The role of autophagy in epileptogenesis and in epilepsy-induced neuronal alterations

PTG protein depletion rescues malin-deficient Lafora disease in mouse

(2014) Julie Turnbull et al.   ANNALS OF NEUROLOGY

Autophagy and amyotrophic lateral sclerosis: The multiple roles of lithium

(2014) Francesco Fornai et al.   Autophagy

Autophagosomes, phagosomes, autolysosomes, phagolysosomes, autophagolysosomes… Wait, I’m confused

(2014) Daniel J Klionsky et al.   Autophagy

Recent Advances in the Pharmacotherapy of Infantile Spasms

(2014) Raili Riikonen   CNS DRUGS

Rationale for using intermittent calorie restriction as a dietary treatment for drug resistant epilepsy

(2014) Alan W.C. Yuen et al.   EPILEPSY & BEHAVIOR

Glycogen accumulation underlies neurodegeneration and autophagy impairment in Lafora disease

(2014) J. Duran et al.   HUMAN MOLECULAR GENETICS

Protein Degradation and Quality Control in Cells from Laforin and Malin Knockout Mice

(2014) Punitee Garyali et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Loss of GABAergic cortical neurons underlies the neuropathology of Lafora disease

(2014) Saida Ortolano et al.   Molecular Brain

mTOR-dependent abnormalities in autophagy characterize human malformations of cortical development: evidence from focal cortical dysplasia and tuberous sclerosis

(2013) Shireena A. Yasin et al.   ACTA NEUROPATHOLOGICA

Crosstalk between the proteasome system and autophagy in the clearance of α-synuclein

(2013) Fang Yang et al.   ACTA PHARMACOLOGICA SINICA

Defining the membrane precursor supporting the nucleation of the phagophore

(2013) Amélie Bernard et al.   Autophagy

High-dose rapamycin blocks mossy fiber sprouting but not seizures in a mouse model of temporal lobe epilepsy

(2013) Kathleen Heng et al.   EPILEPSIA

Understanding the interplay between the proteasome pathway and autophagy in response to dual PI3K/mTOR inhibition in myeloma cells is essential for their effective clinical application

(2013) L I Aronson et al.   LEUKEMIA

De novo mutations in the autophagy gene WDR45 cause static encephalopathy of childhood with neurodegeneration in adulthood

(2013) Hirotomo Saitsu et al.   NATURE GENETICS

The role of autophagy in neurodegenerative disease

(2013) Ralph A Nixon   NATURE MEDICINE

Focal Cortical Dysplasia

(2013) John N. Gaitanis et al.   PEDIATRIC NEUROLOGY

Spatiotemporal Characterization of mTOR Kinase Activity Following Kainic Acid Induced Status Epilepticus and Analysis of Rat Brain Response to Chronic Rapamycin Treatment

(2013) Matylda Macias et al.   PLoS One

Autophagy Activation Clears ELAVL1/HuR-Mediated Accumulation of SQSTM1/p62 during Proteasomal Inhibition in Human Retinal Pigment Epithelial Cells

(2013) Johanna Viiri et al.   PLoS One

Alpha-synuclein’s degradation in vivo

(2012) Darius Ebrahimi-Fakhari et al.   Autophagy

α-synuclein fate

(2012) Simone Engelender   Autophagy

Crosstalk between the ubiquitin–proteasome system and autophagy in a human cellular model of Alzheimer's disease

(2012) Valentina Cecarini et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Suppressed Expression of Autophagosomal Protein LC3 in Cortical Tubers of Tuberous Sclerosis Complex

(2012) Hiroaki Miyahara et al.   BRAIN PATHOLOGY

The Role of Autophagy: What can be Learned from the Genetic Forms of Amyotrophic Lateral Sclerosis

(2012) Livia Pasquali et al.   CNS & Neurological Disorders-Drug Targets

Rapamycin has paradoxical effects on S6 phosphorylation in rats with and without seizures

(2012) Linglin Chen et al.   EPILEPSIA

Finding a better drug for epilepsy: The mTOR pathway as an antiepileptogenic target

(2012) Aristea S. Galanopoulou et al.   EPILEPSIA

Rapamycin has age-, treatment paradigm-, and model-specific anticonvulsant effects and modulates neuropeptide Y expression in rats

