Article
Biochemistry & Molecular Biology
Feng Tang, Feng-Ping Li, Xue-Tao Huang, Guo-Hua Wang, Ze-Fen Wang, Zhi-Qiang Li
Summary: In this study, the interaction between glioma-associated endothelial cells (GAEs) and glioma cells was explored. It was found that different subtypes of glioma had different abundance of GAEs, with high GAE abundance associated with poor prognosis in glioma patients. GAEs were found to promote glioma cell invasion, and this effect was partially abolished by anti-vascular endothelial growth factor (VEGF) therapy. The upregulation of IL-2 expression in GAEs after anti-VEGF therapy inhibited GAE-induced glioma cell invasion.
JOURNAL OF MOLECULAR NEUROSCIENCE
(2023)
Article
Oncology
Chenlu Wu, Jiafei Ying, Mei Dai, Jing Peng, Danhua Zhang
Summary: The study found that DDR2 and IFITM1 are highly expressed in breast cancer and are associated with poor clinical outcomes and patient survival. Knockdown of DDR2 or IFITM1 can inhibit the viability and invasiveness of breast cancer cells and restrict tumor growth. Simultaneous knockdown of IFITM1 and DDR2 can more effectively suppress breast cancer development.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Waleed A. Badawi, Mohamed Samir, Hazem M. Fathy, Tarek M. Okda, Mohamed H. Noureldin, Gamal M. K. Atwa, Omaima M. AboulWafa
Summary: This study focused on the signaling pathway of adenosine diphosphate receptor α1 in lingual osteoblasts and found that hydrazine methyl isoindole has selectivity towards adenosine diphosphate receptor α1. Compared to other pathway inhibitors, hydrazine methyl isoindole shows better selectivity. Furthermore, hydrazine methyl isoindole exhibits significant inhibitory effects on the activity and function of adenosine diphosphate receptor α1 in lingual osteoblasts.
BIOORGANIC CHEMISTRY
(2023)
Article
Multidisciplinary Sciences
Jialin Wang, Zhendong Liu, Cheng Zhang, Hongbo Wang, Ang Li, Binfeng Liu, Xiaoyu Lian, Zhishuai Ren, Wang Zhang, Yanbiao Wang, Bo Zhang, Bo Pang, Yanzheng Gao
Summary: High expression of HOXD11 is significantly associated with survival and clinical characteristics of glioma patients, serving as a potential biomarker for targeted therapy and prognostic assessment. Knockout of HOXD11 can inhibit proliferation and invasion of glioma cells, altering cell behavior.
Article
Biochemistry & Molecular Biology
Yuxue Sun, Haiyan Huang, Zhixin Zhan, Haijun Gao, Chaochao Zhang, Jiacheng Lai, Junguo Cao, Chaoyue Li, Yong Chen, Ziqiang Liu
Summary: In this study, it was found that berberine inhibits the migration and invasion of glioma cells by suppressing the TGF-beta 1/COL11A1 pathway and altering actin cytoskeleton arrangement. These findings suggest that berberine could be a promising candidate for the development of anti-glioma drugs.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Article
Endocrinology & Metabolism
Lin Zhao, Mingchao Shang, Xiaofang Hu, Jun Li, Jun Tian, Lianjie Li, Bangqing Yuan
Summary: This study investigated the role and mechanism of LINC01578 in glioma. The results showed that LINC01578 was highly expressed in glioma tissues and cells. Overexpression of LINC01578 promoted the proliferation, invasion, and migration abilities of glioma cells, while inhibiting apoptosis and inducing epithelial-mesenchymal transition. In contrast, inhibition of LINC01578 weakened the survival of glioma cells and increased apoptosis. Therefore, LINC01578 plays an important role in the development of glioma.
JOURNAL OF BIOLOGICAL REGULATORS AND HOMEOSTATIC AGENTS
(2023)
Article
Pharmacology & Pharmacy
Jaroon Wandee, Piyarat Srinontong, Auemduan Prawan, Laddawan Senggunprai, Sarinya Kongpetch, Chavi Yenjai, Veerapol Kukongviriyapan
Summary: Derrischalcone (DC) demonstrated cytotoxic, anti-proliferative, anti-migration, and anti-invasion effects on CCA cells through inducing apoptosis, inhibiting cell proliferation, and suppressing cell migration and invasion by modulating ROS formation and the Akt/mTOR/cyclin D1 and FAK signaling pathways. These findings suggest that DC may be a promising novel treatment strategy for cancer therapy.
NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Zhengjie Wang, Limin Liu, Honglin Dai, Xiaojie Si, Luye Zhang, Erdong Li, Zhang Yang, Gao Chao, Jiaxin Zheng, Yu Ke, Lihong Shan, Qiurong Zhang, Hongmin Liu
Summary: A series of novel 4-aminoquinazoline derivatives containing N-phenylacetamide structure were designed, synthesized and evaluated for antitumor activity against four human cancer cell lines. Compound 19e showed potent antiproliferative activity and targeted H1975 cells via interfering with EGFR-PI3K signaling pathway, inducing apoptosis and inhibiting cell migration and colony formation. This compound has implications for further design of anti-tumor agents.
BIOORGANIC & MEDICINAL CHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Cheng-Hong Hsieh, Tzu-Yuan Wang, Bo-Chen Tung, Hui-Ping Liu, Lien-Te Yeh, Kuo-Chiang Hsu
Summary: Protein hydrolysates from soy protein isolate showed the greatest inhibition of cell growth. The hydrolysates induced cell cycle arrest and apoptosis in HSC-3 cells.
Article
Biochemistry & Molecular Biology
Quoc Anh Ngo, Thuy Hang Nguyen Thi, Minh Quan Pham, Domenico Delfino, Thi Thao Do
Summary: Newly synthesized aryl-substituted pyrazole derivatives showed strong antiproliferative and antiinflammatory activities, with two lead compounds being able to inhibit PGE2 production and suppress cell cycle progression, while only one compound induced apoptosis. Both lead compounds had good docking energies with protein targets COX-2 and tubulin.
MOLECULAR DIVERSITY
(2021)
Article
Oncology
Deshuai Ren, Xiaoyu Zhuang, Yanxin Lv, Yun Zhang, Jiazhi Xu, Fengquan Gao, Dagang Chen, Yu Wang
Summary: This study found that FAM84B is highly expressed in glioma tissues and inhibits the proliferation of glioma cells through regulating the cell cycle pathways.
WORLD JOURNAL OF SURGICAL ONCOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Lu Liu, Yaqiong Kong, Liang He, Xiuxiu Wang, Meng-Meng Wang, Hongjiao Xu, Cai-Guang Yang, Zhi Su, Jing Zhao, Zong-Wan Mao, Yue Huang, Hong-Ke Liu
Summary: This study reported a rhein-based metallo-drug Rh1 that could induce cell death through autophagy, cell cycle arrest, and accumulation of reactive oxygen species (ROS). Rh1 also upregulated the global N-6-methyladenosine (m(6)A) levels in a fat mass- and obesity-associated protein (FTO)-dependent manner. These findings highlight the potential of metal-based agents to target and regulate epitranscriptomics for tumor suppression.
CHINESE JOURNAL OF CHEMISTRY
(2022)
Article
Oncology
Chunhong Wang, Haiyang Su, Rui Cheng, Hongming Ji
Summary: The study demonstrated that high expression of SPAG5 in glioma patients is associated with poor prognosis. Knockdown of SPAG5 can inhibit proliferation, migration, and invasion of glioma cells, promote apoptosis, and is associated with the expression of CDH2.
FRONTIERS IN ONCOLOGY
(2021)
Article
Chemistry, Medicinal
Honglin Dai, Xiaojie Si, Hao Wang, Lingling Chi, Chao Gao, Zhengjie Wang, Limin Liu, Zhuo Qian, Yu Ke, Qiurong Zhang, Hongmin Liu
Summary: A series of novel 4,6,7-substituted quinazoline derivatives were synthesized and evaluated for their anti-proliferative activities against human cancer cell lines. Among these derivatives, compound 22s exhibited the most potent anti-proliferative activity against MGC-803 cells, inhibiting colony formation and migration, inducing apoptosis, and causing cell cycle arrest at the G1-phase. Therefore, compound 22s may be a valuable solution for optimizing anilinoquinazoline-based antineoplastic agents.
