Review
Biochemistry & Molecular Biology
Victoria Campos-Pena, Pavel Pichardo-Rojas, Talia Sanchez-Barbosa, Emma Ortiz-Islas, Citlali Ekaterina Rodriguez-Perez, Pedro Montes, Gerardo Ramos-Palacios, Daniela Silva-Adaya, Rafael Valencia-Quintana, Jorge Francisco Cerna-Cortes, Danira Toral-Rios
Summary: The presence of insoluble aggregates of amyloid beta (A beta) in the brain is a hallmark of Alzheimer's disease, and it has been shown to contribute to extensive neuronal loss. The distribution and content of cholesterol in the membrane play an important role in the production and accumulation of A beta peptides, leading to dysfunction and neuronal death. The monomeric forms of A beta peptides can trigger changes in Tau phosphorylation and cognitive function through their internalization by specific receptors.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Neurosciences
Vladimir Rudajev, Jiri Novotny
Summary: Alzheimer's disease is a neurodegenerative disorder characterized by the production and aggregation of amyloid beta, which leads to cell membrane disruption and cell death. Cholesterol, as a major component of cell membranes, plays a significant role in the progression of AD, although its effects are inconsistent.
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2022)
Review
Cell Biology
Adriana Limone, Iolanda Veneruso, Valeria D'Argenio, Daniela Sarnataro
Summary: Genetic studies support the amyloid cascade as the leading hypothesis for the pathogenesis of Alzheimer's disease (AD). Recent genetic advances have identified numerous risk genes associated with late-onset AD, including genes related to intracellular endosomal trafficking.
JOURNAL OF CELLULAR PHYSIOLOGY
(2022)
Article
Pharmacology & Pharmacy
Liyuan Tao, Miaoyang Hu, Xiaobao Zhang, Xi Wang, Yujuan Zhang, Xufeng Chen, Jinrong Tang, Jun Wang
Summary: This study revealed that Meth significantly impacted the ingestion and accumulation of Aβ(42) in microglia and led to impaired degradation of Aβ, promoting Aβ(42) spreading through the exosomal pathway.
TOXICOLOGY AND APPLIED PHARMACOLOGY
(2022)
Article
Chemistry, Physical
Asra Nasir Khan, Kundlik Gadhave, Mohammad Furkan, Prateek Kumar, Mohammad Khursheed Siddiqi, Rajanish Giri, Rizwan Hasan Khan
Summary: Thionamide antibiotics prothionamide and ethionamide could effectively inhibit amyloid formation of human insulin and A beta 42, and protect neuroblastoma cells from the toxic effects of amyloids. These drugs exert their anti-amyloid potency by stabilizing proteins in their native state and also possess antioxidant properties.
JOURNAL OF MOLECULAR LIQUIDS
(2021)
Article
Biochemistry & Molecular Biology
Jiang Chen, Anran Fan, Song Li, Yan Xiao, Yanlin Fu, Jun-Sheng Chen, Dan Zi, Ling-Hui Zeng, Jun Tan
Summary: Alzheimer's disease (AD), the most common type of dementia, is characterized by the presence of extracellular senile plaques composed of beta-amyloid peptides and intracellular neurofibrillary tangles containing phosphorylated-tau protein. This study has demonstrated the interaction between soluble tau and the N-terminal of amyloid precursor protein (APP) in vitro and in vivo, as well as the involvement of APP in the cellular uptake of tau through endocytosis. Targeting the pathological interaction between N-terminal APP and tau could be a promising therapeutic strategy for AD.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2023)
Review
Chemistry, Medicinal
Weimin Qiu, Hui Liu, Yijun Liu, Xin Lu, Lei Wang, Yanyu Hu, Feng Feng, Qi Li, Haopeng Sun
Summary: Alzheimer's disease (AD) is a difficult to treat progressive neurodegenerative disease characterized by the accumulation of amyloid beta (A beta) plaques in the brain. A beta interacts with various receptors on the plasma membrane and mediates signaling pathways that contribute to the development of AD. Despite ongoing research, there are currently no effective medications for AD. This review discusses the importance of A beta in the pathogenesis of AD, recent progress in targeting A beta-related receptors and compounds, and the challenges and opportunities in developing effective therapies for AD.