(2012) Tamar Chachua et al.   EPILEPSIA

The mTOR pathway is activated in glial cells in mesial temporal sclerosis

(2012) Alexander A. Sosunov et al.   EPILEPSIA

The intrahippocampal kainate model of temporal lobe epilepsy revisited: Epileptogenesis, behavioral and cognitive alterations, pharmacological response, and hippoccampal damage in epileptic rats

(2012) Marta Rattka et al.   EPILEPSY RESEARCH

Aggregate Clearance of α-Synuclein inSaccharomyces cerevisiaeDepends More on Autophagosome and Vacuole Function Than on the Proteasome

(2012) Doris Petroi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Laforin and Malin Deletions in Mice Produce Similar Neurologic Impairments

(2012) Ana M. García-Cabrero et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Multiple Roles for Mammalian Target of Rapamycin Signaling in Both Glutamatergic and GABAergic Synaptic Transmission

(2012) M. C. Weston et al.   JOURNAL OF NEUROSCIENCE

Impaired Autophagy in Neurons after Disinhibition of Mammalian Target of Rapamycin and Its Contribution to Epileptogenesis

(2012) J. McMahon et al.   JOURNAL OF NEUROSCIENCE

Pten Deletion in Adult Hippocampal Neural Stem/Progenitor Cells Causes Cellular Abnormalities and Alters Neurogenesis

(2012) A. Amiri et al.   JOURNAL OF NEUROSCIENCE

Efficacy and safety of everolimus for subependymal giant cell astrocytomas associated with tuberous sclerosis complex (EXIST-1): a multicentre, randomised, placebo-controlled phase 3 trial

(2012) David Neal Franz et al.   LANCET

Alpha-synuclein and Protein Degradation Systems: a Reciprocal Relationship

(2012) Maria Xilouri et al.   MOLECULAR NEUROBIOLOGY

Prion-like mechanisms in epileptogenesis

(2012) F. Orzi et al.   NEUROLOGICAL SCIENCES

Assessing the effectiveness of rapamycin on angiomyolipoma in tuberous sclerosis: a two years trial

(2012) Cristina Cabrera-López et al.   Orphanet Journal of Rare Diseases

Mapping the Spatio-Temporal Pattern of the Mammalian Target of Rapamycin (mTOR) Activation in Temporal Lobe Epilepsy

(2012) Long-Ze Sha et al.   PLoS One

The mTOR Inhibitor Rapamycin Has Limited Acute Anticonvulsant Effects in Mice

(2012) Adam L. Hartman et al.   PLoS One

Reticulon 3 attenuates the clearance of cytosolic prion aggregates via inhibiting autophagy

(2011) Rui Chen et al.   Autophagy

F-actin depolymerization accelerates clasmatodendrosis via activation of lysosome-derived autophagic astroglial death

(2011) H.J. Ryu et al.   BRAIN RESEARCH BULLETIN

p65/RelA-Ser529 NF-κB Subunit Phosphorylation Induces Autophagic Astroglial Death (Clasmatodendrosis) Following Status Epilepticus

(2011) Hea Jin Ryu et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

Neurodegeneration and functional impairments associated with glycogen synthase accumulation in a mouse model of Lafora disease

(2011) Jordi Valles-Ortega et al.   EMBO Molecular Medicine

Rapamycin suppresses axon sprouting by somatostatin interneurons in a mouse model of temporal lobe epilepsy

(2011) Paul S. Buckmaster et al.   EPILEPSIA

Neuron–astrocyte signaling and epilepsy

(2011) Gerald Seifert et al.   EXPERIMENTAL NEUROLOGY

Dysfunctions in endosomal–lysosomal and autophagy pathways underlie neuropathology in a mouse model for Lafora disease

(2011) Rajat Puri et al.   HUMAN MOLECULAR GENETICS

Lafora bodies and neurological defects in malin-deficient mice correlate with impaired autophagy

(2011) Olga Criado et al.   HUMAN MOLECULAR GENETICS

Dual Regulation of Fragile X Mental Retardation Protein by Group I Metabotropic Glutamate Receptors Controls Translation-Dependent Epileptogenesis in the Hippocampus

