Review
Biochemistry & Molecular Biology
Victor Markus, Abraham Abbey Paul, Kerem Terali, Nazmi Ozer, Robert S. Marks, Karina Golberg, Ariel Kushmaro
Summary: An imbalance in gut microbiota, called dysbiosis, can affect host health and lead to diseases like inflammatory bowel disease, cancer, obesity, depression, and autism. The inhibition of bacterial quorum sensing (QS) by artificial sweeteners has been found to contribute to this dysbiosis. QS is a communication system mediated by small molecules, called autoinducers (AIs), which enable bacteria to interact and coordinate their gene expression. AIs play a role in maintaining the equilibrium of gut microbiota and interference in QS can disrupt this balance.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Sania Sahreen, Hamid Mukhtar, Kalman Imre, Adriana Morar, Viorel Herman, Sundas Sharif
Summary: This review discusses the role of quorum sensing (QS) in biofilm formation and its importance in biological wastewater treatment. The different types of autoinducers and their mechanisms are explained, along with the methods of QS regulation and inhibition. The potential applications of QS-regulated biofilms in wastewater treatment are also summarized. The article concludes with an analysis of knowledge gaps in current research and proposed future study requirements.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Microbiology
Liang Wu, Yubin Luo
Summary: The field of quorum sensing (QS) system is rapidly expanding our understanding of bacteria communication and social activities. Recent studies have shown that QS-related autoinducers play important roles in maintaining homeostasis in the gut microbiome and also in interactions between pathogens and their hosts under pathological conditions. This knowledge is crucial for developing novel antimicrobial therapeutic strategies.
FRONTIERS IN MICROBIOLOGY
(2021)
Review
Cell Biology
Nourhan G. Naga, Dalia E. El-Badan, Khaled M. Ghanem, Mona I. Shaaban
Summary: Multiple drug resistance is a significant threat to public health worldwide, leading to increased morbidity and mortality rates. Searching for new strategies to control microbial pathogenicity is necessary, and quorum sensing (QS) mediated by auto-inducers (AIs) is an important regulatory mechanism. AIs are small signaling molecules produced during stationary phase, regulating the expression of genes responsible for virulence factors in bacteria.
CELL COMMUNICATION AND SIGNALING
(2023)
Article
Engineering, Environmental
Chunxiao Dai, Yuanyuan Qu, Weize Wu, Shuzhen Li, Zhuo Chen, Shengyang Lian, Jiawei Jing
Summary: This study established a QS-related protein database and an automatic annotation pipeline for rapid and accurate annotation and classification of QS-related sequences in aquatic environments. It provides a useful tool for understanding bacterial communication in water environments.
Review
Food Science & Technology
Yucheng Zhang, Ning Ma, Peng Tan, Xi Ma
Summary: This review provides an overview of how gut bacteria use quorum sensing (QS) to communicate and coordinate their activities, and the role of QS in the interaction between the gut host and microbiota. Understanding the communication network of gut microbiota is crucial for developing strategies against bacterial illnesses and improving gut health.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2022)
Article
Microbiology
Rodrigo Santos-Pascual, Ivan Campoy, David Sanz Mata, Maria Jesus Martinez, Alicia Prieto, Jorge Barriuso
Summary: This manuscript presents a comprehensive study on the molecular mechanisms triggered by the quorum sensing (QS) molecule farnesol in the biotechnologically relevant fungus Ophiostoma piceae. We present for the first time, using a multiomics approach, an in-depth analysis of the QS response in a saprotroph fungus, detailing the molecular components involved in the response and their possible mechanisms of action. We think that these results are particularly relevant in the knowledge of the functioning of the QS in eukaryotes, as well as for the exploitation of these mechanisms.
MICROBIOLOGY SPECTRUM
(2023)
Review
Microbiology
Evgeniya V. Prazdnova, Andrey V. Gorovtsov, Nikita G. Vasilchenko, Maxim P. Kulikov, Varvara N. Statsenko, Anna A. Bogdanova, Alexandr G. Refeld, Yaroslav A. Brislavskiy, Vladimir A. Chistyakov, Michael L. Chikindas
Summary: This review focuses on the mechanisms of quorum-sensing suppression by Gram-positive microorganisms and its practical applications in food fermentation, probiotics, and biotechnology. It also discusses the possible evolutionary role of quorum-quenching mechanisms during the development of interspecies interactions of bacteria.
Article
Chemistry, Medicinal
Andrea Muras, Ana Parga, Celia Mayer, Ana Otero
Summary: Interfering with quorum sensing systems of bacteria is a promising strategy to control biofilm formation, and the xCELLigence(R) system is proposed as an efficient method for quantifying biofilm formation.
Review
Microbiology
Patricia P. Wright, Srinivas Sulugodu Ramachandra
Summary: Quorum sensing plays a crucial role in the pathogenicity and virulence of biofilms. This review focuses on the role of quorum sensing in cariogenic and periodontopathic biofilms and highlights the potential of quorum quenching as an antimicrobial tool to attenuate biofilm pathogenicity. Further research is needed to determine the clinical value of quorum sensing inhibitors against oral polymicrobial biofilms in vivo.
Review
Fisheries
P. Snega Priya, Seenivasan Boopathi, Raghul Murugan, B. Haridevamuthu, Aziz Arshad, Jesu Arockiaraj
Summary: Bacteria produce virulence factors that cause mortality in fish and crustaceans, and these factors require abundant quorum sensing (QS) signals and high cell density. QS signals not only interfere with cellular pathways and induce cell death in mammalian cells, but also impair the immune system, indicating their importance as a major virulence factor. In aquatic organisms, the impact of QS signals is still being explored. However, aquatic organisms produce enzymes that degrade and detoxify these signals, and physical and chemical factors also affect their stability. Understanding the influence of QS signals on aquatic organisms is crucial for controlling disease progression.
REVIEWS IN AQUACULTURE
(2023)
Article
Environmental Sciences
Natalia Herrera, Fernando Echeverri
Summary: This study investigated the biochemical origin of cyanobacterial blooms, specifically looking at bacterial communication in Microcystis aeruginosa and Cylindrospermopsis raciborskii. It was found that different acylhomoserine lactones had varying effects on cell proliferation, potentially providing an explanation for the formation of cyanobacterial blooms.
Review
Microbiology
Leon M. T. Dicks
Summary: The human gut contains almost 3000 microbial species, primarily bacteria, which produce quorum sensing molecules that influence the gut microbiome and communicate with the host. These molecules have a significant effect on our physiological and mental health.
Review
Biotechnology & Applied Microbiology
Yuxin Wang, Jianjun Dai, Xuhang Wang, Yang Wang, Fang Tang
Summary: This review paper summarizes the function of quorum sensing systems in the interaction between bacteriophage and their host bacteria, and its potential application in alternative control strategies for antibiotic-resistant and biofilm-forming pathogens.
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
(2022)
Review
Biotechnology & Applied Microbiology
Qingying Fan, Jing Zuo, Haikun Wang, Daniel Grenier, Li Yi, Yang Wang
Summary: Quorum sensing (QS) is an important part of cell/cell communication, especially in bacteria. Bacteria use QS to perceive and regulate gene expression to adapt to their complex habitats, including controlling the expression of virulence factors and antibiotic resistance. Targeting QS has proven to be a promising alternative strategy for controlling infections, especially in zoonotic bacteria.
BIOTECHNOLOGY ADVANCES
(2022)
Review
Agricultural Engineering
Kumari Uma Mahto, Surajit Das
Summary: Moving bed biofilm reactors (MBBR) are widely used in wastewater treatment due to their low operational costs, technical feasibility, and stability. They are capable of achieving high removal rates of nitrogen, organic carbon, and ammonium nitrogen, and modifications in the surface properties of the biocarrier materials can further improve removal efficiency.
BIORESOURCE TECHNOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Kumari Uma Mahto, Swetambari Kumari, Surajit Das
Summary: Biofilms are complex structures formed by bacteria regulated through intracellular and intercellular signaling systems. Secondary messenger molecules and Quorum Sensing play key roles in the regulation of biofilm formation, allowing bacteria to adapt and survive in toxic environments.
CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY
(2022)
Review
Environmental Sciences
Krishna Palit, Sonalin Rath, Shreosi Chatterjee, Surajit Das
Summary: Mangroves, one of the most productive ecosystems in the world, are facing threats from increasing greenhouse gas concentration, global warming, and human interventions. The conservation of mangrove ecosystems is crucial for preserving the global ecological balance.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)
Article
Medicine, Legal
Hirak Ranjan Dash, Eduardo Avila, Soumya Ranjan Jena, Kamlesh Kaitholia, Radhika Agarwal, Clarice Sampaio Alho, Ankit Srivastava, Anil Kumar Singh
Summary: The emergence of next-generation sequencing technology has led to the exploration of SNP markers as an alternative to traditional capillary electrophoresis-based STR typing, offering advantages such as low mutation rates and short amplicons. To achieve a sufficient level of discrimination, a higher number of SNPs need to be characterized simultaneously, highlighting the usefulness of NGS technology. Analysis of 124 SNPs in the central Indian population demonstrated the potential utility of SNP markers for forensic applications.
INTERNATIONAL JOURNAL OF LEGAL MEDICINE
(2022)
Review
Engineering, Environmental
Monika Priyadarshanee, Shreosi Chatterjee, Sonalin Rath, Hirak R. Dash, Surajit Das
Summary: Mercury (Hg) is a highly toxic element found in low concentrations in nature, but human and natural sources contribute around 5000 to 8000 metric tons of Hg per year, rapidly deteriorating environmental conditions. Mercury-resistant bacteria with the mer operon system play a crucial role in Hg biogeochemistry and bioremediation by converting reactive forms of Hg to inert, volatile forms.
JOURNAL OF HAZARDOUS MATERIALS
(2022)
Article
Genetics & Heredity
Hirak Ranjan Dash, Kamayani Vajpayee, Ritesh Shukla, Ankit Srivastava, Pankaj Shrivastava, Surajit Das
Summary: The shift from size-based allele determination to sequence-based allele determination in forensic DNA analysis has shown significant improvements in forensic and paternity applications, with Penta E marker being the most useful among the considered markers. Sequence variant alleles in D1S1656 have shown a substantial increase in forensic and paternity parameters, with the substitution of TAGA responsible for generating these variants. Observations of rs4847015 SNP further highlight the evidentiary value of D1S1656 compared to other STR markers analyzed in this study.
Article
Environmental Sciences
Shivananda Behera, Monika Priyadarshanee, Vandana, Surajit Das
Summary: The rising plastic pollution has negative impacts on the environment due to the non-biodegradable nature of petroleum-based plastics. Polyhydroxyalkanoates (PHAs) offer a sustainable and eco-friendly alternative as they can be synthesized using various microorganisms and possess enhanced biodegradability and other useful properties. This review provides an overview of the synthesis mechanism, properties, and applications of microbially synthesized PHAs, as well as discussing the classification, detection techniques, genetic regulation, and industrial production of these biopolymers.
Review
Biotechnology & Applied Microbiology
Hirak Ranjan Dash, Mansi Arora
Summary: CRISPR-Cas technology has revolutionized biotechnology by enabling precise therapeutic applications in the fields of genetics and infectious diseases. It has also shown promising use in forensic DNA analysis. However, there is a potential threat of generating ghost DNA profiles through modification of target genetic markers, highlighting the need for analysis of additional markers.
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Srimanta Patra, Shankargouda Patil, Surajit Das, Sujit Kumar Bhutia
Summary: This review discusses the post-transcriptional modulation of autophagy genes during viral-induced oral carcinogenesis mediated by epigenetic regulation, with a special focus on epi-drugs as next-generation oral cancer therapeutic agents targeting autophagy regulation.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2022)
Review
Chemistry, Applied
Vandana, Surajit Das
Summary: Bacterial biofilm formation depends on the Quorum Sensing system and c-di-GMP, which regulate the production of extracellular polysaccharides through genetic pathways. Understanding these mechanisms is crucial for customized polymer production.
CARBOHYDRATE POLYMERS
(2022)
Article
Environmental Sciences
Sonalin Rath, Krishna Palit, Surajit Das
Summary: This study investigates the impact of varying pH and pCO(2) on the survivability, biofilm formation, and synthesis of extracellular polymeric substances (EPS) in a biofilm-forming marine bacterium. The findings highlight the adaptability of the bacterium to different pH conditions, with the maximum biofilm formation and EPS synthesis observed at pH 6. Understanding the role of EPS in providing structural and functional stability in varying pH conditions is essential for comprehending the future effects of ocean acidification on marine bacteria.
ENVIRONMENTAL RESEARCH
(2022)
Article
Biophysics
Ritu Raj, Sandra N. Pinto, Carina I. C. Crucho, Surajit Das, Carlos Baleizao, Jose Paulo S. Farinha
Summary: Fluorescent silica nanoparticles with a polymer shell can traceably deliver anticancer drugs, protecting them during delivery and releasing them intracellularly. These nanoparticles can accommodate a large drug payload and efficiently release the drug inside cells, showing excellent prospects for controlled drug delivery.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2022)
Article
Medicine, Legal
Hirak Ranjan Dash, Mansi Arora, Subia Khatoon
Summary: After the COVID-19 pandemic began, there was a significant increase in the use of face masks worldwide. A survey of 252 individuals showed that cotton masks were the most commonly used (41%), followed by N-95 masks (31%) and surgical disposable masks (26%). The survey also revealed that a high percentage of individuals (37%) wore a face mask more than 3 times before disposing of it. A study on 50 healthy individuals found that different parts of the masks contained sufficient DNA for forensic analysis, regardless of the mask type.
INTERNATIONAL JOURNAL OF LEGAL MEDICINE
(2023)
Article
Anthropology
Mansi Arora, Hirak Ranjan Dash
Summary: By analyzing genotype data, it was found that there are significant differences in STR genotypes between different populations, which can be used to predict an individual’s geolocation. Three different prediction models, including the use of unique genotypes, the use of the most frequent genotype, and a combined approach, could assist investigation agencies in criminal investigations when no reference sample is available.
ANNALS OF HUMAN BIOLOGY
(2023)
