Article
Biochemistry & Molecular Biology
Pi-Cheng Cheng, Ruo-Ciao Cheng, Rong-Chi Huang
Summary: Glutamate induces Ca2+ signaling in the suprachiasmatic nucleus (SCN) by activating intracellular mechanisms involving Na+ loads, Na+/K+-ATPase (NKA), and Na+/Ca2+-exchanger (NCX). The presence of Na+ loads leads to slower Ca2+ clearance and increased rebound Ca2+ suppression. However, even in the absence of external Na+, additional Ca2+ handlers are involved in the slower Ca2+ clearance induced by glutamate.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Maria Crespo, David Agustin Leon-Navarro, Mairena Martin
Summary: Febrile seizures, classified as short or prolonged, are common in childhood. Prolonged febrile seizures have been linked to temporal lobe epilepsy, and animal models have shown that they can alter neuronal function. Na+/K+-ATPase and Mg2+-ATPase have been suggested to play a role in this process. The study found that hyperthermia-induced seizures increased the activity of Na+/K+-ATPase and Mg2+-ATPase, and also increased the protein level of the AMPA subunit GluR1.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Multidisciplinary Sciences
Rawad Hodeify, Mohamed Chakkour, Reem Rida, Sawsan Kreydiyyeh
Summary: The Na+/K+ ATPase plays a crucial role in regulating the ionic homeostasis of hepatocytes, and its stimulation by PGE2 is mediated through EP4, PKA, and intracellular calcium pathways.
Article
Nanoscience & Nanotechnology
Xuli Hu, Jiebang Peng, Fei Xu, Mingyue Ding
Summary: This study investigates the performance of hybrid batteries based on magnesium and sodium, potassium ions, and reveals that the co-intercalation of magnesium and sodium ions in VS2 cathode exhibits the highest reversibility and cycling stability. It offers insights for the development of high-performance rechargeable magnesium metal batteries.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Biochemistry & Molecular Biology
Ivan Kushkevych, Mykola Bychkov, Solomiia Bychkova, Mario Gajdacs, Romana Merza, Monika Vitezova
Summary: Autophagy allows prolonged survival in tumor cells with defects in apoptosis, and NAADP may affect the release of Ca2+ from organelles. The activity of ATPases in colorectal cancer tissues is higher, and NAADP has different effects on ion transport in cancer and control samples, showing promising possibilities for the treatment of colorectal cancer.
Article
Pharmacology & Pharmacy
Adeola Temitope Salami, Gloria Enevwo Okotie, Precious Nekachi Echendu, Uwaifoh Akpamu, Samuel Babafemi Olaleye
Summary: The study found that KBrO3 may mitigate NaOH-induced Crohn's colitis by inhibiting mast cell population and oxidative and inflammatory content, while stimulating colonic sulfhydryl and Ca2+- and Na+/K+-ATPase activities.
CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Aline Yammine, Lizette Auezova, Gerard Lizard, Helene Greige-Gerges
Summary: The aim of this study was to investigate whether quercetin, resveratrol, or caffeic acid, at nano-and low micromolar concentrations, can improve the activity of Na+/K+- and Ca2+-ATPases in human erythrocyte membranes with excess cholesterol. These polyphenols belong to different chemical classes and are widely present in plant foods.
Article
Toxicology
Xuan Ni, Xiaoyu Yin, Chelimuge Qi, Chunyu Liu, Hao Chen, Yini Zhou, Wuliji Ao, Shuyin Bao, Jiangdong Xue, Jingfeng Yang, Wu Dong
Summary: In this study, the effects of three isomers of borneol on heart development in zebrafish embryos were examined. The results showed that all three isomers of borneol reduced heart rate and affected the expression and activity of genes related to ATPase. Isoborneol exhibited the most significant toxic effect.
JOURNAL OF APPLIED TOXICOLOGY
(2023)
Article
Multidisciplinary Sciences
Subashini Thirukkalukundram Singarapriyavardhanan, Prakash Srinivasan Timiri Shanmugam, Sunil Kumar Koppala Narayana, Aiman A. Ammari, Ramzi A. Amran, Ahmad R. Alhimaidi
Summary: The study validated the protective role of Mimosa pudica plant extracts in diabetic rats, showing effects such as reducing blood glucose levels, improving liver and renal function, and antioxidant properties.
JOURNAL OF KING SAUD UNIVERSITY SCIENCE
(2022)
Article
Plant Sciences
Magda F. El-Adl, Taha M. El-Katony, Reham M. Nada
Summary: The study found that the specific ion effects of Na+ and K+ were different on the growth of Ulva lactuca. Ulva lactuca showed better growth with high concentrations of NaCl, while KCl might have adverse effects on photosynthesis and cell wall. Transcription of PM H+-ATPase was induced specifically by high concentrations of Na+, while the induction of PM-Na+/K+-ATPase-like alone could not improve the growth of KCl-treated Ulva lactuca.
PLANT PHYSIOLOGY AND BIOCHEMISTRY
(2021)
Article
Medicine, Research & Experimental
Muhammad Torequl Islam, Cristina Quispe, Md Amirul Islam, Eunus S. Ali, Sushmita Saha, Umma Hafsa Asha, Milon Mondal, Ahmad Faizal Abdull Razis, Usman Sunusi, Ramla Muhammad Kamal, Manoj Kumar, Javad Sharifi-Rad
Summary: The study demonstrated that nerol exhibited significant hepatoprotective activity against paracetamol-induced liver toxicity in rats. It decreased hepatotoxic markers, improved antioxidant enzyme levels, and maintained normal liver structure. Future research will focus on the mechanisms of action of nerol in Wistar albino rats.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Plant Sciences
Qi Chen, Kai Xu, Yan Xu, Dehua Ji, Changsheng Chen, Chaotian Xie, Wenlei Wang
Summary: This study analyzed the function of Na+/K+-ATPase in the response of Neoporphyra haitanensis to salt stress and found that it played a crucial role in maintaining the K+/Na+ homeostasis in the algae. The inhibitor ouabain caused Na+ accumulation and K+ leakage in the cells, disrupting the K+/Na+ balance and leading to decreased photosynthesis and oxidative damage in the algae.
FRONTIERS IN PLANT SCIENCE
(2023)
Article
Biochemistry & Molecular Biology
Marlene U. Fruergaard, Ingrid Dach, Jacob L. Andersen, Mette Ozol, Azadeh Shahsavar, Esben M. Quistgaard, Hanne Poulsen, Natalya U. Fedosova, Poul Nissen
Summary: In this study, the crystal structure and functional properties of the E2-BeFx complex of pig kidney Na+,K+-ATPase are investigated. The complex resembles the E2P intermediate and is able to bind ADP/ATP and Na+. The results suggest a relation between E2-BeFx and the E*P intermediate in the functional cycle of Na+, K+-ATPase.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Santiago E. Faraj, Wanda M. Valsecchi, Mariela Ferreira-Gomes, Mercedes Centeno, Elina Malen Saint Martin, Natalya U. Fedosova, Juan Pablo FC. Rossi, Monica R. Montes, Rolando C. Rossi
Summary: The Na+/K+-ATPase is a plasma membrane glycoprotein that exchanges intracellular Na+ for extracellular K+ by hydrolyzing ATP. The asymmetric distribution of Na+ and K+ is essential for cellular life. Current research indicates that Na+ becomes spontaneously occluded in the E1 dephosphorylated form of the Na+/K+-ATPase, showing positive interactions between binding sites. Adding ATP does not increase Na+ occlusion.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2023)
Article
Multidisciplinary Sciences
Yingying Guo, Yuanyuan Zhang, Renhong Yan, Bangdong Huang, Fangfei Ye, Liushu Wu, Ximin Chi, Yi Shi, Qiang Zhou
Summary: This study reports the structures of human NKA, providing insights into the cytoplasmic Na+ entrance pathway and the mechanism of cytoplasmic gate closure coupled with ATP hydrolysis. This fills crucial gaps in understanding the working cycle of NKA.
NATURE COMMUNICATIONS
(2022)
Article
Biochemistry & Molecular Biology
Amal A. Aloud, Chinnadurai Veeramani, Chandramohan Govindasamy, Mohammed A. Alsaif, Khalid S. Al-Numair
Article
Medicine, Research & Experimental
Chinnadurai Veeramani, Mohammed A. Alsaif, Khalid S. Al-Numair
BIOMEDICINE & PHARMACOTHERAPY
(2018)
Article
Biochemistry & Molecular Biology
Chinnadurai Veeramani, Mohammed A. Alsaif, Khalid S. Al-Numair
CHEMICO-BIOLOGICAL INTERACTIONS
(2018)
Article
Biochemistry & Molecular Biology
Amal A. Aloud, Veeramani Chinnadurai, Govindasamy Chandramohan, Mohammed A. Alsaif, Khalid S. Al-Numair
ARCHIVES OF PHYSIOLOGY AND BIOCHEMISTRY
(2020)
Article
Biology
Mani Suganya, Balasubramanian Mythili Gnanamangai, Chandramohan Govindasamy, Mohamed Farouk Elsadek, Arivalagan Pugazhendhi, Veeramani Chinnadurai, Arokiyaraj Selvaraj, Balasubramani Ravindran, Soon Woong Chang, Ponnusamy Ponmurugan
SAUDI JOURNAL OF BIOLOGICAL SCIENCES
(2019)
Article
Chemistry, Inorganic & Nuclear
Chinnadurai Veeramani, Mohammed A. Alsaif, Khalid S. Al-Numair
JOURNAL OF CLUSTER SCIENCE
(2020)
Article
Chemistry, Physical
Chinnadurai Veeramani, Ahmed S. El Newehy, Mohammed A. Alsaif, Khalid S. Al-Numair
Summary: This study focused on synthesizing biogenic silver nanoparticles and core-shell nanospheres from PC fruit extract using an eco-friendly method, and evaluating their effectiveness in preventing oral cancer. The results showed that these nanomaterials exhibited promising anticancer and antioxidant properties against oral cancer.
JOURNAL OF MOLECULAR STRUCTURE
(2021)
Article
Medicine, General & Internal
Chinnadurai Veeramani, Ahmed S. El Newehy, Mohammed A. Alsaif, Khalid S. Al-Numair
Summary: In this study, production and characterization of biomimetic iron oxide nanoparticles (ICF) from Cassia fistula flower tea were investigated. The synthesized ICF exhibited powerful anti-hyperglycemic and antioxidant mechanisms.
AFRICAN HEALTH SCIENCES
(2022)
Article
Medicine, General & Internal
Chinnadurai Veeramani, Ahmed S. El Newehy, Mohammed A. Alsaif, Khalid S. Al-Numair
Summary: In this study, a nontoxic method for synthesizing iron oxide nanoparticles using the fruit of Pouteria caimito was developed and evaluated for its cytotoxicity. The results showed that these nanoparticles exhibited good morphology and uniform surface charge distribution, and could be utilized for targeting cancer cells and treating other diseases.
AFRICAN HEALTH SCIENCES
(2022)
Article
Food Science & Technology
Chinnadurai Veeramani, Ahmed S. El Newehy, Amal A. Aloud, Mohammed A. Alsaif, Khalid S. Al-Numair
Summary: This study assessed the fusion of nanoparticles from Lavatera critica leaf extract and calcium chloride and their impact on the safety and shelf life of fresh-sliced fruits. It was found that the synthesized LCCaNP could effectively preserve the fruits for up to 20 days, with improved shelf life and sensory quality.
JOURNAL OF FOOD PROCESSING AND PRESERVATION
(2022)
Article
Tropical Medicine
Amal A. Aloud, Chinnadurai Veeramani, Chandramohan Govindasamy, Mohammed A. Alsaif, Khalid S. Al-Numair
ASIAN PACIFIC JOURNAL OF TROPICAL BIOMEDICINE
(2019)
Article
Chemistry, Multidisciplinary
Mani Suganya, Balasubramanian Mythili Gnanamangai, Balasubramani Ravindran, Soon Woong Chang, Arokiyaraj Selvaraj, Chandramohan Govindasamy, Mohamed Farouk Elsadek, Ponnusamy Ponmurugan