MEDICINAL CHEMISTRY RESEARCH
(2022)
Article
Oncology
Xuezhu Chen, Yuhong Li, Chenghai Zuo, Kaiyuan Zhang, Xuejiao Lei, Ju Wang, Yang Yang, Jianmin Zhang, Kang Ma, Shi Wang, Ning Mu, Chuanyan Yang, Jishu Xian, Hua Feng, Rongrui Tang, Tunan Chen
Summary: Research shows that lncRNA H19 promotes proliferation, invasion, and migration of glioma cells through the H19/miR-200a/CDK6/ZEB1 axis, with miR-200a playing a key role in reversing H19-induced malignant behavior. This novel signaling pathway may hold promise for the diagnosis and targeted treatment of glioma.
FRONTIERS IN ONCOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Ran Ke, Samson I. S. Lok, Kailash Singh, Billy K. C. Chow, Leo T. O. Lee
Summary: The study identified the heterocomplex formation between PAC1R and GIPR, which suppressed downstream signaling events of PAC1R, leading to inhibition of neuronal differentiation.
JOURNAL OF NEUROCHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Ran Ke, Samson Ian Sam Lok, Kailash Singh, Billy Kwok Chong Chow, Harald Janovjak, Leo Tsz On Lee
Summary: The study reveals that the formation of heterocomplexes between Kiss1R and GPER significantly reduces Kiss1R-mediated signaling, showcasing a regulatory mechanism of hypothalamic hormone receptors through receptor cooperation and modulation of receptor sensitivity in the reproductive system.
JOURNAL OF MOLECULAR BIOLOGY
(2021)
Article
Multidisciplinary Sciences
Hong Lin, Yuan Yan, Yifan Luo, Wing Yan So, Xiayun Wei, Xiaozhe Zhang, Xiaoli Yang, Jun Zhang, Yang Su, Xiuyan Yang, Bobo Zhang, Kangjun Zhang, Nan Jiang, Billy Kwok Chong Chow, Weiping Han, Fengchao Wang, Feng Rao
Summary: The study uncovers an antagonistic relationship between COP1 and CSN in glucose-induced insulin secretion, with disruption of the CRL4(COP1)-ETV5 proteolytic axis leading to hyperinsulinemia and obesity. The findings suggest that deregulation of the IP6-CSN-CRL4(COP1)-ETV5 axis underlies these pathologies, and that targeting this pathway could reduce the risk of obesity and diabetes. Furthermore, inhibition of CRL neddylation can correct these pathological phenotypes.
NATURE COMMUNICATIONS
(2021)
Review
Cell Biology
Mukesh Kumar, Karthi Duraisamy, Billy-Kwok-Chong Chow
Summary: MRGPRX2, a class A GPCR exclusively expressed on mast cells, has been identified as the receptor responsible for non-IgE-mediated mast cell activation, shedding light on the mechanism of drug-induced MC degranulation and pseudo-allergic reactions. Its diverse affinity for various molecules and the plethora of agonists make MRGPRX2 an intriguing player in allergic diseases.
Article
Allergy
Karthi Duraisamy, Kailash Singh, Mukesh Kumar, Benjamin Lefranc, Elsa Bonnafe, Michel Treilhou, Jerome Leprince, Billy K. C. Chow
Summary: This study investigates the mechanism of action and immunomodulatory effects of P17 mediated through MRGPRX2. The results show that P17 activates MRGPRX2 in a dose-dependent manner and induces various immune responses, including cell migration and differentiation. These findings provide important insights into the molecular mechanisms of immune modulation.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Lamei Xue, Juan Sun, Jinxin Liu, Chaoping Hu, Dandan Wu, Chenzhipeng Nie, Kuiliang Zhang, Yu Wang, Lei Zhao, Xihua Li, Yan Lu, Li Zhang, Duo Zhang, Mingcong Fan, Haifeng Qian, Haowen Jiang, Jiemin Wong, Yuying Li, Hao Ying, Billy K. C. Chow, Li Wang, Yan Li
Summary: Our study reveals that overnutrition downregulates the expression of secretin (SCT), a brain-gut peptide, in pregnant mice and women. Loss of maternal SCT results in undesirable phenotypes in offspring, such as obesity and attenuated browning of iWAT. Mechanistically, SCT facilitates degradation of DNMT1 through AMPK alpha activation, leading to alterations in offspring's genome methylation pattern.
