Sorting receptor sortilin—a culprit in cardiovascular and neurological diseases

The Hypercholesterolemia-Risk Gene SORT1 Facilitates PCSK9 Secretion

(2014) Camilla Gustafsen et al.   Cell Metabolism

The identification of AF38469: An orally bioavailable inhibitor of the VPS10P family sorting receptor Sortilin

(2013) Tenna Juul Schrøder et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Targeted manipulation of the sortilin–progranulin axis rescues progranulin haploinsufficiency

(2013) Wing C. Lee et al.   HUMAN MOLECULAR GENETICS

A sequence variant associated with sortilin-1 (SORT1) on 1p13.3 is independently associated with abdominal aortic aneurysm

(2013) Gregory T. Jones et al.   HUMAN MOLECULAR GENETICS

Upregulation of blood proBDNF and its receptors in major depression

(2013) Li Zhou et al.   JOURNAL OF AFFECTIVE DISORDERS

Saturated fatty acids activate ERK signaling to downregulate hepatic sortilin 1 in obese and diabetic mice

(2013) Lipeng Bi et al.   JOURNAL OF LIPID RESEARCH

The Pro-Neurotrophin Receptor Sortilin Is a Major Neuronal Apolipoprotein E Receptor for Catabolism of Amyloid-  Peptide in the Brain

(2013) A.-S. Carlo et al.   JOURNAL OF NEUROSCIENCE

Sortilin and SorLA Display Distinct Roles in Processing and Trafficking of Amyloid Precursor Protein

(2013) C. Gustafsen et al.   JOURNAL OF NEUROSCIENCE

The Sorting Receptor Sortilin Exhibits a Dual Function in Exocytic Trafficking of Interferon-γ and Granzyme A in T Cells

(2012) Stefanie Herda et al.   IMMUNITY

Hepatic sortilin regulates both apolipoprotein B secretion and LDL catabolism

(2012) Alanna Strong et al.   JOURNAL OF CLINICAL INVESTIGATION

Differential Expression of Neurotensin and Specific Receptors, NTSR1 and NTSR2, in Normal and Malignant Human B Lymphocytes

(2012) S. Saada et al.   JOURNAL OF IMMUNOLOGY

The PCSK9 decade

(2012) Gilles Lambert et al.   JOURNAL OF LIPID RESEARCH

Hippocampal ProNGF Signaling Pathways and β-Amyloid Levels in Mild Cognitive Impairment and Alzheimer Disease

(2012) Elliott J. Mufson et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Misregulation of human sortilin splicing leads to the generation of a nonfunctional progranulin receptor

(2012) M. Prudencio et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Proteolytic processing of the p75 neurotrophin receptor: A prerequisite for signalling?

(2011) Sune Skeldal et al.   BIOESSAYS

Precursor of Brain-derived Neurotrophic Factor (proBDNF) Forms a Complex with Huntingtin-associated Protein-1 (HAP1) and Sortilin That Modulates proBDNF Trafficking, Degradation, and Processing

(2011) Miao Yang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Neuronal Brain-derived Neurotrophic Factor Is Synthesized in Excess, with Levels Regulated by Sortilin-mediated Trafficking and Lysosomal Degradation

(2011) Sarah Felice Evans et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

BACE1 Retrograde Trafficking Is Uniquely Regulated by the Cytoplasmic Domain of Sortilin

(2011) Gina M. Finan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Progranulin and TDP-43: Mechanistic Links and Future Directions

(2011) Samir Kumar-Singh   JOURNAL OF MOLECULAR NEUROSCIENCE

Long pre-mRNA depletion and RNA missplicing contribute to neuronal vulnerability from loss of TDP-43

(2011) Magdalini Polymenidou et al.   NATURE NEUROSCIENCE

Endogenous Neurotrophins and Trk Signaling in Diffuse Large B Cell Lymphoma Cell Lines Are Involved in Sensitivity to Rituximab-Induced Apoptosis

(2011) Cynthia Bellanger et al.   PLoS One

Genome-wide Screen Identifies rs646776 near Sortilin as a Regulator of Progranulin Levels in Human Plasma

(2010) Minerva M. Carrasquillo et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Sort1, Encoded by the Cardiovascular Risk Locus 1p13.3, Is a Regulator of Hepatic Lipoprotein Export

(2010) Mads Kjolby et al.   Cell Metabolism

Identification of a Linear Epitope in Sortilin That Partakes in Pro-neurotrophin Binding

(2010) Olga Serup Andersen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

From noncoding variant to phenotype via SORT1 at the 1p13 cholesterol locus

(2010) Kiran Musunuru et al.   NATURE

Sortilin associates with Trk receptors to enhance anterograde transport and neurotrophin signaling

(2010) Christian B Vaegter et al.   NATURE NEUROSCIENCE

Sortilin-Mediated Endocytosis Determines Levels of the Frontotemporal Dementia Protein, Progranulin

(2010) Fenghua Hu et al.   NEURON

Age-dependent alterations in nerve growth factor (NGF)-related proteins, sortilin, and learning and memory in rats

(2010) Alvin V. Terry et al.   PHYSIOLOGY & BEHAVIOR

ProNGF induces TNFα-dependent death of retinal ganglion cells through a p75NTR non-cell-autonomous signaling pathway

(2010) Frédéric Lebrun-Julien et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Significant impact of chromosomal locus 1p13.3 on serum LDL cholesterol and on angiographically characterized coronary atherosclerosis

(2009) Axel Muendlein et al.   ATHEROSCLEROSIS

Genetic variation at chromosome 1p13.3 affects sortilin mRNA expression, cellular LDL-uptake and serum LDL levels which translates to the risk of coronary artery disease

(2009) Patrick Linsel-Nitschke et al.   ATHEROSCLEROSIS

The proNGF-p75NTR-Sortilin Signalling Complex as New Target for the Therapeutic Treatment of Parkinsons Disease

(2009) L. Chen et al.   CNS & Neurological Disorders-Drug Targets

Involvement of TNF-α in abnormal adipocyte and muscle sortilin expression in obese mice and humans

(2009) V. Kaddai et al.   DIABETOLOGIA

Ligands bind to Sortilin in the tunnel of a ten-bladed β-propeller domain

(2009) Esben M Quistgaard et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Up-regulation of pro-nerve growth factor, neurotrophin receptor p75, and sortilin is associated with retrovirus-induced spongiform encephalomyelopathy

(2008) George Stoica et al.   BRAIN RESEARCH

Neurotoxic and neurotrophic roles of proNGF and the receptor sortilin in the adult and ageing nervous system

(2008) Raya Al-Shawi et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Newly identified loci that influence lipid concentrations and risk of coronary artery disease

(2008) Cristen J Willer et al.   NATURE GENETICS

Six new loci associated with blood low-density lipoprotein cholesterol, high-density lipoprotein cholesterol or triglycerides in humans

(2008) Sekar Kathiresan et al.   NATURE GENETICS

Loci influencing lipid levels and coronary heart disease risk in 16 European population cohorts

(2008) Yurii S Aulchenko et al.   NATURE GENETICS

Emerging roles for centromeres in meiosis I chromosome segregation

(2008) Gloria A. Brar et al.   NATURE REVIEWS GENETICS

AP-1 and retromer play opposite roles in the trafficking of sortilin between the Golgi apparatus and the lysosomes

(2007) Maryssa Canuel et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS