Ferroptosis, a Recent Defined Form of Critical Cell Death in Neurological Disorders

Selenium Utilization by GPX4 Is Required to Prevent Hydroperoxide-Induced Ferroptosis

(2018) Irina Ingold et al.   CELL

Brain mitochondrial iron accumulates in Huntington's disease, mediates mitochondrial dysfunction, and can be removed pharmacologically

(2018) Sonal Agrawal et al.   FREE RADICAL BIOLOGY AND MEDICINE

Regulation of lipid peroxidation and ferroptosis in diverse species

(2018) Marcus Conrad et al.   GENES & DEVELOPMENT

Iron and Alzheimer’s Disease: An Update on Emerging Mechanisms

(2018) Darius J.R. Lane et al.   JOURNAL OF ALZHEIMERS DISEASE

Unique properties associated with the brain penetrant iron chelator HBED reveal remarkable beneficial effects after brain trauma

(2018) Saher Khalaf et al.   JOURNAL OF NEUROTRAUMA

Iron Redox Chemistry Promotes Antiparallel Oligomerization of α-Synuclein

(2018) Dinendra L. Abeyawardhane et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

FINO2 initiates ferroptosis through GPX4 inactivation and iron oxidation

(2018) Michael M. Gaschler et al.   Nature Chemical Biology

12/15 lipoxygenase: A crucial enzyme in diverse types of cell death

(2018) Qiu-Qi Li et al.   NEUROCHEMISTRY INTERNATIONAL

α-Lipoic acid improves abnormal behavior by mitigation of oxidative stress, inflammation, ferroptosis, and tauopathy in P301S Tau transgenic mice

(2018) Yan-Hui Zhang et al.   Redox Biology

Increased Iron Levels and Decreased Tissue Integrity in Hippocampus of Alzheimer's Disease Detected in vivo with Magnetic Resonance Imaging

(2018) Erika P. Raven et al.   JOURNAL OF ALZHEIMERS DISEASE

Selenomethionine Mitigates Cognitive Decline by Targeting Both Tau Hyperphosphorylation and Autophagic Clearance in an Alzheimer's Disease Mouse Model

(2017) Zhong-Hao Zhang et al.   JOURNAL OF NEUROSCIENCE

Post translational changes to α-synuclein control iron and dopamine trafficking; a concept for neuron vulnerability in Parkinson’s disease

(2017) James A. Duce et al.   Molecular Neurodegeneration

NADPH oxidases in Parkinson’s disease: a systematic review

(2017) Karim Belarbi et al.   Molecular Neurodegeneration

NADPH oxidase in brain injury and neurodegenerative disorders

(2017) Merry W. Ma et al.   Molecular Neurodegeneration

Iron regulatory protein (IRP)-iron responsive element (IRE) signaling pathway in human neurodegenerative diseases

(2017) Zhi Dong Zhou et al.   Molecular Neurodegeneration

Tau-mediated iron export prevents ferroptotic damage after ischemic stroke

(2017) Q-z Tuo et al.   MOLECULAR PSYCHIATRY

Neuronal Death After Hemorrhagic Stroke In Vitro and In Vivo Shares Features of Ferroptosis and Necroptosis

(2017) Marietta Zille et al.   STROKE

A selenium species in cerebrospinal fluid predicts conversion to Alzheimer’s dementia in persons with mild cognitive impairment

(2017) Marco Vinceti et al.   Alzheimers Research & Therapy

Ablation of ferroptosis regulator glutathione peroxidase 4 in forebrain neurons promotes cognitive impairment and neurodegeneration

(2017) William Sealy Hambright et al.   Redox Biology

Lithium suppression of tau induces brain iron accumulation and neurodegeneration

(2016) P Lei et al.   MOLECULAR PSYCHIATRY

Oxidized arachidonic and adrenic PEs navigate cells to ferroptosis

(2016) Valerian E Kagan et al.   Nature Chemical Biology

ACSL4 dictates ferroptosis sensitivity by shaping cellular lipid composition

(2016) Sebastian Doll et al.   Nature Chemical Biology

Ferroptosis, a newly characterized form of cell death in Parkinson's disease that is regulated by PKC

(2016) Bruce Do Van et al.   NEUROBIOLOGY OF DISEASE

A Novel Iron Chelator-Radical Scavenger Ameliorates Motor Dysfunction and Improves Life Span and Mitochondrial Biogenesis in SOD1G93A ALS Mice

(2016) Sagit Golko-Perez et al.   NEUROTOXICITY RESEARCH

Peroxidation of polyunsaturated fatty acids by lipoxygenases drives ferroptosis

(2016) Wan Seok Yang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mammalian lipoxygenases and their biological relevance

(2015) Hartmut Kuhn et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Expression of a Catalytically Inactive Mutant Form of Glutathione Peroxidase 4 (Gpx4) Confers a Dominant-negative Effect in Male Fertility

(2015) Irina Ingold et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Parkinson's Disease Iron Deposition Caused by Nitric Oxide-Induced Loss of  -Amyloid Precursor Protein

(2015) S. Ayton et al.   JOURNAL OF NEUROSCIENCE

Glutaminolysis and Transferrin Regulate Ferroptosis

(2015) Minghui Gao et al.   MOLECULAR CELL

Enduring Elevations of Hippocampal Amyloid Precursor Protein and Iron Are Features of β-Amyloid Toxicity and Are Mediated by Tau

(2015) Xuling Li et al.   Neurotherapeutics

Ferritin levels in the cerebrospinal fluid predict Alzheimer’s disease outcomes and are regulated by APOE

(2015) Scott Ayton et al.   Nature Communications

Regional vulnerability of longitudinal cortical association connectivity

(2015) Rafael Ceschin et al.   NeuroImage-Clinical

Relative importance of redox buffers GSH and NAD(P)H in age-related neurodegeneration and Alzheimer disease-like mouse neurons

(2014) Debolina Ghosh et al.   AGING CELL

Protective Effect of Chinonin in MPTP-Induced C57BL/6 Mouse Model of Parkinson’s Disease

(2014) Guoshuai Feng et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Luteolin provides neuroprotection in models of traumatic brain injury via the Nrf2–ARE pathway

(2014) Jianguo Xu et al.   FREE RADICAL BIOLOGY AND MEDICINE

Ceruloplasmin and β-amyloid precursor protein confer neuroprotection in traumatic brain injury and lower neuronal iron

(2014) Scott Ayton et al.   FREE RADICAL BIOLOGY AND MEDICINE

Neuroglobin expression and oxidant/antioxidant balance after graded traumatic brain injury in the rat

(2014) Valentina Di Pietro et al.   FREE RADICAL BIOLOGY AND MEDICINE

Ferrostatins Inhibit Oxidative Lipid Damage and Cell Death in Diverse Disease Models

(2014) Rachid Skouta et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Inactivation of the ferroptosis regulator Gpx4 triggers acute renal failure in mice

(2014) Jose Pedro Friedmann Angeli et al.   NATURE CELL BIOLOGY

Lower motor neuron disease with respiratory failure caused by a novel MAPT mutation

(2014) A. Di Fonzo et al.   NEUROLOGY

Biometals and Their Therapeutic Implications in Alzheimer’s Disease

(2014) Scott Ayton et al.   Neurotherapeutics

Sesamin attenuates neurotoxicity in mouse model of ischemic brain stroke

(2014) Saif Ahmad et al.   NEUROTOXICOLOGY

Nigral Iron Elevation Is an Invariable Feature of Parkinson’s Disease and Is a Sufficient Cause of Neurodegeneration

(2014) Scott Ayton et al.   Biomed Research International

Inhibition of 12/15-lipoxygenase as therapeutic strategy to treat stroke

(2012) Kazim Yigitkanli et al.   ANNALS OF NEUROLOGY

Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death

(2012) Scott J. Dixon et al.   CELL

Metallostasis in Alzheimer's disease

(2012) Scott Ayton et al.   FREE RADICAL BIOLOGY AND MEDICINE

Tau deficiency induces parkinsonism with dementia by impairing APP-mediated iron export

(2012) Peng Lei et al.   NATURE MEDICINE

Iron Accumulation in Deep Cortical Layers Accounts for MRI Signal Abnormalities in ALS: Correlating 7 Tesla MRI and Pathology

(2012) Justin Y. Kwan et al.   PLoS One

Dysregulation of Glutathione Homeostasis in Neurodegenerative Diseases

(2012) William M. Johnson et al.   Nutrients

Glutathione: a key component of the cytoplasmic labile iron pool

(2011) Robert C. Hider et al.   BIOMETALS

Alpha-Synuclein Is a Cellular Ferrireductase

(2011) Paul Davies et al.   PLoS One

Iron-Export Ferroxidase Activity of β-Amyloid Precursor Protein Is Inhibited by Zinc in Alzheimer's Disease

(2010) James A. Duce et al.   CELL

The Neuropathology of Late-Onset Friedreich’s Ataxia

(2010) Arnulf H. Koeppen et al.   CEREBELLUM

Iron-Related Brain Damage in Patients With Intracerebral Hemorrhage

(2010) Natalia Pérez de la Ossa et al.   STROKE

Delineating the Role of Glutathione Peroxidase 4 in Protecting Cells Against Lipid Hydroperoxide Damage and in Alzheimer's Disease

(2009) Min-Hyuk Yoo et al.   ANTIOXIDANTS & REDOX SIGNALING

Intranasal Deferoxamine Provides Increased Brain Exposure and Significant Protection in Rat Ischemic Stroke

(2009) L. R. Hanson et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Synthetic Lethal Screening Identifies Compounds Activating Iron-Dependent, Nonapoptotic Cell Death in Oncogenic-RAS-Harboring Cancer Cells

(2008) Wan Seok Yang et al.   CHEMISTRY & BIOLOGY

Glutathione-dependent redox status of frataxin-deficient cells in a yeast model of Friedreich's ataxia

(2008) F. Auchere et al.   HUMAN MOLECULAR GENETICS

Oxidant–antioxidant imbalance in the erythrocytes of sporadic amyotrophic lateral sclerosis patients correlates with the progression of disease

(2008) G. Nagesh Babu et al.   NEUROCHEMISTRY INTERNATIONAL

Association Between Serum Ferritin Level and Perihematoma Edema Volume in Patients With Spontaneous Intracerebral Hemorrhage

(2008) Manu Mehdiratta et al.   STROKE