Review
Oncology
Jennifer Sally Samson, Venkatachalam Deepa Parvathi
Summary: Lung cancer is the second most common cancer worldwide and the leading cause of cancer-related deaths. Non-small-cell lung carcinoma (NSCLC) accounts for more than 85% of lung cancer cases, and despite advancements in therapy, the survival rate for NSCLC patients remains low. miRNAs have been identified as molecules that play a crucial role in tumorigenesis and progression of various cancers, including NSCLC. Dysregulation of miRNAs has been recognized as a causative mechanism in NSCLC tumorigenesis. This review discusses the role of miRNAs in NSCLC tumor progression and their potential as therapeutic biomarkers, highlighting specific miRNAs that could be explored for NSCLC management.
Review
Biochemistry & Molecular Biology
Surendra Kumar Sagar
Summary: This review focuses on the function of miR-106b and its downstream targets in cancer, providing insights into how miR-106b regulates cancer cell proliferation, migration, invasion, and metastasis by modulating tumor suppressor genes. The potential of miR-106b as a candidate for detection, diagnosis, and prognosis assessment in different cancer types is highlighted.
Review
Biochemistry & Molecular Biology
Antonino B. D'Assoro, Roberto Leon-Ferre, Eike-Benjamin Braune, Urban Lendahl
Summary: The Notch signaling pathway is important for normal development, but dysregulation of this pathway is associated with various types of tumors. In addition to its role in tumor cells, Notch signaling also affects non-mutated cells in the tumor microenvironment and their interactions with tumor cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Oncology
Antonio Ferreira, Jon C. Aster
Summary: Notch receptors participate in a conserved signaling pathway that has diverse effects on normal cells and is highly dependent on the cellular context and signaling dosage. Notch plays different roles in various types of cancers, acting as either an oncogene or a tumor suppressor and affecting tumor cells and stromal elements in multiple ways. This review provides an overview of the roles of Notch in cancer and discusses the challenges and potential approaches for clinical translation of Notch targeting agents.
SEMINARS IN CANCER BIOLOGY
(2022)
Review
Pathology
Nehal I. Rizk, Heba M. Midan, Gouda Kamel Helal, Ahmed I. Abulsoud, Shereen Saeid Elshaer, Ahmed A. El-Husseiny, Doaa Fathi, Nourhan M. Abdelmaksoud, Sherif S. Abdel Mageed, Mohammed S. Elballal, Mohamed Bakr Zaki, Mai A. Abd-Elmawla, Tohada M. AL-Noshokaty, Mahmoud A. Elrebehy, Walaa A. El-Dakroury, Logyna A. Abulsoud, Ahmed S. Doghish
Summary: Merkel cell carcinoma (MCC) is a rare invasive form of skin cancer characterized by nodules on the face, head, or neck. It has a high mortality rate and lacks a universal molecular signature for its pathogenesis. Variations in microRNA expression have been associated with MCC and studying their potential role beyond survival in MCC is important.
PATHOLOGY RESEARCH AND PRACTICE
(2023)
Review
Pathology
Maghawry Hegazy, Mohamed A. Elkady, Amr Mohamed Yehia, Elsayed G. E. Elsakka, Ahmed I. Abulsoud, Nourhan M. Abdelmaksoud, Ahmed Elshafei, Tamer M. Abdelghany, Samy Y. Elkhawaga, Ahmed Ismail, Mahmoud Mohamed Mokhtar, Hesham A. El-Mahdy, Ahmed S. Doghish
Summary: Laryngeal cancer is a malignancy of the larynx and is associated with various risk factors. Dysregulated microRNA expressions play a significant role in LC progression, apoptosis, EMT, and angiogenesis. Furthermore, microRNAs are involved in important signaling pathways and can modulate LC response to different therapies.
PATHOLOGY RESEARCH AND PRACTICE
(2023)
Review
Biochemistry & Molecular Biology
Da Young Lee, Jung Nyeo Chun, Minsoo Cho, Insuk So, Ju-Hong Jeon
Summary: E2F8 is a multifaceted transcription factor that is involved in various aspects of cancer development and progression. It has the ability to promote cancer cell proliferation and survival while also exhibiting tumor-suppressing activity. This review highlights the recent progress in understanding the role of E2F8 in human cancers and its implications for developing therapeutic strategies.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2023)
Article
Biochemistry & Molecular Biology
Javier Robles-Valero, Lucia Fernandez-Nevado, L. Francisco Lorenzo-Martin, Myriam Cuadrado, Isabel Fernandez-Pisonero, Sonia Rodriguez-Fdez, N. Astorga-Simon, Antonio Abad, Ruben Caloto, Xose R. Bustelo
Summary: Mutations in the VAV1 gene can be classified into five subtypes based on their functional impact on the three main signaling branches, leading to changes in VAV1 signaling output and potential therapeutic vulnerabilities. The most frequent VAV1 mutant subtype drives PTCL formation by engaging downstream signaling branches to promote chronic activation and transformation of follicular helper T cells.
Article
Pathology
Samy Y. Elkhawaga, Ahmed Elshafei, Mohamed A. Elkady, Amr Mohamed Yehia, Ahmed I. Abulsoud, Nourhan M. Abdelmaksoud, Elsayed G. E. Elsakka, Ahmed Ismail, Mahmoud Mohamed Mokhtar, Hesham A. El-Mahdy, Maghawry Hegazy, Mohammed S. Elballal, Osama A. Mohammed, Mustafa Ahmed Abdel-Reheim, Walaa A. El-Dakroury, Sherif S. Abdel Mageed, Mahmoud A. Elrebehy, Reem K. Shahin, Mohamed Bakr Zaki, Ahmed S. Doghish
Summary: This study investigates the potential role of miRNAs in the development of PCC and explores their association with survival rates and treatment options.
PATHOLOGY RESEARCH AND PRACTICE
(2023)
Review
Pathology
Ahmed Hjazi, Rasha Fadhel Obaid, Sally Saad Ali, Bekhzod Abdullaev, Hashem O. Alsaab, Huldani Huldani, Rosario Mireya Romero-Parra, Yasser Fakri Mustafa, Beneen M. Hussien, Sarah Jaafar Saadoon
Summary: Long non-coding RNAs (lncRNAs) transcribed from the human genome have emerged as important regulators in cellular activities, particularly in controlling gene expression. They have been found to regulate various factors related to tumorigenesis through the JAK-STAT signaling pathway, either by directly targeting or indirectly modulating its components. Moreover, lncRNAs can also act as downstream effectors of the pathway. The relationship between JAK-STAT signaling and lncRNAs varies among different types of cancers, and lncRNAs play a dual role in tumorigenesis or tumor suppression. This review focuses on the reciprocal regulation and functions of lncRNAs and the JAK-STAT pathway, providing insights into potential targets for clinical therapeutics.
PATHOLOGY RESEARCH AND PRACTICE
(2023)
Review
Oncology
Maja T. Tomicic, Mona Dawood, Thomas Efferth
Summary: Colorectal cancer (CRC) is a common type of tumor, with half of all patients carrying missense mutations in the TP53 tumor suppressor gene. In addition to genetic mutations, epigenetic changes also play a role in CRC development. This review focuses on epigenetic modifications related to the entire p53 signaling pathway, which can impact the tumor suppressor function of p53 regardless of genetic mutations. The complexity of p53's role in CRC development and patient prognosis suggests the potential for novel diagnostic methods to evaluate genetic and epigenetic changes in the p53 signal pathway for improved diagnostics and management of CRC.
Review
Cell Biology
Priyanka Samji, Manoj K. Rajendran, Vidya P. Warrier, Akshayaa Ganesh, Karunagaran Devarajan
Summary: Recent studies have shown that dysregulation of Hippo signaling, particularly the hyper activation of YAP/TAZ, can lead to uncontrolled cell proliferation and malignancy. Additionally, Hippo pathway may play a role in mediating chemotherapeutic resistance in cancer cells.
CELLULAR SIGNALLING
(2021)
Article
Biochemistry & Molecular Biology
Francisco Alejandro Lagunas-Rangel
Summary: KDM6B is a histone demethylase that can act as a tumor suppressor or an oncogene depending on the cellular context. This study summarizes the role of KDM6B in different oncological contexts, aiming to guide its clinical application.
Article
Medicine, Research & Experimental
Shahin Alizadeh-Fanalou, Mohsen Khosravi, Fatemeh Alian, Shirin Rokhsartalb-Azar, Ali Nazarizadeh, Maryam Karimi-Dehkordi, Forogh Mohammadi
Summary: miR-1297, a microRNA with dual functions, exhibits abnormal expression in various human cancers, acting as both a tumor suppressor and an oncogene.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Cell Biology
Min Yue Zhang, Lu Qian Wang, Chor Sang Chim
Summary: miR-1250-5p is a novel tumor suppressive intronic miRNA co-regulated and silenced by promoter DNA methylation of its host gene AATK in NHL. MAPK1 and WDR1 are novel miR-1250-5p direct targets rendering inhibition of MAPK/ERK signaling and SDF-1-dependent cell migration, hence implicated in survival and dissemination of lymphoma.
CELL COMMUNICATION AND SIGNALING
(2021)