MEDICINAL RESEARCH REVIEWS
(2023)
Review
Biochemistry & Molecular Biology
Anne-Cathrine S. Vogt, Gary T. Jennings, Mona O. Mohsen, Monique Vogel, Martin F. Bachmann
Summary: Alzheimer's disease is the most common form of dementia and is responsible for 60-70% of cases. The number of people with dementia is expected to triple by 2050 due to an aging population. Currently, there are only symptomatic treatments available, making it crucial to develop novel therapeutic strategies to prevent or delay the onset of Alzheimer's disease. This mini-review focuses on the understanding of Alzheimer's disease pathobiology and discusses current immunomodulating therapies targeting amyloid-beta protein.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Neurosciences
Keyoumu Nazere, Tetsuya Takahashi, Naoyuki Hara, Kazuki Muguruma, Masahiro Nakamori, Yu Yamazaki, Hiroyuki Morino, Hirofumi Maruyama
Summary: Intracellular accumulation of oligomerized Aβ is mediated by lipid raft and heparan sulfate proteoglycan, while macropinocytosis is the major endocytic pathway for oligomer-Aβ entry into cells.
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2022)
Review
Biochemistry & Molecular Biology
Lucia Gallego Villarejo, Lisa Bachmann, David Marks, Maite Brachthaeuser, Alexander Geidies, Thorsten Mueller
Summary: Intracellular amyloid beta (iAβ) plays a crucial role in neurodegeneration and serves as a pathological marker. Modulating iAβ through pharmacological treatment has shown beneficial effects on cognitive properties. Future research should focus on the impact of viral infections on iAβ generation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Oh-Hoon Kwon, Yoon Young Cho, Jung Hee Lee, Sungkwon Chung
Summary: The study demonstrated that O-GlcNAcylation of APP can regulate lipid raft-dependent APP endocytosis by translocating APP into non-raft microdomains, offering new insight into the mechanism of Aβ production.
Review
Biochemistry & Molecular Biology
Elena Tamagno, Michela Guglielmotto, Valeria Vasciaveo, Massimo Tabaton
Summary: The pathogenesis of Alzheimer's disease involves the accumulation of beta amyloid and vulnerability of the brain to oxidative stress, which are linked to each other. It is difficult to determine which comes first, Aβ or oxidative stress. Evidence suggests that oxidative stress occurs early in the development of Alzheimer's disease and plays a crucial role in the manifestation of clinical and pathological symptoms.
Review
Biochemistry & Molecular Biology
Yuanxin Zhao, Buhan Liu, Jian Wang, Long Xu, Sihang Yu, Jiaying Fu, Xiaoyu Yan, Jing Su
Summary: Neuroinflammation mediated by microglia is a common feature in neurodegenerative diseases. The accumulation of Aβ and tau proteins can disrupt the metabolism of microglia, leading to neuroinflammation.
Article
Clinical Neurology
Stephen Zicha, Randall J. Bateman, Leslie M. Shaw, Henrik Zetterberg, Anthony W. Bannon, Wesley A. Horton, Mike Baratta, Hartmuth C. Kolb, Iwona Dobler, Yulia Mordashova, Ziad S. Saad, David L. Raunig, Emmanouil (Manos) Spanakis, Yan Li, Suzanne E. Schindler, Kyle Ferber, Carrie E. Rubel, Robert L. Martone, Christopher J. Weber, Rebecca M. Edelmayer, Emily A. Meyers, James G. Bollinger, Erin G. Rosenbaugh, William Z. Potter
Summary: This study evaluated the performance of six plasma A beta assays in predicting amyloid positivity compared to age and APOE genotype. The results showed that three of the assays significantly improved the prediction accuracy, and plasma A beta 42/40 predicted amyloid PET status better than A beta 42 or A beta 40 alone.
