Review
Pharmacology & Pharmacy
Xiaoli Pan, Junping Pei, Aoxue Wang, Wen Shuai, Lu Feng, Faqian Bu, Yumeng Zhu, Lan Zhang, Guan Wang, Liang Ouyang
Summary: This review provides an overview of the roles of the ERKs signaling pathway in cancer and the structure-activity relationships of small molecule inhibitors targeting ERKs. It offers important insights for drug design and optimization as well as potential therapeutic strategies to overcome drug resistance.
ACTA PHARMACEUTICA SINICA B
(2022)
Article
Biochemistry & Molecular Biology
Heba Ali Hassan, Sara S. Muhammed, Ahmad Al-Khdhairawi, Sayed F. Abdelwahab, Islam M. Abdel-Rahman, Mahmoud M. Abdelhamid
Summary: In this study, a deep-learning protocol was used to design 100 compounds by modifying the chemical structure of DHC to improve its inhibitory performance against ERK-2. Calculations and molecular docking revealed that five compounds had better docking scores and higher stability compared to DHC. Further molecular mechanics and MM/PBSA binding energy calculations confirmed that Cmd-1 and Cmd-4 showed superior stability and inhibition against ERK-2. This study highlights the potential of using Cmd-1 and Cmd-4 as promising anti-ERK-2 drug candidates.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2023)
Article
Cell & Tissue Engineering
Jie Zhou, Junying Yang, Yuan Dong, Yaru Shi, Endong Zhu, Hairui Yuan, Xiaoxia Li, Baoli Wang
Summary: Our study has for the first time established the direct role of OSMR in regulating osteogenic differentiation of marrow stromal progenitor cells through ERK-mediated autophagy signaling. OSMR thus contributes to bone homeostasis through dual regulation of osteoblasts and osteoclasts. It also suggests that OSMR may be a potential target for the treatment of metabolic disorders such as osteoporosis.
STEM CELL RESEARCH & THERAPY
(2022)
Article
Pharmacology & Pharmacy
Nozomi Tokunaga, Tomoyo Takimoto, Yoki Nakamura, Kazue Hisaoka-Nakashima, Norimitsu Morioka
Summary: This study investigates the relationship between Connexin 43 (Cx43) expression and induction of brain-derived neurotrophic factor(BDNF) production by antidepressants. The results show that downregulated Cx43 expression in depression patients might contribute to the therapeutic efficacy of antidepressants rather than the pathogenesis of depression. Furthermore, the study reveals that amitriptyline treatment potentiates BDNF expression in Cx43-knockdown astrocytes through LPA receptor(1/3) stimulation and subsequent activation of Src-ERK signaling.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2022)
Article
Medicine, Research & Experimental
Jieun Jeon, Tamanna Jahan Mony, Eunbi Cho, Huiyoung Kwon, Wan-Seob Cho, Ji Woong Choi, Byeong C. Kim, Jong Hoon Ryu, Se Jin Jeon, Kyoung Ja Kwon, Chan Young Shin, Se Jin Park, Dong Hyun Kim
Summary: In this study, it was found that rubrofusarin enhances learning and memory in mice and promotes neurite outgrowth. These effects may be achieved through activation of the ERK pathway.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Review
Toxicology
Yujia Xie, Jixuan Ma, Meng Yang, Lieyang Fan, Weihong Chen
Summary: Silicosis is a scarring lung disease caused by inhaling fine particles of crystalline silica in the workplace. The underlying molecular mechanisms of silicosis are not fully understood, but recent studies have highlighted the role of the activated ERK signaling pathway in regulating oxidative stress, inflammatory response, fibroblast activation, and other processes involved in the formation and development of silicosis.
TOXICOLOGY RESEARCH
(2021)
Article
Pharmacology & Pharmacy
Kanako Miyano, Seiya Hasegawa, Noriho Asai, Miaki Uzu, Wakako Yatsuoka, Takao Ueno, Miki Nonaka, Hideaki Fujii, Yasuhito Uezono
Summary: The Japanese herbal medicine Hangeshashinto (HST) has been shown to improve chemotherapy-induced oral ulcerative mucositis (OUM) through enhancing the migration of human oral keratinocytes (HOK) by upregulating CXCL12 via ERK.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Pharmacology & Pharmacy
Ruoqi Yang, Guiping Zhao, Lili Zhang, Yu Xia, Huijuan Yu, Bin Yan, Bin Cheng
Summary: This study constructed an efficient and reliable multi-stage virtual screening-in vitro biological validation system to identify potential inhibitors targeting ERK2. By using machine learning models, ADME/T prediction, and molecular docking, several candidate inhibitors were identified from natural products, and one of them exhibited acceptable inhibitory activity in vitro.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Virology
Jie Ni, Shunlin Hu, Xiaoquan Wang, Xiaowen Liu, Zenglei Hu, Xiufan Liu
Summary: This study investigates the relationship between the ERK pathway and Newcastle disease virus (NDV) replication. It was found that activation of the ERK pathway is required for NDV replication, as specific blockage of this pathway significantly decreased viral gene expression, replication, and cytopathogenic effects caused by NDV.
