. Martin, Ignacio Martinez-Zalacain, David Mataix-Cols, Bernard Mazoyer, Colm McDonald, Brenna C. McDonald, Andrew M. McIntosh, Katie L. McMahon, Genevieve McPhilemy, Jose M. Menchon, Sarah E. Medland, Andreas Meyer-Lindenberg, Jilly Naaijen, Pablo Najt, Tomohiro Nakao, Jan E. Nordvik, Lars Nyberg, Jaap Oosterlaan, Victor Ortiz-Garcia De la Foz, Yannis Paloyelis, Paul Pauli, Giulio Pergola, Edith Pomarol-Clotet, Maria J. Portella, Steven G. Potkin, Joaquim Radua, Andreas Reif, Daniel A. Rinker, Joshua L. Roffman, Pedro G. P. Rosa, Matthew D. Sacchet, Perminder S. Sachdev, Raymond Salvador, Pascual Sanchez-Juan, Salvador Sarro, Theodore D. Satterthwaite, Andrew J. Saykin, Mauricio H. Serpa, Lianne Schmaal, Knut Schnell, Gunter Schumann, Kang Sim, Jordan W. Smoller, Iris Sommer, Carles Soriano-Mas, Dan J. Stein, Lachlan T. Strike, Suzanne C. Swagerman, Christian K. Tamnes, Henk S. Temmingh, Sophia Thomopoulos, Alexander S. Tomyshev, Diana Tordesillas-Gutierrez, Julian N. Trollor, Jessica A. Turner, Anne Uhlmann, Odile A. van den Heuvel, Dennis van den Meer, Nic J. A. van der Wee, Neeltje E. M. van Haren, Dennis Van't Ent, Theo G. M. van Erp, Ilya M. Veer, Dick J. Veltman, Aristotle Voineskos, Henry Voelzke, Henrik Walter, Esther Walton, Lei Wang, Yang Wang, Thomas H. Wassink, Bernd Weber, Wei Wen, John D. West, Lars T. Westlye, Heather Whalley, Lara M. Wierenga, Steven C. R. Williams, Katharina Wittfeld, Daniel H. Wolf, Amanda Worker, Margaret J. Wright, Kun Yang, Yulyia Yoncheva, Marcus Zanetti, Georg C. Ziegler, Paul M. Thompson, Sophia Frangou
Summary: Age has a significant impact on brain volume, with different regions showing varying trajectories. Basal ganglia volume decreases with age, while lateral ventricles continue to enlarge. These findings provide important insights into the functional significance of age-related morphometric patterns in the brain.
HUMAN BRAIN MAPPING
(2022)
Article
Neurosciences
Sophia Frangou, Amirhossein Modabbernia, Steven C. R. Williams, Efstathios Papachristou, Gaelle E. Doucet, Ingrid Agartz, Moji Aghajani, Theophilus N. Akudjedu, Anton Albajes-Eizagirre, Dag Alnaes, Kathryn Alpert, Micael Andersson, Nancy C. Andreasen, Ole A. Andreassen, Philip Asherson, Tobias Banaschewski, Nuria Bargallo, Sarah Baumeister, Ramona Baur-Streubel, Alessandro Bertolino, Aurora Bonvino, Dorret Boomsma, Stefan Borgwardt, Josiane Bourque, Daniel Brandeis, Alan Breier, Henry Brodaty, Rachel M. Brouwer, Jan K. Buitelaar, Geraldo F. Busatto, Randy L. Buckner, Vincent Calhoun, Erick J. Canales-Rodriguez, Dara M. Cannon, Xavier Caseras, Francisco X. Castellanos, Simon Cervenka, Tiffany M. Chaim-Avancini, Christopher R. K. Ching, Victoria Chubar, Vincent P. Clark, Patricia Conrod, Annette Conzelmann, Benedicto Crespo-Facorro, Fabrice Crivello, Eveline A. Crone, Anders M. Dale, Christopher Davey, Eco J. C. de Geus, Lieuwe de Haan, Greig de Zubicaray, Anouk den Braber, Erin W. Dickie, Annabella Di Giorgio, Nhat Trung Doan, Erlend S. Dorum, Stefan Ehrlich, Susanne Erk, Thomas Espeseth, Helena Fatouros-Bergman, Simon E. Fisher, Jean-Paul Fouche, Barbara Franke, Thomas Frodl, Paola Fuentes-Claramonte, David C. Glahn, Ian H. Gotlib, Hans-Joergen Grabe, Oliver Grimm, Nynke A. Groenewold, Dominik Grotegerd, Oliver Gruber, Patricia Gruner, Rachel E. Gur, Ruben C. Gur, Ben J. Harrison, Catharine A. Hartman, Sean N. Hatton, Andreas Heinz, Dirk J. Heslenfeld, Derrek P. Hibar, Ian B. Hickie, Beng-Choon Ho, Pieter J. Hoekstra, Sarah Hohmann, Avram J. Holmes, Martine