ALZHEIMERS & DEMENTIA
(2023)
Review
Biochemistry & Molecular Biology
Bibiana C. Mota, Magdalena Sastre
Summary: PGC1 alpha plays a crucial role in neurodegenerative disorders, especially in Alzheimer's disease. Overexpression of PGC1 alpha can reduce A beta generation, potentially serving as a novel therapeutic avenue for AD.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Balasubramaniam Annamalai, Je-Seong Won, Seungho Choi, Inderjit Singh, Avtar K. Singh
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2015)
Article
Neurosciences
Je-Seong Won, Balasubramaniam Annamalai, Seungho Choi, Inderjit Singh, Autar K. Singh
Article
Biochemistry & Molecular Biology
Kolanjiappan Kaliyaperuma, Anand K. Sharma, Daniel G. McDonald, Jasdeep S. Dhindsa, Caroline Yount, Avtar K. Singh, Je-Seong Won, Inderjit Singh
Review
Neurosciences
Je-Seong Won, Avtar K. Singh, Inderjit Singh
JOURNAL OF NEUROSCIENCE RESEARCH
(2016)
Article
Biochemistry & Molecular Biology
Jinsu Kim, Seungho Choi, Nishant Saxena, Avtar K. Singh, Inderjit Singh, Je-Seong Won
FREE RADICAL BIOLOGY AND MEDICINE
(2017)
Article
Biochemistry & Molecular Biology
Nishant Saxena, Jeseong Won, Seungho Choi, Avtar K. Singh, Inderjit Singh
FREE RADICAL BIOLOGY AND MEDICINE
(2018)
Article
Immunology
Inderjit Singh, Devadoss J. Samuvel, Seungho Choi, Nishant Saxena, Avtar K. Singh, Jeseong Won
Article
Neurosciences
Seungho Choi, Je-Seong Won, Steven L. Carroll, Balasubramaniam Annamalai, Inderjit Singh, Avtar K. Singh
Article
Biochemistry & Molecular Biology
Jinsu Kim, Je-Seong Won, Avtar K. Singh, Anand K. Sharma, Inderjit Singh
ANTIOXIDANTS & REDOX SIGNALING
(2014)
Article
Neurosciences
Je-Seong Won, Jinsu Kim, Manjeet Kaur Paintlia, Inderjit Singh, Avtar K. Singh
Article
Neurosciences
Je-Seong Won, Jinsu Kim, Balasubramaniam Annamalai, Anandakumar Shunmugavel, Inderjit Singh, Avtar K. Singh
JOURNAL OF ALZHEIMERS DISEASE
(2013)
Article
Biochemistry & Molecular Biology
Seungho Choi, Nishant Saxena, Tajinder Dhammu, Mushfiquddin Khan, Avtar K. Singh, Inderjit Singh, Jeseong Won
NITRIC OXIDE-BIOLOGY AND CHEMISTRY
(2019)
Article
Neurosciences
Mushfiquddin Khan, Pavan Kumar, Fei Qiao, S. M. Touhidul Islam, Avtar K. Singh, Je-Seong Won, Wayne Feng, Inderjit Singh
Article
Neurosciences
S. M. Touhidul Islam, Jeseong Won, Judong Kim, Fei Qiao, Avtar K. Singh, Mushfiquddin Khan, Inderjit Singh
Summary: This study demonstrates the therapeutic efficacy of ALDH2-agonist Alda-1 in alleviating EAE disease by detoxifying reactive aldehydes, suggesting Alda-1 as a potential therapeutic intervention for MS.
Review
Immunology
S. M. Touhidul Islam, Jeseong Won, Mushfiquddin Khan, Mark D. Mannie, Inderjit Singh
Summary: HIF-1 plays a crucial role in autoimmune diseases by regulating the balance of Th17/T-reg/Tr1 cells and promoting the expression of anti-inflammatory cytokines. It also controls the activation of immune cells such as macrophages, neutrophils, and dendritic cells, influencing the development of effector/regulatory T cells in the inflammatory lesions.
Article
Biochemistry & Molecular Biology
Pei-Yang Gao, Ya-Nan Ou, Yi-Ming Huang, Zhi-Bo Wang, Yan Fu, Ya-Hui Ma, Qiong-Yao Li, Li-Yun Ma, Rui-Ping Cui, Yin-Chu Mi, Lan Tan, Jin-Tai Yu
Summary: Liver function may play a role in the progression of Alzheimer's disease. The study found that as AD progressed, certain liver function markers increased while others decreased. The relationship between liver function and CSF AD biomarkers indicates a potential mediation effect on cognition.
JOURNAL OF NEUROCHEMISTRY
(2024)