Article
Endocrinology & Metabolism
Jason S. W. On, Liuru Su, Hong Shen, Aloysius W. R. Arokiaraj, Joao C. R. Cardoso, Guang Li, Billy K. C. Chow
Summary: Based on anatomy and gene expression, the Hatschek's pit in the cephalochordate amphioxus is suggested to be the functional homolog of the vertebrate adenohypophysis. This study explored the distribution and potential function of the amphioxus PACAP/GCG precursor, which is the ortholog of the hypothalamic PACAP neuropeptide in vertebrates. The results support the hypothesis that the amphioxus Hatschek's pit is likely the functional homolog of the vertebrate pituitary gland.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Fengwei Zhang, Sarah O. K. Mak, Yuchu Liu, Ya Ke, Feng Rao, Wing Ho Yung, Li Zhang, Billy Kwok Chong Chow
Summary: This study reveals the neural mechanism of secretin in managing thirst in the central nervous system. The results demonstrate that the local ablation of SCT receptor (SCTR) in the subfornical organ (SFO) reduces water intake in dehydrated mice, while salt intake remains unaffected. Furthermore, it is found that SCT elicits inward currents in the neuronal nitric oxide synthase (SFOnNOS) neurons via SCTR in the presence of glutamate receptor antagonists.
Article
Chemistry, Medicinal
Kailash Singh, Shaik Abdullah Nawabjan, Li Zhang, Hani El-Nezami, Rajasekar Reddy Annapureddy, Billy KC. Chow
Summary: Recent studies have identified a small compound-based Secretin receptor modulator with potential anti-hypertensive effects through structure based drug design strategy. The modulator has shown similar blood pressure lowering effect as SCT peptide, with a longer half-life and oral bioavailability.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2022)
Meeting Abstract
Toxicology
S. A. Nawabjan, H. S. El-Nezami, B. K. Chow
TOXICOLOGY LETTERS
(2022)
Article
Multidisciplinary Sciences
Ji-an Wei, Qing Han, Zhihua Luo, Linglin Liu, Jing Cui, Jiahui Tan, Billy K. C. Chow, Kwok-Fai So, Li Zhang
Summary: This study identifies secretin as a regulator of social investigation behaviors and suggests potential strategies for addressing social deficits. Secretin expression in a subset of excitatory neurons in the basolateral amygdala promotes social interest, while other neurons in this region hinder social behaviors. Exogenous secretin application effectively enhances social interest in both healthy and autism spectrum disorder model mice.
NATIONAL SCIENCE REVIEW
(2023)
Article
Allergy
Mukesh Kumar, Karthi Duraisamy, Rajasekar Reddy Annapureddy, Chi Bun Chan, Billy K. C. Chow
Summary: The research team designed and synthesized a series of novel small molecule antagonists for the treatment of MRGPRX2-mediated allergies and inflammation. These small molecules showed high binding affinity and inhibitory activity in both in vitro and in vivo experiments, effectively inhibiting mast cell activation and related signaling pathways. Therefore, these small molecules may hold significant therapeutic promise for MRGPRX2-mediated allergies and inflammation.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2023)
Article
Urology & Nephrology
Peder Berg, Tobias Jensen, Jesper Frank Andersen, Samuel L. Svendsen, Ida Maria Modvig, Tobias Wang, Sebastian Frische, Billy K. C. Chow, Hans Malte, Jens Juul Holst, Mads Vaarby Sorensen, Jens Leipziger
Summary: This study found that loss of SCTR impairs renal base excretion during acute metabolic alkalosis, and KO mice develop prolonged metabolic alkalosis after acute base loading. Additionally, the study found that increased blood alkalinity promotes secretin release from the small intestine and secretin is critical for bicarbonate homeostasis.
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2023)
Meeting Abstract
Physiology
P. Berg, T. Jensen, J. F. Andersen, M. V. Sorensen, T. Wang, H. Malte, B. K. Chow, J. Leipziger
Article
Biochemistry & Molecular Biology
Yujie Sun, Zhijun Wang, Chenzhipeng Nie, Lamei Xue, Yu Wang, Jinxin Liu, Mingcong Fan, Duo Zhang, Ruikun He, Xuguang Zhang, Haifeng Qian, Billy K. C. Chow, Yan Li, Li Wang
Summary: Hydroxysafflor yellow A (HSYA), the main bioactive component of safflower, triggers fast-to-slow myofiber-type shift by regulating gene expression and mitochondrial biosynthesis.
