Article
Biochemistry & Molecular Biology
Carmen Vida, Carlos Oliva, Claudia Yuste, Noemi Ceprian, Paula Jara Caro, Gemma Valera, Ignacio Gonzalez de Pablos, Enrique Morales, Julia Carracedo
Summary: The study reveals the significant role of oxidative stress in CKD patients, with dialysis procedures helping to maintain the GSSG/GSH balance in PMNs. PD patients showed higher oxidative stress than HD patients, particularly in MNs. The assessment of redox state parameters in PMNs and MNs may serve as potential biomarkers for CKD progression.
Review
Pharmacology & Pharmacy
Kawthar Dhayni, Kazem Zibara, Hawra Issa, Said Kamel, Youssef Bennis
Summary: CXCR1 and CXCR2 chemokine receptors are critical in inflammation, and CXCR1/2 inhibitors show beneficial effects in preventing cardiovascular disease progression.
PHARMACOLOGY & THERAPEUTICS
(2022)
Review
Biochemistry & Molecular Biology
Alejandro Olivares-Hernandez, Luis Figuero-Perez, Juan Jesus Cruz-Hernandez, Rogelio Gonzalez Sarmiento, Ricardo Usategui-Martin, Jose Pablo Miramontes-Gonzalez
Summary: The dysfunction of renal dopamine receptors is closely linked to essential hypertension, insulin resistance, and redox balance. The dopaminergic system plays a protective role against hypertension and kidney disorders. Therapeutic efforts should focus on restoring the normal functioning of dopamine receptors, particularly D1-like receptors.
Article
Immunology
Kun-Rui Rao, Ru-Yi Bao, Hu Ming, Jian-Wei Liu, Yi-Fei Dong
Summary: This study investigated the correlations between leukocyte-related inflammation parameters and plasma aldosterone concentration (PAC) in primary aldosteronism (PA) patients and blood pressure-matched essential hypertension (EH) patients. The results showed that PA patients had significantly lower lymphocyte count and higher neutrophil-lymphocyte ratio (NLR) and monocyte-lymphocyte ratio (MLR) compared to EH patients. Only NLR maintained an independent correlation with PAC in EH patients.
JOURNAL OF INFLAMMATION RESEARCH
(2023)
Article
Peripheral Vascular Disease
Jacob. K. K. Kresovich, Zongli Xu, Katie. M. M. O'Brien, Christine. G. G. Parks, Clarice. R. R. Weinberg, Dale. P. P. Sandler, Jack. A. A. Taylor
Summary: This study found that shifts in lymphocyte subsets occur before the development of hypertension, followed by changes to neutrophils and additional lymphocytes.
Article
Medicine, General & Internal
Sounak Gupta, Paige Nichols, Christine M. Lohse, Farhad Kosari, Andrea G. Kattah, Faye R. Harris, Giannoula Karagouga, Rohit Mehra, Samson W. Fine, Victor E. Reuter, Loren Herrera-Hernandez, Andrew J. Zganjar, Cameron J. Britton, Aaron M. Potretzke, Stephen A. Boorjian, R. Houston Thompson, Rafael E. Jimenez, Bradley C. Leibovich, Vesna D. Garovic, John C. Cheville, Vidit Sharma
Summary: This study profiles juxtaglomerular cell tumors (JXG) and histologic mimics by analyzing renin expression and identifies non-JXG renin-producing tumors. Furthermore, the study reveals improved patient outcomes with angiotensin signaling inhibitor (ASI) use in hypertensive patients with high renin expression tumors.
MAYO CLINIC PROCEEDINGS
(2022)
Article
Urology & Nephrology
Hassan N. Ibrahim, Sean A. Hebert, Dina N. Murad, Horacio E. Adrogue, Duc T. Nguyen, Edward A. Graviss, Hana Nguyen, Arthur Matas
Summary: The study found that kidney donors with hypertension defined by past criteria do not appear to incur higher mortality, CVD, or ESKD. Donors with the current definition of hypertension enjoyed similar renal outcomes but were more likely to develop CVD.
KIDNEY INTERNATIONAL REPORTS
(2021)
Article
Immunology
Liting Wu, Along Gao, Lan Li, Jianlin Chen, Jun Li, Jianmin Ye
Summary: This study utilized single-cell RNA sequencing to explore the immune cell heterogeneity in the anterior kidney of teleost fish. The research identified 22 clusters corresponding to five distinct immune cell subsets, with a focus on detailed classification of B cell subsets.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Pharmacology & Pharmacy
Bethany L. Goodlett, Chang Sun Kang, Eunsoo Yoo, Shobana Navaneethabalakrishnan, Dakshnapriya Balasubbramanian, Sydney E. Love, Braden M. Sims, Daniela L. Avilez, Winter Tate, Delilah R. Chavez, Gaurav Baranwal, Mary B. Nabity, Joseph M. Rutkowski, Dongin Kim, Brett M. Mitchell
Summary: Renal lymphangiogenesis can lower blood pressure and is associated with favorable alterations in renal immune cells and increased sodium excretion.
Review
Medicine, General & Internal
Ann Bugeja, Mariam Eldaba, Sumaiya Ahmed, Risa Shorr, Edward G. Clark, Kevin D. Burns, Greg Knoll, Swapnil Hiremath
Summary: This article aims to systematically review the safety of living kidney donation in patients with hypertension and provide evidence for clinical guidelines.
Article
Cardiac & Cardiovascular Systems
Ellen G. Avery, Hendrik Bartolomaeus, Ariana Rauch, Chia-Yu Chen, Gabriele N'Diaye, Ulrike Loeber, Theda U. P. Bartolomaeus, Raphaela Fritsche-Guenther, Andre F. Rodrigues, Alex Yarritu, Cheng Zhong, Lingyan Fei, Dmitry Tsvetkov, Mihail Todiras, Joon-Keun Park, Lajos Marko, Andras Maifeld, Andreas Patzak, Michael Bader, Stefan Kempa, Jennifer A. Kirwan, Sofia K. Forslund, Dominik N. Mueller, Nicola Wilck
Summary: This study investigated the impact of microbial colonization on organ damage in hypertension using germ-free and colonized mice models. The results showed that the kidney is more sensitive to microbial influence, and the colonization status is associated with circulating metabolites and inflammatory cells relevant to hypertension.
CARDIOVASCULAR RESEARCH
(2023)
Article
Peripheral Vascular Disease
Azuma Nanamatsu, Takayasu Mori, Fumiaki Ando, Taisuke Furusho, Shintaro Mandai, Koichiro Susa, Eisei Sohara, Tatemitsu Rai, Shinichi Uchida
Summary: Desmopressin, a vasopressin type 2 receptor agonist, significantly increases short-term tubular uromodulin secretion in mice and reduces uromodulin abundance in the kidney. It activates uromodulin secretion in kidney epithelial cells through vasopressin/cAMP signaling, dependent on epithelial cell polarity and cyclic AMP-dependent PKA pathway. This discovery of vasopressin/cAMP/PKA signaling as a physiological stimulus for urinary uromodulin secretion may lead to novel treatment strategies for urinary tract infections, kidney stones, hypertension, and chronic kidney disease.
Article
Peripheral Vascular Disease
Agnieszka Latosinska, Rosa Maria Bruno, Marco Pappaccogli, Alessandra Bacca, Christophe Beauloye, Pierre Boutouyrie, Hakim Khettab, Jan A. Staessen, Stefano Taddei, Laurent Toubiana, Miikka Vikkula, Harald Mischak, Alexandre Persu
Summary: This study investigates the use of urinary proteomics in the diagnosis of FMD and develops a classifier to distinguish FMD patients from healthy controls and other diseases. Furthermore, the study finds a positive correlation between the proteomic score and the arterial geometry and mechanics in FMD patients.
Review
Peripheral Vascular Disease
Vincent D. Salvador, George L. Bakris
Summary: Finding novel therapeutic agents for better blood pressure control in patients with resistant hypertension is a new area of exploration. Several mechanisms have been explored and operationalized in drug development, and some agents are undergoing clinical trials.
HYPERTENSION RESEARCH
(2022)
Article
Gastroenterology & Hepatology
Kavish R. Patidar, Mobasshir A. Naved, Ananth Grama, Mohammad Adibuzzaman, Arzina Aziz Ali, James E. Slaven, Archita P. Desai, Marwan S. Ghabril, Lauren Nephew, Naga Chalasani, Eric S. Orman
Summary: This study investigated hospitalized patients with cirrhosis and acute kidney injury in the US and found that acute kidney disease developed in 1 in 3 patients, which was associated with worse survival and chronic kidney disease.
JOURNAL OF HEPATOLOGY
(2022)
Review
Biotechnology & Applied Microbiology
Matteo Sobrero, Fabrizio Montecucco, Federico Carbone
Summary: Venous thromboembolism is a common cause of acute cardiovascular syndrome, with acute pulmonary embolism being the most life-threatening complication. Clinical prediction tests and D-dimer are currently used for the diagnosis of APE, but the role of miRNA in APE diagnosis is still unclear.
BIOMED RESEARCH INTERNATIONAL
(2022)
Article
Cell Biology
Federico Carbone, Jennifer Meessen, Marco Magnoni, Daniele Andreini, Aldo Pietro Maggioni, Roberto Latini, Fabrizio Montecucco
Summary: Inflammation may play a role in the development of coronary artery disease (CAD) in different cardiovascular risk factor categories. Osteopontin (OPN) levels were highest in the low risk factor group and associated with CAD. Other biomarkers, such as myeloperoxidase (MPO) and resistin, did not differ based on CAD presence.
Article
Cell Biology
Fabienne Burger, Daniela Baptista, Aline Roth, Karim J. Brandt, Rafaela Fernandes da Silva, Fabrizio Montecucco, Francois Mach, Kapka Miteva
Summary: This study found that res-like macrophages expressing LYVE-1 play a role in vascular calcification in atherosclerosis. These macrophages promote the transdifferentiation of VSMCs into osteogenic-like cells through the secretion of CCL24. The abundance of LYVE-1(+)CCL24(+) macrophages and elevated systemic levels of CCL24 are associated with vascular calcification and CAD events.
Article
Medicine, General & Internal
Patricia Yarnoz-Esquiroz, Laura Olazaran, Maite Aguas-Ayesa, Carolina M. Perdomo, Marta Garcia-Goni, Camilo Silva, Jose Antonio Fernandez-Formoso, Javier Escalada, Fabrizio Montecucco, Piero Portincasa, Gema Fruhbeck
Summary: Academic medicine aims to promote research that moves from discovery to translation and educate the next generation of professionals. However, in the field of obesity, integration of knowledge and translation research is hindered by the inability of the body mass index classification to account for multiple subtypes of obesity, and the lack of a universally shared definition, which prevents the determination of the true burden of different obesity phenotypes.
EUROPEAN JOURNAL OF CLINICAL INVESTIGATION
(2022)
Article
Cardiac & Cardiovascular Systems
Luca Liberale, Simon Kraler, Yustina M. Puspitasari, Nicole R. Bonetti, Alexander Akhmedov, Stefano Ministrini, Fabrizio Montecucco, Nikolaus Marx, Michael Lehrke, Niels Ulrik K. Hartmann, Jurg H. Beer, Florian A. Wenzl, Francesco Paneni, Thomas F. Luscher, Giovanni G. Camici
Summary: The study showed that SGLT-2 inhibition by empagliflozin does not impact experimental arterial thrombus formation, neither under baseline conditions nor during sustained low-grade inflammation. The results suggest that the beneficial effects of empagliflozin are likely independent of pathways mediating arterial thrombosis.
CARDIOVASCULAR RESEARCH
(2023)
Article
Cardiac & Cardiovascular Systems
Luca Liberale, Yustina M. Puspitasari, Stefano Ministrini, Alexander Akhmedov, Simon Kraler, Nicole R. Bonetti, Georgia Beer, Ana Vukolic, Dario Bongiovanni, Jiaying Han, Kilian Kirmes, Isabell Bernlochner, Jaroslav Pelisek, Jurg H. Beer, Zheng-Gen Jin, Daniela Pedicino, Giovanna Liuzzo, Konstantinos Stellos, Fabrizio Montecucco, Filippo Crea, Thomas F. Luscher, Giovanni G. Camici
Summary: JCAD promotes arterial thrombosis by modulating coagulation and fibrinolysis. Knockout of JCAD reduces thrombogenicity in mice, and silencing of JCAD inhibits the expression of coagulation factors and fibrinolysis factors. These findings suggest JCAD as a potential therapeutic target for atherothrombosis.
EUROPEAN HEART JOURNAL
(2023)
Review
Medicine, General & Internal
Maddalena Toffali, Federico Carbone, Enrico Fainardi, Andrea Morotti, Fabrizio Montecucco, Luca Liberale, Alessandro Padovani
Summary: Intracerebral haemorrhage (ICH) has high mortality and poor functional outcome. Recurrence of ICH is a major concern, and ICH patients are at high risk of future ischaemic vascular events. This narrative review provides an overview of diagnostic tools and therapeutic strategies for secondary prevention in ICH survivors.
EUROPEAN JOURNAL OF CLINICAL INVESTIGATION
(2023)
Editorial Material
Medicine, General & Internal
Fabrizio Montecucco, Hendrik Nathoe
EUROPEAN JOURNAL OF CLINICAL INVESTIGATION
(2023)
Article
Biochemistry & Molecular Biology
Elisa Russo, Maria Bertolotto, Valentina Zanetti, Daniela Picciotto, Pasquale Esposito, Federico Carbone, Fabrizio Montecucco, Roberto Pontremoli, Giacomo Garibotto, Francesca Viazzi, Daniela Verzola
Summary: This study demonstrates that uric acid (UA) can induce changes in VSMC cytoskeleton, leading to increased cell migration and activation of specific signaling pathways. These findings suggest that UA may play a critical role in vascular remodeling, emphasizing the importance of interventions to prevent the development of cardiovascular diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Cardiac & Cardiovascular Systems
Federico Carbone, Luca Liberale, Peter Libby, Fabrizio Montecucco
Summary: Experimental and clinical findings linking vitamin D to cardiovascular risk have prompted consideration of its supplementation for overall health improvement. However, several meta-analyses do not support its clinical effectiveness, and recent research has revealed complex non-classical effects of vitamin D in cardiovascular diseases.
EUROPEAN HEART JOURNAL
(2023)
Review
Medicine, General & Internal
Amedeo Tirandi, Cosimo Sgura, Federico Carbone, Fabrizio Montecucco, Luca Liberale
Summary: Ischemic stroke is the second leading cause of death globally and a major cause of morbidity. Current therapeutic options are limited to early reperfusion strategies, while pharmacological neuroprotective strategies have failed to enter clinical practice despite promising results in experiments. Inflammation plays a significant role in the pathophysiology of ischemic stroke, and inflammatory mediators have been investigated as potential prognostic markers and therapeutic targets. This article summarizes the available evidence on the role of cytokines, soluble adhesion molecules, and adipokines in the pathophysiology, prognosis, and therapy of ischemic stroke.
INTERNAL AND EMERGENCY MEDICINE
(2023)
Editorial Material
Cardiac & Cardiovascular Systems
Fabrizio Montecucco, Thomas H. Schindler
EUROPEAN HEART JOURNAL
(2023)
Editorial Material
Medicine, General & Internal
Amedeo Tirandi, Fabrizio Montecucco, Luca Liberale
EUROPEAN JOURNAL OF CLINICAL INVESTIGATION
(2023)
Review
Biochemistry & Molecular Biology
Alessandra Puddu, Fabrizio Montecucco, Davide Maggi
Summary: Caveolae are cell surface plasma membrane invaginations observed in terminally differentiated cells, characterized by the presence of caveolin-1. They play a central role in regulating atherosclerosis and can have both pro-atherogenic and anti-atherogenic functions depending on the cell type examined. This study focuses on the role of caveolin-1 in regulating the fate of LDLs in endothelial cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Endocrinology & Metabolism
Alberto Preda, Federico Carbone, Amedeo Tirandi, Fabrizio Montecucco, Luca Liberale
Summary: The obesity epidemic is a global health crisis, affecting over one billion people worldwide. Obesity has a significant impact on cardiovascular health, causing various structural, functional, humoral, and hemodynamic changes. Accurate assessment of cardiovascular risk in individuals with obesity is crucial for reducing mortality rates and maintaining quality of life. Recent evidence suggests the existence of different phenotypes of obesity, each associated with varying degrees of cardiovascular risk. Diagnosis should not solely rely on anthropometric parameters, but also include a thorough evaluation of metabolic status. The World Heart Federation and World Obesity Federation have proposed an action plan for managing obesity-related cardiovascular risk and mortality, emphasizing the importance of comprehensive multidisciplinary programs. This review aims to provide an updated summary of the different obesity phenotypes, their specific effects on cardiovascular risk, and differences in clinical management.
REVIEWS IN ENDOCRINE & METABOLIC DISORDERS
(2023)