Hoogman, Norbert Hosten, Fleur M. Howells, Hilleke E. Hulshoff Pol, Chaim Huyser, Neda Jahanshad, Anthony James, Terry L. Jernigan, Jiyang Jiang, Erik G. Jonsson, John A. Joska, Rene Kahn, Andrew Kalnin, Ryota Kanai, Marieke Klein, Tatyana P. Klyushnik, Laura Koenders, Sanne Koops, Bernd Kraemer, Jonna Kuntsi, Jim Lagopoulos, Luisa Lazaro, Irina Lebedeva, Won Hee Lee, Klaus-Peter Lesch, Christine Lochner, Marise W. J. Machielsen, Sophie Maingault, Nicholas G. Martin, Ignacio Martinez-Zalacain, David Mataix-Cols, Bernard Mazoyer, Colm McDonald, Brenna C. McDonald, Andrew M. McIntosh, Katie L. McMahon, Genevieve McPhilemy, Jose M. Menchon, Sarah E. Medland, Andreas Meyer-Lindenberg, Jilly Naaijen, Pablo Najt, Tomohiro Nakao, Jan E. Nordvik, Lars Nyberg, Jaap Oosterlaan, Victor Ortiz-Garcia de la Foz, Yannis Paloyelis, Paul Pauli, Giulio Pergola, Edith Pomarol-Clotet, Maria J. Portella, Steven G. Potkin, Joaquim Radua, Andreas Reif, Daniel A. Rinker, Joshua L. Roffman, Pedro G. P. Rosa, Matthew D. Sacchet, Perminder S. Sachdev, Raymond Salvador, Pascual Sanchez-Juan, Salvador Sarro, Theodore D. Satterthwaite, Andrew J. Saykin, Mauricio H. Serpa, Lianne Schmaal, Knut Schnell, Gunter Schumann, Kang Sim, Jordan W. Smoller, Iris Sommer, Carles Soriano-Mas, Dan J. Stein, Lachlan T. Strike, Suzanne C. Swagerman, Christian K. Tamnes, Henk S. Temmingh, Sophia Thomopoulos, Alexander S. Tomyshev, Diana Tordesillas-Gutierrez, Julian N. Trollor, Jessica A. Turner, Anne Uhlmann, Odile A. van den Heuvel, Dennis van den Meer, Nic J. A. van der Wee, Neeltje E. M. van Haren, Dennis van't Ent, Theo G. M. van Erp, Ilya M. Veer, Dick J. Veltman, Aristotle Voineskos, Henry Voelzke, Henrik Walter, Esther Walton, Lei Wang, Yang Wang, Thomas H. Wassink, Bernd Weber, Wei Wen, John D. West, Lars T. Westlye, Heather Whalley, Lara M. Wierenga, Katharina Wittfeld, Daniel H. Wolf, Amanda Worker, Margaret J. Wright, Kun Yang, Yulyia Yoncheva, Marcus Zanetti, Georg C. Ziegler, Paul M. Thompson, Danai Dima
Summary: The study used data from the ENIGMA Consortium to explore the relationship between age and cortical thickness, finding that most regions peak in cortical thickness during childhood, with a negative association between age and cortical thickness where the slope is steeper before the age of 30 and more gradual afterwards.
HUMAN BRAIN MAPPING
(2022)
Article
Biochemistry & Molecular Biology
Britt Mossink, Jon-Ruben Van Rhijn, Shan Wang, Katrin Linda, Maria R. Vitale, Johanna E. M. Zoller, Eline J. H. van Hugte, Jitske Bak, Anouk H. A. Verboven, Martijn Selten, Moritz Negwer, Brooke L. Latour, Ilse van der Werf, Jason M. Keller, Teun M. Klein Gunnewiek, Chantal Schoenmaker, Astrid Oudakker, Alessia Anania, Sophie Jansen, Klaus-Peter Lesch, Monica Frega, Hans van Bokhoven, Dirk Schubert, Nael Nadif Kasri
Summary: This study revealed the regulatory role of CDH13 in inhibitory synapse function by establishing a human neuronal model. By culturing iGABAs in vitro, we found that CDH13 deficiency increases inhibition, thereby reducing the excitatory/inhibitory balance. Through these findings, we identified a potential mechanism by which CDH13 may contribute to the pathophysiology of brain disorders.
MOLECULAR PSYCHIATRY
(2022)
Article
Neurosciences
Judith Schweimer, Julia T. Brouard, Yan Li, Connie Sanchez, Trevor Sharp
Summary: The study found that vortioxetine inhibits 5-HT3R-INs and excites pyramidal neurons, thereby changing the balance between excitatory and inhibitory activity in the cortex.
EUROPEAN JOURNAL OF NEUROSCIENCE
(2022)
Meeting Abstract
Clinical Neurology
Ditte Demontis, Jinjie Duan, Frederick Satterstrom, Leila Farajzadeh, Jakob Grove, Klaus-Peter Lesch, Thomas Werge, Merete Nordentoft, Preben Bo Mortensen, Barbara Franke, David Hougaard, Andreas Reif, Mark Daly, Benjamin Neale, Anders Borglum
EUROPEAN NEUROPSYCHOPHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Tatyana Strekalova, Dmitrii Pavlov, Alexander Trofimov, Daniel C. Anthony, Andrei Svistunov, Andrey Proshin, Aleksei Umriukhin, Alexei Lyundup, Klaus-Peter Lesch, Raymond Cespuglio
Summary: The role of hippocampal cyclooxygenase-2 (COX-2) in stress-induced anhedonia has been investigated. Inhibition of COX-2 in the hippocampus has antidepressant effects.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Neurosciences
Tatyana Strekalova, Yanzhi Liu, Daniel Kiselev, Sharafuddin Khairuddin, Jennifer Lok Yu Chiu, Justin Lam, Ying-Shing Chan, Dmitrii Pavlov, Andrey Proshin, Klaus-Peter Lesch, Daniel C. Anthony, Lee Wei Lim
Summary: The Chronic Mild Stress (CMS) paradigm is a widely used model for finding antidepressant drugs for Major Depressive Disorder (MDD). While literature analysis supports the validity of this model, further improvements could be achieved by stratifying animals, using refined experimental protocols, and systematically evaluating non-specific effects.
PSYCHOPHARMACOLOGY
(2022)
Article
Cell & Tissue Engineering
Georg C. Ziegler, Franziska Radtke, Maria Rosaria Vitale, Andre Preusse, Eva Klopocki, Stefan Herms, Klaus-Peter Lesch
Summary: In this study, peripheral blood mononuclear cells from carriers of SLC2A3 copy number variants were successfully reprogrammed into iPSCs and transgene-free cell clones were generated, which showed high expression of pluripotency genes, the ability to differentiate into cells of all three germ layers, and a normal karyotype. These cell lines will be useful for elucidating the role of metabolic alterations in shared pathophysiological processes across organ boundaries.
STEM CELL RESEARCH
(2021)
Article
Psychiatry
Teresa M. Luffe, Andrea D'Orazio, Moritz Bauer, Zoi Gioga, Victoria Schoeffler, Klaus-Peter Lesch, Marcel Romanos, Carsten Drepper, Christina Lillesaar
Summary: Recent advancements in the genetics of neurodevelopmental disorders have identified the transcription factor FOXP2 as a potential risk gene, with its function suggested to be involved in GABAergic signaling that may affect the behavioral phenotypes commonly observed in NDDs. Further research indicates that Foxp2 may regulate locomotor activity via GABAergic signaling, shedding light on potential targetable mechanisms for understanding and treating NDDs.
TRANSLATIONAL PSYCHIATRY
(2021)
Article
Genetics & Heredity
Noelia Fernandez-Castillo, Judit Cabana-Dominguez, Djenifer B. Kappel, Barbara Torrico, Heike Weber, Klaus-Peter Lesch, Oscar Lao, Andreas Reif, Bru Cormand
Summary: By studying genes related to Mendelian disorders presenting with ADHD symptoms, we identified new candidate risk genes for ADHD that are mainly associated with neurodevelopment and brain function. We also found rare variants associated with the severity of inattention symptoms and identified common variants associated with ADHD and its comorbidities.
Article
Genetics & Heredity
Andrew D. Grotzinger, Travis T. Mallard, Wonuola A. Akingbuwa, Hill F. Ip, Mark J. Adams, Cathryn M. Lewis, Andrew M. McIntosh, Jakob Grove, Soren Dalsgaard, Klaus-Peter Lesch, Nora Strom, Sandra M. Meier, Manuel Mattheisen, Anders D. Borglum, Ole Mors, Gerome Breen, Phil H. Lee, Kenneth S. Kendler, Jordan W. Smoller, Elliot M. Tucker-Drob, Michel G. Nivard
Summary: A joint analysis of 11 major psychiatric disorders identified four broad factors underlying the genetic correlations among the disorders, along with multiple loci acting on these factors. These findings suggest the presence of genetic overlap among different psychiatric disorders, but also highlight the heterogeneity within each factor. However, a single dimension of genetic risk does not appear to be useful in explaining the biobehavioral correlates or individual variants of psychiatric disorders.
Article
Cell Biology
Evgeniy Svirin, Ekaterina Veniaminova, Joao Pedro Costa-Nunes, Anna Gorlova, Aleksei Umriukhin, Allan Kalueff, Andrey Proshin, Daniel C. Anthony, Andrey Nedorubov, Anna Chung Kwan Tse, Susanne Walitza, Lee Wei Lim, Klaus-Peter Lesch, Tatyana Strekalova
Summary: The interaction between brain serotonin deficiency and environmental adversity leads to excessive aggression in females. Complete inactivation of the gene encoding tryptophan hydroxylase-2 results in the absence of neuronal serotonin synthesis and aggression in male and female mice. Moderate reduction in brain serotonin levels and exposure to stress also lead to increased aggression in male mice. Furthermore, changes in gene expression and myelination-related processes may underlie the molecular mechanisms of aggressive behavior.