ARCHIVES OF VIROLOGY
(2021)
Article
Medicine, Research & Experimental
KyoungJoo Cho, Gyung Whan Kim
Summary: This study investigated the causes of selectively striatal cell loss in mice infused with 3-nitropropionic acid (3-NP). It found that mitochondrial dysfunction was higher in the striatum than in the cortex, and autophagy that may restore energy depletion occurred less in the striatum. Inhibition of ASK1 by NQDI1 regulates MAPK signaling, apoptosis, and autophagy, improving the damaged condition in the striatum.
Article
Pharmacology & Pharmacy
Svetlana A. Litvinova, Tatyana A. Voronina, Evgeny A. Kondrakhin, Igor O. Gaydukov, Artem I. Davletshin, Ekaterina V. Vasileva, Georgy I. Kovalev, David G. Garbuz
Summary: The study suggests that GIZH-298 may alleviate seizures in mice by modulating dopamine D2 receptors and ERK1/2 kinase activity.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Yang Liu, Ziqiang Luo, Zhengchang Liao, Mingjie Wang, Yan Zhou, Siwei Luo, Ying Ding, Teng Liu, Chuangding Cao, Shaojie Yue
Summary: Intrauterine hypoxia during pregnancy can increase the risk of cardiovascular disease in offspring, but the underlying mechanism is controversial. This study found that antenatal memantine treatment can protect the heart from injury in neonatal offspring exposed to intrauterine hypoxia by improving mitochondrial function and structure.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Atsushi Sato, Yusuke Yumita, Kazuki Kagami, Yuki Ishinoda, Toyokazu Kimura, Ayumu Osaki, Takumi Toya, Takayuki Namba, Shogo Endo, Yasuo Ido, Yuji Nagatomo, Yasushi Satoh, Takeshi Adachi
Summary: This study aimed to investigate the role of endothelial ERK2 in metabolic syndrome. The results showed that endothelial ERK2 increased superoxide level and decreased NO bioactivity, resulting in the deterioration of endothelial function, insulin resistance, and steatohepatitis. These adverse conditions could be improved by using a TP receptor antagonist.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2022)
Article
Gastroenterology & Hepatology
Wen-Zhi Qu, Luan Wang, Juan-Juan Chen, Yang Wang
Summary: This study aims to detect the expression of RKIP, P-ERK, and P-MEK proteins in GIST and analyze their relationship with clinicopathological characteristics and prognosis. A new prognosis evaluation model using RKIP and P-ERK is established and its efficacy is evaluated.
WORLD JOURNAL OF GASTROENTEROLOGY
(2023)
Article
Psychiatry
Kai-Chun Yang, Yen-Yu Chen, Mu-N Liu, Bang-Hung Yang, Yuan-Hwa Chou
Summary: This study found that patients with schizophrenia exhibited poorer cognitive performance and elevated concentrations of certain amino acids in plasma. The interactions between striatal dopamine transporter and NMDAR-related amino acids play a role in cognitive impairments in schizophrenia.
SCHIZOPHRENIA RESEARCH
(2022)
Article
Genetics & Heredity
Won Sub Kang, Young Jong Kim, Hae Jeong Park, Su Kang Kim, Jong-Woo Paik, Jong Woo Kim
Article
Psychiatry
Hwayoung Lee, Hyung-Ki Kim, Jun-Tack Kwon, Shohyun Park, Hae Jeong Park, Su Kang Kim, Jin Kyung Park, Won Sub Kang, Young Jong Kim, Joo-Ho Chung, Jong Woo Kim, Hak-Jae Kim
PSYCHIATRY RESEARCH
(2018)
Article
Neurosciences
Soyoen Lee, Sang Min Lee, Won Sub Kang, Geon-Ho Jahng, Chang-Woo Ryu, Jin Kyung Park
NEUROSCIENCE LETTERS
(2019)
Article
Psychiatry
Sun Mi Kim, Young-Hoon Ko, Seoyoung Yoon, Won Sub Kang, Hye-Geum Kim, Hye Youn Park, Cheolmin Shin, Yoo Hyun Um, Soyoung Youn, Jae-Hon Leen, Seung-Ho Jang, Sang Won Jeon, Hong Jun Jeon, Seockhoon Chung, Jae-Won Choi, Kyu-Man Han, Sang-Yeol Lee
PSYCHIATRY INVESTIGATION
(2019)
Article
Psychiatry
Won Sub Kang, Su Kang Kim, Hae Jeong Park
PSYCHIATRY INVESTIGATION
(2020)
Article
Psychiatry
Miae Oh, Jong-Woo Kim, Nan-He Yoon, Seong Ae Lee, Sang Min Lee, Won Sub Kang
PSYCHIATRY INVESTIGATION
(2019)
Article
Psychiatry
Jun Ho Song, Jong Woo Kim, Chi Hyuk Oh, Hyo Jong Kim, Chang Kyun Lee, Won Sub Kang
PSYCHIATRY INVESTIGATION
(2020)
Article
Biochemistry & Molecular Biology
Hae Jeong Park, Sang A. Kim, Won Sub Kang, Jong Woo Kim
Summary: This study found that early-life stress induced by maternal separation can lead to changes in gut microbiota composition, inflammatory cytokines, and tryptophan-kynurenine metabolism in rats. These alterations were shown to be sex-dependent, with differences in gut microbe abundance and inflammatory cytokine levels observed between male and female rats.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Psychology, Clinical
Sang Min Lee, Minha Hong, Saengryeol Park, Won Sub Kang, In-Hwan Oh
Summary: The study investigated the treatment prevalence and economic burden of eating disorders in South Korea between 2010 and 2015, finding an increase in treatment prevalence and medical expenditures over the years. The total economic cost of eating disorders was USD 5455626 in 2015, with the highest economic cost and prevalence observed in the 20-29 age group.
JOURNAL OF EATING DISORDERS
(2021)
Article
Psychiatry
Hae Jeong Park, Won Sub Kang, Jong Woo Kim
Summary: Previous studies have suggested that the TGA haplotype of RTN4 is significantly associated with schizophrenia, potentially increasing the susceptibility to the disorder. The rare TGA haplotype was shown to decrease promoter activity, further supporting its role in the pathogenesis of schizophrenia.
PSYCHIATRY RESEARCH
(2021)
Article
Medicine, General & Internal
Sanga Kim, Bup Kyung Choi, Ji Ae Park, Hyung Joong Kim, Tong In Oh, Won Sub Kang, Jong Woo Kim, Hae Jeong Park
Summary: Previous imaging studies have shown morphological malformation and alterations in ionic mobility, water contents, electrical properties, or metabolites in seizure brains. This study examined the potential of MREPT as a technique to detect seizure-induced functional changes in rat brains. The results revealed significantly decreased high-frequency conductivity in the hippocampus of NMDA-treated rats, accompanied by changes in cell structure and neuronal loss.
Article
Medicine, General & Internal
Won Sub Kang, Sang Min Lee, Dongkee Hwang, Hae Jeong Park, Jong Woo Kim
Summary: Accumulating evidence suggests that the autophagy process is involved in the pathogenesis of schizophrenia. This study found that specific ULK2 polymorphisms are associated with susceptibility to schizophrenia in the Korean population.
Article
Medicine, Research & Experimental
Chi Hoon Maeng, Bo-Hyung Kim, Jinmann Chon, Won Sub Kang, Kyounglan Kang, Mihye Woo, Il Ki Hong, Junhee Lee, Kil Yeon Lee
Summary: This study aims to evaluate the effect of a multimodal intervention on preventing or alleviating cancer cachexia in patients undergoing palliative chemotherapy. The results are expected to provide new insights and significantly improve the quality of life for cancer patients.
Letter
Psychiatry
Hae Jeong Park, Won Sub Kang, Miae Oh, Jong Woo Kim
PSYCHIATRY RESEARCH
(2022)
Article
Pharmacology & Pharmacy
Young Joo Park, Sang Min Lee, Won Sub Kang
Summary: Schizophrenia patients using clozapine may have an increased risk of pulmonary infection, but they are less likely to report physical symptoms. In this case report, a schizophrenia patient using clozapine did not complain of respiratory symptoms initially, but was later diagnosed with streptococcus intermedius empyema. Thanks to timely admission and proper treatment, the patient fully recovered.
PSYCHIATRY AND CLINICAL PSYCHOPHARMACOLOGY
(2022)