Neuronal Brain-derived Neurotrophic Factor Is Synthesized in Excess, with Levels Regulated by Sortilin-mediated Trafficking and Lysosomal Degradation

NRH2 is a trafficking switch to regulate sortilin localization and permit proneurotrophin-induced cell death

(2009) Taeho Kim et al.   EMBO JOURNAL

New Insights in the Biology of BDNF Synthesis and Release: Implications in CNS Function

(2009) M. E. Greenberg et al.   JOURNAL OF NEUROSCIENCE

ADAMs 10 and 17 Represent Differentially Regulated Components of a General Shedding Machinery for Membrane Proteins Such as Transforming Growth Factor α, L-Selectin, and Tumor Necrosis Factor α

(2009) Sylvain M. Le Gall et al.   MOLECULAR BIOLOGY OF THE CELL

Neuroprotective effects of brain-derived neurotrophic factor in rodent and primate models of Alzheimer's disease

(2009) Alan H Nagahara et al.   NATURE MEDICINE

Neuronal release of proBDNF

(2009) Jianmin Yang et al.   NATURE NEUROSCIENCE

Ligands bind to Sortilin in the tunnel of a ten-bladed β-propeller domain

(2009) Esben M Quistgaard et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Dendritic trafficking of BDNF mRNA is mediated by translin and blocked by the G196A (Val66Met) mutation

(2009) C. Chiaruttini et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Sortilin mediates the lysosomal targeting of cathepsins D and H

(2008) Maryssa Canuel et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Distinct Role of Long 3′ UTR BDNF mRNA in Spine Morphology and Synaptic Plasticity in Hippocampal Neurons

(2008) Juan Ji An et al.   CELL

Proneurotrophins Require Endocytosis and Intracellular Proteolysis to Induce TrkA Activation

(2008) Jacqueline Boutilier et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Inhibition of heme synthesis alters Amyloid Precursor Protein processing

(2008) Luisa Benerini Gatta et al.   JOURNAL OF NEURAL TRANSMISSION

BDNFgene: functional Val66Met polymorphism in mood disorders and schizophrenia

(2008) Janusz K Rybakowski   PHARMACOGENOMICS

The “A Disintegrin And Metalloprotease” (ADAM) family of sheddases: Physiological and cellular functions

(2008) Karina Reiss et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

SNX1 Defines an Early Endosomal Recycling Exit for Sortilin and Mannose 6-Phosphate Receptors

(2008) Muriel Mari et al.   TRAFFIC

AP-1 and retromer play opposite roles in the trafficking of sortilin between the Golgi apparatus and the lysosomes

(2007) Maryssa Canuel et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS