Article
Cell Biology
Yaxuan Wang, Haixia Zhu, Haifei Xu, Yifan Qiu, Yonghong Zhu, Xiaolin Wang
Summary: Patients with advanced bladder cancer often develop chemoresistance, leading to tumor recurrence. In this study, the senescence program in solid tumors was shown to improve short-term drug sensitivity. The important role of c-Myc in bladder cancer cell senescence was determined using bioinformatics analysis. The study also revealed that reducing the expression levels of c-Myc and HSP90B1 could inhibit bladder cancer cell proliferation, promote cellular senescence, and enhance cisplatin chemosensitivity. The HSP90B1/c-Myc interaction was found to regulate the p21 signaling pathway, which affects cisplatin sensitivity by modulating bladder cancer cell senescence.
Article
Developmental Biology
Olga Zaytseva, Naomi C. Mitchell, Damien Muckle, Caroline Delandre, Zuqin Nie, Janis K. Werner, John T. Lis, Eduardo Eyras, Ross D. Hannan, David L. Levens, Owen J. Marshall, Leonie M. Quinn
Summary: FUBP1 and Psi, members of the FUSE Binding Protein family, regulate gene transcription by binding to single-stranded DNA and RNA, promoting cell growth and division. Psi activates Myc and stg to promote cell proliferation, while repressing the transcription of tok, a growth inhibitor.
Article
Cardiac & Cardiovascular Systems
Aleksandra Boikova, Megan J. Bywater, Gregory A. Quaife-Ryan, Jasmin Straube, Lucy Thompson, Camilla Ascanelli, Trevor D. Littlewood, Gerard I. Evan, James E. Hudson, Catherine H. Wilson
Summary: The study reveals that Myc and HRas can cooperate to induce proliferation in adult mammalian cardiomyocytes, but the activity of HRas also leads to cell death, limiting its potential as a regenerative therapeutic target.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Cell Biology
Yimeng Zhang, Peng Ding, Yuanyong Wang, Changjian Shao, Kai Guo, Hanyi Yang, Yingtong Feng, Jiayi Ning, Minghong Pan, Ping Wang, Xiaolong Yan, Zhiqiang Ma, Jing Han
Summary: This study found that HDAC7 is overexpressed in choroidal melanoma tissues and promotes cell proliferation and metastasis, while inhibition of HDAC7 suppresses cell proliferation and metastasis. Furthermore, HDAC7 achieves its cancer-promoting effect in choroidal melanoma through the c-Myc signaling pathway.
CELL DEATH & DISEASE
(2023)
Article
Immunology
Rahul Sharma, Ryan M. Smolkin, Priyanka Chowdhury, Keith Conrad Fernandez, Youngjun Kim, Montserrat Cols, William Alread, Wei-Feng Yen, Wei Hu, Zhong-Min Wang, Sara Violante, Ronan Chaligne, Ming O. Li, Justin R. Cross, Jayanta Chaudhuri
Summary: Sharma et al. identify an early metabolic checkpoint dependent upon lactate dehydrogenase for newly activated B cells to enter germinal centers. The metabolic requirements of naive and activated B cells differ and are regulated by niche and cellular interactions.
Review
Oncology
Sofia Zanotti, Bieke Decaesteker, Suzanne Vanhauwaert, Bram De Wilde, Winnok H. De Vos, Frank Speleman
Summary: Neuroblastoma, a common tumor in children under five, has poor treatment outcomes for high-risk cases and causes long-term side effects. Cellular senescence has been considered a barrier against tumorigenesis, but recent research suggests a more complex and reversible nature for this process, which may impact treatment strategies. Neuroblastoma cells in a senescent state may escape treatment and promote relapse, but senescence could also provide opportunities for new therapies.
BRITISH JOURNAL OF CANCER
(2022)
Article
Multidisciplinary Sciences
Yapei Huang, Juliana E. Shin, Alexander M. Xu, Changfu Yao, Sandy Joung, Min Wu, Ruan Zhang, Bongha Shin, Joslyn Foley, Simeon B. Mahov, Matthew E. Modes, Joseph E. Ebinger, Matthew Driver, Jonathan G. Braun, Caroline A. Jefferies, Tanyalak Parimon, Chelsea Hayes, Kimia Sobhani, Akil Merchant, Sina A. Gharib, Stanley C. Jordan, Susan Cheng, Helen S. Goodridge, Peter Chen
Summary: Host factors such as age, sex, obesity, and other comorbidities can impact the effectiveness of COVID-19 vaccines. A study identified healthcare workers with unexpectedly low antibody levels after receiving the BNT162b2 vaccine. These individuals had fewer antibody-producing cells and weaker T cell responses, potentially due to premature lymphocyte aging.
Article
Medicine, General & Internal
Zhi-Qiang Ma, Ying-Tong Feng, Kai Guo, Dong Liu, Chang-Jian Shao, Ming-Hong Pan, Yi-Meng Zhang, Yu-Xi Zhang, Di Lu, Di Huang, Fan Zhang, Jin-Liang Wang, Bo Yang, Jing Han, Xiao-Long Yan, Yi Hu
Summary: This study investigates the antitumor effect of melatonin on esophageal squamous cell carcinoma (ESCC). The results demonstrate that melatonin inhibits the proliferation of ESCC cells and reduces the expression of specific genes. Furthermore, the study reveals the involvement of the HDAC7 / beta-catenin / c-Myc axis and the USP10 / HDAC7 pathway in the regulation of ESCC cell growth by melatonin.
MILITARY MEDICAL RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Raquel Sales-Gil, Dorothee C. Kommer, Ines J. de Castro, Hasnat A. Amin, Veronica Vinciotti, Cristina Sisu, Paola Vagnarelli
Summary: H2A.Z is a histone variant crucial for various biological processes, with two paralogues - H2A.Z.1 and H2A.Z.2 - having distinct functions in cell cycle regulation. While H2A.Z.1 regulates cell cycle genes and can lead to G1 arrest and cellular senescence upon depletion, H2A.Z.2 is important for centromere integrity and sister chromatid cohesion regulation for proper chromosome segregation.
Article
Immunology
James S. Chavez, Jennifer L. Rabe, Dirk Loeffler, Kelly C. Higa, Giovanny Hernandez, Taylor S. Mills, Nouraiz Ahmed, Rachel L. Gessner, Zhonghe Ke, Beau M. Idler, Katia E. Nino, Hyunmin Kim, Jason R. Myers, Brett M. Stevens, Pavel Davizon-Castillo, Craig T. Jordan, Hideaki Nakajima, John Ashton, Robert S. Welner, Timm Schroeder, James DeGregori, Eric M. Pietras
Summary: Long-term HSCs can rapidly repress protein synthesis and cell cycle genes in response to inflammatory signals via the transcription factor PU.1, and PU.1 deficiency leads to aberrant proliferation and expansion of HSCs. This PU.1-dependent mechanism limits HSC proliferation and pool size in response to innate immune stimulation.
JOURNAL OF EXPERIMENTAL MEDICINE
(2021)
Article
Multidisciplinary Sciences
Lucy LeBlanc, Mijeong Kim, Aparna Kambhampati, Albert J. Son, Nereida Ramirez, Jonghwan Kim
Summary: Cell density impacts gene expression and differentiation in mouse embryonic stem cells; β-catenin is primarily at adherens junctions at high density but translocates to the nucleus at low density; Esrrb maintains pluripotency gene expression at high density and decreases DNA association at low density.
Article
Cell Biology
Guoxi Zhang, Junrong Zou, Jinglin Shi, Biao Qian, Kaiyang Qiu, Quanliang Liu, Tianpeng Xie, Zhihua He, Hui Xu, Yunfeng Liao, Yuting Wu, Yanmin Li, Guancheng Xiao, Yuanhu Yuan, Rihai Xiao, Gengqing Wu, Xiaofeng Zou
Summary: UBA2 expression is higher in clear cell renal cell carcinoma compared to normal tissues, and is significantly related to tumor size, Fuhrman grade, and tumor stage. Knockdown of UBA2 inhibits ccRCC cell growth, promotes apoptosis, and decreases key enzyme abundance of the SUMO modification system. Targeting UBA2 may have therapeutic potential against ccRCC.
CELL DEATH & DISEASE
(2021)
Review
Cell Biology
Rajiv Kumar Jha, Fedor Kouzine, David Levens
Summary: MYC is a universal transcription amplifier that regulates various physiological processes and is associated with multiple diseases. Understanding the biology and regulation of MYC is crucial.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Chen Xu, Bingyan Li, Ning Yu, Bo Yao, Fang Wang, Yide Mei
Summary: The c-Myc oncoprotein is important in tumorigenesis and its overexpression has been linked to various human cancers, including lung adenocarcinoma. This study identified hnRNPAB as a direct transcriptional target of c-Myc and showed that it promotes lung adenocarcinoma cell proliferation by regulating CDK4 and the G1/S cell cycle progression.
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
(2023)
Article
Cell & Tissue Engineering
Laura Garcia-Prat, Kerstin B. Kaufmann, Florin Schneiter, Veronique Voisin, Alex Murison, Jocelyn Chen, Michelle Chan-Seng-Yue, Olga Gan, Jessica L. McLeod, Sabrina A. Smith, Michelle C. Shoong, Darrien Parris, Kristele Pan, Andy G. X. Zeng, Gabriela Krivdova, Kinam Gupta, Shin-Ichiro Takayanagi, Elvin Wagenblast, Weijia Wang, Mathieu Lupien, Timm Schroeder, Stephanie Z. Xie, John E. Dick
Summary: This study reveals that transcription factor EB-mediated control of lysosomal activity plays a central role in regulating the fate determination of stem cells. TFEB induces the endolysosomal pathway to limit LT-HSC activation, promoting quiescence and self-renewal, while MYC engages biosynthetic processes to drive stem cell activation.