(2011) W. Zhao et al.   JOURNAL OF NEUROSCIENCE

Rapamycin Suppresses Mossy Fiber Sprouting But Not Seizure Frequency in a Mouse Model of Temporal Lobe Epilepsy

(2011) P. S. Buckmaster et al.   JOURNAL OF NEUROSCIENCE

The Laforin-Malin Complex Negatively Regulates Glycogen Synthesis by Modulating Cellular Glucose Uptake via Glucose Transporters

(2011) P. K. Singh et al.   MOLECULAR AND CELLULAR BIOLOGY

A pulse rapamycin therapy for infantile spasms and associated cognitive decline

(2011) Emmanuel Raffo et al.   NEUROBIOLOGY OF DISEASE

Impaired autophagy: a link between neurodegenerative diseases and progressive myoclonus epilepsies

(2011) Mira Polajnar et al.   TRENDS IN MOLECULAR MEDICINE

Laforin, the most common protein mutated in Lafora disease, regulates autophagy

(2010) Carmen Aguado et al.   HUMAN MOLECULAR GENETICS

Selective autophagy: ubiquitin-mediated recognition and beyond

(2010) Claudine Kraft et al.   NATURE CELL BIOLOGY

Pharmacological inhibition of the mammalian target of rapamycin pathway suppresses acquired epilepsy

(2010) Xiaoxing Huang et al.   NEUROBIOLOGY OF DISEASE

Astrocytes and epilepsy

(2010) Nihal C. Lanerolle et al.   Neurotherapeutics

Autophagy is upregulated in rats with status epilepticus and partly inhibited by Vitamin E

(2009) Lili Cao et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The autosomal recessively inherited progressive myoclonus epilepsies and their genes

(2009) Nivetha Ramachandran et al.   EPILEPSIA

Autophagy for the avoidance of neurodegeneration

(2009) F. Madeo et al.   GENES & DEVELOPMENT

Inhibition of the Mammalian Target of Rapamycin Signaling Pathway Suppresses Dentate Granule Cell Axon Sprouting in a Rodent Model of Temporal Lobe Epilepsy

(2009) P. S. Buckmaster et al.   JOURNAL OF NEUROSCIENCE

The Mammalian Target of Rapamycin Signaling Pathway Mediates Epileptogenesis in a Model of Temporal Lobe Epilepsy

(2009) L.-H. Zeng et al.   JOURNAL OF NEUROSCIENCE

Focal cortical dysplasia type II: biological features and clinical perspectives

(2009) Sanjay M Sisodiya et al.   LANCET NEUROLOGY

Autophagy, lithium, and amyotrophic lateral sclerosis

(2009) Livia Pasquali et al.   MUSCLE & NERVE

A model of symptomatic infantile spasms syndrome

(2009) Morris H. Scantlebury et al.   NEUROBIOLOGY OF DISEASE

Lithium prevents excitotoxic cell death of motoneurons in organotypic slice cultures of spinal cord

(2009) J. Calderó et al.   NEUROSCIENCE

Inhibition of lysosomal functions reduces proteasomal activity

(2009) Liyan Qiao et al.   NEUROSCIENCE LETTERS

The role of autophagy-lysosome pathway in neurodegeneration associated with Parkinson's disease

(2008) T. Pan et al.   BRAIN

Hippocampal epileptogenesis in animal models of mesial temporal lobe epilepsy with hippocampal sclerosis: The importance of the “latent period” and other concepts

(2008) Robert S. Sloviter   EPILEPSIA

The malin–laforin complex suppresses the cellular toxicity of misfolded proteins by promoting their degradation through the ubiquitin–proteasome system

(2008) Punitee Garyali et al.   HUMAN MOLECULAR GENETICS

Suppression of autophagy precipitates neuronal cell death following low doses of methamphetamine

(2008) Roberta Castino et al.   JOURNAL OF NEUROCHEMISTRY

Parkinson’s disease and the gut: a well known clinical association in need of an effective cure and explanation

(2008) g. natale et al.   NEUROGASTROENTEROLOGY AND MOTILITY

Alpha-synuclein and autophagy as common steps in neurodegeneration

(2008) Michela Ferrucci et al.   PARKINSONISM & RELATED DISORDERS

Lithium delays progression of amyotrophic lateral sclerosis

(2008) F. Fornai et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA