Article
Chemistry, Physical
Mohamed Ali Ibrahim Al-Gaber, Hany M. Abd El-Lateef, Mai M. Khalaf, Saad Shaaban, Mohamed Shawky, Gehad G. Mohamed, Aly Abdou, Mohamed Gouda, Ahmed M. Abu-Dief
Summary: A new heterocyclic azo dye ligand (L) was synthesized and coordinated with various metal ions to form complexes. The structures of the complexes were determined using multiple techniques. The ligand exhibited tri-dentate behavior and coordinated to the metal ions through multiple functional groups. The complexes showed good antimicrobial activity and potential for future study.
Article
Chemistry, Physical
Nevin Turan, Kenan Buldurun, Ragip Adiguzel, Abdulmelik Aras, Fikret Turkan, Ercan Bursal
Summary: In this study, novel azo dye metal complexes were synthesized and tested for their biochemical properties, including antioxidant and enzyme inhibitory activities. The results showed that the Ru(II) complex exhibited the best inhibition values against GST, AChE, and BChE enzymes.
JOURNAL OF MOLECULAR STRUCTURE
(2021)
Article
Environmental Sciences
Mozarte Santos Santana, Rafael Pereira Alves, Lucas Santos Santana, Mateus Aquino Goncalves, Mario Cesar Guerreiro
Summary: The hydrothermal carbonization process was used to convert defective coffee beans into hydrochars for potential applications in agronomic and environmental fields. The hydrochars were characterized and analyzed for their adsorption capacity, showing promising results and potential for technological use.
JOURNAL OF ENVIRONMENTAL MANAGEMENT
(2022)
Article
Engineering, Environmental
Abdallah Reghioua, Djamel Barkat, Ali H. Jawad, Ahmed Saud Abdulhameed, Abdullah A. Al-Kahtani, Zeid A. ALOthman
Summary: By optimizing various parameters, a new multifunctional nanocomposite adsorbent was developed for effective removal of dyes from water, with high adsorption capacity and rapid removal rate, as well as environmental friendly characteristics.
JOURNAL OF ENVIRONMENTAL CHEMICAL ENGINEERING
(2021)
Article
Chemistry, Multidisciplinary
Fatma Abouzayed, Saeyda A. Abouel-Enein, Amira M. Hammad
Summary: A novel bisazo ligand was synthesized and chelates of different metallic ions were prepared, characterized, and studied for their thermal behavior. The chelates exhibited different structures with Fe2O3 nanooxide showing remarkable activity and Cu(II) complex showing no activity. The study also revealed that Co(II) had higher antioxidant activity compared to other complexes.
Article
Crystallography
Abdullah A. Alotaibi, Chaima Ayari, Elham Bajuavfir, Ashfaq Ahmad, Fatima Al-Nahdi, Abdullah M. Alswieleh, Khalid M. Alotaibi, Jin-Xiao Mi, Cherif Ben Nasr, Mohamed Habib Mrad
Summary: The crystal structure, morphology, chemical composition, functional groups, as well as optical and thermal properties of two isostructural compounds were studied.
Article
Chemistry, Physical
Moamen S. Refat, Hosam A. Saad, Adil A. Gobouri, Mohammed Alsawat, Abdel Majid A. Adam, Samy M. El-Megharbel
Summary: This study synthesized nanostructured CuO, Co3O4, and NiO oxides through the thermal decomposition of precursors, and compared their catalytic degradation performance on Congo red dye.
JOURNAL OF MOLECULAR LIQUIDS
(2022)
Article
Chemistry, Inorganic & Nuclear
Priyanka Devi, Kiran Singh, Bhupender Kumar, Jahnavi Kumari Singh
Summary: Many pyrazoles-based Schiff bases were reported to exhibit high activity against bacterial, parasitic strains, and cancer cells. A new pyrazole based 'NO' bidentate ligand was synthesized and metal complexes with Co+2, Ni+2, Cu+2, and Zn+2 were also prepared. The characterization of the compounds and their metal complexes was performed, and the metal complexes showed enhanced activity compared to the ligand. They exhibited significant anticancer and antibacterial activity, as well as antifungal activity.
INORGANIC CHEMISTRY COMMUNICATIONS
(2023)
Article
Chemistry, Organic
Mohamed A. Salem, Samir Y. Abbas, Mohamed H. Helal, Abdullah Y. Alzahrani
Summary: The newly synthesized diazenylschiff's bases showed significant antifungal activity against Aspergillus fumigatus, moderate activity against Bacillus subtilis and Candida albicans.
SYNTHETIC COMMUNICATIONS
(2021)
Article
Polymer Science
Mamdouh S. Masoud, Sokaina S. Hemdan, Rehab M. Elsamra
Summary: The synthesis of new Fe(III), Co(II), Ni(II), and Cu(II) complexes of two azo ligands has been reported. The stoichiometry and geometry of the synthesized complexes were determined through various analytical techniques. The results showed that the metal complexes exhibited higher biological activity and lipophilicity compared to their precursor ligands, and also exhibited moderate inhibitory effects on certain proteins. Experimental testing confirmed the biological effectiveness of the complexes and provided guidelines for toxicological investigations.
JOURNAL OF INORGANIC AND ORGANOMETALLIC POLYMERS AND MATERIALS
(2023)
Article
Environmental Sciences
Daniel Puppe, Martin Leue, Michael Sommer, Jorg Schaller, Danuta Kaczorek
Summary: This study utilized various analytical methods to investigate the fluorescence behavior of modern phytoliths. The results revealed that the fluorescence of phytoliths is influenced by temperature and molecular structure. Organic compounds cause fluorescence at low temperatures, while molecular changes in phytolith silica induce fluorescence at high temperatures. The fluorescence is caused by clusterization-triggered emissions, which result from overlapping electron clouds forming non-conventional chromophores. Additionally, the extractable phytoliths were found to be dominated by lumen phytoliths.
FRONTIERS IN ENVIRONMENTAL SCIENCE
(2022)
Article
Chemistry, Inorganic & Nuclear
Jana Tomicova, Miroslava Matikova-Malarova, Juraj Kuchar, Jaroslav Briancin, Juraj Cernak
Summary: Three heteroleptic neutral complex molecules [Fe(acac)(bpy)Cl-2] (1), [Fe(acac)Cl-2(phen)] (2), and [Fe(acac)Cl-2(4dmbpy)] (3) were synthesized using solvothermal syntheses. These complexes were characterized by chemical analysis and spectroscopic methods (IR and UV-Vis), and their molecular structures were determined. The crystal structures of the complexes were stabilized by hydrogen bonds (complexes 1-3) and p-p interactions (complexes 1 and 2). The thermal stability of the complexes was found to be relatively high, with the first weight loss corresponding to the decomposition of the acac ligand. The residues of the thermal decompositions were identified as α-Fe2O3 using PXRD, SEM, and EDX.
INORGANICA CHIMICA ACTA
(2023)
Article
Chemistry, Inorganic & Nuclear
M. M. El-Zahed, A. Z. El-Sonbati, F. M. S. Ajadain, M. A. Diab, M. I. Abou-Dobara
Summary: In this study, a novel symmetric bis-Schiff base (H2L) was synthesized and its structure was determined using various spectral and physicochemical techniques. The synthesized compounds were found to have octahedral geometry, except for one which had a tetrahedral structure. Additionally, one of the complexes (5) exhibited the highest antibacterial activity among the ligand, complexes, and standard antibiotic.
INORGANIC CHEMISTRY COMMUNICATIONS
(2023)
Article
Chemistry, Physical
Asma A. Alothman, Munirah D. Albaqami, Razan A. Alshgari
Summary: The present study focused on synthesizing novel azo-dye Cu(II), Ni(II) and Co(II) chelates of Schiffbase based ligands with antimicrobial properties. The chelates displayed superior inhibition potential against pathogenic fungi and bacteria compared to the parent ligand due to enhanced antimicrobial activity attributed to chelation. Spectral studies and thermal analysis confirmed the octahedral geometry of the chelates.
JOURNAL OF MOLECULAR STRUCTURE
(2021)
Article
Chemistry, Multidisciplinary
Aysha Bukhari, Irfan Ijaz, Hina Zain, Ezaz Gilani, Ammara Nazir, Awais Bukhari, Sibtain Raza, Jahanzaib Ansari, Sajjad Hussain, Saleh S. Alarfaji, Ramsha Saeed, Yasra Naseer, Rizwana Aftab, Shmaaila Iram
Summary: In this study, lemon peel was utilized as a natural sorbent for the removal of eosin dye from aqueous media. The biosorbent was characterized and analyzed, and the adsorption process was optimized. The results showed that lemon peel is an effective and affordable biosorbent for the removal of eosin dye.
ARABIAN JOURNAL OF CHEMISTRY
(2022)
Article
Chemistry, Physical
Marwa F. Harras, Rehab Sabour, Yousry A. Ammar, Ahmed B. M. Mehany, Amel M. Farrag, Sally I. Eissa
Summary: A new series of structurally related indomethacin analogues were synthesized and evaluated for their cytotoxic effects against human cancer cell lines, with compound 12 showing the most potent activity against colon cancer cell lines and inducing cell cycle arrest and apoptosis through the up-regulation of Bax and p53, and down-regulation of Bcl-2. The chemo-informatic properties of compounds 11 and 12 indicated their oral bioavailability without permeation of the blood-brain barrier.
JOURNAL OF MOLECULAR STRUCTURE
(2021)
Article
Chemistry, Multidisciplinary
Moustafa S. Abusaif, M. A. Abu-Saied, M. Fathy, Ahmed A. El-Sherif, A. B. Kashyout, Mohamed R. Selim, Yousry A. Ammar
Summary: Hexyl carbazole derivatives are prominent dye scaffolds in dye-sensitized solar cells, with DCA-HC dye showing the highest efficiency among synthesized dyes through a study on the relation between dye structures, photophysical/electrochemical properties, molecular structure, and DSSC manufacturing.
JOURNAL OF THE IRANIAN CHEMICAL SOCIETY
(2021)
Article
Chemistry, Organic
Magda M. F. Ismail, Hend El-Sehrawi, Heba S. A. Elzahabi, Taghreed Shawer, Yousry A. Ammar
Summary: A series of novel compounds were synthesized and evaluated for their in vitro antitumor activity at NCI. Among the tested compounds, compound 8 showed significant growth inhibition and exhibited potent activity in five-dose testing.
POLYCYCLIC AROMATIC COMPOUNDS
(2022)
Article
Chemistry, Organic
Yousry A. Ammar, Maha M. Khalifa, Sally I. Eisa, Magda M. F. Ismail
Summary: Naproxen analogs were synthesized and screened through docking studies with COX-2, with compound 3 showing higher anti-inflammatory activity than Naproxen, while compound 10f displayed comparable inhibition rate. The compounds showed promising pharmacological data and lacked ulcerogenic effects.
POLYCYCLIC AROMATIC COMPOUNDS
(2022)
Article
Chemistry, Organic
Magda M. F. Ismail, Nehad A. M. El-Sayed, Heba S. Rateb, Yousry A. Ammar
Summary: This study describes the design and synthesis of new hybrids of N-substituted-N'-(4-(piperidin-1-yl-sulfonyl)phenylthiourea and condensed thiourea derivatives through a facile synthetic route. In silico study shows that these compounds are bioavailable and comply with Lipinski rule of five. Some of the hybrids exhibit stronger antihypertensive activity compared to the reference standard.
POLYCYCLIC AROMATIC COMPOUNDS
(2022)
Article
Chemistry, Physical
Eman A. Fayed, Rogy R. Ezz Eldin, Ahmed B. M. Mehany, Ashraf H. Bayoumi, Yousry A. Ammar
Summary: Isatin derivatives exhibit significant anti-tumor activity against three human cancer cell lines by inducing apoptosis and cell cycle arrest. The compounds also show effective EGFR inhibitory activity and oral bioavailability without blood-brain barrier permeation. Molecular docking studies revealed a strong binding of the most potent derivative inside the active site of EGFR.
JOURNAL OF MOLECULAR STRUCTURE
(2021)
Article
Chemistry, Medicinal
Yousry A. Ammar, Gamil A. M. Elhagali, Moustafa S. Abusaif, Mohamed R. Selim, Medhat A. Zahran, Tamer Naser, Ahmed B. M. Mehany, Eman A. Fayed
Summary: The targeted approach of protein kinases has shown promise in cancer treatment by analyzing the potential of quinoline-carboxamide derivatives as anticancer agents. Among the derivatives tested, some showed good anti-proliferative activities and inhibition of Pim-1 kinase, indicating further research potential. In addition, in silico assessment revealed these compounds are orally bioavailable without blood-brain barrier penetration.
MEDICINAL CHEMISTRY RESEARCH
(2021)
Article
Chemistry, Medicinal
Abdullah Y. Alzahrani, Yousry A. Ammar, Mohamed A. Salem, Mohammed Abu-Elghait, Ahmed Ragab
Summary: A series of novel 3-[(1H-pyrazol-3-yl)imino]indolin-2-one derivatives exhibited promising antimicrobial activity, with some compounds showing comparable efficacy to conventional antibiotics. Two derivatives were also capable of preventing biofilm formation by Staphylococcus aureus.
ARCHIV DER PHARMAZIE
(2022)
Article
Biochemistry & Molecular Biology
Eman A. Fayed, Ahmed Ragab, Rogy R. Ezz Eldin, Ashraf H. Bayoumi, Yousry A. Ammar
Summary: A series of isatin derivatives containing thiazole moiety were synthesized and evaluated for their anticonvulsant activity in vivo, showing most compounds exhibited relative potency compared to standard drug phenobarbitone. The most active compounds demonstrated good toxic properties on liver and kidney functions with mild changes in hematological parameters, kidney and liver tissues.
BIOORGANIC CHEMISTRY
(2021)
Article
Chemistry, Physical
Yousry A. Ammar, Sondos M. A. Abd El-Hafez, Sadia A. Hessein, Abeer M. Ali, Ahmed A. Askar, Ahmed Ragab
Summary: The study involved synthesis of quinoline-based thiazole analogues for antibiotic class, which showed good antimicrobial activity against standard microbial pathogens and MDR bacterial strains. Active derivatives were effective in treating bacterial infection by inhibiting DHFR enzyme, with molecular docking study supporting the binding mode. DFT calculation generated MEP surfaces to determine interaction regions for different types of interactions.
JOURNAL OF MOLECULAR STRUCTURE
(2021)
Article
Chemistry, Physical
Doaa M. Elsisi, Ahmed Ragab, Ahmed A. Elhenawy, Awatef A. Farag, Abeer M. Ali, Yousry A. Ammar
Summary: This study aimed to synthesize a safe antimicrobial agent based on dihydroquinoxalinedione derivatives and evaluate their antimicrobial activity. Molecular docking and dynamic simulation were used to validate the antimicrobial activity and stability of these compounds.
JOURNAL OF MOLECULAR STRUCTURE
(2022)
Article
Chemistry, Organic
Sawsan A. Fouad, Marwa S. El-Gendey, Entsar M. Ahmed, Sadia A. Hessein, Yousry A. Ammar, Yasser H. Zaki
Summary: The research focused on the synthesis and characterization of new heterocyclic compounds containing the N-carbamimidoylsulfamoyl pharmacophore relevant to antibacterial and antifungal activities. Most of the synthesized compounds showed good to excellent antimicrobial activity against six standard microbial pathogens, indicating potential therapeutic value.
POLYCYCLIC AROMATIC COMPOUNDS
(2022)
Article
Chemistry, Multidisciplinary
Ahmed Ragab, Doaa M. Elsisi, Ola A. Abu Ali, Moustafa S. Abusaif, Ahmed A. Askar, Awatef A. Farag, Yousry A. Ammar
Summary: A series of compounds based on 6-(morpholinosulfonyl)quinoxalin-2(1H)-one were designed, synthesized, and evaluated for their in vitro antimicrobial activity, showing good potential against multi-drug resistance bacteria. These compounds also exhibited immunomodulatory and DNA gyrase inhibition activities.
ARABIAN JOURNAL OF CHEMISTRY
(2022)
Article
Engineering, Chemical
T. M. Tamer, A. M. Omer, R. E. Khalifa, A. A. Ali, Y. A. Ammar, M. S. Mohy Eldin
Summary: The study investigated the kinetics, isotherm, and thermodynamics of heavy oil spills removal by aminated chitosan-g-poly(butyl acrylate) copolymer. The results showed that the removal process followed pseudo-first-order and pseudo-second-order kinetics, and adhered to Langmuir and Freundlich isotherm models, with high monolayer sorption capacities. Thermodynamic studies indicated that the sorption process was spontaneous and endothermic.
DESALINATION AND WATER TREATMENT
(2021)
Article
Engineering, Chemical
Randa Eslah Khalifa, Ahmed Abd El-Wahed Ali, Gaber Abo-Zaid, Ahmed Mohamed Omer, Tamer Mahmoud Tamer, Yossry Ammar, Mohamed Samir Mohy Eldin
Summary: This study optimized the sorption of oil from seawater using chitosan grafted poly(butyl acrylate) copolymer and identified the best sorption conditions through response surface methodology. The grafted chitosan derivatives showed higher sorption capacity compared to native chitosan, making them effective for environmental control of crude heavy oil spills. The Plackett-Burman design and Box-Behnken design were utilized for parameter screening and optimization, respectively.
DESALINATION AND WATER TREATMENT
(2021)
Article
Chemistry, Physical
Xinlei Chen, Shiyi Chen, Xuele Lin, Jingxuan Zhou, Xingjun Gao, Yaoqi Zhen, Xiaodan Ma, Shouwen Jin, Linfang Shi, Hui Liu, Daqi Wang
Summary: Nine mixed-ligand Cd2+ complexes with different geometric structures were synthesized and characterized. The complexes exhibit various coordination modes and form both intra- and intermolecular hydrogen bonds.
JOURNAL OF MOLECULAR STRUCTURE
(2024)
Article
Chemistry, Physical
Rupali Mahajan, Abhishek Sharma, Bhagyashree Patra, Lijo Mani, Parul Grover, Sandeep Kumar, Santosh Kumar Guru, Gananadhamu Samanthula, Amol G. Dikundwar, Amit Asthana
Summary: This research article provides a comprehensive characterization and toxicological assessment of a photoisomeric impurity of the antianemic drug Roxadustat. The impurity has a distinct structure compared to the drug and its formation due to light exposure is a concern. Through various experiments, including single crystal XRD, physicochemical characterization, and in vitro cytotoxicity assays, the researchers confirmed the structure of the impurity, evaluated its conversion with Roxadustat, and assessed its toxicological activity. These findings contribute to the understanding of drug stability, safety, and formulation development.
JOURNAL OF MOLECULAR STRUCTURE
(2024)
Article
Chemistry, Physical
Laila S. Alqarni, Azzah M. Alghamdi, Nuha Y. Elamin, A. Rajeh
Summary: The solution casting method was used to produce a new type of nanocomposites made of chitosan, gelatin, and co-doped ZnO nanoparticles. The addition of 3.5% co-doped ZnO nanoparticles improved the physicochemical characteristics and antimicrobial effects of the nanocomposites, indicating their significant potential in food packaging and energy storage.
JOURNAL OF MOLECULAR STRUCTURE
(2024)
Article
Chemistry, Physical
Ruchi Gaur
Summary: The structure and intermolecular interactions of a newly synthesized bis-chalcone THXA were studied using experimental and computational methods. The importance of non-covalent interactions such as pi center dot center dot center dot pi, C-H center dot center dot center dot S, and C-H center dot center dot center dot pi was revealed.
JOURNAL OF MOLECULAR STRUCTURE
(2024)
Article
Chemistry, Physical
Andrii Bazylevich, Leonid Patsenker, Sarit Aviel-Ronen, Gary Gellerman
Summary: Drug combination therapy is commonly used for treating various skin disorders, but its effectiveness is often limited. In this study, researchers synthesized conjugates of anti-pigmenting drugs and hyaluronic acid (HA) to improve treatment efficacy. These HA-drug conjugates exhibited measurable drug release profiles and demonstrated superior depigmentation effects compared to control groups in a swine model.
JOURNAL OF MOLECULAR STRUCTURE
(2024)
Article
Chemistry, Physical
Xiaodan Ma, Xinlei Chen, Yaoqi Zhen, Xunjie Zheng, Chengzhe Shi, Shouwen Jin, Bin Liu, Bin Chen, Daqi Wang
Summary: Cocrystallization experiments between minoxidil and aryl acids coformers resulted in the successful formation of multi-component samples. The nature of these samples was determined using various techniques and their structural and supramolecular aspects were investigated. The outcomes revealed the importance of nonbonding contacts and different types of interactions in stabilizing and expanding the crystal structures.
JOURNAL OF MOLECULAR STRUCTURE
(2024)
Article
Chemistry, Physical
Najla A. Alshaye, Magdy A. Ibrahim, Al-Shimaa Badran
Summary: The chemical behavior of 3-substituted-6,8-dimethylchromones towards phenylhydrazine was examined. Different reaction conditions produced various products, and the molecular geometries and reactivity descriptors of the compounds were also investigated. The results suggest that these compounds are suitable for nonlinear optical applications.
JOURNAL OF MOLECULAR STRUCTURE
(2024)
Article
Chemistry, Physical
Hayette Alliouche, Houria Bouria, Rafik Bensegueni, Mounia Guergouri, Abdelmalek Bouraiou, Ali Belfaitah
Summary: In this paper, a combined experimental and theoretical study was conducted to synthesize and characterize new 2-quinolone-piperidine and -morpholine hybrids. The results from experiments were validated using computational calculations, and the affinity between these compounds and Acetylcholinesterase/Butyrylcholinesterase was estimated through molecular docking.
JOURNAL OF MOLECULAR STRUCTURE
(2024)
Article
Chemistry, Physical
Wei-Min Chen, Juan-Juan Shao, Yi Zhang, Zhen-Dong Xue, Peng-Lai Liu, Jian-Ling Ni, Li-Zhuang Chen, Qiang Gao, Fang-Ming Wang
Summary: This study synthesized and characterized a novel Mn-based LMOF, and achieved good results in detecting heavy metal Al3+ in water, showing good stability, high selectivity and sensitivity. This provides new insights into the potential applications of Mn-based MOFs in chemical sensing.
JOURNAL OF MOLECULAR STRUCTURE
(2024)
Article
Chemistry, Physical
Jun-Xia Li, Yi-Jing Lu, Ke-Ying Quan, Li-Bing Wu, Xun Feng, Wei-Zhou Wang
Summary: This study synthesized two cobalt(II) complexes and analyzed their crystal structures using single-crystal X-ray diffraction. The results showed that the crystal structures of these complexes were different, and they exhibited different crystal packing and magnetic properties.
JOURNAL OF MOLECULAR STRUCTURE
(2024)
Article
Chemistry, Physical
Yang Li, Yan Zhang, Hong Xu, Min Li, Zhen Li, Zi-yu Song, Ji-shi Chen, Yan-Jun Liu, Yong Sun, Zhao Yang
Summary: This study reports the synthesis and solid-state characterization of a new pharmaceutical cocrystal, PRO-BPE, which can enhance the solubility of the highly water-insoluble prodrug probenecid. The PRO-BPE cocrystals were found to have superior water solubility compared to pure PRO. This research provides valuable insights into improving the solubility of poorly soluble drugs.
JOURNAL OF MOLECULAR STRUCTURE
(2024)
Article
Chemistry, Physical
Lucas G. B. Felicio, Bianca B. M. Vieira, Ivana S. Lula, Renata Diniz, Frank Alexis, Flavio B. Miguz, Frederico B. De Sousa
Summary: A novel spiropyran derivative was synthesized for heavy metals sensing in water. The results demonstrated that the new derivative can serve as a rapid, sensitive, and simple tool for detecting Hg2+ ions in water with high selectivity.
JOURNAL OF MOLECULAR STRUCTURE
(2024)
Article
Chemistry, Physical
Junqing Meng, Jie Wang, Lijuan Wang, Chunhui Lyu, Haiyan Chen, Yingpei Lyu, Baisheng Nie
Summary: Material modification with low surface energy can achieve lower surface free energy on micro-and nano-rough structures, which is crucial for developing superhydrophobic surfaces. In this study, attapulgite (APT) was modified with alkylamine, alkylammonium salt, and stearic acid, and the interaction between low surface materials and attapulgite was explained. The results showed that the hydrophobicity of APT was significantly modified by the modifiers, and the surface free energy of the composites first decreased and then increased with increasing molecular number of low surface energy monomers.
JOURNAL OF MOLECULAR STRUCTURE
(2024)
Article
Chemistry, Physical
Karan Goswami, Dipak Das, Parthasarathi Bera, Sounak Roy, Md. Motin Seikh, Prasanta Kumar Sinha, Arup Gayen
Summary: This work presents the development of a simple and highly active heterogeneous Pd catalyst for Suzuki-Miyaura carbon-carbon cross-coupling reaction. The NiPdFe-1 catalyst shows the best activity and stability among the prepared catalysts. It efficiently promotes the coupling reaction between aryl bromide and phenyl boronic acid under mild reaction conditions with high isolated yields.
JOURNAL OF MOLECULAR STRUCTURE
(2024)
Article
Chemistry, Physical
Ekta Pardhi, Devendra Singh Tomar, Rahul Khemchandani, Gananadhamu Samanthula, Pankaj Kumar Singh, Neelesh Kumar Mehra
Summary: The main aim of this study was to prepare a drug-drug coamorphous system to improve the physiochemical properties, solubility and stability of Apremilast and Indomethacin. Various solid-state characterization techniques were used to characterize the prepared system. Molecular level interactions were studied using molecular modeling and ATR-FTIR and 1H NMR. Solubility and dissolution studies showed the benefits of the coamorphous system. The system was found to be stable for a period of five months. Permeation study also demonstrated improved flux for both drugs compared to their crystalline forms. The coamorphous system showed anti-psoriatic and anti-melanogenic activity based on molecular docking results. Overall, the developed CAM-based supersaturated system exhibited improved physicochemical properties and physical stability.
JOURNAL OF MOLECULAR STRUCTURE
(2024)